Progetto di un sistema di navigazione pedonale al coperto

Quest’articolo ha lo scopo di porre le basi per il progetto di un sistema di navigazione dedicato all’uso pedonale e in ambienti chiusi. Si vuole, infatti, progettare un sistema di posizionamento alternativo al GPS che sia in grado di sostituirlo in ambienti in cui non sia possibile ricevere il segnale satellitare. Questo avviene tramite l’utilizzo del Map Matching che, con l’aiuto di un modulo INS e l’applicazione del filtro di Kalman, dovrebbe poter permettere la creazione di un software per la navigazione assistita pedonale indoor.ope

A MILP model for quasi-periodic strategic train timetabling

In railways, the long-term strategic planning is the process of evaluating improvements to the railway network (e.g., upgrading a single track line to a double track line) and changes to the composition/frequency of train services (e.g., adding 1 train per hour along a certain route). The effects of different combinations of infrastructure upgrades and updated train services (also called scenarios), are usually evaluated by creating new feasible timetables followed by extensive simulation. Strategic Train Timetabling (STT) is indeed the task of producing new tentative timetables for these what-if scenarios. Unlike the more classic train timetabling, STT can often overlook (or at least give less importance to) some complementary aspects, such as crew and rolling stock scheduling. On the other hand, the different scenarios are likely to lead to very different timetables, hindering the common and effective practice of using existing timetables to warm start the solution process. We introduce the concept of quasi-periodic timetables, that are timetables where certain subsets of trains need to start at almost (rather than precisely) the same minute of every period. The additional flexibility offered by quasi-periodic timetables turned out to be crucial in real-life scenarios characterized by elevated train traffic. We describe a MILP based approach for strategic quasi-periodic train timetabling and we test it on 4 different realistic what-if scenarios for an important line in Norway. The timetables produced by our algorithm were ultimately used by the Norwegian Railway Directorate to select 3 out of the 4 scenarios for phasing the progressive expansion of the JȪren line.publishedVersio

European Association of Nuclear Medicine Focus 5:Consensus on Molecular Imaging and Theranostics in Prostate Cancer

BACKGROUND: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications.OBJECTIVE: We aimed to critically review developments in molecular hybrid imaging and systemic radioligand therapy, to reach a multidisciplinary consensus on the current state of the art in PCa.DESIGN, SETTING, AND PARTICIPANTS: The results of a systematic literature search informed a two-round Delphi process with a panel of 28 PCa experts in medical or radiation oncology, urology, radiology, medical physics, and nuclear medicine. The results were discussed and ratified in a consensus meeting.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Forty-eight statements were scored on a Likert agreement scale and six as ranking options. Agreement statements were analysed using the RAND appropriateness method. Ranking statements were analysed using weighted summed scores.RESULTS AND LIMITATIONS: After two Delphi rounds, there was consensus on 42/48 (87.5%) of the statements. The expert panel recommends PSMA PET to be used for staging the majority of patients with unfavourable intermediate and high risk, and for restaging of suspected recurrent PCa. There was consensus that oligometastatic disease should be defined as up to five metastases, even using advanced imaging modalities. The group agreed that [177Lu]Lu-PSMA should not be administered only after progression to cabazitaxel and that [223Ra]RaCl2 remains a valid therapeutic option in bone-only metastatic castration-resistant PCa. Uncertainty remains on various topics, including the need for concordant findings on both [18F]FDG and PSMA PET prior to [177Lu]Lu-PSMA therapy.CONCLUSIONS: There was a high proportion of agreement among a panel of experts on the use of molecular imaging and theranostics in PCa. Although consensus statements cannot replace high-certainty evidence, these can aid in the interpretation and dissemination of best practice from centres of excellence to the wider clinical community.PATIENT SUMMARY: There are situations when dealing with prostate cancer (PCa) where both the doctors who diagnose and track the disease development and response to treatment, and those who give treatments are unsure about what the best course of action is. Examples include what methods they should use to obtain images of the cancer and what to do when the cancer has returned or spread. We reviewed published research studies and provided a summary to a panel of experts in imaging and treating PCa. We also used the research summary to develop a questionnaire whereby we asked the experts to state whether or not they agreed with a list of statements. We used these results to provide guidance to other health care professionals on how best to image men with PCa and what treatments to give, when, and in what order, based on the information the images provide.</p

Parma consensus statement on metabolic disruptors

A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16–18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as “metabolic disruptors”, in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome

Progetto di un sistema di navigazione pedonale al coperto

Quest’articolo ha lo scopo di porre le basi per il progetto di un sistema di navigazione dedicato all’uso pedonale e in ambienti chiusi. Si vuole, infatti, progettare un sistema di posizionamento alternativo al GPS che sia in grado di sostituirlo in ambienti in cui non sia possibile ricevere il segnale satellitare. Questo avviene tramite l’utilizzo del Map Matching che, con l’aiuto di un modulo INS e l’applicazione del filtro di Kalman, dovrebbe poter permettere la creazione di un software per la navigazione assistita pedonale indoor