Tagalog

Tagalog is a member of the Central Philippine subgroup of Philippine languages, forming part of the Western-Malayo-Polynesian set of Austronesian languages. It belongs in a subgroup with Bikol, Bisayan and Mansakan languages and was originally probably native to the eastern Visayas or northeast Mindanao in the Central Philippines (Zorc 1993). By the time the Spanish arrived in the Philippines (1521), Tagalog speakers had migrated north into the southern part of the island of Luzon in the Philippines, with Tagalog becoming the major language spoken in Manila and surrounding provinces; it has in recent years spread as a second language over virtually the entire Philippine archipelago. Thus, while only about a quarter of the population of the Philippines were Tagalog-speaking in 1940, in 1970 approximately half of the population were, and today it is estimated that well over 90 per cent of the 80 million total population of the Philippines is either a first- or second-language speaker of the language

Finding the rarest objects in the universe: A new, efficient method for discovering BL Lacertae objects

We present a new, efficient method for discovering new BL Lac Objects based upon the results of the Einstein Extended Medium Sensitivity Survey (EMSS). We have found that all x-ray selected BL Lacs are radio emitters, and further, that in a 'color-color' diagram (radio/optical and optical/x-ray) the BL Lac Objects occupy an area distinct from both radio loud quasars and the radio quiet QSOs and Seyferts which dominate x-ray selected samples. After obtaining radio counterparts via VLA 'snapshot' observations of a large sample of unidentified x-ray sources, the list of candidates is reduced. These candidates then can be confirmed with optical spectroscopy and/or polarimetry. Since greater than 70 percent of these sources are expected to be BL Lacs, the optical observations are very efficient. We have tested this method using unidentified sources found in the Einstein Slew Survey. The 162 Slew Survey x-ray source positions were observed with the VLA in a mixed B/C configuration at 6 cm resulting in 60 detections within 1.5 position error circle radii. These x-ray/optical/radio sources were then plotted, and 40 BL Lac candidates were identified. To date, 10 candidates have been spectroscopically observed resulting in 10 new BL Lac objects! Radio flux, optical magnitude, and polarization statistics (obtained in white light with the Steward Observatory 2.3 m CCD polarimeter) for each are given

Social innovation futures: beyond policy panacea and conceptual ambiguity

Social innovation is once more an increasingly popular notion circulating as an apparent means to solve the Grand Challenges of the 21st Century. But this common-sense idea of social innovation is based on a quasi-concept, where processes of innovation are absent. To restore some academic rigour to this important concept, we argue more attention need be paid to these innovation processes in social innovation, and that there is value in using innovation concepts drawn from other areas of innovation studies (disruptive innovation, innovation systems, institutional innovation and socio-technical transitions) in highlighting how small-scale social experiments can ultimately lead to the solution of pressing societal problems. Through a subtle critique of the current policy conception of social innovation, it is possible for the field of Innovation Studies in general to help provide better insights into social innovation processes and ultimately to lead to better support frameworks and interventions for promoting solutions to these Grand Challenges.We would like to acknowledge the financial support of the Eu-SPRI Forum for our exploratory project “Social innovation futures: beyond policy panacea and conceptual ambiguity” for developing the ideas in this paper.Peer reviewe

Baseline elevation and reduction in cardiac electrical instability assessed by quantitative T-wave alternans in patients with drug-resistant epilepsy treated with vagus nerve stimulation in the AspireSR E-36 trial

