Students’ perceptions of the role of pharmacists in the healthcare system in Lahore, Pakistan

Purpose: To explore the role of pharmacists in the healthcare system of Lahore, Pakistan; and to determine association between students’ socio-demographic indicators and the likelihood of consulting with a pharmacist.Methods: In this exploratory study, data were collected from 589 students at a private sector university in Lahore, Pakistan, using a convenient sampling design. Information was collected using a semistructured questionnaire. Descriptive statistics (i.e., mean, standard deviation, percentages) and chi square were employed.Results: Of 621 questionnaires, a total of 589 were returned, giving a response rate of 94.85 %. The results showed that 289 students (49.06 %) have interacted with pharmacists; however, the majority of the students (98.64 %) agreed there is a strong need for pharmacists who can provide guidance on medication safety. Furthermore, there was a statistically significant association between family system (x2 (1) = 4.046, p = 0.004), age of family head (x2 (1) = 11.755, p = 0.001), education level of family head (x2 (1) = 10.473, p = 0.001), and consulting a pharmacist.Conclusion: There are important roles for pharmacists to play in order to improve the healthcare system of Lahore, Pakistan. Some social demographics affect the likelihood that a person will seek professional counseling from a pharmacist.Keywords: Medication safety, Healthcare system, Pharmacist consultation, Students’ perceptio

Comparison of Single-Stage Reverse Sural Artery Flap Versus Two-Staged Interpolated Flap in Distal Lower Limb Injuries

Background and Objective: Plastic surgeons face challenging conditions when dealing with soft tissue injuries or defects involving the lower part of the leg and the proximal part of the foot. The objective of the current study is to compare single-staged reverse sural artery flaps with two-staged interpolated flaps in distal lower limb injuries. Methods: It was a prospective study carried out at the Department of Plastic Surgery, Allama Iqbal Memorial Teaching Hospital, Sialkot, Pakistan, over 5 years from 2015 to 2020. Sixty-eight (n = 68) patients with distal lower limb soft-tissue defects were enrolled and randomly allotted a two-stage interpolated flap design (group A) or single-stage reverse sural artery flap design (group B). The measured outcomes included the frequency of flap-tip necrosis, epidermolysis, partial or total flap loss, and additional procedures needed for managing these complications. Results: Out of all the patients, 72% were of male gender and 28% were females with a mean age of 38.38 &plusmn; 10.76 years. In group A, there were 6% of the cases where tip necrosis was the only impediment as compared to 17% in group B. In patients of group A, epidermolysis was seen in 12% as compared to 35% in group B whereas only 6% of patients in group A required secondary procedures for flap tip necrosis as compared to group B (47%). Paired t-test was used to calculate the statistical significance of the outcome between the two groups (p-value of 0.0491). Conclusion: The two-staged interpolated flap procedure results in fewer complications as compared to a single-staged reverse sural artery flap procedure. However, the shorter hospital stay in single-staged flap design is satisfying for the patients who did not report any complications with this procedure.</p

Effect of tip clearance and rotor–stator axial gap on the efficiency of a multistage compressor

International audienceMultistage compressor is the most important constituent of gas turbines used in land, naval and aeronautical applications. Overall performance of such machinery depends mainly on the axial compressor performance. Due to the relative motion between rotor and stator blades, the flow field in this machinery is highly unsteady. Furthermore several technological effects like tip clearances, complexity of the blade shapes, variation of axial distance between stator and rotor, seal leakages and cooling holes among others complicate the machine. Therefore the study of a complicated, strongly three-dimensional flow field inside a compressor is considered to be one of the most difficult tasks to be performed by a CFD expert. The present work is the extensive numerical study of the effect of: (1) tip clearance of rotor blades and (2) the axial gap between rotor and stator on the overall performance of a multistage axial compressor. A commercial software package is used for this study. Reynolds-averaged Navier–Stokes equations are solved using Spalart–Allmaras model. A number of steady-state viscous flow simulations were run for both the tip clearance effect and different axial gaps between stator and rotor. All simulations were performed for the first stage, i.e. Stator–Rotor–Stator. Simulations were carried out with coarse, medium and fine meshes to find an optimum, mesh-independent solution. It has been found that larger tip clearance has a detrimental effect on the stage pressure ratio and efficiency of a multistage axial compressor. Similarly there exists a certain distance ratio between the stator1–rotor and rotor–stator2, where stage performance is optimum. Overall performance characteristics obtained through simulation for both the tip clearance and axial gap variation were also compared with the experimental studies and found to be in good agreement

