No association between chromosome 12p13 single nucleotide polymorphisms and early-onset ischemic stroke

[No abstract available

Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility

Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7–15.7 vs 11.3, 95%CI 11.0–11.6 µmol/L; p<0.0001). In both populations, a genotype-phenotype association (p<0.0001) between Hcy and C677T MTHFR polymorphism was observed; in controls a significant (p = 0.029) association between tHcy and −786C/T eNOS polymorphism was also observed. At the multivariate analysis the NVAF risk significantly increased in the upper quartiles of Hcy compared to the lowest: OR from 2.8 (1.68–4.54 95%CI) in Q2 to 12.9 (7.96–21.06 95%CI) in Q4. or in combination

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies (GWAS). Methods and Results: Through a meta-analysis of 6 GWAS datasets and a validation study totalling 10,204 cases and 107,766 controls we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches we observed no new associations between the lead AAA SNPs and coronary artery disease, blood pressure, lipids or diabetes. Network analyses identified ERG, IL6R and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. Conclusions: The 4 new risk loci for AAA appear to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease

Performance predictions and postdictions in prospective memory of school-aged children

Prospective memory (PM) undergoes important developmental changes during the primary school years, particularly around 7 and 8 years of age. Recent studies have suggested that, as well as executive functions (EFs), PM development also benefits from age-related increments in metamemory (MM) abilities. The primary aim of the current study was to explore the role of MM monitoring and control processes (i.e., procedural MM) of 7- and 8-year-old children in a PM task including specific cues. Monitoring processes were assessed by asking children to judge their own PM performance before (predictions) and after (postdictions) in performing a PM task. In addition, children were asked to report the strategy they used to remember the PM task. Reactive effects of making predictions and using strategies were assessed via both an ongoing task (OT) and PM performance. EF and declarative MM performance was also examined. Results showed that children who were asked to predict PM performance had faster PM response times (RTs), but not higher accuracy rates, than children in a control group. However, strategy use affected both PM and OT performance, with those children reporting active strategy use obtaining higher PM accuracy rates and slower OT RTs. Finally, switching abilities were also predictive of OT performance. This investigation highlights the importance of studying MM monitoring and control processes in relation to children's PM

Travelling salesperson in an immersive virtual environment: Experimental evaluation of tracking system device

Nowadays Virtual Reality (VR) is an extremely versatile technology capable to cope with many areas of human life, and its fast development requires constant evaluation and validation. Cognitive models of human behavior play a central role in this evaluation, aiming at obtaining high quality, safe and usable products. A problem currently faced by VR users inside immersive Virtual Environments (iVEs) consists in the Simulator-induced Sickness (SS), a particular kind of motion sickness evoked by the simulated visual motion. SS can reduce subjects’ performances, and bias data collected with VR. Although Tracking Systems (TS) were thought to reduce SS symptoms, their effective contribution is not clear. A task based on the Traveling Salaperson was implemented in an iVE to investigate whether TS (a) evoked less SS symptoms and (b) facilitated performance in participants with respect to a control condition without TS. Results showed that TS allowed reduction of many SS symptoms, but this did not produced clear benefits on the cognitive performance, mainly true for female subjects. While TSs may facilitate enjoyment of iVE reducing SS, the higher susceptibility of females suggested that VR designers and producers should consider valuable a certain training before using the iVEs

Give me the control, I can see the robot!

Emergency and exploration missions are accomplished by remote stationary personnel and on-site responders that can deploy robots for dealing with situations involving hazard or inaccessibility. Thus, human-robot interaction (HRI) plays a key role in these kinds of applications. Intra-scenario operator mobility is often considered to be advantageous for acquiring situational awareness (SA) in the context of robot teleoperation, but non portable devices can provide a greater volume of processed information. This should not be discounted when trying to build more effective human-robot interaction (HRI) in search and rescue (SAR) or exploration missions. In this paper, we report a set of experiments comparing a desktop-based interface with a PDA-based interface for remote control of mobile robots. Our goal is twofold. First we aim at defining which kinds of operators have the best SA under different conditions. Second, we investigate a control transfer policy for determining when an operator should hand over to another, depending on the device, the task and the context