Objective: Reports of cardiac arrhythmias and cardiac pathology at postmortem examination of patients with epilepsy suggest a possible cardiac component of risk for sudden unexpected death in epilepsy (SUDEP). T-wave alternans (TWA) is an established marker of cardiac electrical instability and risk for sudden death in patients with cardiovascular disease. We determined the TWA level before vagus nerve stimulation (VNS) system implantation and subsequently the effect of VNS on TWA in patients with drug-resistant epilepsy. Methods: Patients (n = 28) from the Seizure Detection and Automatic Magnet Mode Performance Study (E-36), a clinical trial of the AspireSR (R) VNS Therapy System (R) (NCT01325623), were monitored with ambulatory electrocardiograms (ECGs) similar to 2 weeks before de novo VNS system implantation and following 2- to 4-week VNS titration during a protocol-specified 3- to 5-day epilepsy monitoring unit stay with concurrent EEG/ECG recordings. The TWA level was assessed interictally by the Modified Moving Average (MMA) method. Results: At preimplantation baseline, TWA was elevated above the 47-mu V abnormality cutpoint in 23 (82%) patients with drug-resistant epilepsy. In 16 (70%) patients, TWA level was reduced during VNS treatment to <47 mu V, thereby converting positive TWA test results to negative. Peak TWA level in all 28 patients improved (group mean, 43%, from 72 +/- 4.3 to 41 +/- 2.3 mu V; p < 0.0001). Vagus nerve stimulation was not associated with reduced heart rate (77 +/- 1.4 to 75 +/- 1.4 beats/min; p = 0.18). Heart rate variability was unchanged. Significance: These findings suggest significant interictal cardiac electrical instability in this population of patients with drug-resistant epilepsy and suggest that VNS may be a novel approach to reducing risk

Studies of Particle Acceleration by an Active Microwave Medium

The PASER is potentially a very attractive method for particle acceleration, in which energy from an active medium is transferred to a charged particle beam. The effect is similar to the action of a maser or laser with the stimulated emission of radiation being produced by the virtual photons in the electromagnetic field of the beam. We have been investigating the possibility of developing a demonstration PASER operating at X-band. The less restrictive beam transport and device dimensional tolerances required for working at X-band rather than optical frequencies as well as the widespread application of X-band hardware in accelerator technology all contribute to the attractiveness of performing a PASER demonstration experiment in this frequency range. Key to this approach is the availability of a new class of active materials that exhibit photoinduced electron spin polarization. We will report on the status of active material development and measurements, numerical simulations, and progress towards a planned microwave PASER acceleration experiment at the Argonne Wakefield Accelerator facility.Comment: 9 pages, 3 figures, submitted to Proceedings of the 2006 Advanced Accelerator Concepts Worksho

Social innovation as institutional innovation

Trabajo presentado a la Annual Conference of the EU-SPRI Forum: "Innovation policies for economic and social transitions: Developing strategies for knowledge, practices and organizations" celebrada en Helsinki (Finlandia) del 9 al 12 de junio de 2015.Common understanding of Social Innovation (SI) as an essential component in policy discourses to solve the so-called Grand Challenges of the 21st Century confronts the need to answer the remaining ‘desperate quest for a definition’ (Djellal & Gallouj, 2012: p. 121). SI has become ‘overdetermined’ that is, associated with a variety of meanings and interpretations rooted in a diversity of disciplines and faces the risk of having its validity challenged (Laclau & Mouffe, 1985). From the theoretical perspectives of science, technology and innovation studies, the EU-SPRI Exploratory study on Social Innovation Futures aspires to open academic debate to overcome current concerns surrounding ‘policy and chaotic’ views on the SI concept. Being the ‘innovation problem’ to understanding what affects innovation processes and how that shapes the change trajectories, the project aims to the nuclear question: How can SI be understood and interpreted as innovation process? (Benneworth et al., 2015). SI processes take parts of an emergent paradigm that needs to explicitly address the issue of purpose and direction of change where the social and technological components of innovation should not be seen as contradictory, but as inherently connected (Howaldt et al., 2014). This paradigm shift claims for a theory of socio-technological innovation and new answers on the nature and purposes of innovation in society (Edwards-Schachter et al., 2012; Benneworth & Cuhna, 2014). It is also intrinsic to policy orientations to deal with global ‘intractable problems’ or ‘global challenges’ which dates back several decades ago, like in the references in the Club of Rome report Limits to Growth (1972), which likewise explicitly names social innovation, in parallel to technical change, to change political processes and structures to favour a sustainable development. In this framework, this paper reviews the burgeoning literature that has developed in recent years a diversity of approaches on the role of institutions and institutional dynamic in innovation processes and explores their possible contributions and research avenues to SI1. The critical review attempts to examine important aspects and characteristics, which have so far remained rather latent, like institutional changes and legitimisation of SIs.Peer Reviewe

