230 research outputs found
The CUORE Cryostat: A 1-Ton Scale Setup for Bolometric Detectors
The cryogenic underground observatory for rare events (CUORE) is a 1-ton
scale bolometric experiment whose detector consists of an array of 988 TeO2
crystals arranged in a cylindrical compact structure of 19 towers. This will be
the largest bolometric mass ever operated. The experiment will work at a
temperature around or below 10 mK. CUORE cryostat consists of a cryogen-free
system based on pulse tubes and a custom high power dilution refrigerator,
designed to match these specifications. The cryostat has been commissioned in
2014 at the Gran Sasso National Laboratories and reached a record temperature
of 6 mK on a cubic meter scale. In this paper, we present results of CUORE
commissioning runs. Details on the thermal characteristics and cryogenic
performances of the system will be also given.Comment: 7 pages, 2 figures, LTD16 conference proceedin
Search for Neutrinoless Double-Beta Decay of Te with CUORE-0
We report the results of a search for neutrinoless double-beta decay in a
9.8~kgyr exposure of Te using a bolometric detector array,
CUORE-0. The characteristic detector energy resolution and background level in
the region of interest are FWHM and ~counts/(keVkgyr), respectively. The
median 90%~C.L. lower-limit sensitivity of the experiment is and surpasses the sensitivity of previous searches. We find
no evidence for neutrinoless double-beta decay of Te and place a
Bayesian lower bound on the decay half-life, ~ at 90%~C.L. Combining CUORE-0 data with the 19.75~kgyr
exposure of Te from the Cuoricino experiment we obtain at 90%~C.L.~(Bayesian), the most stringent
limit to date on this half-life. Using a range of nuclear matrix element
estimates we interpret this as a limit on the effective Majorana neutrino mass,
-- .Comment: 6 pages, 5 figures, updated version as published in PR
Analysis Techniques for the Evaluation of the Neutrinoless Double-Beta Decay Lifetime in Te with CUORE-0
We describe in detail the methods used to obtain the lower bound on the
lifetime of neutrinoless double-beta () decay in Te and
the associated limit on the effective Majorana mass of the neutrino using the
CUORE-0 detector. CUORE-0 is a bolometric detector array located at the
Laboratori Nazionali del Gran Sasso that was designed to validate the
background reduction techniques developed for CUORE, a next-generation
experiment scheduled to come online in 2016. CUORE-0 is also a competitive
decay search in its own right and functions as a platform to
further develop the analysis tools and procedures to be used in CUORE. These
include data collection, event selection and processing, as well as an
evaluation of signal efficiency. In particular, we describe the amplitude
evaluation, thermal gain stabilization, energy calibration methods, and the
analysis event selection used to create our final decay search
spectrum. We define our high level analysis procedures, with emphasis on the
new insights gained and challenges encountered. We outline in detail our
fitting methods near the hypothesized decay peak and catalog
the main sources of systematic uncertainty. Finally, we derive the
decay half-life limits previously reported for CUORE-0,
yr, and in combination with the Cuoricino
limit, yr.Comment: 18 pages, 18 figures. (Version 3 reflects only minor changes to the
text. Few additional details, no major content changes.
Measurement of the Two-Neutrino Double Beta Decay Half-life of Te with the CUORE-0 Experiment
We report on the measurement of the two-neutrino double beta decay half-life
of Te with the CUORE-0 detector. From an exposure of 33.4 kgy of
TeO, the half-life is determined to be = [8.2 0.2
(stat.) 0.6 (syst.)] 10y. This result is obtained after a
detailed reconstruction of the sources responsible for the CUORE-0 counting
rate, with a specific study of those contributing to the Te
neutrinoless double beta decay region of interest.Comment: Corrected typo in section 9: 3.43E5 Bq/kg should have read 3.43E-5
Bq/k
Antipsychotic prescribing for vulnerable populations: a clinical audit at an acute Australian mental health unit at two-time points
Background: Antipsychotics are recognised as a critical intervention for schizophrenia and bipolar disorder. Guidelines globally endorse the routine practice of antipsychotic monotherapy, at the minimum effective dose. Even in treatmentresistant schizophrenia, clozapine use is endorsed before combining antipsychotics. This aim of this study was to review antipsychotic polytherapy alone, high-dose therapy alone, polytherapy and highdose prescribing patterns in adults discharged from an inpatient mental health unit at two time-points, and the alignment of this prescribing with clinical guideline recommendations. Additionally, associations with polytherapy and high-dose antipsychotic prescribing, including patient and clinical characteristics, were explored.
Methods: A retrospective clinical audit of 400 adults (200 patients at two different time-points) discharged with at least one antipsychotic. Preliminary findings and education sessions were provided to physicians between Cohorts. Outcomes (polytherapy alone, high-dose therapy alone, polytherapy and high-dose therapy) were compared between
study Cohorts using chi-squared and rank-sum tests. Associations between outcomes and covariates were assessed
using multivariable logistic regression.
