Asymptotic Solution for the Current Profile of Passive Bare Electrodynamic Tethers

A relatively high-accuracy analytical solution for the current and potential profile along a passive bare electrodynamic tether is provided using perturbation theory. An ad hoc nondimensional formulation of the governing local bias and orbital motion limited current collection equations allows one to approach the problem with a perturbation technique in which a parameter, epsilon, quantifies the influence of ohmic effects on the final solution. For the case of small ohmic effects an approximate solution is obtained with a third-order expansion. Conversely, the case of dominant ohmic effects is treated based on an extension of the exact analytical solution available for the particular case of zero load and negligible potential drop at the cathodic end of the tether. After computing the analytical current and potential profile the maximum and average current, the Lorentz force and torque, as well as the optimum load impedance for maximum power generation are obtained. When compared with the exact, numerically-computed solution an accuracy of better than5%is achieved for the computation of the average current across the full parameter space. The error with respect to the generated power becomes negligible when the load impedance is set to the optimum value, while it can grow to a maximum of about 30% for the less relevant case in which the load impedance of the power generation system is badly mismatched. The results, which are valid for a general rectilinear passive electrodynamic tether with constant cross section satisfying orbital motion limited theory and irrespective of the particular orbit configuration, will be of aid in the design and analysis of space missions involving bare electrodynamic tethers

Space Test of Bare-Wire Anode Tethers

An international team, lead by Tokyo Metropolitan University, is developing a mission concept for a suborbital test of orbital-motion-limited (OML) bare-wire anode current collection for application to electrodynamic tether propulsion. The tether is a tape with a 50-mm width, 0.05-mm thickness, and 1-km length. This will be the first space test of the OML theory. In addition, by being an engineering demonstration (of space tethers), the mission will demonstrate electric beam generation for "sounding" determination of the neutral density profile in the ionospheric "E-layer." If selected by the Institute of Space and Astronautical Science/Japanese Aerospace Exploration Agency (JAXA), the mission will launch in early 2009 using an $520 Sounding Rocket. During ascent, and above =100 km in attitude, the 1-km tape tether will be deployed at a rate of 8 m/s. Once deployed, the tape tether will serve as an anode, collecting ionospheric electrons. The electrons will be expelled into space by a hollow cathode device, thereby completing the circuit and allowing current to flow.This paper will describe the objectives of the proposed mission, the technologies to be employed, and the application of the results to future space missions using electrodynamic tethers for propulsion or power generation

Fortissimo: A Japanese Space Test Of Bare Wire Anode Tethers

A Japanese led international team is developing a suborbital test of orbital-motion-limited (OML) bare wire anode current collection for application to electrodynamic tether (EDT) propulsion. The tether is a tape with a width of 25 mm, thickness of 0.05 mm, and is 300 m in length. This will be the first space test of OML theory. The mission will launch in the summer of 2009 using an S520 Sounding Rocket. During ascent, and above approx. 100 km in attitude, the tape tether will be deployed at a rate of approx. 8 m/s. Once deployed, the tape tether will serve as an anode, collecting ionospheric electrons. The electrons will be expelled into space by a hollow cathode device, thereby completing the circuit and allowing current to flow. The total amount of current collected will be used to assess the validity of OML theory. This paper will describe the objectives of the proposed mission, the technologies to be employed, and the application of the results to future space missions using EDTs for propulsion or power generation

Power density of a bare electrodynamic tether generator

The maximum performance of bare electrodynamic tethers as power generating systems under OML-theory is analyzed. Results show that best performance in terms of power density is achieved by designing the tether in such a way to increase ohmic impedance with respect to plasma contact impedance, hence favoring longer and thinner tethers. In such condition the corresponding optimal value of the load impedance is seen to approach the ohmic impedance of the conducting tether. At the other extreme, when plasma contact impedance dominates (which is not optimal but can be relevant for some applications) optimum power generation is found by matching the load impedance with an effective tether-plasma contact impedance whose expression is derived

Electrodynamic Propulsion System Tether Experiment (T-REX)

A Japanese-led international team is developing a suborbital test of orbital-motion-limited (OML) bare wire anode current collection for application to electrodynamic tether (EDT) propulsion. The tether is a tape with a width of 25 mm, thickness of 0.05 mm, and is 300 m in length. This will be the first space test of OML theory. The mission will launch in the summer of 2010 using an S520 Sounding Rocket. During ascent, and above approximately 100 km in attitude, the tape tether will be deployed at a rate of approximately8 m/s. Once deployed, the tape tether will serve as an anode, collecting ionospheric electrons. The electrons will be expelled into space by a hollow cathode device, thereby completing the circuit and allowing current to flow. The total amount of current collected will be used to assess the validity of OML theory. This paper will describe the objectives of the proposed mission, the technologies to be employed, and the application of the results to future space missions using EDTs for propulsion or power generatio

