Multiple causes of interannual sea surface temperature variability in the equatorial Atlantic Ocean

The eastern equatorial Atlantic Ocean is subject to interannual fluctuations of sea surface temperatures, with climatic impacts on the surrounding continents. The dynamic mechanism underlying Atlantic temperature variability is thought to be similar to that of the El Nino/Southern Oscillation (ENSO) in the equatorial Pacific, where air-sea coupling leads to a positive feedback between surface winds in the western basin, sea surface temperature in the eastern basin, and equatorial oceanic heat content. Here we use a suite of observational data, climate reanalysis products, and general circulation model simulations to reassess the factors driving the interannual variability. We show that some of the warm events can not be explained by previously identified equatorial wind stress forcing and ENSO-like dynamics. Instead, these events are driven by a mechanism in which surface wind forcing just north of the equator induces warm ocean temperature anomalies that are subsequently advected toward the equator. We find the surface wind patterns are associated with long-lived subtropical sea surface temperature anomalies and suggest they therefore reflect a link between equatorial and subtropical Atlantic variability

Performance of organically grown tomato cultivars under greenhouse conditions

A agricultura orgânica no Brasil cresce a taxas superiores a 30% ao ano, devido principalmente à maior conscientização dos consumidores que buscam alimentos saudáveis, livres de resíduos químicos e biológicos. Dentre as hortaliças cultivadas em sistema orgânico, o tomate constitui grande desafio para os produtores devido à inexistência de recomendações de manejo cultural e de cultivares desenvolvidas específicas para esse sistema de cultivo. Diante disso, o presente trabalho teve como objetivo avaliar o desempenho de cultivares de tomate sob sistema orgânico, em ambiente protegido. O experimento foi conduzido de maio a outubro de 2004 em campo, no município de Araraquara-SP. O delineamento experimental adotado foi blocos ao acaso, com quatro repetições e oito tratamentos (cultivares Avalon, Colibri, HTX-5415, HTX-8027, Sahel, San Marzano, San Vito e Jane). As plantas foram conduzidas em fileiras duplas, com duas hastes por planta no espaçamento de 0,8 m entre linhas e 0,6 m entre plantas (cerca de 20.000 plantas ha-1), sem poda apical. O híbrido Sahel destacou-se com o melhor desempenho para rendimento comercial. A traça-do-tomateiro se revelou como fator limitante à produção de tomate em sistema orgânico, sendo responsável, em média, por 17% de danos nos frutos colhidos das oito cultivares que foram avaliadas.Organic agriculture in Brazil has been increasing about 30% per year over the last few years, since consumers are seeking for healthier foods, i.e. nutritious and free of pesticide residues. Among organically grown vegetable crops, tomato is an attractive economic opportunity for growers. However, the lack of information about management practices and adapted cultivars to organic production systems under protected cultivation are pointed out as important constraints that prevents this activity to expand. This work aimed at evaluating the performance of indeterminate tomato cultivars in organic management systems in unheated plastic greenhouse. In both experiments tomato plants were staked. Plant spacing was 1.5 m between rows and 0.35 m between plants. They were planted in double line and spaced 0.8 m between lines and 0.6 m between plants (about 20,000 plants ha-1). The experiment was set up in a randomized complete block design, with four replications and eight treatments (cultivars: Avalon, Colibri, HTX-5415, HTX-8027, Sahel, San Marzano, San Vito, and Jane). Sahel hybrid exhibited an outstanding performance for marketable yield under organic cultivation. Tomato pinworm (Tuta absoluta) was a serious limiting pest for organically grown tomatoes, responding for 17% of damage in the fruits harvested from the evaluated cultivars

Study of the excess Fe XXV line emission in the central degrees of the Galactic centre using XMM-Newton data

The diffuse Fe XXV (6.7 keV) line emission observed in the Galactic ridge is widely accepted to be produced by a superposition of a large number of unresolved X-ray point sources. In the very central degrees of our Galaxy, however, the existence of an extremely hot (~7 keV) diffuse plasma is still under debate. In this work we measure the Fe XXV line emission using all available XMM-Newton observations of the Galactic centre (GC) and inner disc (-10 < l < 10, -2 < b < 2). We use recent stellar mass distribution models to estimate the amount of X-ray emission originating from unresolved point sources, and find that within a region of l = ±1 and b = ±0.25 the 6.7keV emission is 1.3-1.5 times in excess of what is expected from unresolved point sources. The excess emission is enhanced towards regions where known supernova remnants are located, suggesting that at least a part of this emission is due to genuine diffuse very hot plasma. If the entire excess is due to very hot plasma, an energy injection rate of at least ~6 × 1040 erg s-1 is required, which cannot be provided by the measured supernova explosion rate or past Sgr A∗ activity alone. However, we find that almost the entire excess we observe can be explained by assuming GC stellar populations with iron abundances ~1.9 times higher than those in the bar/bulge, a value that can be reproduced by fitting diffuse X-ray spectra from the corresponding regions. Even in this case, a leftover X-ray excess is concentrated within l = ±0.3 and b = ±0.15, corresponding to a thermal energy of ~2 × 1052 erg, which can be reproduced by the estimated supernova explosion rate in the GC. Finally we discuss a possible connection to the observed GC Fermi-LAT excess

