The method of mothers for non-overlapping non-matching DDM

In this paper we introduce a variant of the three-field formulation where we use only two sets of variables. Considering, to fix the ideas, the homogeneous Dirichlet problem for the Laplace operator in a bounded domain, our variables are: 1) an approximation of the solution on the skeleton (the union of the interfaces of the sub-domains) on an independent grid (that could often be uniform), and 2) the approximations of the solution in each sub-domain, each on its own grid. The novelty is in the way to derive, from the approximation on the skeleton, the values of each trace of the approximations in the subdomains. We do it by solving an auxiliary problem, that resembles the mortar method but is more flexible. Under suitable assumptions, quasi-optimal error estimates are proved, uniformly with respect to the number and size of the subdomains

Remote digital monitoring during the retention phase of orthodontic treatment: A prospective feasibility study

Objective: To evaluate if a remote digital monitoring system added at the end of orthodontic treatment could positively influence the retention phase by reducing the occurrence of misfit of removable appliances, number of emergency appointments (EA), and orthodontic relapse. Methods: Twenty-seven patients who completed active orthodontic treatment were divided into the study and control groups. In addition to the standard chairside follow-up appointments at month 1 (T1), month 3 (T2), month 6 (T3), the study group patients were monitored using Dental Monitoring® with monthly intra-oral scans. Occurrence of misfit of removable retainers, number of EAs, and intercanine width change were recorded for both groups. Differences in EAs and retainer fit were assessed using the chi-square test. Intra-group and inter-group differences in the intercanine width were assessed with Friedman test and Mann–Whitney U test, respectively (α = 0.05). Results: The study group showed a significantly lower occurrence of misfit of removable retainers (p = 0.027) compared to the control group. No significant inter-and intra-group difference was found in the EAs and intercanine width change at each time-point. Conclusions: Integrating remote monitoring systems, such as Dental Monitoring®, to the retention phase of the orthodontic treatment may lower the occurrence of misfit of removable retainers. However, a small sample size and a short observation period limit the strength of this evidence. These preliminary results tentatively suggest that remote monitoring technologies may be beneficial, especially during the COVID-19 pandemic, when the regularity of in-office visits might be disrupted

Spline Upwind for space--time Isogeometric Analysis of cardiac electrophysiology

We present an elaboration and application of Spline Upwind (SU) stabilization method, designed in space--time Isogeometric Analysis framework, in order to make this stabilization as suitable as possible in the context of cardiac electrophysiology. Our aim is to propose a formulation as simple and efficient as possible, effectual in preventing spurious oscillations present in plain Galerkin method and also reasonable from the computational cost point of view. For these reasons we validate the method's capability with numerical experiments, focusing on accuracy and computational aspects

Viabilidade econômica agrícola e responsabilidade ambiental em unidades rurais de produção orgânica e convencional em Mundo Novo, MS.

bitstream/item/69064/1/099-recalde-viabilidade.pdfPublicado também no Cadernos de Agroecologia, v. 7, n.2, 2012

Effects of remote digital monitoring on oral hygiene of orthodontic patients: a prospective study

Background: Remote digital monitoring during orthodontic treatment can help patients in improving their oral hygiene performance and reducing the number of appointments due to emergency reasons, especially in time of COVID-19 pandemic where non-urgent appointments might be discouraged. Methods: Thirty patients scheduled to start an orthodontic treatment were divided into two groups of fifteen. Compared to controls, study group patients were provided with scan box and cheek retractor (Dental Monitoring®) and were instructed to take monthly intra-oral scans. Plaque Index (PI), Gingival Index (GI), and White Spot Lesions (WSL) were recorded for both groups at baseline (t0), every month for the first 3 months (t1, t2, t3), and at 6 months (t4). Carious Lesions Onset (CLO) and Emergency Appointments (EA) were also recorded during the observation period. Inter-group differences were assessed with Student's t test and Chi-square test, intra-group differences were assessed with Cochran’s Q-test (significance α = 0.05). Results: Study group patients showed a significant improvement in plaque control at t3 (p = 0.010) and t4 (p = 0.039), compared to control group. No significant difference was observed in the number of WSL between the two groups. No cavities were detected in the study group, while five CLO were diagnosed in the control group (p = 0.049). A decreased number of EA was observed in the study group, but the difference was not significant. Conclusions: Integration of a remote monitoring system during orthodontic treatment was effective in improving plaque control and reducing carious lesions onset. The present findings encourage orthodontists to consider this technology to help maintaining optimal oral health of patients, especially in times of health emergency crisis

