311 research outputs found
Study of thermometers for measuring a microcanonical phase transition in nuclear fragmentation
The aim of this work is to study how the thermodynamic temperature is related
to the known thermometers for nuclei especially in view of studying the
microcanonical phase transition. We find within the MMMC-model that the
"S-shape" of the caloric equation of state e^*(T) which is the signal of a
phase transition in a system with conserved energy, can be seen in the
experimentally accessible slope temperatures T_slope for different particle
types and also in the isotopic temperatures T_He-Li. The isotopic temperatures
T_H-He are weaker correlated to the shape of the thermodynamic temperature and
therefore are less favorable to study the signal of a microcanonical phase
transition. We also show that the signal is very sensitive to variations in
mass of the source
Fragmentation phase transition in atomic clusters I --- Microcanonical thermodynamics
Here we first develop the thermodynamics of microcanonical phase transitions
of first and second order in systems which are thermodynamically stable in the
sense of van Hove. We show how both kinds of phase transitions can
unambiguously be identified in relatively small isolated systems of
atoms by the shape of the microcanonical caloric equation of state
I.e. within microcanonical thermodynamics one does not need to go to the
thermodynamic limit in order to identify phase transitions. In contrast to
ordinary (canonical) thermodynamics of the bulk microcanonical thermodynamics
(MT) gives an insight into the coexistence region. The essential three
parameters which identify the transition to be of first order, the transition
temperature , the latent heat , and the interphase surface
entropy can very well be determined in relatively small
systems like clusters by MT. The phase transition towards fragmentation is
introduced. The general features of MT as applied to the fragmentation of
atomic clusters are discussed. The similarities and differences to the boiling
of macrosystems are pointed out.Comment: Same as before, abstract shortened my e-mail address: [email protected]
Experimental and Theoretical Search for a Phase Transition in Nuclear Fragmentation
Phase transitions of small isolated systems are signaled by the shape of the
caloric equation of state e^*(T), the relationship between the excitation
energy per nucleon e^* and temperature. In this work we compare the
experimentally deduced e^*(T) to the theoretical predictions. The
experimentally accessible temperature was extracted from evaporation spectra
from incomplete fusion reactions leading to residue nuclei. The experimental
e^*(T) dependence exhibits the characteristic S-shape at e^* = 2-3 MeV/A. Such
behavior is expected for a finite system at a phase transition. The observed
dependence agrees with predictions of the MMMC-model, which simulates the total
accessible phase-space of fragmentation
Fragmentation Phase Transition in Atomic Clusters II - Coulomb Explosion of Metal Clusters -
We discuss the role and the treatment of polarization effects in many-body
systems of charged conducting clusters and apply this to the statistical
fragmentation of Na-clusters. We see a first order microcanonical phase
transition in the fragmentation of for Z=0 to 8. We can
distinguish two fragmentation phases, namely evaporation of large particles
from a large residue and a complete decay into small fragments only. Charging
the cluster shifts the transition to lower excitation energies and forces the
transition to disappear for charges higher than Z=8. At very high charges the
fragmentation phase transition no longer occurs because the cluster
Coulomb-explodes into small fragments even at excitation energy .Comment: 19 text pages +18 *.eps figures, my e-mail adress: [email protected]
submitted to Z. Phys.
The Multifragmentation Freeze--Out Volume in Heavy Ion Collisions
The reduced velocity correlation function for fragments from the reaction Fe
+ Au at 100 A~MeV bombarding energy is investigated using the
dynamical--statistical approach QMD+SMM and compared to experimental data to
extract the Freeze--Out volume assuming simultaneous multifragmentation.Comment: 8 pages; 3 uuencoded figures available with figures command, LateX,
UCRL-J-1157
Charge-Induced Fragmentation of Sodium Clusters
The fission of highly charged sodium clusters with fissilities X>1 is studied
by {\em ab initio} molecular dynamics. Na_{24}^{4+} is found to undergo
predominantly sequential Na_{3}^{+} emission on a time scale of 1 ps, while
Na_{24}^{Q+} (5 \leq Q \leq 8) undergoes multifragmentation on a time scale
\geq 0.1 ps, with Na^{+} increasingly the dominant fragment as Q increases. All
singly-charged fragments Na_{n}^{+} up to size n=6 are observed. The observed
fragment spectrum is, within statistical error, independent of the temperature
T of the parent cluster for T \leq 1500 K. These findings are consistent with
and explain recent trends observed experimentally.Comment: To appear in Physical Review Letter
Statistical Multifragmentation of Non-Spherical Expanding Sources in Central Heavy-Ion Collisions
We study the anisotropy effects measured with INDRA at GSI in central
collisions of Xe+Sn at 50 A.MeV and Au+Au at 60, 80, 100 A.MeV incident energy.
The microcanonical multifragmentation model with non-spherical sources is used
to simulate an incomplete shape relaxation of the multifragmenting system. This
model is employed to interpret observed anisotropic distributions in the
fragment size and mean kinetic energy. The data can be well reproduced if an
expanding prolate source aligned along the beam direction is assumed. An either
non-Hubblean or non-isotropic radial expansion is required to describe the
fragment kinetic energies and their anisotropy. The qualitative similarity of
the results for the studied reactions suggests that the concept of a
longitudinally elongated freeze-out configuration is generally applicable for
central collisions of heavy systems. The deformation decreases slightly with
increasing beam energy.Comment: 35 pages, 19 figures, submitted to Nuclear Physics
Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment.
Establishing causal relationships between genetic alterations of human cancers and specific phenotypes of malignancy remains a challenge. We sequentially introduced mutations into healthy human melanocytes in up to five genes spanning six commonly disrupted melanoma pathways, forming nine genetically distinct cellular models of melanoma. We connected mutant melanocyte genotypes to malignant cell expression programs in vitro and in vivo, replicative immortality, malignancy, rapid tumor growth, pigmentation, metastasis, and histopathology. Mutations in malignant cells also affected tumor microenvironment composition and cell states. Our melanoma models shared genotype-associated expression programs with patient melanomas, and a deep learning model showed that these models partially recapitulated genotype-associated histopathological features as well. Thus, a progressive series of genome-edited human cancer models can causally connect genotypes carrying multiple mutations to phenotype
An unusual cause of granulomatous disease
BACKGROUND: Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue granuloma formation. CASE PRESENTATION: We describe a case of X-linked Chronic granulomatous disease (CGD) diagnosed in an 18-year-old male. He initially presented with granulomatous disease mimicking sarcoidosis and was treated with corticosteroids. He subsequently developed Burkholderia cepacia complex pneumonia and further investigation confirmed a diagnosis of CGD. CONCLUSION: Milder phenotypes of CGD are now being recognised. CGD should be considered in patients of any age with granulomatous diseases, especially if there is a history of recurrent or atypical infection
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
Crucial transitions in cancerâincluding tumor initiation, local expansion, metastasis, and therapeutic resistanceâinvolve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer
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