Neutrino-nucleus reactions in the delta resonance region

Reliable estimates of neutrino-nucleus reactions in the resonance-excitation region play an important role in many of the on-going and planned neutrino oscillation experiments. We study here neutrino-nucleus reactions in the delta-particle excitation region with the use of neutrino pion-production amplitudes calculated in a formalism in which the resonance contributions and the background amplitudes are treated on the same footing. Our approach leads to the neutrino-nucleus reaction cross sections that are significantly different from those obtained in the conventional approach wherein only the pure resonance amplitudes are taken into account. To assess the reliability of our formalism, we calculate the electron-nucleus scattering cross sections in the same theoretical framework; the calculated cross sections agree reasonably well with the existing data.Comment: 14 pages, 8 figures; typo, references and one figure adde

The Emergence of Women\u27s Mass Magazines and the Formation of a New Reading Culture in Early Twenties\u27 Japan

Translation of Culture and Culture of Translation, ベルギー, ルーヴァン・カトリック大学, 1998年10月12日-15

Japanese Women\u27s Magazines : Between Indoctrination and Pleasure, Intellectual History and Popular Culture

Translation of Culture and Culture of Translation, ベルギー, ルーヴァン・カトリック大学, 1998年10月12日-15

Performance do supply portuário : o caso da eficiência no processo de manuseio de containers refrigerados

Orientador: Prof. Dr. Gustavo Valentim LochCoorientador: Prof. Dr José Eduardo Pécora JuniorDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas, Programa de Pós-Graduação em Gestão de Organizações, Liderança e Decisão. Defesa : Curitiba, 28/03/2024Inclui referênciasResumo: O contêiner refrigerado (também conhecido como contêiner reefer), é um dispositivo significativo na cadeia marítima de transporte de mercadorias, que visa garantir a segurança da qualidade do produto refrigerado transportado, bem como suas especificações originais de validade. Estudar questões organizacionais no transporte de contêineres refrigerados se torna, entretanto, um desafio e uma abordagem de relevância significativa. Este estudo tem como objetivo realizar uma análise abrangente do processo da cadeia de frios em portos, visando identificar oportunidades de melhoria que garantam a eficiência operacional e a preservação da qualidade de produtos perecíveis. Para tanto, realizou-se um estudo de caso de abordagem combinada, de natureza aplicada, de caráter exploratório e descritivo. Utilizou-se a visita técnica para busca de dados primários, e a pesquisa de dados secundários foi realizada por meio da revisão bibliográfica da literatura e sítios da internet. Estudou-se a relação entre o processo da cadeia de frios (destaque para o fator humano) e o contêiner refrigerado (equipamento) em suas capacidades técnicas de refrigeração. Os resultados da análise destacam a necessidade de implementar melhorias no contêiner refrigerado, como aprimoramentos nos sistemas de controle de temperatura e isolamento térmico. Além disso, é crucial desenvolver embalagens internas que proporcionem uma barreira eficaz contra variações de temperatura, garantindo a integridade dos produtos perecíveis. Em paralelo, é fundamental capacitar a equipe responsável pelo manuseio e monitoramento da cadeia de frios, assegurando práticas adequadas de armazenamento e transporte. Essas medidas combinadas visam reduzir significativamente o risco de oscilação de temperatura e preservar a qualidade dos produtos ao longo da cadeia de distribuição.Abstract: The refrigerated container (also known as a reefer container), is a significant device in the maritime chain of goods transportation, which aims to guarantee the safety of the quality of the transported refrigerated product as well as its original shelf life specifications. Studying organizational issues in the transport of reefer containers, however, becomes a challenge and an approach of significant relevance. The aim of this study is to carry out a comprehensive analysis of the cold chain process in ports, with a view to identifying opportunities for improvement that guarantee operational efficiency and preserve the quality of perishable products. To this end, a case study was carried out with a combined approach, of an applied work, descriptive and exploratory study. A technical visit was used to search for primary data, and secondary data was searched through a bibliographic review of the literature. The relationship between the cold chain process (especially the human factor) and the refrigerated container (equipment) in terms of its technical refrigeration capabilities was studied. The results of the analysis highlight the need to implement improvements to the refrigerated container, such as improvements to the temperature control and thermal insulation systems. In addition, it is crucial to develop internal packaging that provides an effective barrier against temperature variations, guaranteeing the integrity of perishable products. In parallel, it is essential to train the staff responsible for handling and monitoring the cold chain, ensuring proper storage and transportation practices. These combined measures aim to significantly reduce the risk of temperature fluctuations and preserve product quality throughout the distribution chain

