The Grizzly, April 8, 2010

First Annual Backwards Beauty Pageant Held • Ursinus Senior to Travel Abroad for a Year with Watson • Kappa Alpha Psi and Seismic Step Emerge on Campus • UC Welcomes New Field Hockey Coach • Sex on Wheels Documentary Screening • Volunteering with St. Christopher\u27s Children\u27s Hospital • Feeling Good in The Skin We\u27re In • The Sacrifice Your Body Makes for [Better] Grades • Opinion: Kyleigh\u27s Law Profiles Drivers by Age in New Jersey • Upper Classmen Off-Campus Living • UC Gymnastics Closes Season with Successhttps://digitalcommons.ursinus.edu/grizzlynews/1810/thumbnail.jp

UK guideline on transition of adolescent and young persons with chronic digestive diseases from paediatric to adult care

The risks of poor transition include delayed and inappropriate transfer that can result in disengagement with healthcare. Structured transition care can improve control of chronic digestive diseases and long-term health-related outcomes. These are the first nationally developed guidelines on the transition of adolescent and young persons (AYP) with chronic digestive diseases from paediatric to adult care. They were commissioned by the Clinical Services and Standards Committee of the British Society of Gastroenterology under the auspices of the Adolescent and Young Persons (A&YP) Section. Electronic searches for English-language articles were performed with keywords relating to digestive system diseases and transition to adult care in the Medline (via Ovid), PsycInfo (via Ovid), Web of Science and CINAHL databases for studies published from 1980 to September 2014. The quality of evidence and grading of recommendations was appraised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The limited number of studies in gastroenterology and hepatology required the addition of relevant studies from other chronic diseases to be included. These guidelines deal specifically with the transition of AYP living with a diagnosis of chronic digestive disease and/or liver disease from paediatric to adult healthcare under the following headings; 1. Patient populations involved in AYP transition 2. Risks of failing transition or poor transition 3. Models of AYP transition 4. Patient and carer/parent perspective in AYP transition 5. Surgical perspectiv

Modificazioni dell’intake calorico e del comportamento alimentare dopo sleeve gastrectomy

L’excess weight loss (%EWL) medio a 3-5 anni dopo Sleeve Gastrectomy Laparoscopica (LSG), è del 60%. La riduzione del volume gastrico ha un ruolo centrale nella perdita di peso post-operatoria,tuttavia diversi studi indicano che, anche il cambiamento delle abitudini alimentari nei pazienti, possa contribuire al calo ponderale. E’ stato dimostrato che diversi pazienti dopo intervento di chirurgia bariatrica, cambino le loro preferenze alimentari verso cibi a bassa densità calorica. La diminuzione nell’assunzione di cibi ad alto contenuto lipidico e di dolci, suggerisce che alcuni interventi bariatrici possano influenzare le scelte alimentari. Gli obiettivi di questo studio prospettico sono: valutare la riduzione quantitativa dell’introito calorico giornaliero e i cambiamenti nelle abitudini alimentari 1 anno dopo LSG utilizzando un Suter Questionnaire modificato. Si è inoltre analizzata la relazione tra la perdita di peso e il cambiamento del gusto e delle abitudini alimentari

Distinct roles of v-Jun:ATF and v-Jun:Fos dimers in skeletal muscle differentiation

The Jun oncoprotein is the major component of the transcriptional complex AP-1, which is involved in several cell functions. Constitutive activation of AP-1 is required for cell transformation, and also occurs in distinct human tumor cells. Jun is able to dimerize with different partners including Fos family members and ATF proteins providing AP-1 with high flexibility in gene regulation and functions. Particularly, by using mutants selective for Fos proteins or ATF2-like proteins, it has been demonstrated that v-Jun-induced transformation phenotype consists of, at least, two distinct, complementing genetic programs. It has been long known that transformation of myogenic cells by v-Jun, as well as by activated c-Jun, prevents terminal differentiation. In order to better dissect the transformation activity exerted by Jun in myogenic cells, C2C12 cells were infected with retroviral vectors expressing v-Jun mutants selective for Fos proteins or ATF2-like proteins. The analysis of the different cell population revealed opposite phenotypes induced by the different mutants. Data supporting the major role of v-Jun:ATF dimer in the inhibition of terminal differentiation will be presented

Endothelial Dysfunction and Extra-Articular Neurological Manifestations in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory autoimmune disease that affects about 1% of the global population, with a female–male ratio of 3:1. RA preferably affects the joints, with consequent joint swelling and deformities followed by ankylosis. However, evidence has accumulated showing that patients suffering from RA can also develop extra-articular manifestations, including cardiovascular disease states, neuropathies, and multiorgan dysfunction. In particular, peripheral nerve disorders showed a consistent impact in the course of the disease (prevalence about 20%) mostly associated to vasculitis of the nerve vessels leading to vascular ischemia, axonal degeneration, and neuronal demyelination. The pathophysiological basis of this RA-associated microvascular disease, which leads to impairment of assonal functionality, is still to be better clarified. However, endothelial dysfunction and alterations of the so-called brain-nerve barrier (BNB) seem to play a fundamental role. This review aims to assess the potential mechanisms underlying the impairment of endothelial cell functionality in the development of RA and to identify the role of dysfunctional endothelium as a causative mechanism of extra-articular manifestation of RA. On the other hand, the potential impact of lifestyle and nutritional interventions targeting the maintenance of endothelial cell integrity in patients with RA will be discussed as a potential option when approaching therapeutic solutions in the course of the disease

