L2 bounds in some non-standard nonlinear problems in partial differential equations

AbstractA priori bounds are determined for certain energy expressions for a class of semi-linear parabolic and hyperbolic initial-boundary value problems when a combination of the values of the solution initially and at a later time is prescribed

Scheduling spacecraft operations

A prototype scheduling system named MAESTRO currently under development is being used to explore possible approaches to the spacecraft operations scheduling problem. Results indicate that the appropriate combination of heuristic and other techniques can provide an acceptable solution to the scheduling problem over a wide range of operational scenarios and management approaches. These can include centralized or distributed instrument or systems control, batch or incremental scheduling, scheduling loose resource envelopes or exact profiles, and scheduling with varying degrees of user intervention. Techniques used within MAESTRO to provide this flexibility and power include constraint propagation mechanisms, multiple asynchronous processes, prioritized transaction-based command management, resource opportunity calculation, user-alterable selection and placement mechanisms, and maintenance of multiple schedules and resource profiles. These techniques and scheduling complexities requiring them are discussed

Structure of a Chiral Cyelopentanone Precursor in Neocarzinostatin Synthetic Studies, C20H21NO3S.H20

(1E,2S,3R)-2-[(4R,5R)-4,5-Dimethyl-l,3-dioxolan-2-yl]-3-(2-naphthylthio)cyclopentanone oxime, 3//,=373.47, orthorhombic, P212121, a = 5-374 (13), b = 18.135 (3), c= 20.487 (5) A, V = 1997 (5)/~3, Z = 4, Dx = 1.24 g cm -3, Mo Ka, a = 0.71073/~, /z = 1-87 cm-1, F(000) = 792, room temperature, crystal volume 2.7 x 10 -4 mm 3, final R = 0.127 for 971 reflections with Fo2>0 out of 1131 data, R = 0.065 for 467 reflections with Fo 2 > 3o'(Fo2). Despite the small crystal size (all larger crystals were twinned), a structural solution of adequate precision was obtained. Bond distances and angles in the molecule are normal; the water molecules are hydrogen bonded in a chain along the a axis and each accepts a hydrogen bond from the oxime group and donates a weak hydrogen bond to 03 in the dioxolane group.Chemistry and Chemical Biolog

Editorial: The Diversity of International ICT Law

Editorial of the Guest Editor

Defining quality physical education: an analysis of international documents

Abstract presented at the 2014 AAHPERD National Convention and Exposition, 2-4 April 2014, St. Louis, United State

Mitophagy-Related Cell Death Mediated by Vacquinol-1 and TRPM7 Blockade in Glioblastoma IV

Glioblastoma IV (GBM) is one of the deadliest malignant diseases in adults and is characterized by a high mutation rate and multiple traits to suppress inborn and acquired immunity. We here approached autophagy-related cell death in newly established GBM cell lines derived from individual tumor isolates. Treatment with a small molecule, termed Vacquinol-1 (Vac) exhibited 100% GBM cell death, which was related to mitochondrial dysfunction, calcium-induced endoplasmic reticulum (ER)-stress, and autophagy. The toxicity of Vac was significantly increased by the inhibition of transient receptor potential cation channel, subfamily M, member 7 (TRPM7). TRPM7 is overexpressed in GBM as well as in many other tumors and thus may be a potential target by the natural compound carvacrol. Of note, at higher concentrations, Vac also induced growth inhibition and cell death in non-transformed cell types. However, in the presence of the TRPM7 inhibitor carvacrol, the tumor-selective effect of Vac was very much increased. Results given in the present study are based on long-term video microscopy using IncuCyteZOOM®, calcium measurements, and 3D ultrastructural analysis using the cryofixed material

Oil generation in the michigan basin: A biological marker and carbon isotope approach

