TDC Chip and Readout Driver Developments for COMPASS and LHC-Experiments

A new TDC-chip is under development for the COMPASS experiment at CERN. The ASIC, which exploits the 0.6 micrometer CMOS sea-of-gate technology, will allow high resolution time measurements with digitization of 75 ps, and an unprecedented degree of flexibility accompanied by high rate capability and low power consumption. Preliminary specifications of this new TDC chip are presented. Furthermore a FPGA based readout-driver and buffer-module as an interface between the front-end of the COMPASS detector systems and an optical S-LINK is in development. The same module serves also as remote fan-out for the COMPASS trigger distribution and time synchronization system. This readout-driver monitors the trigger and data flow to and from front-ends. In addition, a specific data buffer structure and sophisticated data flow control is used to pursue local pre-event building. At start-up the module controls all necessary front-end initializations.Comment: 5 pages, 4 figure

Demand response strategy applied to planning the operation of an air conditioning system: Application to a medical center

Large air conditioning systems, such as those used in shopping and health centers, typically demand high amounts of energy. Several air conditioning technologies and energy management strategies seek to minimize consumption to reduce billing expenses and improve system efficiency. This work proposes a demand response framework to plan the daily operation of an air conditioning system with the aim of minimizing the energy cost and guaranteeing thermal comfort. The framework includes an electrical-analogous thermal model, the formulation of the energy optimization problem with thermal and electrical constraints. The ISO 7730 standard is used to evaluate thermal comfort. The approach is applied to the air conditioning system of a radiotherapy and medical imaging center in Argentina. The optimization problem is solved through a genetic algorithm. To evaluate the strategy, two scenarios with different power demands are proposed: Case 1 (with demands lower than 300 kW) and Case 2 (with a peak demand greater than 300 kW). The results are compared with those obtained from an on-off strategy control with hysteresis. Penalties for large demands are avoided in Case 2, and therefore an economic saving of ≅ 16.8% is achieved. The thermal comfort is improved in both cases, with thermal cost reduction of 40.6% and 29.2% for Cases 1 and 2, respectively.Fil: Bragagnolo, Sergio Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Tecnologica Nacional. Facultad Regional Cordoba. Centro de Investigacion Desarrollo y Transferencia de Ingenieria En Energia Electrica.; ArgentinaFil: Schierloh, R. M.. Universidad Tecnológica Nacional. Facultad Regional Paraná; ArgentinaFil: Vega, Jorge Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Vaschetti, Jorge Carlos. Universidad Tecnologica Nacional. Facultad Regional Cordoba. Centro de Investigacion Desarrollo y Transferencia de Ingenieria En Energia Electrica.; Argentin

Evaluación Económica de Micro-redes Eléctricas con Generación Renovable

Argentina debe incrementar la incorporación de energía renovable a su matriz energética y simultáneamente generar estrategias eficientes para su gestión. En tal sentido, las microrredes eléctricas permiten enfrentar los desafíos técnicos asociados a la gestión de energía orientada a compensar la baja predictibilidad de la generación debido a la elevada variabilidad de las fuentes renovables. Este trabajo analiza la viabilidad económica de instalar dos microrredes (con aporte de energía renovable), de interés para la región Litoral-Centro de Argentina. El primer caso analizado consiste en alimentar un aserradero aislado. El segundo caso es una propuesta de interés para que un gran usuario (más de trescientos kilowatts ?300 kW? de potencia instalada) cumpla de manera rentable su obligación de autogenerar energía renovable utilizando una turbina hidrocinética de río para abastecer un sector de alumbrado público. Se utiliza Homer Pro para dimensionar en forma óptima los componentes de la microrred y para simular su desempeño eléctrico y económico a lo largo de su vida útil. Los resultados son prometedores para la región considerando los recursos disponibles en el Litoral argentino.Fil: Godoy, José Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Schierloh, R. M.. Universidad Tecnológica Nacional. Facultad Regional Paraná; ArgentinaFil: Vega, Jorge Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

