976 research outputs found
Chronic sildenafil therapy in experimental hypertension and metabolic syndrome associated heart failure with preserved ejection fraction rat model
New physiological mechanisms, diagnostic and therapeutic approaches in heart failure with preserved ejection fraction.
LÃquen Estriado Seguido de LÃquen Plano Clássico: Estados dum Espectro de Doença?
Classical lichen planus and lichen striatus represent separate entities within the group of lichenoid dermatoses with clinical and histologic well-defined differences. A possible relationship between both has been proposed. We present a case of a 38-year-old woman with a consecutive diagnosis of lichen striatus followed by classical lichen planus within three months. Some authors have questioned whether there is an intermediate form between these two entities or if they represent different states or opposite ends of the same disease spectrum. These questions are unlikely to be resolved until the pathophysiology of these two diseases is clarified.O lÃquen plano clássico e o lÃquen estriado representam duas patologias dentro do grupo das dermatoses liquenóides com caracterÃsticas clinicas e histológicas bem estabelecidas. No entanto, a possibilidade de uma correlação entre elas tem sido proposto. Os autores apresentam o caso de uma doente do sexo feminino de 38 anos com diagnóstico consecutivo de lÃquen estriado e lÃquen plano clássico com apenas três meses de diferença. De facto alguns autores levantam a questão se existe uma forma intermédia entre estas duas patologias ou se representam extremos opostos da mesma doença. No entanto estas questões apenas serão resolvidas quando se identificar por completo a fisiopatologia destas doenças
Da pintura abstrata ao movimento: um processo coreográfico com alunos do 11.º ano do Balleteatro Escola Profissional
Relatório Final de Estágio apresentado à Escola Superior de Dança com vista à obtenção do Grau de Mestre em Ensino de DançaO presente Relatório de Estágio insere-se no âmbito do Curso de Mestrado em Ensino de Dança, da Escola Superior de Dança, do Instituto Politécnico de Lisboa. Surgiu com o intuito de se aprofundar os conhecimentos e competências ao nÃvel do processo de composição coreográfica, partindo-se de um estÃmulo visual – diferentes obras de artistas plásticos portugueses e internacionais de arte abstrata –, em que se desenhou um projeto dirigido aos alunos do 11.º ano, do Curso Profissional de Intérprete de Dança Contemporânea, do Balleteatro Escola Profissional do Porto, a ser implementado no ano letivo de 2020/2021.
Tendo como ponto de partida a pintura abstrata como estÃmulo visual pretendeu-se fomentar as competências interpretativas do público-alvo, criando estÃmulos ideacionais que se foram transformando em movimentos e sequências, que depois de estruturados deram origem a uma pintura em movimento. Todo este processo criativo de composição coreográfica teve por base um ambiente colaborativo, no qual a professora estagiária foi o elemento mediador com poder de decisão, e os alunos foram intérpretes e cocriadores.
Estabelecendo-se nas áreas da Educação e da Dança, o Estágio foi suportado por uma metodologia de investigação-ação, servindo-se de fichas de observação, diário de bordo, gravação audiovisual e análise de documentos como instrumentos de recolha de dados.
A partir de um método qualitativo e cÃclico de investigação – ação, reflexão, ação – compreendeu-se de que forma o estÃmulo visual pode ser o ponto de partida para o desenvolvimento das competências interpretativas e de criação dos alunos e de que forma a utilização desse estÃmulo resulta num produto coreográfico final.ABSTRACT - The present report reflects the culmination of the investigation done under the Master’s Dance Teaching, of the Escola Superior de Dança, of the Instituto Politécnico de Lisboa. Its intent is to deepen the knowledge and competences at the choreography composition process level, starting from a visual stimulus – different works from portuguese and international plástic artists of abstract painting –, in which a project was intentionally designed for the 11th grade students of the Curso Profissional de Intérprete de Dança Contemporânea, of the Balleteatro Escola Profissional do Porto, and implemented on the school year of 2020/2021.
