Regulation, competition, and liberalization

In many countries throughout the world, regulators are struggling to determine whether and how to introduce competition into regulated industries. This essay examines the complexities involved in the liberalization process. While stressing the importance of case-specific analyses, this essay distinguishes liberalization policies that generally are pro-competitive from corresponding anti-competitive liberalization policies

Host-free Survival of Boll Weevils (Coleoptera: Curculionidae) from Two Regions of Texas

New information regarding boll weevil, Anthonomus grandis Boheman, overwintering is important to efforts to improve efficiency of eradication efforts. The boll weevil diapause remains a contentious issue despite intense study and some evidence suggests the diapause response differs among weevil populations

Boll Weevil (Coleoptera: Curculionidae) Feeding and Reproduction as Functions of Cotton Square Availability

The influence of food item availability on boll weevil, Anthonomus grandis grandis Boheman, feeding and reproduction was determined by providing different numbers of cotton squares (flower buds) to individual weevils. Squares were replaced daily after a 5-d feeding and mating conditioning period. The number of lifetime punctures produced by boll weevil females and males increased with square availability. The total number of punctures caused by boll weevil females was 2.7-fold higher than that caused by males. Fecundity was significantly higher in the 10:1, 15:1, and 20:1 (squares:female) treatments than in the 1:1 treatment. The relationship between eggs laid per day and the square to female ratio significantly changed over the life of the female, with the largest differences among treatments occurring in the first 3 wk of adulthood. Survival of weevil progeny to adulthood was about two-fold higher in the 10:1, 15:1, and 20:1 treatments than in the 1:1 and 5:1 treatments. When each boll weevil female was provided 10, 15, or 20 cotton squares per day, estimates of a population growth index (percent of immatures surviving to adulthood divided by immature development time) and the exponential rate of increase (rm) were significantly higher than for those provided only one or five squares per day. Boll weevil populations maintained at a square:weevil ratio of 10:1 or above will increase \u3e60-fold each generation (Ro), a rate significantly higher than that exhibited under 5:1 or 1:1 square:female regimens. These data show that daily provision of 10 squares per female provides sufficient resources to elicit a maximal oviposition response in the laboratory. Our results also will be useful in predicting changes in boll weevil populations relative to crop phenology and starting population density

Hydrostatic pressure does not cause detectable changes to survival of human retinal ganglion

Purpose: Elevated intraocular pressure (IOP) is a major risk factor for glaucoma. One consequence of raised IOP is that ocular tissues are subjected to increased hydrostatic pressure (HP). The effect of raised HP on stress pathway signaling and retinal ganglion cell (RGC) survival in the human retina was investigated. Methods: A chamber was designed to expose cells to increased HP (constant and fluctuating). Accurate pressure control (10-100mmHg) was achieved using mass flow controllers. Human organotypic retinal cultures (HORCs) from donor eyes (<24h post mortem) were cultured in serum-free DMEM/HamF12. Increased HP was compared to simulated ischemia (oxygen glucose deprivation, OGD). Cell death and apoptosis were measured by LDH and TUNEL assays, RGC marker expression by qRT-PCR (THY-1) and RGC number by immunohistochemistry (NeuN). Activated p38 and JNK were detected by Western blot. Results: Exposure of HORCs to constant (60mmHg) or fluctuating (10-100mmHg; 1 cycle/min) pressure for 24 or 48h caused no loss of structural integrity, LDH release, decrease in RGC marker expression (THY-1) or loss of RGCs compared with controls. In addition, there was no increase in TUNEL-positive NeuN-labelled cells at either time-point indicating no increase in apoptosis of RGCs. OGD increased apoptosis, reduced RGC marker expression and RGC number and caused elevated LDH release at 24h. p38 and JNK phosphorylation remained unchanged in HORCs exposed to fluctuating pressure (10-100mmHg; 1 cycle/min) for 15, 30, 60 and 90min durations, whereas OGD (3h) increased activation of p38 and JNK, remaining elevated for 90min post-OGD. Conclusions: Directly applied HP had no detectable impact on RGC survival and stress-signalling in HORCs. Simulated ischemia, however, activated stress pathways and caused RGC death. These results show that direct HP does not cause degeneration of RGCs in the ex vivo human retina

GMOs: Non-Health Issues

The controversy over genetically modified [GM] organisms is often framed in terms of possible hazards for human health. Articles in a previous volume of this *Encyclopedia* give a general overview of GM crops [@Mulvaney2014] and specifically examine human health [@Nordgard2014] and labeling [@Bruton2014] issues surrounding GM organisms. This article explores several other aspects of the controversy: environmental concerns, political and legal disputes, and the aim of "feeding the world" and promoting food security. Rather than discussing abstract, hypothetical GM organisms, this article explores the consequences of the GM organisms that have actually been deployed in the particular contexts that they have been deployed, on the belief that there is little point in discussing GM organisms in an idealized or context-independent way

Comparative Performance of Single Nucleotide Polymorphism and Microsatellite Markers for Population Genetic Analysis

Microsatellite loci are standard genetic markers for population genetic analysis, whereas single nucleotide polymorphisms (SNPs) are more recent tools that require assessment of neutrality and appropriate use in population genetics. Twelve SNP markers were used to describe the genetic structure of Diabrotica virgifera virgifera (LeConte; Coleoptera: Chrysomelidae) in the United States of America and revealed a high mean observed heterozygosity (0.40 ± 0.059) and low global FST (0.029). Pairwise FST estimates ranged from 0.007 to 0.045, and all but 2 populations showed significant levels of genetic differentiation (P ≤ 0.008). Population parameters and conclusions based on SNP markers were analogous to that obtained by use of microsatellite markers from the identical population samples. SNP-based FST estimates were 3-fold higher than corresponding estimates from microsatellites, wherein lower microsatellite FST estimates likely resulted from an overestimate of migration rates between subpopulations due to convergence of allele size (homoplasy). No significant difference was observed in the proportion of SNP or microsatellite markers loci that were nonneutral within populations. SNP markers provided estimates of population genetic parameters consistent with those from microsatellite data, and their low back mutation rates may result in reduced propensity for error in estimation of population parameters

Bottleneck co-ownership as a regulatory alternative

This paper proposes a regulatory mechanism for vertically related industries in which the upstream “bottleneck” segment faces significant returns to scale while other (downstream) segments may be more competitive. In the proposed mechanism, the ownership of the upstream firm is allocated to downstream firms in proportion to their shares of input purchases. This mechanism, while preserving downstream competition, partially internalizes the benefits of exploiting economies of scale resulting from an increase in downstream output. We show that this mechanism is more efficient than a disintegrated market structure in which the upstream natural monopoly bottleneck sets a price equal to average cost

Apollo Spacecraft Systems Analysis Program. Task E-34E - LM Landing Radar Performance over Rough Terrain

Performance prediction for LM landing radar over rough terrai