Internações por causas sensíveis a atenção básica no Tocantins, de 2008 a 2015: um estudo epidemiológico experimental sobre a importância da atenção primária na redução das internações / Hospitalizations for causes sensitive to primary care in Tocantins, from 2008 to 2015: an experimental epidemiological study on the importance of primary care in reducing hospitalizations

O número de Internações por Condições Sensíveis à Atenção Primária (ICSAP) é um indicador que mede a quantidade de internações por doenças tratáveis na atenção básica, utilizado para avaliar indiretamente a Atenção Primária de Saúde (APS). O objetivo desse estudo está centrado em comparar as taxas padronizadas de internações por causas sensíveis a atenção primária (ICSAP) no estado Tocantins, no período de 2008 a 2015. Demonstrando por meio de uma análise epidemiológica experimental dos dados obtidos a partir da base de dados DATASUS, (utilizando informações de saúde -TABNET - indicadores municipais de Internações por Causas Sensíveis à Atenção Básica) a importância da APS como forma de promoção, proteção e prevenção a saúde, além da sua efetividade quanto aos problemas de saúde através da capacidade de redução das ICSAP. Os resultados evidenciaram uma diminuição das ICSAP no período estudado de 38,23% para 30,63%, demonstrando que a maior cobertura da APS e a melhor efetividade de programas como a Estratégia de Saúde da Família, são fatores que contribuem para a eficiência do Sistema Único de Saúde (SUS). São notórios os efeitos esperados na redução das ICSAP, conforme a expansão observada da APS. Por isso, é de suma importância que a Saúde Básica continue sendo categoricamente expandida, fortalecida e preservada

Content of basil essential oil on a loam texture soil under water regimes and different harvest stages

The essential oil of basil (Ocimum basilicum L.) has high economic value and is produced in the plant by secondary metabolism. Its quantity and composition tend to vary as a response of the plant to stress situations due to changes in the environment and phenological phase. This work aimed to evaluate the development, the chemical composition, content, and the yield of essential oil of basil rich in Linalool, as a function of the soil water tensions and the harvest stages, in a loam texture soil. The experiment was carried out in a greenhouse and consisted of three harvest times (BF - beginning of flowering,  FF - full flowering,  and EF - end of flowering) and five values of soil water tension to define when to irrigate (20, 30, 40, 50, and 60 kPa), totalizing 15 treatments. The irrigation in the soil water tension of 60 kPa generated a reduction in the content and the yield of essential oils compared with 20 kPa, only in the FF harvest stage. However, it did not modify the composition of the essential oil. Regardless of the soil water tension to define irrigation, the highest levels and yields of essential oil were found in the EF harvest stage. Harvest stages did not change the composition of the essential oil or the content of Linalool. In turn, the contents of the components Cineol, Camphor, ∝-Terpeneol, and Isobornyl acetate increased with the harvesting period from BF to EF. Eugenol had the opposite trend, reducing the content from BF to EF. Linalool, a component in greater proportion in essential oil, showed a higher content in soil water tensions up to 50 kPa, decreasing only by 60 kPa. In loam textured soils, it is recommended that basil producers, who aim to extract Linalool, irrigate when the soil water tension reaches up to 50 kPa, with the harvest at any stage of flowering

Exercise Attenuates Renal Dysfunction with Preservation of Myocardial Function in Chronic Kidney Disease