Endothelial Dysfunction and Extra-Articular Neurological Manifestations in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory autoimmune disease that affects about 1% of the global population, with a female–male ratio of 3:1. RA preferably affects the joints, with consequent joint swelling and deformities followed by ankylosis. However, evidence has accumulated showing that patients suffering from RA can also develop extra-articular manifestations, including cardiovascular disease states, neuropathies, and multiorgan dysfunction. In particular, peripheral nerve disorders showed a consistent impact in the course of the disease (prevalence about 20%) mostly associated to vasculitis of the nerve vessels leading to vascular ischemia, axonal degeneration, and neuronal demyelination. The pathophysiological basis of this RA-associated microvascular disease, which leads to impairment of assonal functionality, is still to be better clarified. However, endothelial dysfunction and alterations of the so-called brain-nerve barrier (BNB) seem to play a fundamental role. This review aims to assess the potential mechanisms underlying the impairment of endothelial cell functionality in the development of RA and to identify the role of dysfunctional endothelium as a causative mechanism of extra-articular manifestation of RA. On the other hand, the potential impact of lifestyle and nutritional interventions targeting the maintenance of endothelial cell integrity in patients with RA will be discussed as a potential option when approaching therapeutic solutions in the course of the disease

Soil and Plant Characteristics in a Restored Area under Mid-Term Site Management

Mid- and long-term monitoring of restoration projects have to be performed, as short-term evaluations do not give comprehensive information about their outcomes. In this study, we assessed the results of a forest restoration project, implemented in former road builder’s yards. We evaluated the recovery of the soil’s physical and chemical properties, the effectiveness and naturalness of sward restoration, and the success of woody species planting. Our hypotheses were that soil–plant interaction strongly influenced the restoration dynamics. The areas were restored in 2016. In 2014, we collected data from 28 restored areas. Eight years after the restoration, the physical and chemical properties of the soil indicated good quality. Suitable soil conditions were reflected in the herbaceous vegetation cover, which was higher than 60% in all the areas. The sown mixture successfully contained spontaneous species, and perennials prevailed over annuals, indicating stability in the composition of the sward. Alien species cover (generally < 10%) was controlled by sown species. Sown species also outcompeted ruderal and typical grassland species, reducing the naturalness of the herbaceous layer. Tree and shrub growth was low, and soil properties did not affect their height. Our results underline the importance of sowing an herbaceous species mixture in degraded areas in order to efficiently restore the soil cover and to reduce the colonization of alien species. Moreover, in our study, we showed how soil properties differently affected plant species groups

Clinical utility of carotid duplex ultrasound prior to cardiac surgery

OBJECTIVE: Clinical utility and cost-effectiveness of carotid duplex examination prior to cardiac surgery have been questioned by the multidisciplinary committee creating the 2012 Appropriate Use Criteria for Peripheral Vascular Laboratory Testing. We report the clinical outcomes and postoperative neurologic symptoms in patients who underwent carotid duplex ultrasound prior to open heart surgery at a tertiary institution. METHODS: Using the combined databases from our clinical vascular laboratory and the Society of Thoracic Surgery, a retrospective analysis of all patients who underwent carotid duplex ultrasound within 13 months prior to open heart surgery from March 2005 to March 2013 was performed. The outcomes between those who underwent carotid duplex scanning (group A) and those who did not (group B) were compared. RESULTS: Among 3233 patients in the cohort who underwent cardiac surgery, 515 (15.9%) patients underwent a carotid duplex ultrasound preoperatively, and 2718 patients did not (84.1%). Among the patients who underwent carotid screening vs no screening, there was no statistically significant difference in the risk factors of cerebrovascular disease (10.9% vs 12.7%; P = .26), prior stroke (8.2% vs 7.2%; P = .41), and prior transient ischemic attack (2.9% vs 3.3%; P = .24). For those undergoing isolated coronary artery bypass grafting (CABG), 306 (17.8%) of 1723 patients underwent preoperative carotid duplex ultrasound. Among patients who had carotid screening prior to CABG, the incidence of carotid disease was low: 249 (81.4%) had minimal or mild stenosis ( CONCLUSIONS: In this study, the correlation between preoperative duplex-documented high-grade carotid stenosis and postoperative stroke was low. Prudent use of preoperative carotid duplex ultrasound should be based on the presence of cerebrovascular symptoms and the type of open heart surgery

Beyond the barrier: the immune-inspired pathways of tumor extravasation

Abstract Extravasation is a fundamental step in the metastatic journey, where cancer cells exit the bloodstream and breach the endothelial cell barrier to infiltrate target tissues. The tactics cancer cells employ are sophisticated, closely reflecting those used by the immune system for tissue surveillance. Remarkably, tumor cells have been observed to form distinct associations or clusters with immune cells where neutrophils stand out as particularly crucial partners. These interactions are not accidental; they are critical for cancer cells to exploit the immune functions of neutrophils and successfully extravasate. In another strategy, tumor cells mimic the behavior and characteristics of immune cells. They release a suite of inflammatory mediators, which under normal circumstances, guide the processes of endothelium reshaping and facilitate the entry and movement of immune cells within tissues. In this review, we offer a new perspective on the tactics employed by cancer cells to extravasate and infiltrate target tissues. We delve into the myriad mechanisms that tumor cells borrow, adapt, and refine from the immune playbook. Video Abstrac