A Latent Variable Approach to Multivariate Quantitative Trait Loci

A novel approach based on latent variable modelling is presented for the analysis of multivariate quantitative and qualitative trait loci. The approach is general in the sense that it enables the joint analysis of many kinds of quantitative and qualitative traits (including count data and censored traits) in a single modelling framework. In the framework, the observations are modelled as functions of latent variables, which are then affected by quantitative trait loci. Separating the analysis in this way means that measurement errors in the phenotypic observations can be included easily in the model, providing robust inferences. The performance of the method is illustrated using two real multivariate datasets, from barley and Scots pine

Turnstile behaviour of the Cooper-pair pump

We have experimentally studied the behaviour of the so-called Cooper pair pump (CPP) with three Josephson junctions, in the limit of small Josephson coupling EJ < EC. These experiments show that the CPP can be operated as a traditional turnstile device yielding a gate-induced current 2ef in the direction of the bias voltage, by applying an RF-signal with frequency f to the two gates in phase, while residing at the degeneracy node of the gate plane. Accuracy of the CPP during this kind of operation was about 3% and the fundamental Landau-Zener limit was observed to lie above 20 MHz. We have also measured the current pumped through the array by rotating around the degeneracy node in the gate plane. We show that this reproduces the turnstile-kind of behavior. To overcome the contradiction between the obtained e-periodic DC-modulation and a pure 2e-behaviour in the RF-measurements, we base our observations on a general principle that the system always minimises its energy. It suggests that if the excess quasiparticles in the system have a freedom to tunnel, they will organize themselves to the configuration yielding the highest current.Comment: 29 pages, 16 figures, uses REVTeX and graphicx-packag

The connection between the radio jet and the gamma-ray emission in the radio galaxy 3C 120

We present the analysis of the radio jet evolution of the radio galaxy 3C 120 during a period of prolonged gamma-ray activity detected by the Fermi satellite between December 2012 and October 2014. We find a clear connection between the gamma-ray and radio emission, such that every period of gamma-ray activity is accompanied by the flaring of the mm-VLBI core and subsequent ejection of a new superluminal component. However, not all ejections of components are associated with gamma-ray events detectable by Fermi. Clear gamma-ray detections are obtained only when components are moving in a direction closer to our line of sight.This suggests that the observed gamma-ray emission depends not only on the interaction of moving components with the mm-VLBI core, but also on their orientation with respect to the observer. Timing of the gamma-ray detections and ejection of superluminal components locate the gamma-ray production to within almost 0.13 pc from the mm-VLBI core, which was previously estimated to lie about 0.24 pc from the central black hole. This corresponds to about twice the estimated extension of the broad line region, limiting the external photon field and therefore suggesting synchrotron self Compton as the most probable mechanism for the production of the gamma-ray emission. Alternatively, the interaction of components with the jet sheath can provide the necessary photon field to produced the observed gamma-rays by Compton scattering.Comment: Already accepted for publication in The Astrophysical Journa

Hardware-efficient compression of neural multi-unit activity

Brain-machine interfaces (BMI) are tools for measuring neural activity in the brain, used to treat numerous conditions. It is essential that the next generation of intracortical BMIs is wireless so as to remove percutaneous connections, i.e. wires, and the associated mechanical and infection risks. This is required for the effective translation of BMIs into clinical applications and is one of the remaining bottlenecks. However, due to cortical tissue thermal dissipation safety limits, the on-implant power consumption must be strictly limited. Therefore, both the neural signal processing and wireless communication power should be minimal, while the implants should provide signals that offer high behavioural decoding performance (BDP). The Multi-Unit Activity (MUA) signal is the most common signal in modern BMIs. However, with an ever-increasing channel count, the raw data bandwidth is becoming prohibitively high due to the associated communication power exceeding the safety limits. Data compression is therefore required. To meet this need, this work developed hardware-efficient static Huffman compression schemes for MUA data. Our final system reduced the bandwidth to 27 bps/channel, compared to the standard MUA rate of 1 kbps/channel. This compression is over an order of magnitude more than has been achieved before, while using only 0.96 uW/channel processing power and 246 logic cells. Our results were verified on 3 datasets and less than 1% loss in BDP was observed. As such, with the use of effective data compression, an order more of MUA channels can be fitted on-implant, enabling the next generation of high-performance wireless intracortical BMIs

Catching the Radio Flare in CTA 102 III. Core-Shift and Spectral Analysis

The temporal and spatial spectral evolution of the jets of AGN can be studied with multi-frequency, multi-epoch VLBI observations. The combination of both, morphological and spectral parameters can be used to derive source intrinsic physical properties such as the magnetic field and the non-thermal particle density. In the first two papers of this series, we analyzed the single-dish light curves and the VLBI kinematics of the blazar CTA 102 and suggested a shock-shock interaction between a traveling and a standing shock wave as a possible scenario to explain the observed evolution of the component associated to the 2006 flare. In this paper we investigate the core-shift and spectral evolution to test our hypothesis of a shock-shock interaction. We used 8 multi-frequency VLBA observations to analyze the temporal and spatial evolution of the spectral parameters during the flare. We observed CTA 102 between May 2005 and April 2007 using the VLBA at six different frequencies spanning from 2 - 86 GHz. After the calibrated VLBA images were corrected for opacity, we performed a detailed spectral analysis. From the derived values we estimated the magnetic field and the density of the relativistic particles. The detailed analysis of the opacity shift reveals that the position of the jet core is proportional to nu^-1 with some temporal variations. The value suggests possible equipartition between magnetic field energy and particle kinetic energy densities at the most compact regions. From the variation of the physical parameters we deduced that the 2006 flare in CTA 102 is connected to the ejection of a new traveling feature (t=2005.9) and the interaction between this shock wave and a stationary structure around 0.1 mas from the core. The source kinematics together with the spectral and structural variations can be described by helical motions in an over-pressured jet.Comment: 35 pages, 46 figure

Delayed visceral malperfusion in aortic dissection—successful surgical revascularization using a saphenous vein graft

Obstruction of the thoracoabdominal aorta and/or its branches with subsequent organ ischemia is a frequent complication of aortic dissection. Surgical and percutaneous fenestrations have been used and endovascular stenting has emerged as an additional less invasive approach. In some cases, surgical revascularization may be the most successful procedure. We report two patients who underwent surgical revascularization of the celiac trunk and superior mesenteric artery for delayed abdominal malperfusion due to aortic dissectio