Results: Most patients (62.5%) were discharged on a single antipsychotic within the recommended dose range. There
was a clear preference for prescribing second generation antipsychotics, and in this respect, prescribing is aligned with current evidence-based guidelines. However, sub-optimal prescribing practices were identified for both Cohorts in relation to polytherapy and high-dose antipsychotic rates. Involuntary treatment, frequent hospitalisations and previous clozapine use significantly increased the risk of all three prescribing outcomes at discharge.
Conclusions: In a significant minority, antipsychotic prescribing did not align with clinical guidelines despite increased training, indicating that the education program alone was ineffective at positively influencing antipsychotic prescribing practices. Further consideration should be given when prescribing antipsychotics for involuntary patients, people with frequent hospitalisations, and those who have previously trialled clozapine
Results from the CUORE experiment
Neutrinoless double beta decay (0¿ßß) is a rare, second-order nuclear transition that occurs only if neutrinos are massive Majorana particles or through new physics beyond Standard Model. This process explicitly violates the lepton number (L) by two units and, therefore, the observation of 0¿ßß would demonstrate that L is not a symmetry of nature. Combined with flavour mixing and cosmological measurements, it can provide unique contraints on neutrino mass scale and establish whether neutrinos are Dirac or Majorana particles. The Cryogenic Underground Observatory for Rare Events (CUORE) is an experiment located at the LNGS searching for 0¿ßß decay of 130Te. CUORE exploits the bolometric technique to reach high resolution around the Q-value (2527.5 keV). It consists of an array of 988 natural TeO2 cubic crystals grouped into 19 towers. With a total active mass of 742 kg (~206 kg of 130Te), CUORE is operated at very low temperature with a new 3He/4He refrigerator. Data taking started at the beginning of 2017. After a brief introduction on the detector and the way data analysis is performed, I describe CUORE first results for the search of the 0¿ßß decay that were published in March 2018
Clinical features and therapeutic management of patients admitted to Italian acute hospital psychiatric units: the PERSEO (psychiatric emergency study and epidemiology) survey
<p>Abstract</p> <p>Background</p> <p>The PERSEO study (psychiatric emergency study and epidemiology) is a naturalistic, observational clinical survey in Italian acute hospital psychiatric units, called SPDCs (Servizio Psichiatrico Diagnosi e Cura; in English, the psychiatric service for diagnosis and management). The aims of this paper are: (i) to describe the epidemiological and clinical characteristics of patients, including sociodemographic features, risk factors, life habits and psychiatric diagnoses; and (ii) to assess the clinical management, subjective wellbeing and attitudes toward medications.</p> <p>Methods</p> <p>A total of 62 SPDCs distributed throughout Italy participated in the study and 2521 patients were enrolled over the 5-month study period.</p> <p>Results</p> <p>Almost half of patients (46%) showed an aggressive behaviour at admission to ward, but they engaged more commonly in verbal aggression (38%), than in aggression toward other people (20%). A total of 78% of patients had a psychiatric diagnosis at admission, most frequently schizophrenia (36%), followed by depression (16%) and personality disorders (14%), and no relevant changes in the diagnoses pattern were observed during hospital stay. Benzodiazepines were the most commonly prescribed drugs, regardless of diagnosis, at all time points. Overall, up to 83% of patients were treated with neuroleptic drugs and up to 27% received more than one neuroleptic either during hospital stay or at discharge. Atypical and conventional antipsychotics were equally prescribed for schizophrenia (59 vs 65% during stay and 59 vs 60% at discharge), while atypical drugs were preferred in schizoaffective psychoses (72 vs 49% during stay and 70 vs 46% at discharge) and depression (41 vs 32% during stay and 44 vs 25% at discharge). Atypical neuroleptics were slightly preferred to conventional ones at hospital discharge (52 vs 44%). Polypharmacy was in general widely used. Patient attitudes toward medications were on average positive and self-reported compliance increased during hospital stay.</p> <p>Conclusion</p> <p>Results confirm the widespread use of antipsychotics and the increasing trend in atypical drugs prescription, in both psychiatric in- and outpatients.</p
Search for Neutrinoless Double-Beta Decay of Te-130 with CUORE-0
We report the results of a search for neutrinoless double-beta decay in a 9.8 kg·yr exposure of 130Te using a bolometric detector array, CUORE-0. The characteristic detector energy resolution and background level in the region of interest are 5.1 ± 0.3 keV FWHM and 0.058 ± 0.004 (stat.) ± 0.002 (syst.) counts/(keV·kg·yr), respectively. The median 90 % C.L. lower-limit half-life sensitivity of the experiment is 2.9 × 1024 yr and surpasses the sensitivity of previous searches. We find no evidence for neutrinoless double-beta decay of 130Te and place a Bayesian lower bound on the decay half-life, T 0¿ > 2.7 × 1024 yr at 90 % C.L. Combining CUORE-0 data with the 19.75 kg·yr exposure 1/2 of 130Te from the Cuoricino experiment we obtain T0¿ > 4.0×1024 yr at 90% C.L. (Bayesian), the 1/2 most stringent limit to date on this half-life. Using a range of nuclear matrix element estimates we interpret this as a limit on the effective Majorana neutrino mass, mßß < 270–760 me
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