Impaired regulation of emotion: Neural correlates of reappraisal and distraction in bipolar disorder and unaffected relatives

Deficient emotion regulation has been proposed as a crucial pathological mechanism in bipolar disorder (BD). We therefore investigated emotion regulation impairments in BD, the related neural underpinnings and their etiological relevance for the disorder. Twenty-two euthymic patients with bipolar-I disorder and 17 unaffected first-degree relatives of BD-I patients, as well as two groups of healthy gender-, age- and education-matched controls (N=22/17, respectively) were included. Participants underwent functional magnetic resonance imaging while applying two different emotion regulation techniques, reappraisal and distraction, when presented with emotional images. BD patients and relatives showed impaired downregulation of amygdala activity during reappraisal, but not during distraction, when compared with controls. This deficit was correlated with the habitual use of reappraisal. The negative connectivity of amygdala and orbitofrontal cortex (OFC) observed during reappraisal in controls was reversed in BD patients and relatives. There were no significant differences between BD patients and relatives. As being observed in BD patients and unaffected relatives, deficits in emotion regulation through reappraisal may represent heritable neurobiological abnormalities underlying BD. The neural mechanisms include impaired control of amygdala reactivity to emotional stimuli and dysfunctional connectivity of the amygdala to regulatory control regions in the OFC. These are, thus, important aspects of the neurobiological basis of increased vulnerability for BD

The Optical Emission from Gamma-ray Quasars

We present photometric observations of six radio-loud quasars that were detected by the COMPTEL gamma-ray telescope. The data encompasses seven wavebands in the optical and near-infrared. After correction for Galactic extinction, we find a wide range in optical slopes. Two sources are as blue as optically-selected quasars, and are likely to be dominated by the accretion disc emission, while three others show colours consistent with a red synchrotron component. We discuss the properties of the COMPTEL sample of quasars, as well as the implications our observations have for multi-wavelength modelling of gamma-ray quasars.Comment: 12 pages, 3 figures, accepted for publication in P.A.S.A; minor typos correcte

The COMPTEL instrumental line background

The instrumental line background of the Compton telescope COMPTEL onboard the Compton Gamma-Ray Observatory is due to the activation and/or decay of many isotopes. The major components of this background can be attributed to eight individual isotopes, namely 2D, 22Na, 24Na, 28Al, 40K, 52Mn, 57Ni, and 208Tl. The identification of instrumental lines with specific isotopes is based on the line energies as well as on the variation of the event rate with time, cosmic-ray intensity, and deposited radiation dose during passages through the South-Atlantic Anomaly. The characteristic variation of the event rate due to a specific isotope depends on its life-time, orbital parameters such as the altitude of the satellite above Earth, and the solar cycle. A detailed understanding of the background contributions from instrumental lines is crucial at MeV energies for measuring the cosmic diffuse gamma-ray background and for observing gamma-ray line emission in the interstellar medium or from supernovae and their remnants. Procedures to determine the event rate from each background isotope are described, and their average activity in spacecraft materials over the first seven years of the mission is estimated.Comment: accepted for publication in A&A, 22 pages, 21 figure

Gene Expression in Hair Follicle Dermal Papilla Cells after Treatment with Stanozolol

Doping with anabolic agents is a topic in sports where strength is crucial, e.g. sprinting, weight lifting and many more. Testosterone and its functional analogs are the drugs of choice taken as pills, creams, tape or injections to increase muscle mass and body performance, and to reduce body fat. Stanozolol (17β-hydroxy-17α-methyl-5α-androst-2-eno[3,2c]pyrazol) is a testosterone analogue with the same anabolic effect like testosterone but its ring structure makes it possible to take it orally. Therefore, stanozolol is one of the most frequently used anabolic steroids

Southern Hemisphere Observations of a 101810^{18}eV Cosmic Ray Source Near the Direction of the Galactic Centre

We report on an analysis of data from the southern hemisphere SUGAR cosmic ray detector. We confirm the existence of an excess of $10^{18}$eV cosmic rays from a direction close to the Galactic Centre, first reported by the AGASA group. We find that the signal is consistent with that from a point source, and we find no evidence for an excess of cosmic rays coming from the direction of the Galactic Centre itself.Comment: 14 pages including 5 postscript figures, corrected the title (replaced "Cosmic Ray Source" instead of "Cosmic Ray"

A Study of the LXeGRIT Detection Efficiency for MeV Gamma-Rays during the 2000 Balloon Flight Campaign

LXeGRIT - Liquid Xenon Gamma-Ray Imaging Telescope - is the first prototype of a Compton telescope for \MeV \g-ray astrophysics based on a LXe time projection chamber. One of the most relevant figures of merit for a Compton telescope is the detection efficiency for \g-rays, which depends on diverse contributions such as detector geometry and passive materials, trigger efficiency, dead time, etc. A detailed study of the efficiency of the LXeGRIT instrument, based both on laboratory measurements and Monte Carlo simulations, is presented in this paper.Comment: 20 pages, 15 figures; submitted to NIM

INTEGRAL and XMM-Newton observations towards the unidentified MeV source GRO J1411-64

The COMPTEL unidentified source GRO J1411-64 was observed by INTEGRAL, and its central part, also by XMM-Newton. The data analysis shows no hint for new detections at hard X-rays. The upper limits in flux herein presented constrain the energy spectrum of whatever was producing GRO J1411-64, imposing, in the framework of earlier COMPTEL observations, the existence of a peak in power output located somewhere between 300-700 keV for the so-called low state. The Circinus Galaxy is the only source detected within the 4$\sigma$ location error of GRO J1411-64, but can be safely excluded as the possible counterpart: the extrapolation of the energy spectrum is well below the one for GRO J1411-64 at MeV energies. 22 significant sources (likelihood $> 10$) were extracted and analyzed from XMM-Newton data. Only one of these sources, XMMU J141255.6-635932, is spectrally compatible with GRO J1411-64 although the fact the soft X-ray observations do not cover the full extent of the COMPTEL source position uncertainty make an association hard to quantify and thus risky. The unique peak of the power output at high energies (hard X-rays and gamma-rays) resembles that found in the SED seen in blazars or microquasars. However, an analysis using a microquasar model consisting on a magnetized conical jet filled with relativistic electrons which radiate through synchrotron and inverse Compton scattering with star, disk, corona and synchrotron photons shows that it is hard to comply with all observational constrains. This and the non-detection at hard X-rays introduce an a-posteriori question mark upon the physical reality of this source, which is discussed in some detail