Black hole superradiant instability from ultralight spin-2 fields

Ultralight bosonic fields are compelling dark-matter candidates and arise in a variety of beyond-Standard-Model scenarios. These fields can tap energy and angular momentum from spinning black holes through superradiant instabilities, during which a macroscopic bosonic condensate develops around the black hole. Striking features of this phenomenon include gaps in the spin-mass distribution of astrophysical black holes and a continuous gravitational-wave~(GW) signal emitted by the condensate. So far these processes have been studied in great detail for scalar fields and, more recently, for vector fields. Here we take an important step forward in the black-hole superradiance program by computing, analytically, the instability time scale, the direct GW emission, and the stochastic background, in the case of massive tensor (i.e., spin-$2$) fields. Our analysis is valid for any black hole spin and for small boson masses. The instability of massive spin-$2$ fields shares some properties with the scalar and vector cases, but its phenomenology is much richer, for example there exist multiple modes with comparable instability time scales, and the dominant GW signal is hexadecapolar rather than quadrupolar. Electromagnetic and GW observations of spinning black holes in the mass range $M\in(1,10^{10})M_\odot$ can constrain the mass of a putative spin-$2$ field in the range $10^{-22} \lesssim m_b\,{\rm c^2/eV} \lesssim 10^{-10}$. For $10^{-17}\lesssim m_b\,{\rm c^2/eV}\lesssim 10^{-15}$, the space mission LISA could detect the continuous GW signal for sources at redshift $z=20$, or even larger.Comment: 13 pages, 4 Figures; v3: minor changes to match published version in Physical Review Letter

Neophobic behavior and life history traits of House Sparrows (Passer domesticus)

The House Sparrow (Passer domesticus) is an introduced, invasive species commonly viewed as undesirable in North America. However, the characteristics that make them such successful pests also make them ideal study species. Their intelligence and curiosity, as well as their lack of fear toward humans, allows for clear observation of behavior and easy access to nestlings. This study of neophobic behavior (avoidance of novel objects) and life history traits provides insight into reaction patterns of House Sparrows, making room for generalizations about similar populations, as well as useful information about breeding biology. In the study population females were more hesitant to approach the unfamiliar object compared to males, and nestling growth demonstrated a linear correlation instead of the more common exponential growth of other species. This information supports more robust studies in the future by expanding knowledge of this frequently used study species

Does personality affect competition, social organization, and fitness? a study using a small social mammal, Octodon degus

Animal personality represents consistent variation among individual behaviors that are repeatable across time and contexts. Recent research in behavioral ecology has revealed that animal personality influences ecological and evolutionary processes, and a growing number of studies demonstrate that personality can play a large role in the interactions among group-living animals. I studied the common degu (Octodon degus), a social and group-living rodent, to evaluate whether three personality traits (aggression, boldness, and activity level) play a role in shaping competitive interactions and composition of social groups, and whether these interactions influence the fitness of individuals in groups. Aggression was the only repeatable trait in the population, and I did not find personality traits to influence competitive outcome or group composition. Personality also did not affect fitness of individuals in groups. I discuss ecological and social contexts that might have influenced this population of degus and provide direction for future personality studies

Environmental phosphate differentially affects virulence phenotypes of uropathogenic Escherichia coli isolates causative of prostatitis

K-12 Escherichia coli cells grown in static media containing a critical phosphate (Pi) concentration 25 mM maintained a high polyphosphate (polyP) level in stationary phase, impairing biofilm formation, a phenomenon that is triggered by polyP degradation. Pi concentration in human urine fluctuates according to health state. Here, the influence of environmental Pi concentration on the occurrence of virulence traits in uropathogenic E. coli (UPEC) isolated from acute prostatitis patients was evaluated. After a first screening, 3 isolates were selected according to differential biofilm formation profiles depending on media Pi concentration. For each isolate, biofilm positive and negative conditions were established. Regardless of the isolate, biofilm formation capacity was accompanied with curli and cellulose production and expression of some key virulence factors associated with adhesion. When the selected isolates were grown in their non-biofilm-forming condition, low concentrations of nalidixic acid and ciprofloxacin induced biofilm formation. Interestingly, similar to laboratory strains, polyP degradation induced biofilm formation in the selected isolates. Data demonstrated the complexity of UPEC responses to environmental Pi and the importance of polyP metabolism in the virulence of clinical isolates.Fil: Grillo Puertas, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Martinez Zamora, Martin Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Rintoul, Maria Regina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Soto, Sara M.. Universidad de Barcelona; EspañaFil: Rapisarda, Viviana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; Argentin