Previous studies have suggested that exercise improves renal and cardiac functions in patients with chronic kidney disease. the aim of this study was to evaluate the effects of long-term aerobic swimming exercise with overload on renal and cardiac function in rats with 5/6 nefrectomy (5/6Nx). Eight Wistar rats were placed into 4 groups: Control (C), Control+Exercise (E), Sedentary 5/6Nx (NxS) and 5/6Nx+Exercise (NxE). the rats were subjected to swimming exercise sessions with overload for 30 min five days per week for five weeks. Exercise reduced the effect of 5/6Nx on creatinine clearance compared to the NxS group. in addition, exercise minimized the increase in mean proteinuria compared to the NxS group (96.9 +/- 10.0 vs. 51.4 +/- 9.9 mg/24 h; p<0.05). Blood pressure was higher in the NxS and NxE groups compared to the C and E groups (216 +/- 4 and 178 +/- 3 vs. 123 +/- 2 and 124 +/- 2 mm Hg, p<0.05). in the 200 glomeruli that were evaluated, the NxS group had a higher sclerosis index than did the NxE group (16% vs. 2%, p<0.05). Echocardiography demonstrated a higher anterior wall of the left ventricle (LV) in diastole in the NxS group compared with the C, E and NxE groups. the NxS group also had a higher LV posterior wall in diastole and systole compared with the E group. the developed isometric tension in Lmax of the heart papillary muscle was lower in the NxS group compared with the C, E and NxE groups. These results suggested that exercise in 5/6Nx animals might reduce the progression of renal disease and lessen the cardiovascular impact of a reduction in renal mass.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundacao Oswaldo Ramos (FOR)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, UNIFESP EPM, Dept Med, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Cardiophysiol & Pathophysiol Lab, São Paulo, BrazilUniv São Paulo, Sch Med, Heart Inst InCor, Lab Genet & Mol Cardiol, São Paulo, BrazilUniversidade Federal de São Paulo, UNIFESP EPM, Dept Med, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Cardiophysiol & Pathophysiol Lab, São Paulo, BrazilWeb of Scienc

Variabilidade espacial da sazonalidade da chuva no semiárido brasileiro

A chuva é um dos principais reguladores dos processos biogeoquímicos de uma região e o entendimento da sua variabilidade espacial e da sua sazonalidade ao longo ano, é fundamental para o gerenciamento dos recursos hídricos e planejamento agrícola do Semiárido brasileiro. Foi avaliada a variabilidade sazonal da chuva no Semiárido brasileiro sob três condições: i) a média mensal das séries temporais, ii) ano considerado mais chuvoso (2009) e o ano considerado mais seco (2012). Informações diárias de chuva foram obtidos da base de dados da Agência Nacional de Águas (ANA) e a partir deles, foram calculadas os valores totais precipitados nos meses e no ano, a entropia relativa (Dk), o índice de sazonalidade (Sk), o tempo característico da chuva (Ck) e a duração da estação chuvosa (Zk). Essas variáveis foram espacializadas para toda a região semiárida de modo à possibilitar a interpretação da variabilidade espacial a partir de técnicas de geoestatística. A magnitude do coeficiente de variação das variáveis foram semelhantes entre a média das séries temporais, o ano mais chuvoso e o ano mais seco, exceto para o Ck e a Zk no ano mais seco. O modelo de semivariograma esférico foi quem melhor representou a variabilidade espacial da maioria das variáveis estudadas. Na parte central do semiárido, mesmo no ano mais chuvoso, ocorreram os menores valores anuais de chuva. As medidas estatísticas de sazonalidade e variabilidade interanual da chuva utilizadas neste estudo mostraram um desempenho satisfatório na caracterização do comportamento das chuvas na região semiárida do Brasil

Artificial neural network model of soil heat flux over multiple land covers in South America

