Meteorology applied to urban air pollution problems: concepts from COST 715

International audienceThis selective review of the COST 715 considers simple descriptive concepts in urban meteorology with particular attention to air pollution assessment. It is shown that these are helpful for understanding the complex structure of the urban boundary layer, but that simple concepts only apply under a limited number of occasions. However such concepts are necessary for insight into how both simple and complex air pollution models perform. Wider considerations are needed when considering routine air quality assessments involving an air quality model's formulation and pedigree. It is argued that there is a reluctance from model developers to move away from familiar concepts of the atmospheric boundary layer even if they are not appropriate to urban areas. An example is given from COST 715 as to how routine urban meteorological measurements of wind speed may be used and adapted for air quality assessments. Reference to the full COST 715 study is made which provides further details

Meteorology applied to urban air pollution problems: concepts from COST 715

International audienceThe outcome of COST 715 is reviewed from the viewpoint of a potential user who is required to consider urban meteorology within an air pollution assessment. It is shown that descriptive concepts are helpful for understanding the complex structure of the urban boundary layer, but that they only apply under a limited number of conditions. However such concepts are necessary to gain insight into both simple and complex air pollution models. It is argued that wider considerations are needed when considering routine air quality assessments involving an air quality model's formulation and pedigree. Moreover there appears to be a reluctance from model developers to move away from familiar concepts of the atmospheric boundary layer even if they are not appropriate to urban areas. An example is given from COST 715 as to how routine urban meteorological measurements of wind speed may be used and adapted for air quality assessments. Reference to the full COST 715 study is made which provides further details

Rheometry for large-particulated fluids: analysis of the ball measuring system and comparison to debris flow rheometry

For large-particulated fluids encountered in natural debris flow, building materials, and sewage treatment, only a few rheometers exist that allow the determination of yield stress and viscosity. In the present investigation, we focus on the rheometrical analysis of the ball measuring system as a suitable tool to measure the rheology of particulated fluids up to grain sizes of 10mm. The ball measuring system consists of a sphere that is dragged through a sample volume of approximately 0.5l. Implemented in a standard rheometer, torques exerted on the sphere and the corresponding rotational speeds are recorded within a wide measuring range. In the second part of this investigation, six rheometric devices to determine flow curve and yield stress of fluids containing large particles with maximum grain sizes of 1 to 25mm are compared, considering both rheological data and application in practical use. The large-scale rheometer of Coussot and Piau, the building material learning viscometer of Wallevik and Gjorv, and the ball measuring system were used for the flow curve determination and a capillary rheometer, the inclined plane test, and the slump test were used for the yield stress determination. For different coarse and concentrated sediment-water mixtures, the flow curves and the yield stresses agree well, except for the capillary rheometer, which exhibits much larger yield stress values. Differences are also noted in the measuring range of the different devices, as well as for the required sample volume that is crucial for applicatio

Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies

Background The arterial pharmacokinetics of ketamine and norketamine enantiomers after racemic ketamine or S-ketamine i.v. administration were evaluated in seven gelding ponies in a crossover study (2-month interval). Methods Anaesthesia was induced with isoflurane in oxygen via a face-mask and then maintained at each pony's individual MAC. Racemic ketamine (2.2mgkg−1) or S-ketamine (1.1mgkg−1) was injected in the right jugular vein. Blood samples were collected from the right carotid artery before and at 1, 2, 4, 8, 16, 32, 64, and 128min after ketamine administration. Ketamine and norketamine enantiomer plasma concentrations were determined by capillary electrophoresis. Individual R-ketamine and S-ketamine concentration vs time curves were analysed by non-linear least square regression two-compartment model analysis using PCNonlin. Plasma disposition curves for R-norketamine and S-norketamine were described by estimating AUC, Cmax, and Tmax. Pulse rate (PR), respiratory rate (Rf), tidal volume (VT), minute volume ventilation (VE), end-tidal partial pressure of carbon dioxide (Pe′CO2), and mean arterial blood pressure (MAP) were also evaluated. Results The pharmacokinetic parameters of S- and R-ketamine administered in the racemic mixture or S-ketamine administered separately did not differ significantly. Statistically significant higher AUC and Cmax were found for S-norketamine compared with R-norketamine in the racemic group. Overall, Rf, VE, Pe′CO2, and MAP were significantly higher in the racemic group, whereas PR was higher in the S-ketamine group. Conclusions Norketamine enantiomers showed different pharmacokinetic profiles after single i.v. administration of racemic ketamine in ponies anaesthetised with isoflurane in oxygen (1 MAC). Cardiopulmonary variables require further investigatio

Development and validation of tools for the implementation of european air quality policy in Germany (Project VALIUM)