Multi-transmission-line-beam interactive system

We construct here a Lagrangian field formulation for a system consisting of an electron beam interacting with a slow-wave structure modeled by a possibly non-uniform multiple transmission line (MTL). In the case of a single line we recover the linear model of a traveling wave tube (TWT) due to J.R. Pierce. Since a properly chosen MTL can approximate a real waveguide structure with any desired accuracy, the proposed model can be used in particular for design optimization. Furthermore, the Lagrangian formulation provides for: (i) a clear identification of the mathematical source of amplification, (ii) exact expressions for the conserved energy and its flux distributions obtained from the Noether theorem. In the case of uniform MTLs we carry out an exhaustive analysis of eigenmodes and find sharp conditions on the parameters of the system to provide for amplifying regimes

Geographic and facility variation in initial use of non-tunneled catheters for incident maintenance hemodialysis patients

Abstract Background Non-tunneled (temporary) hemodialysis catheters (NTHCs) are the least-optimal initial vascular access for incident maintenance hemodialysis patients yet little is known about factors associated with NTHC use in this context. We sought to determine factors associated with NTHC use and examine regional and facility-level variation in NTHC use for incident maintenance hemodialysis patients. Methods We analyzed registry data collected between January 2001 and December 2010 from 61 dialysis facilities within 12 geographic regions in Canada. Multi-level models and intra-class correlation coefficients were used to evaluate variation in NTHC use as initial hemodialysis access across facilities and geographic regions. Facility and patient characteristics associated with the lowest and highest quartiles of NTHC use were compared. Results During the study period, 21,052 patients initiated maintenance hemodialysis using a central venous catheter (CVC). This included 10,183 patients (48.3 %) in whom the initial CVC was a NTHC, as opposed to a tunneled CVC. Crude variation in NTHC use across facilities ranged from 3.7 to 99.4 % and across geographic regions from 32.4 to 85.1 %. In an adjusted multi-level logistic regression model, the proportion of total variation in NTHC use explained by facility-level and regional variation was 40.0 % and 34.1 %, respectively. Similar results were observed for the subgroup of patients who received greater than 12 months of pre-dialysis nephrology care. Patient-level factors associated with increased NTHC use were male gender, history of angina, pulmonary edema, COPD, hypertension, increasing distance from dialysis facility, higher serum phosphate, lower serum albumin and later calendar year. Conclusions There is wide variation in NTHC use as initial vascular access for incident maintenance hemodialysis patients across facilities and geographic regions in Canada. Identifying modifiable factors that explain this variation could facilitate a reduction of NTHC use in favor of more optimal initial vascular access

Integrating an NTD with One of “The Big Three”: Combined Malaria and Trachoma Survey in Amhara Region of Ethiopia

The “big three” killer diseases are malaria, HIV/AIDS, and tuberculosis; control programs for these diseases are usually well developed and financed. The neglected tropical diseases (NTDs) are a group of ancient afflictions that are frequently sidelined by planners and are under-resourced. Opportunities of integrating the big three with NTDs have been talked about but not widely acted upon. There is potential synergy for an integrated trachoma and malaria control program since control of both diseases is community-based. The first step in accessing these synergies has been an integrated malaria prevalence and indicator and trachoma prevalence and risk factor survey. This has been achieved at the incremental cost of one additional staff member per field team. The results give unprecedented precision for the calculation of intervention targets for the integrated program and demonstrate that it is possible to integrate NTDs with the “big three.

Five-year analysis on the long-term effects of dabrafenib plus trametinib (D + T) in patients with BRAF V600–mutant unresectable or metastatic melanoma

Background: First-line treatment with D+T demonstrated prolonged progression-free survival (PFS) and overall survival (OS) in patients with BRAF V600–mutant unresectable or metastatic melanoma. With 5 years of follow-up, we report survival and describe characteristics of patients in the phase 3 COMBI-d and COMBI-v trials with long-term benefit. Methods: Pooled 5-year landmark data for patients treated with D+T in the phase 3 COMBId (NCT01584648) and COMBI-v (NCT01597908) trials were analyzed. The trials enrolled patients with previously untreated BRAF V600E/K–mutant unresectable or metastatic melanoma. Patients received D 150 mg twice daily plus T 2 mg once daily vs either D + placebo (COMBI-d) or vemurafenib (COMBI-v). The primary endpoints were PFS in COMBI-d and OS in COMBI-v. Results: The pooled population included 563 patients who received D+T (COMBI-d, n = 211; COMBI-v, n = 352)