Soil heat flux (G) is an important component for the closure of the surface energy balance (SEB) and the estimation of evapotranspiration (ET) by remote sensing algorithms. Over the last decades, efforts have been focused on parameterizing empirical models for G prediction, based on biophysical parameters estimated by remote sensing. However, due to the existing models’ empirical nature and the restricted conditions in which they were developed, using these models in large-scale applications may lead to significant errors. Thus, the objective of this study was to assess the ability of the artificial neural network (ANN) to predict mid-morning G using extensive remote sensing and meteorological reanalysis data over a broad range of climates and land covers in South America. Surface temperature (Ts), albedo (α), and enhanced vegetation index (EVI), obtained from a moderate resolution imaging spectroradiometer (MODIS), and net radiation (Rn) from the global land data assimilation system 2.1 (GLDAS 2.1) product, were used as inputs. The ANN’s predictions were validated against measurements obtained by 23 flux towers over multiple land cover types in South America, and their performance was compared to that of existing and commonly used models. The Jackson et al. (1987) and Bastiaanssen (1995) G prediction models were calibrated using the flux tower data for quadratic errors minimization. The ANN outperformed existing models, with mean absolute error (MAE) reductions of 43% and 36%, respectively. Additionally, the inclusion of land cover information as an input in the ANN reduced MAE by 22%. This study indicates that the ANN’s structure is more suited for large-scale G prediction than existing models, which can potentially refine SEB fluxes and ET estimates in South America

Percepções de enfermeiros acerca das vulnerabilidades para DST/Aids diante das conexões do processo de adolescer

Objetivo: conhecer a percepção de enfermeiros acerca das vulnerabilidades para as DST/Aids diante das conexões do processo de adolescer.Método: pesquisa qualitativa, com 15 enfermeiros, em um núcleo de estudos da saúde do adolescente de um hospital universitário do Rio de Janeiro/Brasil. Utilizou-se como referenciais teórico e metodológico, respectivamente, a Teoria da Complexidade e a Teoria Fundamentada nos Dados. Técnica de coleta de dados: entrevistas semiestruturadas, realizadas de janeiro a agosto de 2012.Resultados: apresenta-se a categoria Percepção de enfermeiros acerca das vulnerabilidades para as DST/Aids diante das conexões do processo de adolescer e as subcategorias: Riscos e incertezas do processo de adolescer: caminhos para as DST/Aids; Complex-idade-adolescência: ampliando entendimentos a partir da percepção de enfermeiros.Conclusão: compreendendo a complexidade da adolescência, os enfermeiros desenvolvem estratégias para a redução de vulnerabilidades para as DST/Aids. Sinaliza-se a necessidade de investimento em ensino, assistência e gerenciamento do cuidado de enfermagem ao adolescente.Palavras-chave: Enfermagem. Adolescente. Doenças sexualmente transmissíveis. Vulnerabilidade em saúde

Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants

Purpose. This work aimed to synthesize the results of recent meta-analysis focusing on polymorphism in inflammatory mediators and its relation with the risk of periodontitis development. Materials and Methods. A systematic search was conducted using databases for publications prior to October 2016. Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of P<0.05 considered significant. Results. A total of 13 meta-analysis articles with 25 polymorphisms in seven interleukins (IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, and IL-18), three cellular receptors (Fcγ receptors: FCGR2A, FCGR3A, and FCGR3B), and five inflammatory mediators (COX-2, MMP-2, MMP-3, MMP-8, and MMP-9), with a total of 71,531 participants, approaching different classifications of the disease. Conclusion. The study demonstrated that polymorphisms in the IL-1A, IL-1B, IL-6, IL-10, MMP-3 (chronic form), and MMP-9 (chronic form) polymorphisms were significantly associated with the risk of developing periodontitis, whereas other polymorphisms in the IL-4, IL-8, IL-18, Fcγ, COX-2, MMP-2, MMP-3 (aggressive), MMP-8, and MMP-9 (aggressive) polymorphisms had no significant association with risk of developing periodontitis

Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor

Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm(2)) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1 beta, IL-6, and TNF-alpha in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.Sao Paulo Research Foundation (FAPESP) [2012/16498-5, 2012/15165-2]FAPESP [2015/23152-6, 2014/14604-8, 2015/13486-4]Univ Nove Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo, SP, BrazilBrazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP, BrazilUniv Nove Julho UNINOVE, Masters Degree & PhD Program Rehabil Sci, Expt Cardioresp Physiol Lab, Sao Paulo, SP, BrazilUniv Calif San Diego UCSD Hlth Sci, Div Trauma Surg Crit Care Burns & Acute Care Surg, Dept Surg, San Diego, CA USAFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP, BrazilUniv Brasil, Postgrad Program Bioengn, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, BrazilFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP, BrazilFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, BrazilFAPESP [2012/16498-5, 2012/15165-2]FAPESP [2015/23152-6, 2014/14604-8, 2015/13486-4]Web of Scienc

