Uncovering the neuroprotective mechanisms of curcumin on transthyretin amyloidosis

Transthyretin (TTR) amyloidoses (ATTR amyloidosis) are diseases associated with transthyretin (TTR) misfolding, aggregation and extracellular deposition in tissues as amyloid. Clinical manifestations of the disease are variable and include mainly polyneuropathy and/or cardiomyopathy. The reasons why TTR forms aggregates and amyloid are related with amino acid substitutions in the protein due to mutations, or with environmental alterations associated with aging, that make the protein more unstable and prone to aggregation. According to this model, several therapeutic approaches have been proposed for the diseases that range from stabilization of TTR, using chemical chaperones, to clearance of the aggregated protein deposited in tissues in the form of oligomers or small aggregates, by the action of disruptors or by activation of the immune system. Interestingly, different studies revealed that curcumin presents anti-amyloid properties, targeting multiple steps in the ATTR amyloidogenic cascade. The effects of curcumin on ATTR amyloidosis will be reviewed and discussed in the current work in order to contribute to knowledge of the molecular mechanisms involved in TTR amyloidosis and propose more efficient drugs for therapy.This research was funded by the European Regional Development Fund (FEDER) through the Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, grant number Norte-01-0145-FEDER-000008—Porto Neurosciences and Neurologic Disease Research Initiative at I3S. Nelson Ferreira was a recipient of a Postdoctoral Fellowship R171-2014-591 from Lundbeck foundation and by Lundbeck Foundation grant R248-2016-2518 for Danish Research Institute of Translational Neuroscience—DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Denmark

Surviving in a second language: survival processing effect in memory of bilinguals

Human memory likely evolved to serve adaptive functions, that is, to help maximise our chances of survival and reproduction. One demonstration of such adaptiveness is the increased retention of information processed in survival contexts, the so-called Survival Processing Effect (SPE). This study examined this effect in a native (L1) and in a second language (L2). This comparison is relevant to explore if emotionality is involved in the SPE, as emotional activation seems to be larger in L1 than in L2. Following the original survival processing procedure, participants rated the relevance of information to the survival and moving scenarios and performed a recognition (Experiment 1) or a free recall (Experiment 2) task in L1 or L2. In both experiments, the SPE was replicated in L1 but not in L2. The absence of the effect when emotional activation is less likely suggests that emotionality might play a role in the survival processing effect; nevertheless, additional studies are needed to further investigate this hypothesis.info:eu-repo/semantics/acceptedVersio

High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola.

In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ). After 28 days of follow-up, there were 2/61 (3.2%) recurrent parasitemias in the Coartem group and 4/64 (6.2%) in the ASAQ group (P = 0.72), all classified as re-infections after PCR genotyping (cure rate = 100% [95%CI: 94-100] in both groups). Only one patient (ASAQ group) had gametocytes on day 28 versus five (Coartem) and three (ASAQ) at baseline. Compared with baseline, anemia was significantly improved after 28 days of follow-up in both groups (Coartem: from 54.1% to 13.4%; ASAQ: from 53.1% to 15.9%). Our findings are in favor of a high efficacy of both combinations in Caala. Now that Coartem has been chosen as the new first-line anti-malarial, the challenge is to insure that this drug is available and adequately used

Para ler a América Latina: Tad Szulc, As relações Interamericanas e a política externa dos Estados Unidos (1955-1965)

This research examines Tad Szulc's writings and performance (1926-2001) in inter-American post-war relations. He was an American intellectual relevant to inter-American relations in the second half of the twentieth century. He was a press professional linked to The New York Times. He made an itinerant journalistic coverage that crossed America writing on key issues of politics at the time: development; nationalism and communism. He spoke with heads of state, bureaucrats and intellectuals, and worked closely with state and private initiatives across the continent, including governments, large corporations and intelligence services. His journalistic work and books published between September 1955 and May 1965. He examines the sociopolitical analyzes that the journalist formulated of the region and the foreign policy of the United States, his trajectory with private institutions, administrations and government agencies in the States United States and Latin America. In that period, Szulc wrote more than one thousand five hundred articles, articles, reviews and travel reports and launched five books on Latin America. These publications are the central sources of research. In addition to these, this work examines a roll of periodicals, diplomatic dispatches, intelligence reports, official speeches and memoir books. This research investigates the role of the United States's international correspondence for inter-American post-war relations. It mobilizes recurrent interpretations for this question that emphasize the correspondents as: interpreters of Latin American reality; critics of internal and external politics; tentacles of US political, military, and economic power; agents of Latin American governments and interests. The thesis argues that all these roles are simultaneous and that the correspondent is a mediator with his own interests

Spondylodiscitis associated with recurrent Serratia bacteremia due to a transjugular intrahepatic portosystemic shunt (TIPS): a case report

We report a case of spondylodiscitis caused by multiresistant Serratia marcescens in a cirrhotic patient who had several Serratia bacteremias after the placement of a transjugular intrahepatic portosystemic shunt (TIPS) device. We concluded that an endovascular stent that can not be removed makes management of recurrent bacteremia difficult. Furthermore, back pain due to bacteremia is indicative of spondylodiscitis. Serratia marcescens can be an aggressive pathogen, causing spinal infection

Immunohistochemical expression of melan-A and tyrosinase in uveal melanoma

BACKGROUND: Melan-A and tyrosinase are new immunohistochemical markers that can be used in the diagnosis of melanocytic lesions. The aim of this study was to investigate the correlation between radiotherapy or clinicohistopathological parameters and the expression of melan-A and tyrosinase in uveal melanoma. METHODS: Thirty-six enucleated cases of uveal melanoma were studied. The formalin-fixed, paraffin-embedded specimens were immunostained with monoclonal antibodies against melan-A and tyrosinase. The samples were classified as either positive or negative. The chi-square or the Student-t tests were used to test for the correlation of the expression rates of melan-A and tyrosinase with clinico-pathological parameters. RESULTS: Melan-A and tyrosinase were positive in 33 (91.7%) and 35 (97.2%) of the specimens, respectively. There was no significant association between the expression of melan-A or tyrosinase and radiotherapy or any clinico-pathological parameter. All specimens were positive for at least one of the immunohistochemical markers. CONCLUSION: To the best of our knowledge this is the first study concluding that the expression of melanocytic markers such as melan-A and tyrosinase is not influenced by radiotherapy or any clinico-pathological parameter. Moreover, when tyrosinase and melan-A are used together, 100% of the formalin-fixed, paraffin-embedded uveal melanoma samples tested positive for one of those markers

Transport through an impurity tunnel coupled to a Si/SiGe quantum dot

Achieving controllable coupling of dopants in silicon is crucial for operating donor-based qubit devices, but it is difficult because of the small size of donor-bound electron wavefunctions. Here we report the characterization of a quantum dot coupled to a localized electronic state, and we present evidence of controllable coupling between the quantum dot and the localized state. A set of measurements of transport through this device enable the determination of the most likely location of the localized state, consistent with an electronically active impurity in the quantum well near the edge of the quantum dot. The experiments we report are consistent with a gate-voltage controllable tunnel coupling, which is an important building block for hybrid donor and gate-defined quantum dot devices.Comment: 5 pages, 3 figure

The use of linoleic acid in in vitro culture of bovine embryos and its effects on production and survival to vitrification.

Proceedings of the 31st Annual Meeting of the Brazilian Embryo Technology Society (SBTE); Cabo de Santo Agostinho, PE, Brazil, August 17th to 19th, 2017. Abstracts