Having the starting point of an abstract painting as visual stimulus, the intention was to foment the interpretative competencies of the target, creating ideational stimulus which transformed into movements and sequences, that after structuralization gave origin to a moving painting. The creative process of choreographic composition was based on a collaborative environment, in which the intern professor was the mediating element with decision power, and the students were interpreters and co-creators.
While based on the areas of Education and Dance, the internship methodology was supported by action-investigation, observation charts, diary log, audiovisual tapings and document analysis as data gathering methods.
From a qualitative and cyclic method of investigation - action, reflexion, action - it was understood the way the visual stimulus can be the starting point to the development of interpretative competencies and student creation and how the effect of that stimulus results in a final choreographic product.N/
Assessing recording delays in general practice records to inform near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD).
PURPOSE: Near real-time vaccine safety surveillance (NRTVSS) is an option for post-licensure vaccine safety assessment. NRTVSS requires timely recording of outcomes in the database used. Our main objective was to examine recording delays in the Clinical Practice Research Datalink (CPRD) for outcomes of interest for vaccine safety to inform the feasibility of NRTVSS using these data. We also evaluated completeness of recording and further assessed reporting delays for hospitalized events in CPRD. METHODS: We selected Guillain-Barré syndrome (GBS), Bell's palsy (BP), optic neuritis (ON) and febrile seizures (FS), from January 2005 to June 2014. We assessed recording delays (e.g. due to feedback from specialist referral) in stand-alone CPRD by comparing the event and system dates and excluding delays >1 year. We used linked CPRD-hospitalization data to further evaluate delays and completeness of recording in CPRD. RESULTS: Among 51 220 patients for the stand-alone CPRD analysis (GBS: n = 830; BP: n = 12 602; ON: n = 1720; and FS: n = 36 236), most had a record entered within 1 month of the event date (GBS: 73.6%; BP: 93.4%; ON: 76.2%; and FS: 85.6%). A total of 13 482 patients, with a first record in hospital, were included for the analysis of linked data (GBS: n = 678; BP: n = 4060; ON: n = 485; and FS: n = 8321). Of these, <50% had a record in CPRD after 1 year (GBS: 41.3%; BP: 22.1%; ON: 22.4%; and FS: 41.8%). CONCLUSION: This work shows that most diagnoses in CPRD for the conditions examined were recorded with delays of ≤30 days, making NRTVSS possible. The pattern of delays was condition-specific and could be used to adjust for delays in the NRTVSS analysis. Despite low sensitivity of recording, implementing NRTVSS in CPRD is worthwhile and could be carried out, at least on a trial basis, for events of interest. © 2017 The Authors. Pharmacoepidemiology & Drug Safety Published by John Wiley & Sons Ltd
Implementing near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD).
INTRODUCTION: Near real-time vaccine safety surveillance (NRTVSS) using electronic health records is increasingly used to rapidly detect vaccine safety signals. NRTVSS has not been fully implemented in the UK. We assessed the feasibility of implementing this surveillance using the UK Clinical Practice Research Datalink (CPRD). METHODS: We selected seasonal influenza vaccine/Guillain-Barré Syndrome (GBS) as an example of a rare outcome and measles-mumps-rubella (MMR) vaccine/febrile seizures as a positive control. For influenza/GBS we implemented a system for the 2013/2014 and 2014/2015 influenza seasons; for MMR/seizures the surveillance period was July 2014-June 2015. We used the continuous Poisson-based maximized sequential probability ratio test (PMaxSPRT), comparing observed-to-expected events, for both pairs. We calculated an age-sex-adjusted rate using 5years of historic data and used this rate to calculate the expected number of events in pre-specified post-vaccination risk-window (GBS: 0-42days, seizures: 6-21days). For MMR/seizures we also implemented the system using the Binominal-based maximized sequential probability ratio test (BMaxSPRT). For this, we compared seizures in the risk-window (6-21days) to a control window (0-5 and 22-32days). Delays in recording outcomes influence the data available, so we adjusted the expected number of events using a historical distribution of delays in recording GBS/febrile seizures. Analyses were run using data up to each CPRD monthly release. We also performed power calculations for detecting increases in relative risk (RR) from 1.5 to 10. RESULTS: For influenza/GBS we implemented a system in both seasons with no signal. Power to detect a signal was >80% for RR≥4. For MMR/seizures we were able to identify a signal with PMaxSPRT but not with BMaxSPRT. Power≥80% for RR≥2.5 for both tests. CONCLUSION: CPRD is a potential data source to implement NRTVSS to exclude large increases in the risk of rare outcomes after seasonal influenza and lower increases in risk for more frequent outcomes
