Understanding different factors affecting Supersonic Particle Deposition (SPD) repaired Al 7075-T651 plate for structural restoration

One of the main challenges in maintaining aging aircraft is to find a reliable, effective and economic repair process, for both non-structural and structural repairs. Supersonic particle technology (SPD) aka Cold Spray (CS) has proved to be an effective geometry restoration technology and has the potential to repair/restore/enhance the airworthiness of aging aircraft. Al 7075-T651 is highly susceptible for stress crossing cracking compared to –T7351 temper. Mechanism involved in environment assisted cracking (EAC) such as corrosion fatigue primarily in conventional product forms such as rolled plate, extrudate or forging in Al 7075 is complex. Fundamental research concerning the driving force and micro-mechanism involved in EAC is still not matured, and, not completely understood in Al alloys. In addition, the effect of different factors such as high strain rate deformed layers, residual stress in the coating and substrate and presence of micro defects makes more complex in understanding the EAC in SPD repair subjects. In light of the complex nature of the SPD structure, systematic evaluation was carried out to determine various factors affecting the EAC behavior of the SPD repair. Thus, this presentation focuses on a brief overview on the application of this technology for corrosion repair followed by experimental study and fractographic analysis of SPD repaired Al 7075-T651 0.25” plate aimed at restoring the structural functionality. To study the structural behavior of the SPD coated 7075 Al, both static and fatigue performance were evaluated in ambient and humid environment. The study involves simulating a 20% thickness loss by milling Al 7075 master plates (9.1” x 8.75”) followed by depositing Al 7075 spray atomized powder using SPD process. Test coupons were extracted from this master plate; orientation and location of the individual test specimen origin were tracked. The presentation includes factors affecting the quality of the SPD coating specifically for structural application and how to exploit these factors in qualifying a SPD coating. Test results are validated and supported by detailed fractographic studies. Emphasis will be given to failure modes and mechanism involved on these SPD coated specimens tested under cyclic loads, and, under ambient and humid environments will be discussed

Analytical method development and validation for simultaneous estimation of Moxifloxacin Hydrochloride and Ketorolac Tromethamine by using RP-HPLC

The main objectives of the present research were to develop the new method for the simultaneous estimation and validation of Moxifloxacin HCl and Ketorolac Tromethamine in pure form and in pharmaceutical dosage form by RP-HPLC. The chromatogram of Moxifloxacin HCl and Ketorolac Tromethamine was developed through column (Inertsil ODS C18), UV detection at 304 nm at a flow rate of 1.0 ml/min with Buffer (pH 4.0):Acetonitrile:Methanol (50:30:20) V/V as mobile phase. The method was validated by various validation parameters such as accuracy, precision, linearity, specificity as per the ICH guidelines. A linearity range of Moxifloxacin HCl and Ketorolac Tromethamine was found to be 60 to 140 µg/ml and 48 to 112 µg/ml respectively. The retention time of Moxifloxacin HCl and Ketorolac Tromethamine was found to be 2.07 min and 4.06 min respectively. % RSD of retention time and peak areas obtained in system precision for Moxifloxacin HCl was 0.21 and 0.80 respectively and for Ketorolac Tromethamine were 0.90 and 1.06 respectively. The % recovery of standard Moxifloxacin HCl and Ketorolac Tromethamine was found to be 100.18 to 100.08% and 99.97 to 99.93% respectively. The % recovery of Moxifloxacin HCl and Ketorolac Tromethamine in dosage form was found to be 98.73 to 100.92% and 98.10 to 100.77% respectively. This method was simple, accurate, precise, and sensitive. Hence, the developed method was employed for the routine analysis of Tenofovir in the pharmaceutical dosage form

In vivo administration of fucoidan from Turbinaria decurrens protects shrimps from white spot syndrome virus

212-216Fucoidan was extracted from the brown seaweed Turbinaria decurrens by hot water extraction and characterized with HPLC, FTIR, NMR and GPC to study the impact against the White Spot Syndrome Virus (WSSV), bacteria and fungi. Fucoidan was fed for shrimps along with the diet (before and after WSSV infection). In the end of the study, the survival percentage of shrimp was 51% (in the case of 5-8 g) and 97% (in the case of 12-15 g), respectively. Among the 10 bacterial pathogens and 7 fungal pathogens, fucoidan inhibited 2 bacterial pathogen such as S. aureus (0.26±0.02 mm) and E. faecalis (1.3±0.1 mm) and A. Niger (0.84 ± 0.03 mm) in fungal pathogens with clear zone of inhibition

