Program on Earth Observation Data Management Systems (EODMS)

An assessment was made of the needs of a group of potential users of satellite remotely sensed data (state, regional, and local agencies) involved in natural resources management in five states, and alternative data management systems to satisfy these needs are outlined. Tasks described include: (1) a comprehensive data needs analysis of state and local users; (2) the design of remote sensing-derivable information products that serve priority state and local data needs; (3) a cost and performance analysis of alternative processing centers for producing these products; (4) an assessment of the impacts of policy, regulation and government structure on implementing large-scale use of remote sensing technology in this community of users; and (5) the elaboration of alternative institutional arrangements for operational Earth Observation Data Management Systems (EODMS). It is concluded that an operational EODMS will be of most use to state, regional, and local agencies if it provides a full range of information services -- from raw data acquisition to interpretation and dissemination of final information products

Understanding Society Innovation Panel Wave 8: results from methodological experiments

This paper presents some preliminary findings from Wave 8 of the Innovation Panel (IP8) of Understanding Society: The UK Household Longitudinal Study. Understanding Society is a major panel survey in the UK. May 2015, the eighth wave of the Innovation Panel went into the field. IP8 used a mixed-mode design, using on-line interviews and face-to-face interviews. This paper describes the design of IP8, the experiments carried and the preliminary findings from early analysis of the data

Observational Mass-to-Light Ratio of Galaxy Systems: from Poor Groups to Rich Clusters

We study the mass-to-light ratio of galaxy systems from poor groups to rich clusters, and present for the first time a large database for useful comparisons with theoretical predictions. We extend a previous work, where B_j band luminosities and optical virial masses were analyzed for a sample of 89 clusters. Here we also consider a sample of 52 more clusters, 36 poor clusters, 7 rich groups, and two catalogs, of about 500 groups each, recently identified in the Nearby Optical Galaxy sample by using two different algorithms. We obtain the blue luminosity and virial mass for all systems considered. We devote a large effort to establishing the homogeneity of the resulting values, as well as to considering comparable physical regions, i.e. those included within the virial radius. By analyzing a fiducial, combined sample of 294 systems we find that the mass increases faster than the luminosity: the linear fit gives M\propto L_B^{1.34 \pm 0.03}, with a tendency for a steeper increase in the low--mass range. In agreement with the previous work, our present results are superior owing to the much higher statistical significance and the wider dynamical range covered (about 10^{12}-10^{15} M_solar). We present a comparison between our results and the theoretical predictions on the relation between M/L_B and halo mass, obtained by combining cosmological numerical simulations and semianalytic modeling of galaxy formation.Comment: 25 pages, 12 eps figures, accepted for publication in Ap

Urinary secretion and extracellular aggregation of mutant uromodulin isoforms

Uromodulin is exclusively expressed in the thick ascending limb and is the most abundant protein secreted in urine where it is found in high-molecular-weight polymers. Its biological functions are still elusive, but it is thought to play a protective role against urinary tract infection, calcium oxalate crystal formation, and regulation of water and salt balance in the thick ascending limb. Mutations in uromodulin are responsible for autosomal-dominant kidney diseases characterized by defective urine concentrating ability, hyperuricemia, gout, tubulointerstitial fibrosis, renal cysts, and chronic kidney disease. Previous in vitro studies found retention in the endoplasmic reticulum as a common feature of all uromodulin mutant isoforms. Both in vitro and in vivo we found that mutant isoforms partially escaped retention in the endoplasmic reticulum and reached the plasma membrane where they formed large extracellular aggregates that have a dominant-negative effect on coexpressed wild-type protein. Notably, mutant uromodulin excretion was detected in patients carrying uromodulin mutations. Thus, our results suggest that mutant uromodulin exerts a gain-of-function effect that can be exerted by both intra- and extracellular forms of the protein

The dearth of halo dwarf galaxies: is there power on short scales?

N-body simulations of structure formation with scale-invariant primordial perturbations show significantly more virialized objects of dwarf-galaxy mass in a typical galactic halo than are observed around the Milky Way. We show that the dearth of observed dwarf galaxies could be explained by a dramatic downturn in the power spectrum at small distance scales. This suppression of small-scale power might also help mitigate the disagreement between cuspy simulated halos and smooth observed halos, while remaining consistent with Lyman-alpha-forest constraints on small-scale power. Such a spectrum could arise in inflationary models with broken scale invariance.Comment: 5 pages LaTeX, 3 figure

