873 research outputs found
Spontaneous Stratification in Granular Mixtures
Granular materials size segregate when exposed to external periodic
perturbations such as vibrations. Moreover, mixtures of grains of different
sizes spontaneously segregate in the absence of external perturbations: when a
mixture is simply poured onto a pile, the large grains are more likely to be
found near the base, while the small grains are more likely to be near the top.
Here, we report a spontaneous phenomenon arising when we pour a mixture between
two vertical plates: the mixture spontaneously stratifies into alternating
layers of small and large grains whenever the large grains are rougher than the
small grains. In contrast, we find only spontaneous segregation when the large
grains are more rounded than the small grains. The stratification is related to
the occurrence of avalanches; during each avalanche the grains comprising the
avalanche spontaneously stratify into a pair of layers through a "kink"
mechanism, with the small grains forming a sublayer underneath the layer of
large grains.Comment: 4 pages, 6 figures, http://polymer.bu.edu/~hmakse/Home.htm
Modeling payback from research into the efficacy of left-ventricular assist devices as destination therapy
Objectives: Ongoing developments in design have improved the outlook for left-ventricular assist device (LVAD) implantation as a therapy in end-stage heart failure. Nevertheless, early cost-effectiveness assessments, based on first-generation devices, have not been encouraging. Against this background, we set out (i) to examine the survival benefit that LVADs would need to generate before they could be deemed cost-effective; (ii) to provide insight into the likelihood that this benefit will be achieved; and (iii) from the perspective of a healthcare provider, to assess the value of discovering the actual size of this benefit by means of a Bayesian value of information analysis.
Methods: Cost-effectiveness assessments are made from the perspective of the healthcare provider, using current UK norms for the value of a quality-adjusted life-year (QALY). The treatment model is grounded in published analyses of the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) trial of first-generation LVADs, translated into a UK cost setting. The prospects for patient survival with second-generation devices is assessed using Bayesian prior distributions, elicited from a group of leading clinicians in the field.
Results: Using established thresholds, cost-effectiveness probabilities under these priors are found to be low (.2 percent) for devices costing as much as £60,000. Sensitivity of the conclusions to both device cost and QALY valuation is examined.
Conclusions: In the event that the price of the device in use would reduce to £40,000, the value of the survival information can readily justify investment in further trials
CAERvest® – a novel endothermic hypothermic device for core temperature cooling: safety and efficacy testing
Limited genomic divergence between intraspecific forms of Culex pipiens under different ecological pressures
Abstract
Background: Divergent selection can be a major driver of ecological speciation. In insects of medical importance,
understanding the speciation process is both of academic interest and public health importance. In the West Nile
virus vector Culex pipiens, intraspecific pipiens and molestus forms vary in ecological and physiological traits.
Populations of each form appear to share recent common ancestry but patterns of genetic differentiation across
the genome remain unknown. Here, we undertook an AFLP genome scan on samples collected from both
sympatric and allopatric populations from Europe and the USA to quantify the extent of genomic differentiation
between the two forms.
Results: The forms were clearly differentiated but each exhibited major population sub-structuring between
continents. Divergence between pipiens and molestus forms from USA was higher than in both inter- and
intra-continental comparisons with European samples. The proportion of outlier loci between pipiens and molestus
(≈3 %) was low but consistent in both continents, and similar to those observed between sibling species of other
mosquito species which exhibit contemporary gene flow. Only two of the outlier loci were shared between
inter-form comparisons made within Europe and USA.
Conclusion: This study supports the molestus and pipiens status as distinct evolutionary entities with low genomic
divergence. The low number of shared divergent loci between continents suggests a relatively limited number of
genomic regions determining key typological traits likely to be driving incipient speciation and/or adaptation of
molestus to anthropogenic habitats
A constitutive law for dense granular flows
A continuum description of granular flows would be of considerable help in
predicting natural geophysical hazards or in designing industrial processes.
However, the constitutive equations for dry granular flows, which govern how
the material moves under shear, are still a matter of debate. One difficulty is
that grains can behave like a solid (in a sand pile), a liquid (when poured
from a silo) or a gas (when strongly agitated). For the two extreme regimes,
constitutive equations have been proposed based on kinetic theory for
collisional rapid flows, and soil mechanics for slow plastic flows. However,
the intermediate dense regime, where the granular material flows like a liquid,
still lacks a unified view and has motivated many studies over the past decade.
