617 research outputs found
Globally Anisotropic High Porosity Silica Aerogels
We discuss two methods by which high porosity silica aerogels can be
engineered to exhibit global anisotropy. First, anisotropy can be introduced
with axial strain. In addition, intrinsic anisotropy can result during growth
and drying stages and, suitably controlled, it can be correlated with
preferential radial shrinkage in cylindrical samples. We have performed small
angle X-ray scattering (SAXS) to characterize these two types of anisotropy. We
show that global anisotropy originating from either strain or shrinkage leads
to optical birefringence and that optical cross-polarization studies are a
useful characterization of the uniformity of the imposed global anisotropy.Comment: 18 pages, 14 figures, submitted to Journal of Non-Crystalline Solid
New, Highly Accurate Propagator for the Linear and Nonlinear Schr\"odinger Equation
A propagation method for the time dependent Schr\"odinger equation was
studied leading to a general scheme of solving ode type equations. Standard
space discretization of time-dependent pde's usually results in system of ode's
of the form u_t -Gu = s where G is a operator (matrix) and u is a
time-dependent solution vector. Highly accurate methods, based on polynomial
approximation of a modified exponential evolution operator, had been developed
already for this type of problems where G is a linear, time independent matrix
and s is a constant vector. In this paper we will describe a new algorithm for
the more general case where s is a time-dependent r.h.s vector. An iterative
version of the new algorithm can be applied to the general case where G depends
on t or u. Numerical results for Schr\"odinger equation with time-dependent
potential and to non-linear Schr\"odinger equation will be presented.Comment: 14 page
Voxel-based 18F-FET PET segmentation and automatic clustering of tumor voxels: A significant association with IDH1 mutation status and survival in patients with gliomas.
Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas.
Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET PET before any histopathologic investigation or treatment were retrospectively included. Each dynamic 18F-FET PET was realigned to the first image and spatially normalized in the Montreal Neurological Institute template. A tumor mask was semi-automatically generated from Z-score maps. Each brain tumor voxel was clustered in one of the 3 following centroids using dynamic time warping and k-means clustering (centroid #1: slowly increasing slope; centroid #2: rapidly increasing followed by slowly decreasing slope; and centroid #3: rapidly increasing followed by rapidly decreasing slope). The percentage of each dynamic 18F-FET TAC within tumors and other conventional 18F-FET PET parameters (maximum and mean tumor-to-brain ratios [TBRmax and TBRmean], time-to-peak [TTP] and slope) was compared between wild-type and IDH1 mutant tumors. Their prognostic value was assessed in terms of progression free-survival (PFS) and overall survival (OS) by Kaplan-Meier estimates.
Twenty patients were IDH1 wild-type and 17 IDH1 mutant. Higher percentage of centroid #1 and centroid #3 within tumors were positively (P = 0.016) and negatively (P = 0.01) correlated with IDH1 mutated status. Also, TBRmax, TBRmean, TTP, and slope discriminated significantly between tumors with and without IDH1 mutation (P range 0.01 to 0.04). Progression occurred in 22 patients (59%) at a median of 13.1 months (7.6-37.6 months) and 13 patients (35%) died from tumor progression. Patients with a percentage of centroid #1 > 90% had a longer survival compared with those with a percentage of centroid #1 < 90% (P = 0.003 for PFS and P = 0.028 for OS). This remained significant after stratification on IDH1 mutation status (P = 0.029 for PFS and P = 0.034 for OS). Compared to other conventional 18F-FET PET parameters, TTP and slope were associated with PFS and OS (P range 0.009 to 0.04).
Based on dynamic 18F-FET PET acquisition, we developed a full automatic clustering approach of TAC which appears to be a valuable noninvasive diagnostic and prognostic marker in patients with gliomas
Strengthening the Performance of Engineering and Technology Educators Across the Disciplines (SPEED)
Interatomic potentials for atomistic simulations of the Ti-Al system
Semi-empirical interatomic potentials have been developed for Al, alpha-Ti,
and gamma-TiAl within the embedded atomic method (EAM) by fitting to a large
database of experimental as well as ab-initio data. The ab-initio calculations
were performed by the linear augmented plane wave (LAPW) method within the
density functional theory to obtain the equations of state for a number of
crystal structures of the Ti-Al system. Some of the calculated LAPW energies
were used for fitting the potentials while others for examining their quality.
