381 research outputs found
Steering the Field Quality in the Production of the Main Quadrupoles of the Large Hadron Collider
The main issues concerning the field quality in the main quadrupoles of the Large Hadron Collider are presented. We show the trend plots for the focusing strength and multipoles at room temperature covering more than 2/3 of the production. We describe the correction of the coil layout to improve b6 at injection field level. A non-negligible fraction of the quadrupoles has been manufactured with collars featuring a magnetic permeability somewhat higher than the specified limits. We show plots for this anomaly. Field quality correlations to measurements in operational conditions are discussed. The dependence of field quality on cable manufacturer is analyse
Stimulation programs for pediatric drug research â do children really benefit?
Most drugs that are currently prescribed in pediatrics have not been tested in children. Pediatric drug studies are stimulated in the USA by the pediatric exclusivity provision under the Food and Drug Administration Modernization Act (FDAMA) that grants patent extensions when pediatric labeling is provided. We investigated the effectiveness of these programs in stimulating drug research in children, thereby increasing the evidence for safe and effective drug use in the pediatric population. All drugs granted pediatric exclusivity under the FDAMA were analyzed by studying the relevant summaries of medical and clinical pharmacology reviews of the pediatric studies or, if these were unavailable, the labeling information as provided by the manufacturer. A systematic search of the literature was performed to identify drug utilization patterns in children. From July 1998 to August 2006, 135 drug entities were granted pediatric exclusivity. Most frequent drug groups were anti-depressants and mood stabilizers, ACE inhibitors, lipid-lowering preparations, HIV antivirals, and non-steroidal anti-inflammatory and anti-rheumatic drugs. The distribution of the different drugs closely matched the distribution of these drugs over the adult market, and not the drug utilization by children
Performance of the LHC Arc Superconducting Quadrupoles Towards the End of their Series Fabrication
The fabrication of the 408 main arc quadrupole magnets and their cold masses will come to an end in summer 2006. A rich collection of measurement and test data has been accumulated and their analysis is presented in this paper. These data cover the fabrication and the efficiency in the use of the main components, the geometrical measurements and the achieved dimensional precision, the warm magnetic measurements in the factory and the performance at cold conditions, especially the training behaviour. The scrap rate of the Nb-Ti/Cu conductor as well as that of other components turned out to be acceptably low and the quench performance measured was in general very good. Most quadrupoles measured so far exceeded the operating field gradient with one or no quench. The multipole content at cold was measured for a limited number of quadrupoles in order to verify the warm-to-cold correlation. From the point of view of field quality, all quadrupoles could be accepted for the machine. The measures taken to overcome the problem of a too high permeability of a batch of collars are discussed
The Bending Magnets for the Proton Transfer Line of CNGS
The project "CERN neutrinos to Gran Sasso (CNGS)", a collaboration between CERN and the INFN (Gran Sasso Laboratory) in Italy, will study neutrino oscillations in a long base-line experiment. High-energy protons will be extracted from the CERN SPS accelerator, transported through a 727 m long transfer line and focused onto a graphite target to produce a beam of pions and kaons and subsequently neutrinos. The transfer line requires a total of 78 dipole magnets. They were produced in the framework of an in-kind contribution of Germany via DESY to the CNGS project. The normal conducting dipoles, built from laminated steel cores and copper coils, have a core length of 6.3 m, a 37 mm gap height and a nominal field range of 1.38 T - 1.91 T at a maximum current of 4950 A. The magnet design was a collaboration between CERN and BINP. The half-core production was subcontracted to EFREMOV Institute; the coil fabrication, magnet assembly and the field measurements were concluded at BINP in June 2004. The main design issues and results of the acceptance tests, including mechanical, electrical and magnetic field measurements, are discussed
Measurement of Spin Correlation Parameters A, A, and A_ at 2.1 GeV in Proton-Proton Elastic Scattering
At the Cooler Synchrotron COSY/J\"ulich spin correlation parameters in
elastic proton-proton (pp) scattering have been measured with a 2.11 GeV
polarized proton beam and a polarized hydrogen atomic beam target. We report
results for A, A, and A_ for c.m. scattering angles between
30 and 90. Our data on A -- the first measurement of this
observable above 800 MeV -- clearly disagrees with predictions of available of
pp scattering phase shift solutions while A and A_ are reproduced
reasonably well. We show that in the direct reconstruction of the scattering
amplitudes from the body of available pp elastic scattering data at 2.1 GeV the
number of possible solutions is considerably reduced.Comment: 4 pages, 4 figure
The Quadrupole Magnets for the LHC Injection Transfer Lines
