The invisibility of women caring for women victims of violence

The objective of this study was to describe the working conditions of professionals who work in centers providing assistance to women victims of violence, to investigate the experience of female workers in caring for women victims of violence and to analyze the self-care practices of this professional group at the personal, professional, collective and institutional levels. Data were collected through the application of an interview script to 12 professionals who assist victims of violence against women in different care centers for this public in Aracaju and the interior of Sergipe. The five classes generated by the Descending Hierarchical Classification (DHC), generated by the Iramuteq analysis, pointed out five themes: care for women victims of violence, conflicts, violence and professional practice, authors of practice of aggression, personal self-care and handling obstacles in the work environment. In view of the results found, the strengthening of the public policy system is appointed as one of the pillars that reconfigure this reality.Este estudio tuvo como objetivo describir las condiciones de trabajo de profesionales que actúan en centros de atención a mujeres víctimas de violencia, investigar la experiencia de trabajadoras en el cuidado de mujeres víctimas de violencia y analizar las prácticas de autocuidado de este grupo profesional en los niveles personal, profesional, colectivo e institucional. Los datos fueron recolectados a través de la aplicación de un guión de entrevista a 12 profesionales que atienden a víctimas de violencia contra la mujer en diferentes centros de atención a este público en Aracaju y el interior de Sergipe. Las cinco clases generadas por la Clasificación Jerárquica Descendente (CHD), análisis Iramuteq, señalaron cinco temas: atención a mujeres víctimas de violencia, conflictos, violencia y práctica profesional, autores de práctica de agresión, autocuidado personal y manejo de obstáculos en el trabajo. Dados los resultados encontrados, se apunta al fortalecimiento del sistema de políticas públicas como uno de los pilares que reconfiguran esta realidad.Resumo: O objetivo deste estudo foi descrever as condições de trabalho dos profissionais que atuam em centros de atendimento a mulheres vítimas de violência, investigar a experiência de trabalhadoras no atendimento a mulheres vítimas de violência e analisar as práticas de autocuidado desse grupo profissional em nos níveis pessoal, profissional, coletivo e institucional. Os dados foram coletados por meio da aplicação de um roteiro de entrevista a 12 profissionais que atendem vítimas de violência contra a mulher em diferentes centros de atendimento a esse público em Aracaju e interior de Sergipe. As cinco classes geradas pela Classificação Hierárquica Descendente (CHD) geradas pela análise Iramuteq, apontaram cinco temas: atendimento à mulher vítima de violência, conflitos, violência e prática profissional, autores da prática de agressão, autocuidado pessoal e manejo de obstáculos no ambiente de trabalho. Diante dos resultados encontrados, o fortalecimento do sistema de políticas públicas é apontado como um dos pilares que reconfiguram essa realidade

Um estudo sobre a abordagem da Classe Insecta nos livros didáticos de Ciências

This paper describes results of a study which analyze the subject “insects” in science textbook from the sixth grade at a fundamental level. The analysis was based on the following criteria: the general features of the text the general approach of the subject and focus on the ecology. The methodological processes were based on “documentary analysis”. The textbook analysis reveals that the approach of the subject favours morpho-physiological aspects in the anthropocentric viewpoint that tends to consider the insects only from the point of view of human interests. In that way, the textbook focuses only partially on ecologic al subjects that include the insects.O artigo apresenta resultados de um estudo que analisou a abordagem do conteúdo “insetos” em 16 livros didáticos de Ciências para a 6a série do Ensino Fundamental. A análise foi desenvolvida com base nos seguintes critérios: características gerais do texto abordagem geral do assunto e enfoque ecológico. Os procedimentos metodológicos foram baseados na estratégia de “análise documental”. A análise dos manuais revelou que a abordagem do assunto continua privilegiando aspectos morfofisiológicos dentro de uma perspectiva antropocêntrica, que tende a tratar os insetos apenas sob a ótica dos interesses humanos. Desta forma, com apenas essa ênfase, os livros enfocam parcialmente questões ecológicas que envolvem os insetos

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding region comprising an expanded ferredoxin-like fold, which recognizes a 3′-overhang of U6 snRNA, and a preceding peptide, which binds U4/U6 stem II. Phylogenetic analyses revealed that the single-stranded RNA-binding domain is exclusively found in Prp3 orthologs, thus qualifying as a spliceosome-specific RNA interaction module. The composite double-stranded /single-stranded RNA-binding region assembles cooperatively with Snu13 and Prp31 on U4/U6 di-snRNAs and inhibits Brr2-mediated U4/U6 di-snRNA unwinding in vitro. RNP-disrupting mutations in Prp3 lead to U4/U6•U5 tri-snRNP assembly and splicing defects in vivo. Our results reveal how Prp3 acts as an important bridge between U4/U6 and U5 in the tri-snRNP and comparison with a Prp24-U6 snRNA recycling complex suggests how Prp3 may be involved in U4/U6 reassembly after splicing