International audienceIn the framework of the German Atmospheric Research Program AFO-2000 a system of consistent coupled numerical models has been developed. The purpose of the model system is to serve as a tool for the execution of European urban air quality regulations. A consortium with the acronym VALIUM was formed, which consisted of German research institutes, environmental consultancies and an environmental agency. A substantial part of the VALIUM program was devoted to the generation of a set of high quality data for the validation of the numerical model system. The validation data are based on a combination of field studies, tracer experiments and corresponding wind tunnel experiments. The field experiments were carried out inside and around a street canyon in a city district of Hanover/Germany. After a brief introduction to the VALIUM project a summary of the main results will be given

Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies

Background. The arterial pharmacokinetics of ketamine and norketamine enantiomers after racemic ketamine or S-ketamine i.v. administration were evaluated in seven gelding ponies in a crossover study (2-month interval). Methods. Anaesthesia was induced with isoflurane in oxygen via a face-mask and then maintained at each pony's individual MAC. Racemic ketamine (2.2 mg kg-1) or S-ketamine (1.1 mg kg-1) was injected in the right jugular vein. Blood samples were collected from the right carotid artery before and at 1, 2, 4, 8, 16, 32, 64, and 128 min after ketamine administration. Ketamine and norketamine enantiomer plasma concentrations were determined by capillary electrophoresis. Individual R-ketamine and S-ketamine concentration vs time curves were analysed by non-linear least square regression two-compartment model analysis using PCNonlin. Plasma disposition curves for R-norketamine and S-norketamine were described by estimating AUC, Cmax, and Tmax. Pulse rate (PR), respiratory rate (Rf), tidal volume (VT), minute volume ventilation (VE), end-tidal partial pressure of carbon dioxide (Pe′CO2), and mean arterial blood pressure (MAP) were also evaluated. Results. The pharmacokinetic parameters of S- and R-ketamine administered in the racemic mixture or S-ketamine administered separately did not differ significantly. Statistically significant higher AUC and Cmax were found for S-norketamine compared with R-norketamine in the racemic group. Overall, Rf, VE, Pe′CO2, and MAP were significantly higher in the racemic group, whereas PR was higher in the S-ketamine group. Conclusions. Norketamine enantiomers showed different pharmacokinetic profiles after single i.v. administration of racemic ketamine in ponies anaesthetised with isoflurane in oxygen (1 MAC). Cardiopulmonary variables require further investigation.Facultad de Ciencias Veterinaria

05/18/1993 - Eastern\u27s 1993 All Student Show Winner Laura Brahos.pdf

This paper reports on the stages forming a model evaluation protocol for urban flow and dispersion models proposed within the COST Action 732 on "Quality Assurance and Improvement of Micro-Scale Meteorological Models". It discusses the different components forming model evaluation with emphasis on validation and implementation of the protocol for the test case Mock Urban Setting Test (MUST). The protocol was proposed with building-resolving models in mind, but integral models have also been included. The suggested approach can be used for further micro-scale model evaluation and for the standardisation of their applications

Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies

Background. The arterial pharmacokinetics of ketamine and norketamine enantiomers after racemic ketamine or S-ketamine i.v. administration were evaluated in seven gelding ponies in a crossover study (2-month interval). Methods. Anaesthesia was induced with isoflurane in oxygen via a face-mask and then maintained at each pony's individual MAC. Racemic ketamine (2.2 mg kg-1) or S-ketamine (1.1 mg kg-1) was injected in the right jugular vein. Blood samples were collected from the right carotid artery before and at 1, 2, 4, 8, 16, 32, 64, and 128 min after ketamine administration. Ketamine and norketamine enantiomer plasma concentrations were determined by capillary electrophoresis. Individual R-ketamine and S-ketamine concentration vs time curves were analysed by non-linear least square regression two-compartment model analysis using PCNonlin. Plasma disposition curves for R-norketamine and S-norketamine were described by estimating AUC, Cmax, and Tmax. Pulse rate (PR), respiratory rate (Rf), tidal volume (VT), minute volume ventilation (VE), end-tidal partial pressure of carbon dioxide (Pe′CO2), and mean arterial blood pressure (MAP) were also evaluated. Results. The pharmacokinetic parameters of S- and R-ketamine administered in the racemic mixture or S-ketamine administered separately did not differ significantly. Statistically significant higher AUC and Cmax were found for S-norketamine compared with R-norketamine in the racemic group. Overall, Rf, VE, Pe′CO2, and MAP were significantly higher in the racemic group, whereas PR was higher in the S-ketamine group. Conclusions. Norketamine enantiomers showed different pharmacokinetic profiles after single i.v. administration of racemic ketamine in ponies anaesthetised with isoflurane in oxygen (1 MAC). Cardiopulmonary variables require further investigation.Facultad de Ciencias Veterinaria