A 0.5 MW/10 Hz option of the spallation source AUSTRON

In 1993-94 a feasibility study for AUSTRON, a neutron spallation source, was made on behalf of the Austrian Ministry of Science and Research. At that time, the machine was synchrotron cycling at 25 Hz and delivering an average beam power of 205 kW at 1.6 GeV. An option to double the power by doubling the frequency was foreseen. Now a more ambitious development of the original concept is proposed that aims at 0.5 MW at 1.6 GeV, pulsed at either 50 Hz or 10 Hz. The slow repetition rate is achieved by the addition of a storage ring holding four consecutive (single bunch) pulses from the 50 Hz synchrotron until a fifth pulse is accelerated and transferred to the target with the four stored ones. In this way, an energy per pulse of 50 kJ (one half of the pulse energy of the 5 MW ESS) is obtained, yielding about 3.5*10/sup 16/ thermal neutrons/(s cm/sup 2/). This peak flux matches well a number of innovative instruments and allows unprecedented resolution for some more conventional ones. On August 20, 1998, the Austrian Government has unanimously decided to contribute one third of the total cost of the facility and invites international partners to participate. (13 refs)

Goldstone models in D+1 dimensions, D=3,4,5, supporting stable and zero topological charge solutions

We study finite energy static solutions to a global symmetry breaking Goldstone model described by an isovector scalar field in D+1 spacetime dimensions. Both topologically stable multisolitons with arbitrary winding numbers, and zero topological charge soliton--antisoliton solutions are constructed numerically in D=3,4,5. We have explored the types of symmetries the systems should be subjected to, for there to exist multisoliton and soliton--antisoliton pairs in D=3,4,5,6. These findings are underpinned by constructing numerical solutions in the $D\le 5$ examples. Subject to axial symmetry, only multisolitons of all topological charges exist in even D, and in odd D, only zero and unit topological charge solutions exist. Subjecting the system to weaker than axial symmetries, results in the existence of all the possibilities in all dimensions. Our findings apply also to finite 'energy' solutions to Yang--Mills and Yang-Mills--Higgs systems, and in principle also sigma models.Comment: 29 pages, 6 figure

New nonuniform black string solutions

We present nonuniform vacuum black strings in five and six spacetime dimensions. The conserved charges and the action of these solutions are computed by employing a quasilocal formalism. We find qualitative agreement of the physical properties of nonuniform black strings in five and six dimensions. Our results offer further evidence that the black hole and the black string branches merge at a topology changing transition. We generate black string solutions of the Einstein-Maxwell-dilaton theory by using a Harrison transformation. We argue that the basic features of these solutions can be derived from those of the vacuum black string configurations.Comment: 30 pages, 12 figures; v2: more details on numerical method, references added; v3: references added, minor revisions, version accepted by journa

Decoding material-specific memory reprocessing during sleep in humans

Neuronal learning activity is reactivated during sleep but the dynamics of this reactivation in humans are still poorly understood. Here we use multivariate pattern classification to decode electrical brain activity during sleep and determine what type of images participants had viewed in a preceding learning session. We find significant patterns of learning-related processing during rapid eye movement (REM) and non-REM (NREM) sleep, which are generalizable across subjects. This processing occurs in a cyclic fashion during time windows congruous to critical periods of synaptic plasticity. Its spatial distribution over the scalp and relevant frequencies differ between NREM and REM sleep. Moreover, only the strength of reprocessing in slow-wave sleep influenced later memory performance, speaking for at least two distinct underlying mechanisms between these states. We thus show that memory reprocessing occurs in both NREM and REM sleep in humans and that it pertains to different aspects of the consolidation process

Phosphonate as a Stable Zinc-Binding Group for "Pathoblocker" Inhibitors of Clostridial Collagenase H (ColH)