F1: An Eight Channel Time-to-Digital Converter Chip for High Rate Experiments

A new TDC chip has been developed for the COMPASS experiment at CERN. The resulting ASIC offers an unprecedented degree of flexibility and functionality. Its capability to handle highest hit and trigger input rates as well as its low power consumption makes it an ideal tool for future collider and fixed target experiments. First front-end boards equipped with the F1 chip have been used recently at testbeam experiments at CERN. A functional description and specification for this new TDC chip is presented.A new TDC chip has been developed for the COMPASS experiment at CERN. The resulting ASIC offers an unprecedented degree of flexibility and functionality. Its capability to handle highest hit and trigger input rates as well as its low power consumption makes it an ideal tool for future collider and fixed target experiments. First front-end boards equipped with the F1 chip have been used recently at testbeam experiments at CERN. A functional description and specification for this new TDC chip is presented

Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial.

BACKGROUND: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1 diabetes and their families. However, research so far has not reported insulin levels while comparing closed-loop to open-loop insulin delivery in children. Therefore, in this study we obtained glucose levels as well as plasma insulin levels in children with type 1 diabetes to evaluate the efficacy of a model-based closed-loop algorithm compared to an open-loop administration. METHODS: Fifteen children with type 1 diabetes, 6-12 years, participated in this open-label single center study. We used a randomized cross over design in which we compared overnight closed-loop insulin delivery with sensor augmented pump therapy for two nights in both the hospital and at home (i.e., 1 night in-patient stay and at home per treatment condition). Only during the in-patient stay, hourly plasma insulin and blood glucose levels were assessed and are reported in this paper. RESULTS: Results of paired sample t-tests revealed that although plasma insulin levels were significantly lower during the closed-loop than in the open-loop (Mean difference 36.51 pmol/l; t(13) = 2.13, p = .03, effect size d = 0.57), blood glucose levels did not vary between conditions (mean difference 0.76 mmol/l; t(13) = 1.24, p = .12, d = 0.37). The administered dose of insulin was significantly lower during the closed-loop compared with the open-loop (mean difference 0.10 UI; t(12) = 2.45, p = .02, d = 0.68). CONCLUSIONS: Lower insulin doses were delivered in the closed-loop, resulting in lower plasma insulin levels, whereby glucose levels were not affected negatively. This suggests that the closed-loop administration is better targeted and hence could be more effective

Revisiting Molossus (Mammalia: Chiroptera: Molossidae) diversity: Exploring southern limits and revealing a novel species in Argentina

Abstract Understanding species diversity and delineating their boundaries are crucial for effective management and conservation efforts. In the case of bats, species identification holds particular importance from an epidemiological standpoint. The genus Molossus (Chiroptera: Molossidae) encompasses 15 species distributed across the Neotropics, ranging from the southeastern United States to Argentina. This genus exhibits two contrasting patterns of variation: some species are cryptic, while others are morphologically distinct yet genetically similar. This study explores the diversity of Molossus in Argentina through a molecular phylogenetic approach. We analyzed sequences from three molecular markers (cyt b, COI, and FGB) along with morphology data obtained from a sample of 64 individuals. Uni- and multivariate analyses of external and cranial measurements were conducted, alongside comparisons of external and cranial characteristics among species. Based on molecular and morphological differences, we describe a new species within the Molossus genus. This newly discovered species exhibits a broad distribution spanning the Paraná River basin across three distinct ecoregions. It is noteworthy that this species is pseudo-cryptic with respect to similar-sized species such as M. molossus and M. melini. Additionally, it is important to mention that all species in Argentina have overlapping distribution ranges. In summary, this study provides valuable insights into the diversity and distribution of Molossus bats in Argentina, employing molecular and morphological analyses. The discovery of a new species underscores the ongoing importance of comprehensive research efforts in understanding and conserving bat populations in the Neotropics

Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes – Baseline Assessment

Background: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental well-being and child behavior. Methods: All parents were invited to fill in baseline questionnaires: hypoglycemia fear survey (HFS), WHO-5, Epworth Sleepiness Scale and Strength and Difficulties Questionnaire (SDQ). Results: 24 children (median age: 5-year, range 1-7 years, 63% male, mean diabetes duration: 3 ± 1.7 years) participated. 23/24 parents filled out the questionnaires. We found a higher score for the hypoglycemia fear behavior 33.9 ± 5.6 compared to hypoglycemia worry 34.6 ± 12.2. Median WHO-5 score was 16 (8 - 22) with poor well-being in two parents. Median daytime sleepiness score was high in five parents (>10). For six children a high total behavioral difficulty score (>16) was reported. Pro social behavior score was lower than normal in six children (<6). Parental well-being was negatively associated with HFS total (r = - 0.50, p <.05) and subscale scores (r = - 0.44, p <.05 for HFS-Worry and HFS-Behavior), child behavior (r = - 0.45, p = .05) and positively with child age and diabetes duration (r = 0.58, p <.01, r = 0.6, p <.01). HFS, parental well-being nor daytime sleepiness are associated with the HbA1c. Conclusion: Regular screening of parental well-being, hypoglycemia fear and child behavior should be part of routine care to target early intervention

Bayesian Approach to Model CD137 Signaling in Human M.tuberculosis in vitro Responses

Abstract Immune responses are qualitatively and quantitatively influenced by a complex network of receptor-ligand interactions. Among them, the CD137:CD137L pathway is known to modulate innate and adaptive human responses against Mycobacterium tuberculosis. However, the underlying mechanisms of this regulation remain unclear. In this work, we developed a Bayesian Computational Model (BCM) of in vitro CD137 signaling, devised to fit previously gathered experimental data. The BCM is fed with the data and the prior distribution of the model parameters and it returns theirposterior distribution and the model evidence, which allows comparing alternative signaling mechanisms. The BCM uses a coupled system of non-linear differential equations to describe the dynamics of Antigen Presenting Cells, Natural Killer and T Cells together with the interpheron (IFN)-c and tumor necrosis factor (TNF)-a levels in the media culture. Fast and complete mixing of the media is assumed. The prior distribution of the parameters that describe the dynamics of the immunological response was obtained from the literature and theoretical considerations Our BCM applies successively the Levenberg-Marquardt algorithm to find the maximum a posteriori likelihood (MAP); the Metropolis Markov Chain Monte Carlo method to approximate the posterior distribution of the parameters and Thermodynamic Integration to calculate the evidence of alternative hypothesis. Bayes factors provided decisive evidence favoring direct CD137 signaling on T cells. Moreover, the posterior distribution of the parameters that describe the CD137 signaling showed that the regulation of IFNc levels is based more on T cells survival than on direct induction. Furthermore, the mechanisms that account for the effect of CD137 signaling on TNF-a production were based on a decrease of TNF-a production by APC and, perhaps, on the increase in APC apoptosis. BCM proved to be a useful tool to gain insight on the mechanisms of CD137 signaling during human response against Mycobacterium tuberculosis.Fil: Darío A Fernández Do Porto. UNIV.DE BUENOS AIRES. FAC.DE CS.EXACTAS Y NATURALES. UNIV.DE BUENOS AIRES. FAC.DE CS.EXACTAS Y NATURALES. INST QUIM FISICA D/L/MATERIALES MED AMB Y ENERG.Fil: Jerónimo Auzmendi. UNIV.DE BUENOS AIRES. FAC.DE CS.EXACTAS Y NATURALES. INST QUIM FISICA D/L/MATERIALES MED AMB Y ENERG.Fil: Delfina Peña. UNIV.DE BUENOS AIRES. FAC.DE CS.EXACTAS Y NATURALES. CONSEJO NAC.DE INVEST.CIENTIF.Y TECNICAS. OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA. INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES. UNIV.DE BUENOS AIRES. FAC.DE CS.EXACTAS Y NATURALES. DTO.DE QUIMICA BIOLOGICA.Fil: Veronica E Garcia. CONSEJO NAC.DE INVEST.CIENTIF.Y TECNICAS. OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA. INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES.Fil: Luciano Moffatt. UNIV.DE BUENOS AIRES. FAC.DE CS.EXACTAS Y NATURALES. INST QUIM FISICA D/L/MATERIALES MED AMB Y ENERG