Museos y cibercultura, websites en la red

Este trabajo doctoral se centra en la elaboración y desarrollo de una herramienta de evaluación para websites de museos de Arte, basada en el empleo de Nuevas Tecnologías de la Información y Comunicación, junto a las ventajas y posibilidades que ofrece la Red, a la que se conecta Internet, en cuanto a comunicación, información y aprendizaje se refiere. Esta herramienta se diseña con el fin de evaluar las capacidades de los websites en referencia al aprendizaje informal, autónomo y permanente que se puede realizar en ellos. Se pretende la elaboración, a partir de los websites, de un artefacto educativo, permanente, social y en línea, que permita un proceso educativo adaptado a las necesidades y preferencias de los usuarios, que además, amplíe virtualmente los límites de los museos de Arte. Tras la elaboración de esta herramienta de análisis y evaluación de websites de museos, se procede en este estudio a su aplicación en cinco websites de instituciones museísticas nacionales, aportando conclusiones y propuestas derivadas de los resultados. Este estudio trata de la creación de una herramienta evaluadora de websites de museos de Arte, de fácil aplicación, que ofrezca un Modelo Ideal y que permita determinar el grado de adaptación a las Áreas y Límites de Evaluación propuestos en él.This doctoral work focuses on the development of an evaluation tool for websites of Art museums, based on the use of New Information and Communication Technologies, along with the advantages and possibilities offered by the Network, which connects the Internet, as far as communication, information and learning is concerned. This tool is designed in order to evaluate the capabilities of the websites in reference to the informal, autonomous and permanent learning that can be done in them. The aim is to draw up, from the websites, an educational, permanent, social and online artifact that allows an educational process adapted to the needs and preferences of users, which also extends the limits of art museums. After the development of this tool for the analysis and evaluation of museum websites, this study is applied to five websites of national museum institutions, contributing conclusions and proposals derived from the results. This study deals with the creation of an evaluation tool for art museum websites, which is easy to apply and offers an Ideal Model, allowing the determination of the degree of adaptation to the proposed Assessment Areas and Limits

Corrosion Effect in Carbon Steel: Process Modeling Using Fuzzy Logic Tools

Acid mine drainage (AMD), resulting from mining activities, poses a significant environmental concern. It adversely affects metallic materials, particularly carbon steel composites used in mining machinery and structures. Highly acidic and oxidizing compounds like sulfuric acid and ferric ions cause corrosion, iron oxide formation, and hydrogen gas release, which degrade carbon steel. AMD also alters the solvent’s properties, dissolving heavy metals and contaminants, and intensifying the environmental impact of mining. A 30-week experiment immersed metal plates in AMD to study its effects. Weekly observations of the plates and solvent were made. The plate measurements and physicochemical data were analyzed using graphical–statistical analysis and fuzzy logic techniques to assess the data quality and identify errors. The results reveal consistent findings with prior studies, such as material degradation with weight loss and alterations in acid drainage media, including increased pH and total dissolved solids (TDS). These changes in the solvent characteristics stem from the dissolution of metal ions from corroded surfaces, reacting with the acid solution. Overall, this study discusses the effects of AMD (acid mine drainage) on metallic materials and emphasizes the significance of monitoring and reducing the environmental consequences of mining activities.This research was funded by the Ministry of Science and Innovation (Spain), grant number PID2021-123130OB-I00

Edition electronic support of didactic material for interactive self-learning

The creation of a new social-virtual space for human interrelations is necessary for new information and communication technologies. This new environment, which is being developed in the area of education, enables new processes of learning and transmission of knowledge through modern communication networks. All this invites us to support ourselves in the principles of hypertext education and autonomous learning together with the collective and cooperative. The aim is to reinforce learning through an interactive learning technique based on problems and selfevaluation. To achieve these objectives, it would be necessary to combine teacher-guided learning, the personal work of the learners and the working group. The project consists of the interactive didactic material electronic edition related to the subjects dealt with in the subject Geological Foundations (Degree of Engineering in Exploitation of Mines and Energy Resources) and Geology, (Degree in Engineering in Exploitation of Mines and Energy Resources). For this purpose, all the contents are integrated into a digital document with digital with sufficient links for the student to navigate throughout the subject. The objectives are: Compilation of the theoretical and practical contents of the subjects; Development and updating of a set of activities for the assimilation of the contents; Integration of all contents in a digital format document with sufficient links for student navigation throughout the subject; Incorporate links to websites of interest that allow the extension of the contents of the subject; Familiarize students with learning. To achieve the objectives proposed in the project, the following methodology is proposed: Phase I. Preparation of teaching material; Phase II Creation of an interactive virtual platform with the didactic material developed: Once all the didactic material has been developed and available, a navigation environment will be programmed with Frontpage (or similar) with which the student can easily access the developed contents. In this way, once all the didactic material has been prepared and available in digital format, a navigation environment will be programmed with which the student can be able to easily access the developed contents. With this didactic material, a publication will be made which will be easily accessible for all interested students. The student will have the theoretical contents developed, as well as a collection of representative problems solved, which will serve as a guide for the study of the subjects mentioned above. In addition, interactive tests will be carried out that allow the student to self-evaluate the theoretical-practical concepts worked on. In this way, this work can be considered as a first phase of the total virtualization of all the subjects