The potentials correctly predict the equilibrium crystal structures of the
phases and accurately reproduce their basic lattice properties. The potentials
are applied to calculate the energies of point defects, surfaces, planar faults
in the equilibrium structures. Unlike earlier EAM potentials for the Ti-Al
system, the proposed potentials provide reasonable description of the lattice
thermal expansion, demonstrating their usefulness in the molecular dynamics or
Monte Carlo studies at high temperatures. The energy along the tetragonal
deformation path (Bain transformation) in gamma-TiAl calculated with the EAM
potential is in a fairly good agreement with LAPW calculations. Equilibrium
point defect concentrations in gamma-TiAl are studied using the EAM potential.
It is found that antisite defects strongly dominate over vacancies at all
compositions around stoichiometry, indicating that gamm-TiAl is an antisite
disorder compound in agreement with experimental data.Comment: 46 pages, 6 figures (Physical Review B, in press
Do Instantons Like a Colorful Background?
We investigate chiral symmetry breaking and color symmetry breaking in QCD.
The effective potential of the corresponding scalar condensates is discussed in
the presence of non-perturbative contributions from the semiclassical
one-instanton sector. We concentrate on a color singlet scalar background which
can describe chiral condensation, as well as a color octet scalar background
which can generate mass for the gluons. Whereas a non-vanishing singlet chiral
field is favored by the instantons, we have found no indication for a
preference of color octet backgrounds.Comment: 25 pages, 7 figure
Gamma Ray Bursts as Probes of Quantum Gravity
Gamma ray bursts (GRBs) are short and intense pulses of -rays
arriving from random directions in the sky. Several years ago Amelino-Camelia
et al. pointed out that a comparison of time of arrival of photons at different
energies from a GRB could be used to measure (or obtain a limit on) possible
deviations from a constant speed of light at high photons energies. I review
here our current understanding of GRBs and reconsider the possibility of
performing these observations.Comment: Lectures given at the 40th winter school of theretical physics:
Quantum Gravity and Phenomenology, Feb. 2004 Polan
Glueballs, gluon condensate, and pure glue QCD below T_c
A quasiparticle description of pure glue QCD thermodynamics at T<T_c is
proposed and compared to recent lattice data. Given that a gas of glueballs
with constant mass cannot quantitatively reproduce the early stages of the
deconfinement phase transition, the problem is to identify a relevant mechanism
leading to the observed sudden increase of the pressure, trace anomaly, etc. It
is shown that the strong decrease of the gluon condensate near T_c combined
with the increasing thermal width of the lightest glueballs might be the
trigger of the phase transition.Comment: 5 pages, 5 figures; analysis refined in v2, explanations added; v3 to
appear in EPJ
Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD
Current guidelines support using in combination more than one class of long-acting bronchodilator for COPD patients whose symptoms are not controlled by mono-therapy. This 2-week, multi-center (34 sites), randomized, modified-blind, parallel group study evaluated the efficacy and safety of concomitant treatment with nebulized arformoterol (the formoterol(R,R)-isomer) BID and tiotropium DPI QD. COPD patients (mean FEV(1) 1.37L, 45.4% predicted) were randomized to receive mono-therapy (either arformoterol 15microg BID [n=76] or tiotropium 18microg QD [n=80]), or combined therapy (sequential dosing of arformoterol 15microg BID and tiotropium 18microg QD [n=78]). Changes in pulmonary function, dyspnea, and rescue levalbuterol use were evaluated, as were safety outcomes. Mean FEV(1)AUC(0-24) (the primary endpoint) improved similarly from baseline for arformoterol (0.10L) and tiotropium (0.08L) treatment groups and greater for the combined therapy group (0.22L; all p-values <0.005). Peak FEV(1), peak FVC, 24-h trough FEV(1), and inspiratory capacity also improved similarly for the mono-therapies and greatest for the combined therapy. Dyspnea (mean transition dyspnea index) improved similarly for arformoterol (+2.3) and tiotropium (+1.8) and greatest with combined therapy (+3.1; p-values <0.05). Levalbuterol use decreased for all treatment groups (range -1.8 to -2.5 actuations/day). All treatments had similar frequency of adverse events. In this study, the combination of nebulized arformoterol 15microg BID plus tiotropium 18microg DPI QD was the most effective in improving pulmonary function and disease symptoms. Mono-therapy improvement with arformoterol or tiotropium was similar. All three treatments were well tolerated
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