Delineating Genetic Alterations for Tumor Progression in the MCF10A Series of Breast Cancer Cell Lines

To gain insight into the role of genomic alterations in breast cancer progression, we conducted a comprehensive genetic characterization of a series of four cell lines derived from MCF10A. MCF10A is an immortalized mammary epithelial cell line (MEC); MCF10AT is a premalignant cell line generated from MCF10A by transformation with an activated HRAS gene; MCF10CA1h and MCF10CA1a, both derived from MCF10AT xenografts, form well-differentiated and poorly-differentiated malignant tumors in the xenograft models, respectively. We analyzed DNA copy number variation using the Affymetrix 500 K SNP arrays with the goal of identifying gene-specific amplification and deletion events. In addition to a previously noted deletion in the CDKN2A locus, our studies identified MYC amplification in all four cell lines. Additionally, we found intragenic deletions in several genes, including LRP1B in MCF10CA1h and MCF10CA1a, FHIT and CDH13 in MCF10CA1h, and RUNX1 in MCF10CA1a. We confirmed the deletion of RUNX1 in MCF10CA1a by DNA and RNA analyses, as well as the absence of the RUNX1 protein in that cell line. Furthermore, we found that RUNX1 expression was reduced in high-grade primary breast tumors compared to low/mid-grade tumors. Mutational analysis identified an activating PIK3CA mutation, H1047R, in MCF10CA1h and MCF10CA1a, which correlates with an increase of AKT1 phosphorylation at Ser473 and Thr308. Furthermore, we showed increased expression levels for genes located in the genomic regions with copy number gain. Thus, our genetic analyses have uncovered sequential molecular events that delineate breast tumor progression. These events include CDKN2A deletion and MYC amplification in immortalization, HRAS activation in transformation, PIK3CA activation in the formation of malignant tumors, and RUNX1 deletion associated with poorly-differentiated malignant tumors

KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development

SummaryUnderstanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor. hESC-derived endoderm cells do not express KDR but, when cultured in media supporting hepatic differentiation, generate KDR+ hepatic progenitors and KDR− hepatic cells. KDR+ progenitors require active KDR signaling both to instruct their own differentiation into hepatic cells and to non-cell-autonomously support the functional maturation of cocultured KDR− hepatic cells. Analysis of human fetal livers suggests that similar progenitors are present in human livers. Lineage tracing in mice provides in vivo evidence of a KDR+ hepatic progenitor for fetal hepatoblasts, adult hepatocytes, and adult cholangiocytes. Altogether, our findings reveal that KDR is a conserved marker for endoderm-derived hepatic progenitors and a functional receptor instructing early liver development

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice

Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair. We employed an oligonucleotide microarray technique to gain further insight into the molecular mechanisms underlying the proangiogenic potential of human PMN. In addition to 18 known angiogenesis-relevant genes, we detected the expression of 10 novel genes, namely midkine, erb-B2, ets-1, transforming growth factor receptor-beta(2) and -beta(3), thrombospondin, tissue inhibitor of metalloproteinase 2, ephrin A2, ephrin B2 and restin in human PMN freshly isolated from the circulation. Gene expression was confi rmed by the RT-PCR technique. In vivo evidence for the role of PMN in neovascularization was provided by studying neovascularization in a skin model of wound healing using CD18-deficient mice which lack PMN infi ltration to sites of lesion. In CD18-deficient animals, neo- vascularization was found to be signifi cantly compromised when compared with wild- type control animals which showed profound neovascularization within the granulation tissue during the wound healing process. Thus, PMN infiltration seems to facilitate inflammation mediated angiogenesis which may be a consequence of the broad spectrum of proangiogenic factors expressed by these cells. Copyright (c) 2006 S. Karger AG, Basel

Spitzer Survey of the Large Magellanic Cloud, Surveying the Agents of a Galaxy's Evolution (SAGE) I: Overview and Initial Results