The hydrodynamic efficiency of laser-target acceleration

The acceleration of a thin foil using a laser pulse is studied. It is shown that the acceleration efficiency eta H is heavily dependent on the behaviour of the corona ejected by the foil: there is no universal relation eta H( Delta M/M0),M0 and Delta M being initial foil mass and ablated mass, respectively. Known results on the coronal flow are used to check the theory against experimental data available in the literature; effects due to both a non-planar corona, and the time-dependence of the laser irradiance, are considered. The agreement with experiments is substantially better than that for previous analyses. Acceleration of thin spherical shells is also discussed

Energy Analysis of Bare Electrodynamic Tethers

The design of an electrodynamic tether is a complex task that involves the control of dynamic instabilities, optimization of the generated power (or the descent time in deorbiting missions), and minimization of the tether mass. The electrodynamic forces on an electrodynamic tether are responsible for variations in the mechanical energy of the tethered system and can also drive the system to dynamic instability. Energy sources and sinks in this system include the following: 1) ionospheric impedance, 2) the potential drop at the cathodic contactor, 3) ohmic losses in the tether, 4) the corotational plasma electric field, and 5) generated power and/or 6) input power. The analysis of each of these energy components, or bricks, establishes parameters that are useful tools for tether design. In this study, the nondimensional parameters that govern the orbital energy variation, dynamic instability, and power generation were characterized, and their mutual interdependence was established. A space-debris mitigation mission was taken as an example of this approach for the assessment of tether performance. Numerical simulations using a dumbbell model for tether dynamics, the International Geomagnetic Reference Field for the geomagnetic field, and the International Reference Ionosphere for the ionosphere were performed to test the analytical approach. The results obtained herein stress the close relationships that exist among the velocity of descent, dynamic stability, and generated power. An optimal tether design requires a detailed tradeoff among these performances in a real-world scenario

New symmetrical quinazoline derivatives selectively induce apoptosis in human cancer cells

In the search of new symmetrical derivatives with anticancer activity, we have looked for novel compounds able to induce a selective proapoptotic mechanism in cancer cells. The potential antitumoral activity of several quinazoline derivatives was evaluated in vitro examining their cytotoxic effects against human breast, colon and bladder cancer cell lines. The IC(50) value of the compounds that showed cytotoxic activity was calculated. These compounds were tested for their ability to induce caspase-3 activation and nuclear chromatin degradation. Non-tumoral human cell lines were used to test the selectivity of the cytotoxic compounds against cancer cells. Several compounds showed no cytotoxicity in these cell lines. Finally, JRF12 (2,4-dibenzylaminoquinazoline) was chosen as the best candidate and its mechanism of action was studied in more detail. A time dependent evaluation of apoptosis was performed in the three cancer cell lines, followed by an evaluation of the cell cycle regulation involvement that showed a decrease of cells in G(1) phase and increase of cells in G(2) phase before cell death. 2,4-dibenzylaminoquinazoline treatment produces few changes in the expression of genes as evaluated by using oligonucleotide microarrays and Q-RT-PCR assays. In conclusion, 2,4-dibenzylaminoquinazoline is a promising anticancer drug showing cytostatic and apoptotic effects mainly in a transcription independent manner

The Homeodomain Derived Peptide Penetratin Induces Curvature of Fluid Membrane Domains

BACKGROUND:Protein membrane transduction domains that are able to cross the plasma membrane are present in several transcription factors, such as the homeodomain proteins and the viral proteins such as Tat of HIV-1. Their discovery resulted in both new concepts on the cell communication during development, and the conception of cell penetrating peptide vectors for internalisation of active molecules into cells. A promising cell penetrating peptide is Penetratin, which crosses the cell membranes by a receptor and metabolic energy-independent mechanism. Recent works have claimed that Penetratin and similar peptides are internalized by endocytosis, but other endocytosis-independent mechanisms have been proposed. Endosomes or plasma membranes crossing mechanisms are not well understood. Previously, we have shown that basic peptides induce membrane invaginations suggesting a new mechanism for uptake, "physical endocytosis". METHODOLOGY/PRINCIPAL FINDINGS:Herein, we investigate the role of membrane lipid phases on Penetratin induced membrane deformations (liquid ordered such as in "raft" microdomains versus disordered fluid "non-raft" domains) in membrane models. Experimental data show that zwitterionic lipid headgroups take part in the interaction with Penetratin suggesting that the external leaflet lipids of cells plasma membrane are competent for peptide interaction in the absence of net negative charges. NMR and X-ray diffraction data show that the membrane perturbations (tubulation and vesiculation) are associated with an increase in membrane negative curvature. These effects on curvature were observed in the liquid disordered but not in the liquid ordered (raft-like) membrane domains. CONCLUSIONS/SIGNIFICANCE:The better understanding of the internalisation mechanisms of protein transduction domains will help both the understanding of the mechanisms of cell communication and the development of potential therapeutic molecular vectors. Here we showed that the membrane targets for these molecules are preferentially the fluid membrane domains and that the mechanism involves the induction of membrane negative curvature. Consequences on cellular uptake are discussed