Dipeptidyl peptidase-3, a marker of the antagonist pathway of the renin-angiotensin-aldosterone system in patients with heart failure

Aims: Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway which is considered to antagonize the renin–angiotensin–aldosterone system (RAAS). Since DPP3 inhibits the counteracting pathway of the RAAS, we hypothesize that DPP3 might be deleterious in the setting of heart failure. However, no data are available on DPP3 in chronic heart failure. We therefore investigated the clinical characteristics and outcome related to elevated DPP3 concentrations in patients with worsening heart failure.Methods and results: Dipeptidyl peptidase 3 was measured in 2156 serum samples of patients with worsening heart failure using luminometric immunoassay (DPP3-LIA) by 4TEEN4 Pharmaceuticals GmbH, Hennigsdorf, Germany. Predictors of DPP3 levels were selected using multiple linear regression with stepwise backward selection. Median DPP3 concentration was 11.45 ng/mL with a range from 2.8 to 84.9 ng/mL. Patients with higher DPP3 concentrations had higher renin [78.3 (interquartile range, IQR 26.3–227.7) vs. 120.7 IU/mL (IQR 34.74–338.9), P &lt; 0.001, for Q1–3 vs. Q4] and aldosterone [88 (IQR 44–179) vs. 116 IU/mL (IQR 46–241), P &lt; 0.001, for Q1–3 vs. Q4] concentrations. The strongest independent predictors for higher concentration of DPP3 were log-alanine aminotransferase, log-total bilirubin, the absence of diabetes, higher osteopontin, fibroblast growth factor-23 and N-terminal pro-B-type natriuretic peptide concentrations (all P &lt; 0.001). In univariable survival analysis, DPP3 was associated with mortality and the combined endpoint of death or heart failure hospitalization (P &lt; 0.001 for both). After adjustment for confounders, this association was no longer significant.Conclusions: In patients with worsening heart failure, DPP3 is a marker of more severe disease with higher RAAS activity. It may be deleterious in heart failure by counteracting the Mas receptor pathway. Procizumab, a specific antibody against DPP3, might be a potential future treatment option for patients with heart failure.</p

Consideraciones metodológicas sobre investigaciones sensibles en metodología cualitativa

Algunos/as autores/as estudian y reconocen la dificultad emocional, por parte de quienes participan en investigaciones científicas, de revivir y relatar historias cuando estas se producen en contextos de violencia sea en el ámbito que sea (escuela, pareja, trabajo, etc.). El presente trabajo expone las dificultades metodológicas surgidas en el marco de una investigación cualitativa sobre la violencia laboral en dos países, Brasil y España. El objetivo de este artículo es ofrecer a la comunidad científica y política un conjunto de estrategias metodológicas para sortear los obstáculos que aparecen en la realización de una investigación con temática sensible. Las conclusiones de este trabajo indican que es necesario revisar las prácticas metodológicas que se llevan a cabo durante el diseño e implementación del estudio, pues esto puede evitar un perjuicio a los/las participantes e investigadores/asAlguns autores estudam e reconhecem a dificuldade emocional, por parte daqueles que participam de pesquisas científicas, de reviver e contar histórias quando estas ocorrem em contextos de violência em qualquer ambiente (escola, casal, trabalho etc.). O presente trabalho expõe as dificuldades metodológicas que surgiram no âmbito de uma pesquisa qualitativa sobre violência no trabalho em dois países, Brasil e Espanha. O objetivo deste artigo é oferecer à comunidade científica e política um conjunto de estratégias metodológicas para superar os obstáculos que surgem na realização de pesquisas sobre temas sensíveis. As conclusões deste trabalho indicam que é necessário rever as práticas metodológicas que são realizadas durante o desenho e implementação do estudo, pois isso pode evitar danos aos participantes e pesquisadoresSome authors study and recognize the emotional difficulty, on the part of those who participate in scientific research, of reliving and telling stories when these occur in contexts of violence in any environment (school, couple, work, etc.). The present work exposes the methodological difficulties that arose in the framework of a qualitative research on workplace violence in two countries, Brazil and Spain. The aim of this article is to offer the scientific and political community a set of methodological strategies for overcoming the obstacles that appear in carrying out research on sensitive subjects. The conclusions of this work indicate that it is necessary to review the methodological practices that are carried out during the design and implementation of the study, as this may avoid harm to participants and researcher