Environmental phosphate differentially affects virulence phenotypes of uropathogenic Escherichia coli isolates causative of prostatitis

K-12 Escherichia coli cells grown in static media containing a critical phosphate (Pi) concentration 25 mM maintained a high polyphosphate (polyP) level in stationary phase, impairing biofilm formation, a phenomenon that is triggered by polyP degradation. Pi concentration in human urine fluctuates according to health state. Here, the influence of environmental Pi concentration on the occurrence of virulence traits in uropathogenic E. coli (UPEC) isolated from acute prostatitis patients was evaluated. After a first screening, 3 isolates were selected according to differential biofilm formation profiles depending on media Pi concentration. For each isolate, biofilm positive and negative conditions were established. Regardless of the isolate, biofilm formation capacity was accompanied with curli and cellulose production and expression of some key virulence factors associated with adhesion. When the selected isolates were grown in their non-biofilm-forming condition, low concentrations of nalidixic acid and ciprofloxacin induced biofilm formation. Interestingly, similar to laboratory strains, polyP degradation induced biofilm formation in the selected isolates. Data demonstrated the complexity of UPEC responses to environmental Pi and the importance of polyP metabolism in the virulence of clinical isolates.Fil: Grillo Puertas, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Martinez Zamora, Martin Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Rintoul, Maria Regina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Soto, Sara M.. Universidad de Barcelona; EspañaFil: Rapisarda, Viviana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; Argentin

A Methodology to Characterize Power Control Systems for Limiting Exposure to Electromagnetic Fields Generated by Massive MIMO Antennas

The fifth-generation (5G) New Radio (NR) cellular network has been launched recently. The assignment of new spectrum bands and the widespread use of Massive MIMO (MaMIMO) and beamforming techniques for better radio coverage are two major features of the new architecture. They imply both opportunities and challenges, one of the most daring one among the latter ones is the research for methods to assess human exposure to electromagnetic fields radiated by the base stations. The long-term time-varying behavior and spatial multiplexing feature of the MaMIMO antennas, along with the radio resource utilization and adoption of Time-Division Duplexing (TDD), requires that the assessment of exposure to electromagnetic fields radiated by 5G systems is based on a statistical approach that relies on the space and time distribution of the radiated power. That, in turn, is determined through simulations based on the actual maximum transmitted power - defined as the 95 th percentile of the empirical distribution obtained from historical data of radiated power - rather than on the nominal one. To ensure that exposure limits are never exceeded, a monitoring and control system (usually referred to as Power Lock (PL)) that limits the transmitted power can be used. In this paper we propose a methodology, independent from the specific technical solution implemented by the manufacturer, to characterize such control systems and determine their capability to limit the average power transmitted over a given time interval to a value that keeps the corresponding average exposure to electromagnetic fields below a specified value. Experimental results show the effectiveness of the methodology and that it can also be used to identify when the PL interacts with the higher levels of the MaMIMO system architecture

Bartonella henselae Persistence within Mesenchymal Stromal Cells Enhances Endothelial Cell Activation and Infectibility That Amplifies the Angiogenic Process (*Scutera S and Mitola S co-first authors; Sozzani S and Musso T co-last authors)