Artificial neural network model of soil heat flux over multiple land covers in South America

Soil heat flux (G) is an important component for the closure of the surface energy balance (SEB) and the estimation of evapotranspiration (ET) by remote sensing algorithms. Over the last decades, efforts have been focused on parameterizing empirical models for G prediction, based on biophysical parameters estimated by remote sensing. However, due to the existing models’ empirical nature and the restricted conditions in which they were developed, using these models in large-scale applications may lead to significant errors. Thus, the objective of this study was to assess the ability of the artificial neural network (ANN) to predict mid-morning G using extensive remote sensing and meteorological reanalysis data over a broad range of climates and land covers in South America. Surface temperature (Ts), albedo (α), and enhanced vegetation index (EVI), obtained from a moderate resolution imaging spectroradiometer (MODIS), and net radiation (Rn) from the global land data assimilation system 2.1 (GLDAS 2.1) product, were used as inputs. The ANN’s predictions were validated against measurements obtained by 23 flux towers over multiple land cover types in South America, and their performance was compared to that of existing and commonly used models. The Jackson et al. (1987) and Bastiaanssen (1995) G prediction models were calibrated using the flux tower data for quadratic errors minimization. The ANN outperformed existing models, with mean absolute error (MAE) reductions of 43% and 36%, respectively. Additionally, the inclusion of land cover information as an input in the ANN reduced MAE by 22%. This study indicates that the ANN’s structure is more suited for large-scale G prediction than existing models, which can potentially refine SEB fluxes and ET estimates in South America

Long-term amphetamine treatment exacerbates inflammatory lung reaction while decreases airway hyper-responsiveness after allergic stimulus in rats

Asthma is an allergic lung disease can be modulated by drugs that modify the activity of central nervous system (CNS) such as amphetamine (AMPH). AMPH is a highly abused drug that exerts potent effects on behavior and immunity. In this study we investigated the mechanism involved in the effects of long-term AMPH treatment on the increased magnitude of allergic lung response. We evaluated mast cells degranulation, cytokines release, airways responsiveness and, expression of adhesion molecules. Male Wistar rats were treated with AMPH or vehicle (PBS) for 21 days and sensitized with ovalbumin (OVA) one week after the first injection of vehicle or AMPH. Fourteen days after the sensitization, the rats were challenged with an OVA aerosol, and 24 h later their parameters were analyzed. In allergic rats, the treatment with AMPH exacerbated the lung cell recruitment due increased expression of ICAM-1, PECAM-1 and Mac-1 in granulocytes and macrophages recovered from bronchoalveolar lavage. Elevated levels of IL-4, but decreased levels of IL-10 were also found in samples of lung explants after AMPH treatment. Conversely, the ex-vivo tracheal hyper-responsiveness to methacholine (MCh) was reduced by AMPH treatment, whereas the force contraction of tracheal segments due to in vitro antigen challenge remained unaltered. Our findings suggest that lung inflammation and airway hyper-responsiveness due to OVA challenge are under the distinct control of AMPH during long-term treatment. Our data strongly indicate that AMPH positively modulates allergic lung inflammation via the increase of ICAM-1, PECAM-1, Mac-1 and IL-4. AMPH also abrogates the release of the anti-inflammatory cytokine IL-10. (c) 2012 Elsevier B.V. All rights reserved.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2007/55631-4, 2009/51886-3, 2009/07208-0, 2008/50766-1]CNPq [300764/2010-3]CAPES [02610/09-4