A comprehensive assessment of phytochemicals from Phyla nodiflora (L.) Greene as a potential enzyme inhibitor, and their biological potential: An in-silico, in-vivo, and in-vitro approach

This work explored Phyla nodiflora (L.) Greene as a potential source of the bioactive medicinal agent. In this aspect, methanol (PN-M) and dichloromethane (PN-D) extracts were prepared from the whole plant and evaluated for phytochemical composition (total bioactive contents, UHPLC-MS analysis, and HPLC-PDA polyphenolic quantification), biological (antioxidant and enzyme inhibition) potential and in-vivo toxicity. The PN-M was found to contain higher phenolic (26.08 mg GAE/g extract) and flavonoid (50.25 mg QE/g extract) contents which might correlate to the higher radical scavenging (DPPH: 52.94 mg TE/g extract; ABTS: 72.11 mg TE/g extract) and reducing power (FRAP: 71.96 mg TE/g extract; CUPRAC: 142.65 mg TE/g extract) antioxidant potential, as well as AChE (4.33 mg GALAE/g extract), tyrosinase (125.36 mg KAE/g extract), and amylase (1.86 mmol ACAE/g extract) inhibition activity of this extract. In contrast, the PN-D extract was found to be most active for phosphomolybdenum (1.30 mg TE/ g extract) and metal chelation (54.84 mg EDTAE/g extract) assays in addition to BChE (4.70 mg GALAE/g extract) and glucosidase (0.62 mmol ACAE/g extract) enzyme inhibition activity. The PN-M extract on UHPLC-MS analysis revealed the tentative identification of 24 different secondary metabolites, most of which belonged to the flavonoid, glycoside, and terpenoid classes of phytochemicals. The polyphenolic composition of the extracts was appraised by HPLC-PDA. Seven phenolic compounds were identified in the extracts. PN-M was found to be rich in catechin (0.25 µg/extract) and 3-OH benzoic acid (0.64 µg/extract), while PN-D contained epicatechin (0.30 µg/extract), 3-OH-4-MeO benzaldehyde (0.21 µg/extract), and 2,3-Di-Meo benzoic acid (0.97 µg/extract) in higher amounts. The methanol extract was found to be non-toxic even at higher doses. Furthermore, the relationship between the phytochemicals and the tested enzymes was highlighted by molecular docking studies. In sum, this research showed that the studied extracts were effective as enzyme inhibitors and antioxidants, suggesting it would be worth investigating in more depth for further advanced studies to explore its pharmacological properties

An Experimental Demonstration of the Effective Application of Thermal Energy Storage in a Particle-Based CSP System

Tests were performed at the particle-based CSP test facility at King Saud University to demonstrate a viable solution to overcome the limitations of using molten salt as a working medium in power plants. The KSU facility is composed of a heliostat field, particle heating receiver (PHR) at the top of a tower, thermal energy storage (TES) bin, a particle-to-working fluid heat exchanger (PWFHX), power cycle (microturbine), and a particle lift. During pre-commissioning, a substantial portion of the collected solar energy was lost during particle flow through the TES bin. The entrained air is shown to be the primary cause of such heat loss. The results show that the particle temperature at the PHR outlet can reach 720 &deg;C after mitigating the entrained air issue. Additionally, during on-sun testing, a higher temperature of the air exiting the PWFHX than that of the air entering is observed, which indicates the effective solar contribution. Half-hour plant operation through stored energy was demonstrated after heliostat defocusing. Lastly, a sealable TES bin configuration for 1.3 MWe pre-commercial demonstration unit to be built in Saudi Arabia by Saudi Electric Company (SEC) is presented. This design modification has addressed the heat loss, pressure build-up, and contamination issues during TES charging