Long-term management of natalizumab discontinuation in a large monocentric cohort of multiple sclerosis patients

Background Pivotal and post-marketing studies demonstrated the impressive efficacy and the good tolerability profile of natalizumab in Multiple Sclerosis patients. On the other hand long-term safety of natalizumab therapy is burdened by the risk of progressive multifocal leukoencephalopathy, especially in anti-JCV seropositive patients treated for more than two years. Some of these patients must stop the drug at the risk of disease reactivation. Objectives To evaluate the effects of natalizumab discontinuation in a monocentric cohort of multiple sclerosis patients followed for a mean time of 22.4 months. Methods One hundred and ten patients, who stopped therapy after at least 12 infusions, were followed with periodic clinical and magnetic resonance imaging evaluations. One hundred patients started either immunomodulant therapy (n=90) or fingolimod (n=10) while 10 remained without any drug. Results "Disease-activity free" patients were 25% at one year after discontinuation and annualized relapse rate significantly increased from 0.06 to 0.84 (p<0.0001). We found that the risk of reactivation peaked despite alternative treatments between the second and the eighth month after suspension, a so-called "high risk period". During this period the majority of patients showed a return to pre-natalizumab disease activity while 10% of patients presented a "rebound activity". A higher pre-natalizumab disease activity was correlated with an increased risk of reactivation (p=0.004). Conclusions Our data suggest that disease reactivation peaked during a "high risk period" between the second and the eighth month since stopping the drug. During this period no alternative treatments seemed to provide an adequate protection from disease reactivation. Though transient, this phase could be potentially dangerous, therefore we need to develop more effective strategies to deal with this challenge

RAAI Project: Life-prediction and prognostics for railway axles under corrosion-fatigue damage

Corrbosion damage induced by atmospheric agents has been shown to be able to trigger fatigue failures of railway axles. In this tphaepenIreDwMetEofiCorl,sDrtleyelpideasirstocmnuesnast nocefowMnseaoculhitadonamitceadtlerEdensgucilnatensenirneinrmga,boIldnesetltilotiunetogffiStchuipeengrtirloyrwaTtnéhcanolyifcsode,aoUmpnatigvcearlusimnddaeedaresucdoreerLmroisesbniotasn,-oAffavt.tihRgeouvceiosacrnroodPdiaetsids,da1ex,tle1ec0ts4iu9or-nf0a.0c1eLainsbdoa, paper we firstly discuss consolidated results in modelling the growth of damage under corrosion-fatigue and its detection. Portugal craTchkisgrioswththebsiamckuglartoiuondtofolrtduensecdribthinrogutghhefduelvl-eslcoaplmemenetaosfuraemneewntpsrofganxolseticotrorolsiwonit-hfiantitghueeRdAamAaIgEeU.-fundedproject.Indetails, This is the background for describing the development of a new prognostic tool within the RAAI EU-funded project. In details, cCeFEMA, Department of Mechanical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, the new tool relies on a new automated scanner able to efficiently analyse optical measurements of the corroded axle surface and a the new tool relies on a new automated scanner able to efficientlPyoartnuaglaylse optical measurements of the corroded axle surface and an axle corrosion-fatigue mode

Detection of a coherent excitonic state in the layered semiconductor BiI3_{3}

The measurement and manipulation of the coherent dynamics of excitonic states constitute a forefront research challenge in semiconductor optics and in quantum coherence-based protocols for optoelectronic technologies. Layered semiconductors have emerged as an ideal platform for the study of exciton dynamics with accessible and technologically relevant energy and time scales. Here, we investigate the sub-picosecond exciton dynamics in a van-der-Waals semiconductor upon quasi-resonant excitation, and achieve to single out an incipient coherent excitonic state. Combining broadband transient reflectance spectroscopy and simulations based on many-body perturbation theory, we reveal a transient enhancement of the excitonic line intensity that originates from the photoinduced coherent polarization that is phase-locked with the interacting electromagnetic field. This finding allows us to define the spectral signature of a coherent excitonic state and to experimentally track the dynamical crossover from coherent to incoherent exciton, unlocking the prospective optical control of an exciton population on the intrinsic quantum-coherence timescale