Some bacterial pathogens can manipulate the angiogenic response, suppressing or inducing it for their own ends. In humans, Bartonella henselae is associated with cat-scratch disease and vasculoproliferative disorders such as bacillary angiomatosis and bacillary peliosis. Although endothelial cells (ECs) support the pathogenesis of B. henselae, the mechanisms by which B. henselae induces EC activation are not completely clear, as well as the possible contributions of other cells recruited at the site of infection. Mesenchymal stromal cells (MSCs) are endowed with angiogenic potential and play a dual role in infections, exerting antimicrobial properties but also acting as a shelter for pathogens. Here, we delved into the role of MSCs as a reservoir of B. henselae and modulator of EC functions. B. henselae readily infected MSCs and survived in perinuclearly bound vacuoles for up to 8 days. Infection enhanced MSC proliferation and the expression of epidermal growth factor receptor (EGFR), Toll-like receptor 2 (TLR2), and nucleotide-binding oligomerization domain-containing protein 1 (NOD1), proteins that are involved in bacterial internalization and cytokine production. Secretome analysis revealed that infected MSCs secreted higher levels of the proangiogenic factors vascular endothelial growth factor (VEGF), fibroblast growth factor 7 (FGF-7), matrix metallopeptidase 9 (MMP-9), placental growth factor (PIGF), serpin E1, thrombospondin 1 (TSP-1), urokinase-type plasminogen activator (uPA), interleukin 6 (IL-6), platelet-derived growth factor D (PDGF-D), chemokine ligand 5 (CCL5), and C-X-C motif chemokine ligand 8 (CXCL8). Supernatants from B. henselae-infected MSCs increased the susceptibility of ECs to B. henselae infection and enhanced EC proliferation, invasion, and reorganization in tube-like structures. Altogether, these results indicate MSCs as a still underestimated niche for persistent B. henselae infection and reveal MSC-EC cross talk that may contribute to exacerbate bacterium-induced angiogenesis and granuloma formation

Molecular Epidemiology, Antimicrobial Susceptibility, and Clinical Features of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections over 30 Years in Barcelona, Spain (1990–2019)

Methicillin-resistant Staphylococcus aureus bloodstream infections (MRSA-BSI) are a significant cause of mortality. We analysed the evolution of the molecular and clinical epidemiology of MRSA-BSI (n = 784) in adult patients (Barcelona, 1990-2019). Isolates were tested for antimicrobial susceptibility and genotyped (PFGE), and a selection was sequenced (WGS) to characterise the pangenome and mechanisms underlying antimicrobial resistance. Increases in patient age (60 to 71 years), comorbidities (Charlson's index > 2, 10% to 94%), community-onset healthcare-associated acquisition (9% to 60%), and 30-day mortality (28% to 36%) were observed during the 1990-1995 and 2014-2019 periods. The proportion of catheter-related BSIs fell from 57% to 20%. Current MRSA-BSIs are caused by CC5-IV and an upward trend of CC8-IV and CC22-IV clones. CC5 and CC8 had the lowest core genome proportions. Antimicrobial resistance rates fell, and only ciprofloxacin, tobramycin, and erythromycin remained high (>50%) due to GyrA/GrlA changes, the presence of aminoglycoside-modifying enzymes (AAC(6 ')-Ie-APH(2 '')-Ia and ANT(4 ')-Ia), and mph(C)/msr(A) or erm (C) genes. Two CC22-IV strains showed daptomycin resistance (MprF substitutions). MRSA-BSI has become healthcare-associated, affecting elderly patients with comorbidities and causing high mortality rates. Clonal replacement with CC5-IV and CC8-IV clones resulted in lower antimicrobial resistance rates. The increased frequency of the successful CC22-IV, associated with daptomycin resistance, should be monitored

Oral health status of adult dysphagic patients that undergo endoscopic gastrostomy for long term enteral feeding

Background: Endoscopic Gastrostomy (PEG) is required to maintain a feeding route when neurological or cancer dysphagia impact oral intake. This study aimed to evaluate the oral health and oral changes of PEG-patients without oral feeding for three months.Methods: Prospective observational study, with a PEG-patients convenience sample. Data were obtained before PEG (T0) and 3 months after gastrostomy (T1). Initial oral hygiene habits were collected through a questionnaire. Intra-oral evaluation was performed using: Plaque Index (IP), Gingival Index (IG), Decayed, Missing and Filled Teeth Index (DMF), Community Periodontal Index (CPI), and Attachment Loss (AL). T0 and T1 were compared to evaluate oral health evolution.Results: Thirty-nine patients aged 65.3 ± 17.4 years were included. Initial (T0) oral health was worse than expectable. Between assessments period, oral indexes suffered a general deterioration with statistical relevance to the DMF. The frequency of deep periodontal pockets and attachment loss remained stable.Conclusions: PEG-patients presented poor oral health and insufficient oral hygiene habits, even before gastrostomy. After three months of PEG feeding, oral health suffered a general deterioration. This outcome was probably associated with the absence of oral feeding activity, which is beneficial to oral homeostasis, and further reduced oral hygiene. Improved oral daily care and dental appointments should become part of the PEG-patients follow-up.info:eu-repo/semantics/publishedVersio