Cineclube Surdo: Expressão estética e política de uma minoria linguística

The present project presented cinematographic productions made by deaf subjects or ones that represent the culture of this linguistic minority. The purpose of this proposal is to present and discuss the 'deaf' audiovisual productions in order to better understand how the deaf subject appropriates the cinematographic language and uses their propensity to visualize their culture through cinema. To achieve this goal, research was carried out on cinematographic works by deaf filmmakers or hearing filmmakers who represent the deaf culture around the world. Subsequently, the most expressive works were selected to be screened in the film club sessions. After each session, a discussion was conducted, guided by questions about the language, aesthetics and representation of the deaf in cinema.O presente projeto apresentou produções cinematográficas realizadas por sujeitos surdos ou que representem a cultura dessa minoria linguística. O objetivo dessa proposta é apresentar e colocar em discussão as produções audiovisuais 'surdas' para melhor entender de que forma o sujeito surdo se apropria da linguagem cinematográfica e utiliza sua propensão à visualidade para representar sua cultura através do cinema. Para atingir esse objetivo, foi realizada pesquisa de obras cinematográficas de realizadores surdos ou de realizadores ouvintes que representem a cultura surda ao redor do mundo. Posteriormente, foram selecionadas as obras mais expressivas para serem exibidas nas sessões do cineclube. Após cada sessão, foi realizado um debate orientado por questões acerca da linguagem, estética e representatividade do surdo no cinema.DOI: http://dx.doi.org/10.35700/ca.2017.ano4n7.p30-36.224

Cineclube Surdo: Expressão Estética e Política de uma Minoria Linguística

The present project presented cinematographic productions made by deaf subjects or ones that represent the culture of this linguistic minority. The purpose of this proposal is to present and discuss the 'deaf' audiovisual productions in order to better understand how the deaf subject appropriates the cinematographic language and uses their propensity to visualize their culture through cinema. To achieve this goal, research was carried out on cinematographic works by deaf filmmakers or hearing filmmakers who represent the deaf culture around the world. Subsequently, the most expressive works were selected to be screened in the film club sessions. After each session, a discussion was conducted, guided by questions about the language, aesthetics and representation of the deaf in cinema.</p

Xyloglucan-block-poly(ε-caprolactone) copolymer nanoparticles coated with chitosan as biocompatible mucoadhesive drug delivery system

International audienc

Nanoparticles Made From Xyloglucan-Block-Polycaprolactone Copolymers: Safety Assessment for Drug Delivery

International audienc

Apoptotic Events Induced by Maleimides on Human Acute Leukemia Cell Lines

Cyclic imides are known for their antitumor activity, especially the naphthalimide derivatives, such as Mitonafide and Amonafide. Recently, we have demonstrated the cytotoxic effect of a series of naphthalimide derivatives against B16F10 melanoma cells. On the basis of this fact, we have developed a study starting from the synthesis of different cyclic imides and the evaluation of their cytotoxic properties on human acute leukemia cells (K562 and Jurkat). Initially, a screening test was conducted to select the compound with the best cytotoxic effect, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. After this selection, structural modifications were performed in the most active compound to obtain five more derivatives. All compounds presented a good cytotoxic effect. The results of cell cycle analysis, fluorescence microscopy, and Annexin V-FITC assay confirmed that the cells observed in the sub-G₀/G₁ phase were undergoing apoptosis. From this set of results, cyclic imides <b>8</b>, <b>10</b>, and <b>12</b> were selected for the evaluation of the mechanisms involved in the apoptotic process. The results demonstrate the involvement of the intrinsic pathway of apoptosis, evidenced by the reduction in mitochondrial potential, an increase in the level of AIF protein expression, a decreased level of expression of anti-apoptotic Bcl-2 protein, and an increased level of expression of pro-apoptotic protein Bax in both K562 and Jurkat cells treated with cyclic imides (<b>8</b>, <b>10</b>, and <b>12</b>). Furthermore, cyclic imides <b>8</b> and <b>10</b> caused an increase in the level of Fas expression in Jurkat cells, indicating the additional involvement of the extrinsic apoptosis pathway. The compounds (<b>8</b>, <b>10</b>, and <b>12</b>) also caused a decreased level of expression of anti-apoptotic protein survivin. The biological effects observed with these cyclic imide derivatives in this study suggest promising applications against acute leukemia