We are performing a uniform and unbiased, ~7x7 degrees imaging survey of the Large Magellanic Cloud (LMC), using the IRAC and MIPS instruments on board the Spitzer Space Telescope in order to survey the agents of a galaxy's evolution (SAGE), the interstellar medium (ISM) and stars in the LMC. The detection of diffuse ISM with column densities >1.2x10^21 H cm^-2 permits detailed studies of dust processes in the ISM. SAGE's point source sensitivity enables a complete census of newly formed stars with masses >3 solar masses that will determine the current star formation rate in the LMC. SAGE's detection of evolved stars with mass loss rates >1x10^-8 solar masses per year will quantify the rate at which evolved stars inject mass into the ISM of the LMC. The observing strategy includes two epochs in 2005, separated by three months, that both mitigate instrumental artifacts and constrain source variability. The SAGE data are non-proprietary. The data processing includes IRAC and MIPS pipelines and a database for mining the point source catalogs, which will be released to the community in support of Spitzer proposal cycles 4 and 5. We present initial results on the epoch 1 data with a special focus on the N79 and N83 region. The SAGE epoch 1 point source catalog has ~4 million sources. The point source counts are highest for the IRAC 3.6 microns band and decrease dramatically towards longer wavelengths consistent with the fact that stars dominate the point source catalogs and that the dusty objects, e.g. young stellar objects and dusty evolved stars that detected at the longer wavelengths, are rare in comparison. We outline a strategy for identifying foreground MW stars, that may comprise as much as 18% of the source list, and background galaxies, that may comprise ~12% of the source list.Comment: Accepted by the Astronomical Journa

Spitzer survey of the Large Magellanic Cloud, surveying the agents of a galaxy's evolution (SAGE). IV. Dust properties in the interstellar medium

The goal of this paper is to present the results of a preliminary analysis of the extended infrared (IR) emission by dust in the interstellar medium (ISM) of the Large Magellanic Cloud (LMC). We combine Spitzer Surveying the Agents of Galaxy Evolution (SAGE) and Infrared Astronomical Satellite (IRAS) data and correlate the infrared emission with gas tracers of H I, CO, and Hα. We present a global analysis of the infrared emission as well as detailed modeling of the spectral energy distribution (SED) of a few selected regions. Extended emission by dust associated with the neutral, molecular, and diffuse ionized phases of the ISM is detected at all IR bands from 3.6 μm to 160 μm. The relative abundance of the various dust species appears quite similar to that in the Milky Way (MW) in all the regions we have modeled. We construct maps of the temperature of large dust grains. The temperature map shows variations in the range 12.1-34.7 K, with a systematic gradient from the inner to outer regions, tracing the general distribution of massive stars and individual H II regions as well as showing warmer dust in the stellar bar. This map is used to derive the far-infrared (FIR) optical depth of large dust grains. We find two main departures in the LMC with respect to expectations based on the MW: (1) excess mid-infrared (MIR) emission near 70 μm, referred to as the 70 μm excess, and (2) departures from linear correlation between the FIR optical depth and the gas column density, which we refer to as FIR excess emission. The 70 μm excess increases gradually from the MW to the LMC to the Small Magellanic Cloud (SMC), suggesting evolution with decreasing metallicity. The excess is associated with the neutral and diffuse ionized gas, with the strongest excess region located in a loop structure next to 30 Dor. We show that the 70 μm excess can be explained by a modification of the size distribution of very small grains with respect to that in the MW, and a corresponding mass increase of ≃13% of the total dust mass in selected regions. The most likely explanation is that the 70 μm excess is due to the production of large very small grains (VSG) through erosion of larger grains in the diffuse medium. This FIR excess could be due to intrinsic variations of the dust/gas ratio, which would then vary from 4.6 to 2.3 times lower than the MW values across the LMC, but X_(CO) values derived from the IR emission would then be about three times lower than those derived from the Virial analysis of the CO data. We also investigate the possibility that the FIR excess is associated with an additional gas component undetected in the available gas tracers. Assuming a constant dust abundance in all ISM phases, the additional gas component would have twice the known H I mass. We show that it is plausible that the FIR excess is due to cold atomic gas that is optically thick in the 21 cm line, while the contribution by a pure H_2 phase with no CO emission remains a possible explanation