Pathogenic Variants Associated with Epigenetic Control and the NOTCH Pathway Are Frequent in Classic Hodgkin Lymphoma

Classic Hodgkin lymphoma (cHL) constitutes a B-cell neoplasm derived from germinal center lymphocytes. Despite high cure rates (80–90%) obtained with the current multiagent protocols, a significant proportion of cHL patients experience recurrences, characterized by a lower sensitivity to second-line treatments. The genomic background of chemorefractory cHL is still poorly understood, limiting personalized treatment strategies based on molecular features. In this study, using a targeted next-generation sequencing (NGS) panel specifically designed for cHL research, we compared chemosensitive and chemorefractory diagnostic tissue samples of cHL patients. Furthermore, we longitudinally examined paired diagnosis–relapsesamples of chemorefractory cHL in order to define patterns of dynamic evolution and clonal selection. Pathogenic variants in NOTCH1 and NOTCH2 genes frequently arise in cHL. Mutations in genes associated with epigenetic regulation (CREBBP and EP300) are particularly frequent in relapsed/refractory cHL. The appearance of novel clones characterized by mutations previously not identified at diagnosis is a common feature in cHL cases showing chemoresistance to frontline treatments. Our results expand current molecular and pathogenic knowledge of cHL and support the performance of molecular studies in cHL prior to the initiation of first-line therapies

Physico-Chemical Influence of Surface Water Contaminated by Acid Mine Drainage on the Populations of Diatoms in Dams (Iberian Pyrite Belt, SW Spain)

Twenty-three water dams located in the Iberian Pyrite Belt were studied during March 2012 (early spring) in order to carry out an environmental assessment based on diatom communities and to define the relationships between these biological communities and the physico-chemical characteristics of the dam surface water. This is the first time that a diatom inventory has been done for dams a ected by acid mine drainage (AMD) in the Spanish part of the Iberian Pyrite Belt (IPB). It was found that the pH was the main factor influencing the behaviour of the diatom communities. Then, using a dbRDA approach it was possible to organize the aggrupation of diatoms into four groups in response to the physico-chemical conditions of the ecosystem, especially pH: (1) Maris, Aac, Gos, Cmora (pH 2–3); (2) Andc, San, And, Dpin (pH 3–4.5); (3) Gran, Pleon, Oliv, Lagu, Chan, SilI, SilII, Joya, Gar, Agrio, Camp, Corum (pH 4.5–6); (4) Herr, Diq I, Diq II (pH 6–7). The obtained results confirmed the response of benthic diatom communities to changes in the physico-chemical characteristics of surface water, and helped to understand the role of diatoms as indicators of the degree of AMD contamination in those 23 dams. Special attention was given to those that have an acidophilic or acid-tolerant profile (pH 2–3 and pH 3–4.5) such as Pinnularia aljustrelica, Pinnularia acidophila, Pinnularia acoricola and Eunotia exigua, which are the two groups found in the most AMD contaminated dams.Cuantificacíon de la carga metalica y sulfatos aportada por procesos AMD a embalses de la Faja Piritica Iberica: modelizacíon del processo y velocidades de colmatacíon” (CGL2010-21268-C02-01), Ministerio de Educación y Ciencia. “Cuantificacion de la carga metálica y sulfatos aportada por procesos AMD a embalses de la Faja Piritica Iberica” (P10-RNM-6570), Junta de Andalucía-Convocatoria Proyectos de Excelencia. Fundação para a Ciência e a Tecnologia (FCT), I.P. National funds in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19