Microbial infections are a significant threat to public health, and resistance is on the rise, so new antibiotics with novel modes of action are urgently needed. The extracellular zinc metalloprotease collagenase H (ColH) from Clostridium histolyticum is a virulence factor that catalyses tissue damage, leading to improved host invasion and colonisation. Besides the major role of ColH in pathogenicity, its extracellular localisation makes it a highly attractive target for the development of new antivirulence agents. Previously, we had found that a highly selective and potent thiol prodrug (with a hydrolytically cleavable thiocarbamate unit) provided efficient ColH inhibition. We now report the synthesis and biological evaluation of a range of zinc‐binding group (ZBG) variants of this thiol‐derived inhibitor, with the mercapto unit being replaced by other zinc ligands. Among these, an analogue with a phosphonate motif as ZBG showed promising activity against ColH, an improved selectivity profile, and significantly higher stability than the thiol reference compound, thus making it an attractive candidate for future drug development

New generalized nonspherical black hole solutions

We present numerical evidence for the existence of several types of static black hole solutions with a nonspherical event horizon topology in $d\geq 6$ spacetime dimensions. These asymptotically flat configurations are found for a specific metric ansatz and can be viewed as higher dimensional counterparts of the $d=5$ static black rings, dirings and black Saturn. Similar to that case, they are supported against collapse by conical singularities. The issue of rotating generalizations of these solutions is also considered.Comment: 47 pages, 11 figures, some comments adde

A Monopole-Antimonopole Solution of the SU(2) Yang-Mills-Higgs Model

As shown by Taubes, in the Bogomol'nyi-Prasad-Sommerfield limit the SU(2) Yang-Mills-Higgs model possesses smooth finite energy solutions, which do not satisfy the first order Bogomol'nyi equations. We construct numerically such a non-Bogomol'nyi solution, corresponding to a monopole-antimonopole pair, and extend the construction to finite Higgs potential.Comment: 11 pages, including 4 eps figures, LaTex format using RevTe

A Slow-Cycling Proton Driver for a Neutrino Factory

An 8 Hz proton driver for a neutrino factory of 4 MW beam power and an energy of 25-30 GeV is under study at CERN, in parallel with a similar investigation using a 2.2 GeV high-energy linac and an accumulator plus a compressor ring cycling at 75 Hz. At RAL, synchrotron drivers with final energies of 5 and 15 GeV cycling at 50 and 25 Hz, respectively, are being studied. With these four scenarios, one hopes to cope with all possible constraints emerging from the studies of the pion production target and the muon rotation and cooling system. The high beam energy of this scenario requires less proton current and could inject into the SPS above transition and upgrade LHC and fixed target physics. Its 440 kW booster would upgrade ISOLDE.The main problems of the driver synchrotron are: the requirement of about 4 MV RF voltage at 10 MHz for acceleration and adiabatic bunch compression to the required r.m.s length of 1 ns; the sensitivity of the compression to the impedance of the vacuum chamber and to non-linearities of the momentum compaction of the high-gt lattice

Deleterious Impact of a Novel CFH Splice Site Variant in Atypical Hemolytic Uremic Syndrome

Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disorder characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and acute kidney injury (AKI). In about 50% of cases, pathogenic variants in genes involved in the innate immune response including complement factors complement factor H (CFH), CFI, CFB, C3, and membrane co-factor protein (MCP/CD46) put patients at risk for uncontrolled activation of the alternative complement pathway. As aHUS is characterized by incomplete penetrance and presence of additional triggers for disease manifestation, genetic variant interpretation is challenging and streamlined functional variant evaluation is urgently needed. Here, we report the case of a 27-year-old female without previous medical and family history who presented with confusion, petechial bleeding, and anuric AKI. Kidney biopsy revealed glomerular thrombotic microangiopathy (TMA). Targeted next generation sequencing identified a paternally transmitted novel heterozygous splice site variant in the CFH gene [c.3134-2A>G; p.Asp1045_Thr1053del] which resulted in a partial in-frame deletion of exon 20 transcript as determined by cDNA analysis. On the protein level, the concomitant loss of 9 amino acids in the short consensus repeat (SCR) domains 17 and 18 of CFH includes a highly conserved cysteine residue, which is assumed to be essential for proper structural folding and protein function. Treatment with steroids, plasmapheresis, and the complement inhibitor eculizumab led to complete hematological and clinical remission after several months and stable renal function up to 6 years later. In conclusion, genetic investigation for pathogenic variants and evaluation of their functional impact, in particular in the case of splice site variants, is clinically relevant and enables not only better molecular understanding but helps to guide therapy with complement inhibitors