How Gaussian competition leads to lumpy or uniform species distributions

A central model in theoretical ecology considers the competition of a range of species for a broad spectrum of resources. Recent studies have shown that essentially two different outcomes are possible. Either the species surviving competition are more or less uniformly distributed over the resource spectrum, or their distribution is 'lumped' (or 'clumped'), consisting of clusters of species with similar resource use that are separated by gaps in resource space. Which of these outcomes will occur crucially depends on the competition kernel, which reflects the shape of the resource utilization pattern of the competing species. Most models considered in the literature assume a Gaussian competition kernel. This is unfortunate, since predictions based on such a Gaussian assumption are not robust. In fact, Gaussian kernels are a border case scenario, and slight deviations from this function can lead to either uniform or lumped species distributions. Here we illustrate the non-robustness of the Gaussian assumption by simulating different implementations of the standard competition model with constant carrying capacity. In this scenario, lumped species distributions can come about by secondary ecological or evolutionary mechanisms or by details of the numerical implementation of the model. We analyze the origin of this sensitivity and discuss it in the context of recent applications of the model.Comment: 11 pages, 3 figures, revised versio

Prescribing practices of primary-care veterinary practitioners in dogs diagnosed with bacterial pyoderma

Concern has been raised regarding the potential contributions of veterinary antimicrobial use to increasing levels of resistance in bacteria critically important to human health. Canine pyoderma is a frequent, often recurrent diagnosis in pet dogs, usually attributable to secondary bacterial infection of the skin. Lesions can range in severity based on the location, total area and depth of tissue affected and antimicrobial therapy is recommended for resolution. This study aimed to describe patient signalment, disease characteristics and treatment prescribed in a large number of UK, primary-care canine pyoderma cases and to estimate pyoderma prevalence in the UK vet-visiting canine population

The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog

Chronic spinal cord dysfunction occurs in dogs as a consequence of diverse aetiologies, including long-standing spinal cord compression and insidious neurodegenerative conditions. One such neurodegenerative condition is canine degenerative myelopathy (DM), which clinically is a challenge to differentiate from other chronic spinal cord conditions. Although the clinical diagnosis of DM can be strengthened by the identification of the Sod1 mutations that are observed in affected dogs, genetic analysis alone is insufficient to provide a definitive diagnosis. There is a requirement to identify biomarkers that can differentiate conditions with a similar clinical presentation, thus facilitating patient diagnostic and management strategies. A comparison of the cerebrospinal fluid (CSF) protein gel electrophoresis profile between idiopathic epilepsy (IE) and DM identified a protein band that was more prominent in DM. This band was subsequently found to contain a multifunctional protein clusterin (apolipoprotein J) that is protective against endoplasmic reticulum (ER) stress-mediated apoptosis, oxidative stress, and also serves as an extracellular chaperone influencing protein aggregation. Western blot analysis of CSF clusterin confirmed elevated levels in DM compared to IE (p < 0.05). Analysis of spinal cord tissue from DM and control material found that clusterin expression was evident in neurons and that the clusterin mRNA levels from tissue extracts were elevated in DM compared to the control. The plasma clusterin levels was comparable between these groups. However, a comparison of clusterin CSF levels in a number of neurological conditions found that clusterin was elevated in both DM and chronic intervertebral disc disease (cIVDD) but not in meningoencephalitis and IE. These findings indicate that clusterin may potentially serve as a marker for chronic spinal cord disease in the dog; however, additional markers are required to differentiate DM from a concurrent condition such as cIVDD