A comparative study of dermatoglyphic markers in schizophrenia patients and normal controls

Background: Schizophrenia is a complex mental illness with multiple etiological factors. Prenatal insult to the developing foetus has been implicated as a major risk factor for the genesis of schizophrenia, according to the neuro-developmental model. As the brain and skin are ectodermal derivatives, insult to developing brain is reflected in several dermatoglyphic markers.Methods: Total finger ridge count (TFRC), Total A-B ridge count (TABRC) and ATD Angle of 100 patients diagnosed with schizophrenia were compared with 100 age and sex matched healthy controls.Results: Statistically significant differences were observed in the values recorded and compared between healthy controls and schizophrenia patients.Conclusions: This study shows the correlation between abnormalities in dermatoglyphic patterns and development of schizophrenia

An Atom Michelson Interferometer on a Chip Using a Bose-Einstein Condensate

An atom Michelson interferometer is implemented on an "atom chip." The chip uses lithographically patterned conductors and external magnetic fields to produce and guide a Bose-Einstein condensate. Splitting, reflecting, and recombining of condensate atoms are achieved by a standing-wave light field having a wave vector aligned along the atom waveguide. A differential phase shift between the two arms of the interferometer is introduced by either a magnetic-field gradient or with an initial condensate velocity. Interference contrast is still observable at 20% with atom propagation time of 10 ms

Tinnitus and Qigong

Subjective tinnitus is the perception of sound despite the absence of an external stimulus. This challenging sensory event affects millions of people per year. There currently is no cure for tinnitus, but there have been many different options researched to help patients manage its effects, albeit with varying efficacy. In a viral internet video, the Beating the Heavenly Drum maneuver, found in the Eastern practice of Qigong, was said to eliminate the perception of tinnitus for the participants. In this current study, the Beating the Heavenly Drum maneuver was compared to a sham maneuver and evaluated for effectiveness in relieving tinnitus. To be included in this study, participants had experienced tinnitus for at least 6 months and were not currently receiving other tinnitus care. Exclusionary criteria included a diagnosis of Post-Traumatic Stress Disorder, Traumatic Brain Injury, any neurological condition, whiplash, neck injury, or severe anxiety or depression, as determined by the Hospital Anxiety and Depression Scale. Participants completed a tinnitus case history form, Tinnitus Functional Index (TFI), Tinnitus Handicap Index (THI), and Visual Analog Scale (VAS) ranking the annoyance of their tinnitus. Participants were assigned to groups in an alternating fashion, with odd identifiers in Group 1 and even identifiers in Group 2. In Group 2, participants received the experimental maneuver (Beating the Heavenly Drum) during the first session and the sham maneuver (circles rubbed at the base of the skull) during the second. In Group 1, participants received a sham maneuver during the first session and the experimental maneuver during the second session. Within 48 hours after each session, participants completed the TFI, THI, and rated the annoyance of their tinnitus on a scale of 0 to 10 (keeping the same parameters from the VAS) via phone call. Of the twelve participants, two reported that the experimental maneuver, Qigong, was effective for tinnitus relief; while five reported the sham condition relieved their tinnitus. The remaining five participants stated that neither maneuver altered their tinnitus sensation. Across all participants, there were no significant difference scores on the THI, and only one significant difference score on the TFI. While participants reported some change in their tinnitus with either maneuver, none of the questionnaire measures corroborated their subjective report. Additionally, the sham maneuver was perceived as more effective than the experimental maneuver. The Qigong maneuver was not effective for tinnitus relief in this study. It should be noted that a limitation to this study is the small sample size. While this Qigong maneuver did not relieve tinnitus, there are other Internet tinnitus “cures” that should be investigated for their effectiveness in tinnitus relief. With the rise of the Internet and more patients searching for “quick fixes” to tinnitus, it is vital that clinicians provide appropriate education and research to best help patients manage their tinnitus

N-(2-Acetyl­phen­yl)benzene­sulfonamide

In the title compound, C14H13NO3S, the phenyl ring makes a dihedral angle of 81.5 (1)° with the benzene ring. The mol­ecular structure is stabilized by an intra­molecular N—H⋯O hydrogen bond and weak C—H⋯O inter­actions. In the crystal structure, mol­ecules are linked by weak inter­molecular C—H⋯O and C—H⋯π inter­actions