The main characteristics of granular liquids are: a yield criterion (a critical
shear stress below which flow is not possible) and a complex dependence on
shear rate when flowing. In this sense, granular matter shares similarities
with classical visco-plastic fluids such as Bingham fluids. Here we propose a
new constitutive relation for dense granular flows, inspired by this analogy
and recent numerical and experimental work. We then test our three-dimensional
(3D) model through experiments on granular flows on a pile between rough
sidewalls, in which a complex 3D flow pattern develops. We show that, without
any fitting parameter, the model gives quantitative predictions for the flow
shape and velocity profiles. Our results support the idea that a simple
visco-plastic approach can quantitatively capture granular flow properties, and
could serve as a basic tool for modelling more complex flows in geophysical or
industrial applications.Comment: http://www.nature.com/nature/journal/v441/n7094/abs/nature04801.htm
Time for curriculum reform: the case of mathematics
Mathematics education is rarely out of the policy spotlight in England. Over the last ten years, considerable attention has been given to improving 14-19 mathematics curriculum pathways. In this paper we consider some of the challenges of enacting curriculum change by drawing upon evidence from our evaluation of the Mathematics Pathways Project. From 2004-10 this project, which was directed by England’s Qualifications and Curriculum Authority, aimed to improve the engagement, attainment and participation rates of 14-19 year old learners of mathematics. Our particular focus is upon the temporal problems of piloting new curriculum and assessment and we draw on Lemke’s discussion of time-scales, heterochrony and the adiabatic principle to consider the interlocking and interference of various change processes
p3d – Python module for structural bioinformatics
<p>Abstract</p> <p>Background</p> <p>High-throughput bioinformatic analysis tools are needed to mine the large amount of structural data via knowledge based approaches. The development of such tools requires a robust interface to access the structural data in an easy way. For this the Python scripting language is the optimal choice since its philosophy is to write an understandable source code.</p> <p>Results</p> <p>p3d is an object oriented Python module that adds a simple yet powerful interface to the Python interpreter to process and analyse three dimensional protein structure files (PDB files). p3d's strength arises from the combination of a) very fast spatial access to the structural data due to the implementation of a binary space partitioning (BSP) tree, b) set theory and c) functions that allow to combine a and b and that use human readable language in the search queries rather than complex computer language. All these factors combined facilitate the rapid development of bioinformatic tools that can perform quick and complex analyses of protein structures.</p> <p>Conclusion</p> <p>p3d is the perfect tool to quickly develop tools for structural bioinformatics using the Python scripting language.</p
Whole-body integration of gene expression and single-cell morphology
Animal bodies are composed of cell types with unique expression programs that implement their distinct locations, shapes, structures, and functions. Based on these properties, cell types assemble into specific tissues and organs. To systematically explore the link between cell-type-specific gene expression and morphology, we registered an expression atlas to a whole-body electron microscopy volume of the nereid Platynereis dumerilii. Automated segmentation of cells and nuclei identifies major cell classes and establishes a link between gene activation, chromatin topography, and nuclear size. Clustering of segmented cells according to gene expression reveals spatially coherent tissues. In the brain, genetically defined groups of neurons match ganglionic nuclei with coherent projections. Besides interneurons, we uncover sensory-neurosecretory cells in the nereid mushroom bodies, which thus qualify as sensory organs. They furthermore resemble the vertebrate telencephalon by molecular anatomy. We provide an integrated browser as a Fiji plugin for remote exploration of all available multimodal datasets
Insulin resistance in type 1 diabetes: what is ‘double diabetes’ and what are the risks?
In this review, we explore the concept of ‘double diabetes’, a combination of type 1 diabetes with features of insulin resistance and type 2 diabetes. After considering whether double diabetes is a useful concept, we discuss potential mechanisms of increased insulin resistance in type 1 diabetes before examining the extent to which double diabetes might increase the risk of cardiovascular disease (CVD). We then go on to consider the proposal that weight gain from intensive insulin regimens may be associated with increased CV risk factors in some patients with type 1 diabetes, and explore the complex relationships between weight gain, insulin resistance, glycaemic control and CV outcome. Important comparisons and contrasts between type 1 diabetes and type 2 diabetes are highlighted in terms of hepatic fat, fat partitioning and lipid profile, and how these may differ between type 1 diabetic patients with and without double diabetes. In so doing, we hope this work will stimulate much-needed research in this area and an improvement in clinical practice
Scaling properties of protein family phylogenies
One of the classical questions in evolutionary biology is how evolutionary
processes are coupled at the gene and species level. With this motivation, we
compare the topological properties (mainly the depth scaling, as a
characterization of balance) of a large set of protein phylogenies with a set
of species phylogenies. The comparative analysis shows that both sets of
phylogenies share remarkably similar scaling behavior, suggesting the
universality of branching rules and of the evolutionary processes that drive
biological diversification from gene to species level. In order to explain such
generality, we propose a simple model which allows us to estimate the
proportion of evolvability/robustness needed to approximate the scaling
behavior observed in the phylogenies, highlighting the relevance of the
robustness of a biological system (species or protein) in the scaling
properties of the phylogenetic trees. Thus, the rules that govern the
incapability of a biological system to diversify are equally relevant both at
the gene and at the species level.Comment: Replaced with final published versio
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