An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability

Corrigendum published on 03 July 2019 Nucleic Acids Research 47 (14) : 7716–7717 (2019) https://doi.org/10.1093/nar/gkz587The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. However, the contribution of E2F7 to cellular responses upon genotoxic damage is still poorly defined. Here we show that E2F7 represses the expression of genes involved in the maintenance of genomic stability, both throughout the cell cycle and upon induction of DNA lesions that interfere with replication fork progression. Knockdown of E2F7 leads to a reduction in 53BP1 and FANCD2 foci and to fewer chromosomal aberrations following treatment with agents that cause interstrand crosslink (ICL) lesions but not upon ionizing radiation. Accordingly, E2F7-depleted cells exhibit enhanced cell-cycle re-entry and clonogenic survival after exposure to ICL-inducing agents. We further report that expression and functional activity of E2F7 are p53-independent in this context. Using a cell-based assay, we show that E2F7 restricts homologous recombination through the transcriptional repression of RAD51. Finally, we present evidence that downregulation of E2F7 confers an increased resistance to chemotherapy in recombination-deficient cells. Taken together, our results reveal an E2F7-dependent transcriptional program that contributes to the regulation of DNA repair and genomic integrity.This work was supported by grants from the Spanish Ministry [SAF2012-33551 and SAF2015-67562-R, co-financed by FEDER funds, and SAF2014-57791-REDC], the Basque Government [IT634-13 and KK-2015/89], and the University of the Basque Country UPV/EHU [UFI11/20] to AMZ; and grants from the Spanish Ministry [SAF2015-69920-R], and Worldwide Cancer Research [15-0278] to MM. JM was recipient of a Basque Government fellowship for graduate studies and JVR is recipient of a UPV/EHU fellowship for graduate studies. M.A.F. was supported by a young investigator grant from MINECO [SAF2014-60442-JIN; co-financed by FEDER funds]. Funding for open access charge: Spanish Ministry [SAF2015-67562-R, co-financed by FEDER funds]; Basque Government [IT634-13]

Odiel River (SW Spain), a Singular Scenario Affected by Acid Mine Drainage (AMD): Graphical and Statistical Models to Assess Diatoms and Water Hydrogeochemistry Interactions

The Odiel River (SW Spain) is one of the most cited rivers in the scientific literature due to its high pollution degree, generated by more than 80 sulphide mines’ (mostly unrestored) contamination in the Iberian Pyritic Belt (IPB), that have been exploited for more than 5000 years. Along the river and its tributaries, the physico-chemical parameters and diatoms, from 15 sampling points, were analyzed in the laboratory. Physico-chemical parameters, water chemical analysis, together with richness and Shannon–Wiener indexes were integrated in a matrix. An initial graphical treatment allowed the definition and proposal of a functioning system model, as well as the establishment of cause–effect relationships between pollution and its effects on biota. Then, the proposed model was statistically validated by factor analysis. For acidic pH waters, high values of Eh, TDS, sulphate, ∑REE and ∑Ficklin were found, while diatomologic indicators took low values. Thus, factor analysis was a very effective tool for graphical treatment validation as well as for pollution–biota interaction models’ formulation, governed by two factors: AMD processes and water balance suffered by the studied river. As a novelty, the cause–effect relationships between high barium concentration and low diversity and richness were demonstrated in the IPB, for the first time: The authors are grateful to the Departments of Biology and Geosciences of the University of Aveiro, Portugal where diatom samples were identified. The authors are grateful to the Sustainable Mining Engineering Research Group, Department of Mining, Mechanic, Energetic and Construction Engineering at the Higher Technical School of Engineering, University of Huelva, Spain for paying for the water analyses. AT Luís is funded by national funds (OE), through FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of 29 August, changed by Law 57/2017, of 19 Jul

Garapen Iraunkorrerako Literaturaren Gida (1-6 Helburuak)

Garapen Iraunkorrerako Helburuak eta Haur eta Gazte Literatura, horiexek uztartzen ditugu gida honetan, eta bi helburu nagusi ditugu: batetik, literaturaren erabilera sustatzea Garapen Iraunkorrerako Helburuak (GIH) lantzeko eta, bestetik, bitartekariei tresnak eskaintzea literatura-lan egokiak hautatzeko eta baliatzeko. Horiek horrela, balore sozialak eta balore literarioak jarri ditugu erdigunean. Gida honen ardatz nagusia izan da bi-biak kontuan hartzea.Vicerrectorado de Innovación, Compromiso Social y Acción Social.Dirección de Sostenibilidad y del Servicio de Asesoramiento Educativo. Programa Campus Bizia Lab