Palaeozoic strata in the Michigan Basin produced crude oils which, despite their rather small volume and economic value, are interesting because of the considerable age of the basin and because of the opportunity to study generation and migration of oils within a relatively simple but ancient geological setting.Based on n-alkane profiles, biological marker distributions and carbon isotope ratios, the oils belong to three main families of different genetic origin and a few less important mixed types. Silurian oils from Salina and Niagara Limestones have broad n-alkane distributions and abundant isoprenoid hydrocarbons. A strong phytane-over-pristane predominance and the lack of diasteranes indicate a carbonate source for these oils. Chemical maturity parameters show that they are more mature than the oils from the other main families from which they are also clearly distinguished by carbon isotope ratios of hydrocarbon fractions and single n-alkanes.Oils found in the calcareous Ordovician Trenton formation contain n-alkane, cyclohexylalkane and alkyl phenanthrene distributions typical of immature oils. Many oils from the Devonian Dundee reservoirs are very similar in overall composition to the Trenton oils.Devonian Traverse oils are considered to be mainly from a Devonian source with some contribution of Ordovician-type oil and are of intermediate maturity. Based on calculations using kinetic parameters of biological marker reactions, considerably deeper subsidence of the Devonian source rock in the past is implied.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26406/1/0000493.pd

The malleable brain: plasticity of neural circuits and behavior: A review from students to students

One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic connections, referred to as long-term potentiation (LTP) and long-term depression (LTD) respectively. Such phenomena have been described in a variety of model organisms, which are used to study molecular, structural, and functional aspects of synaptic plasticity. This review originated from the first International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Alpbach, Austria (Sep 2016), and will use its curriculum and discussions as a framework to review some of the current knowledge in the field of synaptic plasticity. First, we describe the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages. We then outline the signaling cascades resulting in the synthesis of new plasticity-related proteins, which ultimately enable sustained changes in synaptic strength. Going beyond the traditional understanding of synaptic plasticity conceptualized by LTP and LTD, we discuss system-wide modifications and recently unveiled homeostatic mechanisms, such as synaptic scaling. Finally, we describe the neural circuits and synaptic plasticity mechanisms driving associative memory and motor learning. Evidence summarized in this review provides a current view of synaptic plasticity in its various forms, offers new insights into the underlying mechanisms and behavioral relevance, and provides directions for future research in the field of synaptic plasticity.Fil: Schaefer, Natascha. University of Wuerzburg; AlemaniaFil: Rotermund, Carola. University of Tuebingen; AlemaniaFil: Blumrich, Eva Maria. Universitat Bremen; AlemaniaFil: Lourenco, Mychael V.. Universidade Federal do Rio de Janeiro; BrasilFil: Joshi, Pooja. Robert Debre Hospital; FranciaFil: Hegemann, Regina U.. University of Otago; Nueva ZelandaFil: Jamwal, Sumit. ISF College of Pharmacy; IndiaFil: Ali, Nilufar. Augusta University; Estados UnidosFil: García Romero, Ezra Michelet. Universidad Veracruzana; MéxicoFil: Sharma, Sorabh. Birla Institute of Technology and Science; IndiaFil: Ghosh, Shampa. Indian Council of Medical Research; IndiaFil: Sinha, Jitendra K.. Indian Council of Medical Research; IndiaFil: Loke, Hannah. Hudson Institute of Medical Research; AustraliaFil: Jain, Vishal. Defence Institute of Physiology and Allied Sciences; IndiaFil: Lepeta, Katarzyna. Polish Academy of Sciences; ArgentinaFil: Salamian, Ahmad. Polish Academy of Sciences; ArgentinaFil: Sharma, Mahima. Polish Academy of Sciences; ArgentinaFil: Golpich, Mojtaba. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Nawrotek, Katarzyna. University Of Lodz; ArgentinaFil: Paid, Ramesh K.. Indian Institute of Chemical Biology; IndiaFil: Shahidzadeh, Sheila M.. Syracuse University; Estados UnidosFil: Piermartiri, Tetsade. Universidade Federal de Santa Catarina; BrasilFil: Amini, Elham. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Pastor, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Wilson, Yvette. University of Melbourne; AustraliaFil: Adeniyi, Philip A.. Afe Babalola University; NigeriaFil: Datusalia, Ashok K.. National Brain Research Centre; IndiaFil: Vafadari, Benham. Polish Academy of Sciences; ArgentinaFil: Saini, Vedangana. University of Nebraska; Estados UnidosFil: Suárez Pozos, Edna. Instituto Politécnico Nacional; MéxicoFil: Kushwah, Neetu. Defence Institute of Physiology and Allied Sciences; IndiaFil: Fontanet, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Turner, Anthony J.. University of Leeds; Reino Unid