Inflation and dark matter in two Higgs doublet models

We consider the Higgs inflation in the extension of the Standard Model with two Higgs doublets coupled to gravity non-minimally. In the presence of an approximate global U(1) symmetry in the Higgs sector, both radial and angular modes of neutral Higgs bosons drive inflation where large non-Gaussianity is possible from appropriate initial conditions on the angular mode. We also discuss the case with single-field inflation for which the U(1) symmetry is broken to a Z_2 subgroup. We show that inflationary constraints, perturbativity and stability conditions restrict the parameter space of the Higgs quartic couplings at low energy in both multi- and single-field cases. Focusing on the inert doublet models where Z_2 symmetry remains unbroken at low energy, we show that the extra neutral Higgs boson can be a dark matter candidate consistent with the inflationary constraints. The doublet dark matter is always heavy in multi-field inflation while it can be light due to the suppression of the co-annihilation in single-field inflation. The implication of the extra quartic couplings on the vacuum stability bound is also discussed in the light of the recent LHC limits on the Higgs mass.Comment: (v1) 28 pages, 8 figures; (v2) 29 pages, a new subsection 3.3 added, references added and typos corrected, to appear in Journal of High Energy Physic

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the DNA damage response pathway. The aim of this study was to investigate whether healthy BRCA1 mutations carriers demonstrate an increased radiosensitivity compared with healthy individuals. Methods: We defined a novel radiosensitivity indicator (RIND) based on two endpoints measured by the G2 micronucleus assay, reflecting defects in DNA repair and G2 arrest capacity after exposure to doses of 2 or 4 Gy. We investigated if a correlation between the RIND score and nonsense-mediated decay (NMD) could be established. Results: We found significantly increased radiosensitivity in the cohort of healthy BRCA1 mutation carriers compared with healthy controls. In addition, our analysis showed a significantly different distribution over the RIND scores (p = 0.034, Fisher’s exact test) for healthy BRCA1 mutation carriers compared with non-carriers: 72 % of mutation carriers showed a radiosensitive phenotype (RIND score 1–4), whereas 72 % of the healthy volunteers showed no radiosensitivity (RIND score 0). Furthermore, 28 % of BRCA1 mutation carriers had a RIND score of 3 or 4 (not observed in control subjects). The radiosensitive phenotype was similar for relatives within several families, but not for unrelated individuals carrying the same mutation. The median RIND score was higher in patients with a mutation leading to a premature termination codon (PTC) located in the central part of the gene than in patients with a germline mutation in the 5′ end of the gene. Conclusions: We show that BRCA1 mutations are associated with a radiosensitive phenotype related to a compromised DNA repair and G2 arrest capacity after exposure to either 2 or 4 Gy. Our study confirms that haploinsufficiency is the mechanism involved in radiosensitivity in patients with a PTC allele, but it suggests that further research is needed to evaluate alternative mechanisms for mutations not subjected to NMD

Glucagon-like peptide-1(7–36) amide is a new incretin/enterogastrone candidate

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72032/1/j.1365-2362.1991.tb01802.x.pd

A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial

<p>Abstract</p> <p>Background</p> <p>This small, pilot study evaluated the impact of treatment with a natural multi-mineral supplement from seaweed (Aquamin) on walking distance, pain and joint mobility in subjects with moderate to severe osteoarthritis of the knee.</p> <p>Methods</p> <p>Subjects (n = 70) with moderate to severe osteoarthritis of the knee were randomized to four double-blinded treatments for 12 weeks: (a) Glucosamine sulfate (1500 mg/d); (b) Aquamin (2400 mg/d); (c) Combined treatment composed of Glucosamine sulfate (1500 mg/d) plus Aquamin (2400 mg/d) and (d) Placebo. Primary outcome measures were WOMAC scores and 6 Minute Walking Distances (6 MWD). Laboratory based blood tests were used as safety measures.</p> <p>Results</p> <p>Fifty subjects completed the study and analysis of the data showed significant differences between the groups for changes in WOMAC pain scores over time (p = 0.009 ANCOVA); however, these data must be reviewed with caution since significant differences were found between the groups at baseline for WOMAC pain and stiffness scores (p = 0.0039 and p = 0.013, respectively, ANOVA). Only the Aquamin and Glucosamine groups demonstrated significant improvements in symptoms over the course of the study. The combination group (like the placebo group) did not show any significant improvements in OA symptoms in this trial. Within group analysis demonstrated significant improvements over time on treatment for the WOMAC pain, activity, composite and stiffness (Aquamin only) scores as well as the 6 minute walking distances for subjects in the Aquamin and Glucosamine treatment groups. The Aquamin and Glucosamine groups walked 101 feet (+7%) and 56 feet (+3.5%) extra respectively. All treatments were well tolerated and the adverse events profiles were not significantly different between the groups.</p> <p>Conclusion</p> <p>This small preliminary study suggested that a multi mineral supplement (Aquamin) may reduce the pain and stiffness of osteoarthritis of the knee over 12 weeks of treatment and warrants further study.</p> <p>Trial registration</p> <p>ClinicalTrials.gov number: NCT00452101.</p