137 research outputs found
Verwirklichung einer vollkommenen GlĂŒcksmöglichkeit/A perfect bliss-potential realized: âWunsch, Indianer zu werdenâ im Lichte des Dao Kafkas ĂŒbersetzend gelesen/Transreading âWish, to Become Indianâ in light of Kafkaâs Dao
Walking an unexplored path, Huiwen Helen Zhang contextualizes Kafka's pithy and cryptic parable, âWish, to Become Indianâ in his transplantation of Daoist philosophyâan astonishing cross-cultural enigma that Zhang terms âKafka's Daoââand parses it through a micro-level approach that Zhang terms âtransreading.â Contextualizing âWish, to Become Indianâ in Kafka's dialogue with ancient Chinese philosophers such as Laozi, Liezi, and Zhuangzi enables the reader to comprehend a series of otherwise incomprehensible puzzles. Zhang's scrutiny of Kafka's Dao shows how, through creative writing, Kafka not only penetrates esoteric Daoist classics, but also furthers their spirit in a way that transcends Richard Wilhelm, the pioneer European Sinologist. Transreading âWish, to Become Indianâ illuminates nuances that otherwise might have been overlooked. Wordplay, punctuational oddity, syntactic complexity, lyric density, and the curiously interlaced tenses and cases are all part of the idiosyncratic delivery of Kafka's message. Integrating the four activities of transreadingâlento reading demanded and enhanced by cultural hermeneutics, creative writing required and inspired by poetic translationâunravels Kafka's riddle as a historical-cultural phenomenon.publishedVersio
Who wants to talk to terrorists?
Interviewing terrorists or former terrorists has become an increasingly popular research method in terrorism studies. What terrorists say can shed light on motivations, decision-making processes and operational details that without first-hand testimony could only be inferred. In this chapter, a selection of these studies is reviewed alongside a consideration of global trends in terrorism and developments in terrorism research
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease
Abstract: Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients (median age-at-diagnosis of 3.5 years), in whom no Mendelian disorders were clinically suspected. In five patients we detect a primary immunodeficiency or enteropathy, with clinical consequences (XIAP, CYBA, SH2D1A, PCSK1). We also present a case study of a VEO-IBD patient with a mosaic de novo, pathogenic allele in CYBB. The mutation is present in ~70% of phagocytes and sufficient to result in defective bacterial handling but not life-threatening infections. Finally, we show that VEO-IBD patients have, on average, higher IBD polygenic risk scores than population controls (99 patients and 18,780 controls; P < 4 Ă 10â10), and replicate this finding in an independent cohort of VEO-IBD cases and controls (117 patients and 2,603 controls; P < 5 Ă 10â10). This discovery indicates that a polygenic component operates in VEO-IBD pathogenesis
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