2,340 research outputs found

    Steps towards the development of an experimentally verified simulation of pool nucleate boiling on a silicon wafer with artificial sites

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    Nucleate boiling is a very effective heat transfer cooling process, used in numerous industrial applications. Despite intensive research over decades, a reliable model of nucleate pool boiling is still not available. This paper presents a numerical and experimental investigation of nucleate boiling from artificial nucleation sites. The numerical investigation described in the first section of the paper is carried out by a hybrid mechanistic numerical code first developed at the University of Ljubljana to simulate the temperature field in a heated stainless steel plate with a large number of nucleation sites during pool boiling of water at atmospheric pressure. It is now being redeveloped to interpret experiments on pool boiling at artificial sites on a silicon plate and as a design tool to investigate different arrangements of sites to achieve high heat fluxes. The code combines full simulation of the temperature field in the solid wall with simplified models or correlations for processes in the liquid-vapour region. The current capabilities and limitations of the code are reviewed and improvements are discussed. Examples are given of the removal of computational constraints on the activation of sites in close proximity and improvements to the bubble growth model. Preliminary simulations are presented to compare the wall conditions to be used in the experiments on silicon at Edinburgh University with the conditions in current experiments on thin metal foils at Ljubljana. An experimental rig for boiling experiments with artificial cavities on a 0.38 mm thick silicon wafer immersed in FC-72, developed at Edinburgh University, is described in the second part of the paper

    Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.

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    BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined. Previous studies suggest spinal cord p38 mitogen-activated protein (MAP) kinase and cytokines participate in nociceptive behavior. We therefore determined whether these pathways also regulate peripheral inflammation in rat adjuvant arthritis, which is a model of rheumatoid arthritis.Methods and findingsSelective blockade of spinal cord p38 MAP kinase by administering the p38 inhibitor SB203580 via intrathecal (IT) catheters in rats with adjuvant arthritis markedly suppressed paw swelling, inhibited synovial inflammation, and decreased radiographic evidence of joint destruction. The same dose of SB203580 delivered systemically had no effect, indicating that the effect was mediated by local concentrations in the neural compartment. Evaluation of articular gene expression by quantitative real-time PCR showed that spinal p38 inhibition markedly decreased synovial interleukin-1 and -6 and matrix metalloproteinase (MMP3) gene expression. Activation of p38 required tumor necrosis factor alpha (TNFalpha) in the nervous system because IT etanercept (a TNF inhibitor) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis.ConclusionsThese data suggest that peripheral inflammation is sensed by the central nervous system (CNS), which subsequently activates stress-induced kinases in the spinal cord via a TNFalpha-dependent mechanism. Intracellular p38 MAP kinase signaling processes this information and profoundly modulates somatic inflammatory responses. Characterization of this mechanism could have clinical and basic research implications by supporting development of new treatments for arthritis and clarifying how the CNS regulates peripheral immune responses

    High precision radial velocities with GIANO spectra

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    Radial velocities (RV) measured from near-infrared (NIR) spectra are a potentially excellent tool to search for extrasolar planets around cool or active stars. High resolution infrared (IR) spectrographs now available are reaching the high precision of visible instruments, with a constant improvement over time. GIANO is an infrared echelle spectrograph at the Telescopio Nazionale Galileo (TNG) and it is a powerful tool to provide high resolution spectra for accurate RV measurements of exoplanets and for chemical and dynamical studies of stellar or extragalactic objects. No other high spectral resolution IR instrument has GIANO's capability to cover the entire NIR wavelength range (0.95-2.45 micron) in a single exposure. In this paper we describe the ensemble of procedures that we have developed to measure high precision RVs on GIANO spectra acquired during the Science Verification (SV) run, using the telluric lines as wavelength reference. We used the Cross Correlation Function (CCF) method to determine the velocity for both the star and the telluric lines. For this purpose, we constructed two suitable digital masks that include about 2000 stellar lines, and a similar number of telluric lines. The method is applied to various targets with different spectral type, from K2V to M8 stars. We reached different precisions mainly depending on the H -magnitudes: for H ~ 5 we obtain an rms scatter of ~ 10 m s-1, while for H ~ 9 the standard deviation increases to ~ 50 - 80 m s-1. The corresponding theoretical error expectations are ~4 m s-1 and 30 m s-1, respectively. Finally we provide the RVs measured with our procedure for the targets observed during GIANO Science Verification.Comment: 26 pages, 15 figures, 6 table