The relative age effect in school and federative sport in basketball
The aim of this study was to analyze the distribution of birth dates among Portuguese basketball players participating in national competitions (academic and federal). The study sample consisted of 1497 federated athletes (744 female and 753 male), and by 411 athletes (214 female and 382 male.) who participated in the finals of Scholar Sports. We analyzed the distribution of birth dates per quartile in federated and scholar sports by gender. In the federated analysis this distribution depended also on the classification and ranking of the teams. All data were analyzed with SPSS for Windows, version 14.0. The statistical significance level was maintained at p = .05. The results suggest that there is a prevalence of athletes born in the first months of the year in both scholar and federated sports. However, only in de the sub-14 federated male group were found significant values (p < .05).El objetivo de este estudio fue analizar la distribución de las fechas de nacimiento de los jugadores de baloncesto portugueses que participan en competiciones nacionales (escolar y federativo). La muestra del estudio consistió en 1.497 deportistas federados (744 femeninos y 753 masculinos), y 411 atletas (214 femeninos y 382 masculinos) quiénes participaron en las finales nacionales del deporte escolar. Se analizó la distribución de las fechas de nacimiento del federado y escolar por cuartil y por sexo. Además, en el federado se ha analizado la distribución en función de la clasificación final de los equipos y categorÃa. Todos los datos se analizaron con el programa SPSS para Windows (SPSS Inc., Chicago, IL). El nivel de significancia se mantuvo en p < .05. Los resultados sugieren que existe una prevalencia de atletas nacidos en los primeros meses del año, tanto en el deporte federado como en el escolar. Sin embargo, sólo en el masculino y en el categorÃa sub-14 del deporte federado se han identificado valores significativos (p < .05).O objetivo do presente estudo foi analisar a distribuição das datas de nascimento entre os jogadores de basquetebol portugueses que participam em competições nacionais (escolar e federativo). A amostra de estudo foi constituÃda por 1497 atletas federados (744 fem. e 753 masc.), e por 411 atletas (214 fem. e 382 masc.) que participaram na fase final de Desporto Escolar. Foram analisadas as distribuições das datas de nascimento por quartil no desporto federado e escolar em função do género, sendo que no federado analisou-se ainda essa distribuição em função da classificação das equipas e escalão. Todos os dados foram analisados com o software SPSS para o Windows, versão 14.0 (SPSS Inc., Chicago, IL). O nÃvel de significância foi mantido em p ≤ .05. Os resultados sugerem que há uma prevalência de atletas nascidos nos primeiros meses do ano, tanto no desporto federado como escolar. Contudo, apenas no escalão de sub-14 masculino do desporto federado se registaram valores significativos (p < .05)
The new words kids hear from translated picturebooks
This study shows how the language in translated picturebooks is enriched by the use of rare words. We document how the translation of picturebooks from English to Portuguese results in the use of rare words in Portuguese. Evidence indicates that children learn new vocabulary through readings of picturebooks (Noble et al., 2019) and that translators make choices that contribute to the use of rare words (Ketola, 2018). The sample of 86 picturebooks was selected from a list recommended by the Portuguese national reading plan for 3-5-year-olds. The identification of rare words was done using a frequency analysis in both Portuguese, using ESCOLEX, and English, using the ChildFreq tool. Findings indicate that translated picturebooks use rich and varied lexicon and include an average of 6.6 rare words. Twenty-two percent of these words originate from literal and non-literal translations and are not rare in the original texts. This indicates that the process of translation contributes to increasing children's exposure to rare words.info:eu-repo/semantics/publishedVersio
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