Full sphere hydrodynamic and dynamo benchmarks

Convection in planetary cores can generate fluid flow and magnetic fields, and a number of sophisticated codes exist to simulate the dynamic behaviour of such systems. We report on the first community activity to compare numerical results of computer codes designed to calculate fluid flow within a whole sphere. The flows are incompressible and rapidly rotating and the forcing of the flow is either due to thermal convection or due to moving boundaries. All problems defined have solutions that allow easy comparison, since they are either steady, slowly drifting or perfectly periodic. The first two benchmarks are defined based on uniform internal heating within the sphere under the Boussinesq approximation with boundary conditions that are uniform in temperature and stress-free for the flow. Benchmark 1 is purely hydrodynamic, and has a drifting solution. Benchmark 2 is a magnetohydrodynamic benchmark that can generate oscillatory, purely periodic, flows and magnetic fields. In contrast, Benchmark 3 is a hydrodynamic rotating bubble benchmark using no slip boundary conditions that has a stationary solution. Results from a variety of types of code are reported, including codes that are fully spectral (based on spherical harmonic expansions in angular coordinates and polynomial expansions in radius), mixed spectral and finite difference, finite volume, finite element and also a mixed Fourier–finite element code. There is good agreement between codes. It is found that in Benchmarks 1 and 2, the approximation of a whole sphere problem by a domain that is a spherical shell (a sphere possessing an inner core) does not represent an adequate approximation to the system, since the results differ from whole sphere results

Interferon β-1a in relapsing multiple sclerosis: four-year extension of the European IFNβ-1a Dose-C omparison Study

Background: Multiple sclerosis (MS) is a chronic disease requiring long-term monitoring of treatment. Objective: To assess the four-year clinical efficacy of intramuscular (IM) IFNb-1a in patients with relapsing MS from the European IFNb-1a Dose-C omparison Study. Methods: Patients who completed 36 months of treatment (Part 1) of the European IFNb-1a Dose-C omparison Study were given the option to continue double-blind treatment with IFNb-1a 30 mcg or 60 mcg IM once weekly (Part 2). Analyses of 48-month data were performed on sustained disability progression, relapses, and neutralizing antibody (NA b) formation. Results: O f 608/802 subjects who completed 36 months of treatment, 493 subjects continued treatment and 446 completed 48 months of treatment and follow-up. IFNb-1a 30 mcg and 60 mcg IM once weekly were equally effective for up to 48 months. There were no significant differences between doses over 48 months on any of the clinical endpoints, including rate of disability progression, cumulative percentage of patients who progressed (48 and 43, respectively), and annual relapse rates; relapses tended to decrease over 48 months. The incidence of patients who were positive for NAbs at any time during the study was low in both treatment groups. Conclusion: C ompared with 60-mcg IM IFNb-1a once weekly, a dose of 30 mcg IM IFNb-1a once weekly maintains the same clinical efficacy over four years

Formation of Disk Galaxies: Warm Dark Matter and the Angular Momentum problem

We have performed TreeSPH simulations of disk galaxy formation in various warm dark matter (WDM) cosmologies. Our results indicate that for a range of WDM free-streaming masses, the disk galaxy formation angular momentum problem can be completely resolved by going to the WDM structure formation scenario, without having to invoke stellar feedback processes at all. We also confirm our previous suspicion, that part of the angular momentum problem is due to numerical effects, most likely related to the shock capturing, artificial viscosity used in SPH. Furthermore we find that we can match the observed I-band Tully-Fisher (TF) relation, provided that the I-band mass-to-light ratio of disk galaxies is about 0.8. We argue that this is quite a reasonable value in comparison with various dynamical and spectrophotometric estimates, including one given in this paper. We speculate that our success in matching the TF relation may be due to WDM halos being less centrally concentrated than CDM halos and suggest to check this exciting possibility with high resolution simulations, in particular in low Omega_M, WDM cosmologies. Finally, we discuss possible physical candidates for WDM particles extensively. We find that the most promising are neutrinos with weaker or stronger interactions than normal, majorons (light pseudogoldstone bosons) or mirror or shadow world neutrinos.Comment: 50 pages incl. 17 figures. Accepted for publication in Ap

On the cosmological mass function theory

This paper provides, from one side, a review of the theory of the cosmological mass function from a theoretical point of view, starting from the seminal paper of Press & Shechter (1974) to the last developments (Del Popolo & Gambera (1998, 1999), Sheth & Tormen 1999 (ST), Sheth, Mo & Tormen 2001 (ST1), Jenkins et al. 2001 (J01), Shet & Tormen 2002 (ST2), Del Popolo 2002a, Yagi et al. 2004 (YNY)), and from another side some improvements on the multiplicity function models in literature. ...Comment: Astronomy Reports, in prin