    Mutual independence of critical temperature and superfluid density under pressure in optimally electron-doped superconducting LaFeAsO1x_{1-x}Fx_{x}

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    The superconducting properties of LaFeAsO1x_{1-x}Fx_{x} in conditions of optimal electron-doping are investigated upon the application of external pressure up to 23\sim 23 kbar. Measurements of muon-spin spectroscopy and dc magnetometry evidence a clear mutual independence between the critical temperature TcT_{c} and the low-temperature saturation value for the ratio ns/mn_{s}/m^{*} (superfluid density over effective band mass of Cooper pairs). Remarkably, a dramatic increase of 30\sim 30 % is reported for ns/mn_{s}/m^{*} at the maximum pressure value while TcT_{c} is substantially unaffected in the whole accessed experimental window. We argue and demonstrate that the explanation for the observed results must take the effect of non-magnetic impurities on multi-band superconductivity into account. In particular, the unique possibility to modify the ratio between intra-band and inter-bands scattering rates by acting on structural parameters while keeping the amount of chemical disorder constant is a striking result of our proposed model.Comment: 8 pages (Main text: 5 pages. Paper merged with supplemental information), 5 figure

    Information flow in intensive care narratives

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    Intrinsic electronic superconducting phases at 60 K and 90 K in double-layer YBa2_2Cu3_3O6+δ_{6+\delta}

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    We study superconducting transition temperature (TcT_c) of oxygen-doped double-layer high-temperature superconductors YBa2_2Cu3_3O6+δ_{6+\delta} (0 \le δ\delta \le 1) as a function of the oxygen dopant concentration (δ\delta) and planar hole-doping concentration (PplP_{pl}). We find that TcT_c, while clearly influenced by the development of the chain ordering as seen in the TcT_c vs.vs. δ\delta plot, lies on a universal curve originating at the critical hole concentration (PcP_c) = 1/16 in the TcT_c vs.vs. PplP_{pl} plot. Our analysis suggests that the universal behavior of TcT_c(PplP_{pl}) can be understood in terms of the competition and collaboration of chemical-phases and electronic-phases that exist in the system. We conclude that the global superconductivity behavior of YBa2_2Cu3_3O6+δ_{6+\delta} as a function of doping is electronically driven and dictated by pristine electronic phases at magic doping numbers that follow the hierarchical order based on PcP_c, such as 2 ×\times PcP_c, 3 ×\times PcP_c and 4 ×\times PcP_c. We find that there are at least two intrinsic electronic superconducting phases of TcT_c = 60 K at 2 ×\times PcP_c = 1/8 and TcT_c = 90 K at 3 ×\times PcP_c = 3/16.Comment: 4 pages, 2 figure

    Anisotropic in-plane optical conductivity in detwinned Ba(Fe1-xCox)2As2

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    We study the anisotropic in-plane optical conductivity of detwinned Ba(Fe1-xCox)2As2 single crystals for x=0, 2.5% and 4.5% in a broad energy range (3 meV-5 eV) across their structural and magnetic transitions. For temperatures below the Neel transition, the topology of the reconstructed Fermi surface, combined with the distinct behavior of the scattering rates, determines the anisotropy of the low frequency optical response. For the itinerant charge carriers, we are able to disentangle the evolution of the Drude weights and scattering rates and to observe their enhancement along the orthorhombic antiferromagnetic a-axis with respect to the ferromagnetic b-axis. For temperatures above Ts, uniaxial stress leads to a finite in-plane anisotropy. The anisotropy of the optical conductivity, leading to a significant dichroism, extends to high frequencies in the mid- and near-infrared regions. The temperature dependence of the dichroism at all dopings scales with the anisotropy ratio of the dc conductivity, suggesting the electronic nature of the structural transition. Our findings bear testimony to a large nematic susceptibility that couples very effectively to the uniaxial lattice strain. In order to clarify the subtle interplay of magnetism and Fermi surface topology we compare our results with theoretical calculations obtained from density functional theory within the full-potential linear augmented plane-wave method.Comment: 17 pages, 9 figure
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