Konsumsi Minyak Goreng dan Vitamin A pada Beberapa Kelompok Umur di Dua Kabupaten

Indonesia plans to implement mandatory vitamin A fortification of cooking oil. A pilot study of voluntary vitamin A fortification in unbranded cooking oil showed that vitamin A status improved significantly a year afterfortification for five age groups except for children 12-23 months of age. The objective of the study was to measure cooking oil consumption and dietary consumption of vitamin A in children, women of reproductive age(WRA), and lactating mothers. The study was a cross-sectional study in Tasikmalaya and Ciamis, Indonesia, covering 1.594 samples randomly selected of poor households. Cooking oil was collected at household byrecall of usual cooking oil purchase and individual sample by 2x24h recall of food consumption. The results showed that households prefer bought unbranded cooking oil sold in plastic pouch at foodstall (warung) nearbyhome (96.2%), purchased oil every 1-3 days (60.6%), each purchace contained < 250 mL oil (73.9%). The average (mean+SE) cooking oil consumption at household was 27.5+1.0 mL/capita/day. Cooking oilconsumption at individual level on the average was 22.3+0.5 mL/capita/day lower compared to household consumption of oil, varied significantly of 2.4+0.4, 13.3+0.8, 23.0+1.0, 30.5+1.3, 33.5+1.2, 33.1+1.3 mL/day in 6-11, 12-23, 24-59 month old, 6-9 year old, WRA, and lactating mothers respectively. Cooking oil consumptionwas lower in children 6-11 and 12-23 months old which contributed to non-significant improvement of serum vitamin A level particularly in children 12-23 months old but not other groups since they consumed higher intake of cooking oil or still brestfed for children 6-11 month old

Caracterización clínico-epidemiológica de pacientes adultos confirmados con COVID-19 en Holguín

Introduction: COVID-19 is caused by the new coronavirus SARS-CoV-2, identified in the city of Wuhan, China at the end of 2019. The exponential increase in cases forced the World Health Organization to declare it as a pandemic.Objective: to clinically and epidemiologically characterize adult patients confirmed to have COVID-19 in a Family Doctor's Office in Holguín.Method: a retrospective, observational, cross-sectional, descriptive study was carried out in adult patients confirmed with COVID-19, in the Family Doctor's Office No. 7 of the "Máximo Gómez Báez" Teaching Polyclinic in the period from January to August 2021. The population and the sample were coincident, with a total of 81 patients.Results: patients in the age range of 50 to 59 years represented 23.45%; and 64.20% of the total were female. 83.95% presented symptoms of the disease and 97.53% were locally acquired. Arterial hypertension was present in 25.93%. 95.06% of the patients studied recovered from the disease.Conclusions: patients in the age range of 50 to 59 years, female, symptomatic and locally acquired COVID cases prevailed. The most frequent comorbidity was arterial hypertension. Most patients recovered.Introducción: la COVID-19 es causada por el nuevo coronavirus SARS-CoV-2, identificado en la ciudad de Wuhan, China a finales de 2019. El incremento exponencial de casos obligó a la Organización Mundial de la Salud a declarar como pandemia a esta nueva enfermedad.Objetivo: caracterizar clínico-epidemiológicamente a pacientes adultos confirmados con COVID-19 en un Consultorio del Médico de la Familia de Holguín.Método: se realizó un estudio retrospectivo, observacional, transversal, descriptivo en pacientes adultos confirmados con COVID-19, en el Consultorio del Médico de la Familia No. 7 del Policlínico Docente “Máximo Gómez Báez” en el periodo comprendido desde enero a agosto de 2021. El universo y la muestra fueron coincidentes, siendo un total de 81 pacientes.Resultados: los pacientes en el rango de edades de 50 a 59 años representaron el 23,45 % y el 64,20 % del total fueron del sexo femenino. El 83,95 % presentaron síntomas de la enfermedad y el 97,53 % fueron casos autóctonos. La hipertensión arterial estuvo presente en el 25,93 %. El 95,06 % de los pacientes estudiados fueron curados de la COVID-19. Conclusiones: predominaron los pacientes en el rango de edades de 50 a 59 años, del sexo femenino, sintomáticos y autóctonos. La comorbilidad más frecuente fue la hipertensión arterial. El mayor número fueron curados de la enfermedad