Two injection transfer lines, each about 2.8 km long, are being built to transfer protons at 450 GeV from the Super Proton Synchrotron (SPS) to the Large Hadron Collider (LHC). A total of 180 quadrupole magnets are required; they are produced in the framework of the contribution of the Russian Federation to the construction of the LHC. The classical quadrupoles, built from laminated steel cores and copper coils, have a core length of 1.4 m, an inscribed diameter of 32 mm and a strength of 53.5 T/m at a current of 530 A. The total weight of one magnet is 1.1 ton. For obtaining the required field quality at the small inscribed diameter, great care in the stamping of the laminations and the assembly of quadrants is necessary. Special instruments have been developed to measure, with a precision of some mm, the variations of the pole gaps over the full length of the magnet and correlate them to the obtained field distribution. The design has been developed in a collaboration between BINP and CERN. Fabrication and the magnetic measurements are done at BINP and should be finished at the end of the year 2000
A Precision Measurement of pp Elastic Scattering Cross Sections at Intermediate Energies
We have measured differential cross sections for \pp elastic scattering with
internal fiber targets in the recirculating beam of the proton synchrotron
COSY. Measurements were made continuously during acceleration for projectile
kinetic energies between 0.23 and 2.59 GeV in the angular range deg. Details of the apparatus and the data analysis are
given and the resulting excitation functions and angular distributions
presented. The precision of each data point is typically better than 4%, and a
relative normalization uncertainty of only 2.5% within an excitation function
has been reached. The impact on phase shift analysis as well as upper bounds on
possible resonant contributions in lower partial waves are discussed.Comment: 23 pages 29 figure
The spatially resolved correlation between [NII] 205ÎŒm line emission and the 24ÎŒm continuum in nearby galaxies
A correlation between the 24 ÎŒm continuum and the [Nii] 205 ÎŒm line emission may arise if both quantities trace the star formation activity on spatially-resolved scales within a galaxy, yet has so far only been observed in the nearby edge-on spiral galaxy NGC 891. We therefore assess whether the [Nii] 205â24 ÎŒm emission correlation has some physical origin or is merely an artefact of line-of-sight projection effects in an edge-on disc. We search for the presence of a correlation in Herschel and Spitzer observations of two nearby face-on galaxies, Mâ51 and Mâ83, and the interacting Antennae galaxies NGC 4038 and 4039. We show that not only is this empirical relationship also observed in face-on galaxies, but also that the correlation appears to be governed by the star formation rate (SFR). Both the nuclear starburst in Mâ83 and the merger-induced star formation in NGC 4038/9 exhibit less [Nii] emission per unit SFR surface density than the normal star-forming discs. These regions of intense star formation exhibit stronger ionization parameters, as traced by the 70/160 ÎŒm far-infrared (FIR) colour. These observations suggest the presence of higher ionization lines that may become more important for gas cooling, thereby reducing the observed [Nii] 205 ÎŒm line emission in regions with higher star formation rates. Finally, we present a general relation between the [Nii] 205 ÎŒm line flux density and SFR density for normal star-forming galaxies, yet note that future studies should extend this analysis by including observations with wider spatial coverage for a larger sample of galaxies
On the origin of M81 group extended dust emission
Galactic cirrus emission at far-infrared wavelengths affects many extragalactic observations. Separating this emission from that associated with extragalactic objects is both important and difficult. In this paper we discuss a particular case, the M81 group, and the identification of diffuse structures prominent in the infrared, but also detected at optical wavelengths. The origin of these structures has previously been controversial, ranging from them being the result of a past interaction between M81 and M82 or due to more local Galactic emission. We show that over an order of a few arcmin scales, the far-infrared (Herschel 250 mu m) emission correlates spatially very well with a particular narrow-velocity (2-3 km s(-1)) component of the Galactic HI. We find no evidence that any of the far-infrared emission associated with these features actually originates in the M81 group. Thus we infer that the associated diffuse optical emission must be due to galactic light-back scattered off dust in our galaxy. Ultraviolet observations pick out young stellar associations around M81, but no detectable far-infrared emission. We consider in detail one of the Galactic cirrus features, finding that the far-infrared HI relation breaks down below arcmin scales and that at smaller scales there can be quite large dust-temperature variation
SPIRE imaging of M82: cool dust in the wind and tidal streams
M82 is a unique representative of a whole class of galaxies, starbursts with
superwinds, in the Very Nearby Galaxy Survey with Herschel. In addition, its
interaction with the M81 group has stripped a significant portion of its
interstellar medium from its disk. SPIRE maps now afford better
characterization of the far-infrared emission from cool dust outside the disk,
and sketch a far more complete picture of its mass distribution and energetics
than previously possible. They show emission coincident in projection with the
starburst wind and in a large halo, much more extended than the PAH band
emission seen with Spitzer. Some complex substructures coincide with the
brightest PAH filaments, and others with tidal streams seen in atomic hydrogen.
We subtract the far-infrared emission of the starburst and underlying disk from
the maps, and derive spatially-resolved far-infrared colors for the wind and
halo. We interpret the results in terms of dust mass, dust temperature, and
global physical conditions. In particular, we examine variations in the dust
physical properties as a function of distance from the center and the wind
polar axis, and conclude that more than two thirds of the extraplanar dust has
been removed by tidal interaction, and not entrained by the starburst wind.Comment: accepted in A&A Herschel special issu
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