Rotas e colisões no trabalho de atendimento às mulheres vítimas de violência na Espanha

Este estudo teve por finalidade descrever as condições de trabalho, investigar a experiência de atendimento a mulheres vítimas de violência e observar as práticas de autocuidado exercidas pelo grupo profissional desta área de assistência em níveis pessoal, profissional, coletivo e institucional. A pesquisa foi promovida através da aplicação de um roteiro de entrevista com 10 profissionais de assistência a vítimas de violência contra a mulher em associações públicas e privadas na Espanha. A exposição a condições de trabalho precarizadas, os indícios de adoecimento pela aproximação com a realidade atendida, os esforços de autocuidado pessoal através da psicoterapia individual e os sinais da presença de relações violentas no trabalho são resultados desta investigação. Com isso, salienta-se a importância da efetivação dos programas de autocuidado vigentes e de elaboração de propostas de cuidar da equipe profissional com enfoque nas particularidades sociais, econômicas e culturais dos locais de intervençãoThis study had by finality describe the conditions of work, investigate the experience of attending to women victims of violence and observe the practices self-care exercised by the professional group of this area of assistance in the personal, professional, collective and institutional level. The research was provided across of application of a script of the interview with 10 professionals of assistance to victims of violence against the woman in public and private associations at Spain. The exhibition to conditions of precarious work, the indices of illness by approximation with the reality attended, the efforts of personal self-care through of individual psychotherapy and the signals of the presence of violent relations in the job are results of this investigation. Thus, stands out the importance of elevation of programs of self-care actual and of elaboration of proposals to care of professional team with a goal in the social particularities, economics, and culture of locals of interventionEste estudio tuvo por finalidad describir las condiciones de trabajo, investigar la experiencia de atención a mujeres víctimas de violencia y observar las prácticas de autocuidado ejercidas por el grupo profesional de esta área de asistencia a nivel personal, profesional, colectivo e institucional. La investigación fue promovida a través de la aplicación de un guión de entrevista con 10 profesionales de asistencia a víctimas de violencia contra la mujer en asociaciones públicas y privadas en España. La exposición a condiciones de trabajo precarizadas, los indicios de enfermedad por la aproximación a la realidad atendida, los esfuerzos de autocuidado personal a través de la psicoterapia individual y los signos de la presencia de relaciones violentas en el trabajo, son resultados de esta investigación. La importancia de la efectividad de los programas de autocuidado vigentes y de elaboración de propuestas de cuidar del equipo profesional con enfoque en las particularidades sociales, económicas y culturales de los locales de intervenció

Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis

Background Novartis and the University of Oxford’s Big Data Institute (BDI) have established a research alliance with the aim to improve health care and drug development by making it more efficient and targeted. Using a combination of the latest statistical machine learning technology with an innovative IT platform developed to manage large volumes of anonymised data from numerous data sources and types we plan to identify novel patterns with clinical relevance which cannot be detected by humans alone to identify phenotypes and early predictors of patient disease activity and progression. Method The collaboration focuses on highly complex autoimmune diseases and develops a computational framework to assemble a research-ready dataset across numerous modalities. For the Multiple Sclerosis (MS) project, the collaboration has anonymised and integrated phase II to phase IV clinical and imaging trial data from ≈35,000 patients across all clinical phenotypes and collected in more than 2200 centres worldwide. For the “IL-17” project, the collaboration has anonymised and integrated clinical and imaging data from over 30 phase II and III Cosentyx clinical trials including more than 15,000 patients, suffering from four autoimmune disorders (Psoriasis, Axial Spondyloarthritis, Psoriatic arthritis (PsA) and Rheumatoid arthritis (RA)). Results A fundamental component of successful data analysis and the collaborative development of novel machine learning methods on these rich data sets has been the construction of a research informatics framework that can capture the data at regular intervals where images could be anonymised and integrated with the de-identified clinical data, quality controlled and compiled into a research-ready relational database which would then be available to multi-disciplinary analysts. The collaborative development from a group of software developers, data wranglers, statisticians, clinicians, and domain scientists across both organisations has been key. This framework is innovative, as it facilitates collaborative data management and makes a complicated clinical trial data set from a pharmaceutical company available to academic researchers who become associated with the project. Conclusions An informatics framework has been developed to capture clinical trial data into a pipeline of anonymisation, quality control, data exploration, and subsequent integration into a database. Establishing this framework has been integral to the development of analytical tools