A summary

Coinciding with the Open Access Week 2010 we publish a study on the perceptions and usage trends amongst CSIC scientific community as regards Open Access in general and CSIC institutional repository in particular.Peer reviewe

Асинхронный электропривод экструдера полипропиленовой нити

В данной выпускной квалификационной работе рассматривается система экструдера линии TL – 60. Проведены исследования работы электропривода экструдера в динамических режимах работы. В основной части работы рассмотрены: объект автоматизации, техно-логический процесс, требования к электроприводу, функциональная схема системы экструдера, структурные схемы экструдера и регулируемого электропривода (РЭП). Расчетная часть включает в себя расчет параметров силовой цепи, характеристик системы векторного управления и тиристорного преобразователя, проверку области существования электромеханических характеристик привода, а также синтез структуры системы регулирования диаметра и их анализ.This qualification system is graduation extruder line TL-60. Studies of the work of the electric drive of the extruder in dynamic modes. In the main part of the work considered: Automation object, techno-logical process, drive requirements, functional scheme of the extruder, extruder structural schemes and controlled electric drive (CED). Estimated portion includes the calculation of parameters of the power circuit, vector control and system characteristics of the thyristor converter, check the field existence of electromechanical actuator characteristics, as well as the regulatory system structure synthesis and analysis of diameter

EMX2 gene expression predicts liver metastasis and survival in colorectal cancer

Background: The Empty Spiracles Homeobox (EMX-) 2 gene has been associated with regulation of growth and differentiation in neuronal development. While recent studies provide evidence that EMX2 regulates tumorigenesis of various solid tumors, its role in colorectal cancer remains unknown. We aimed to assess the prognostic significance of EMX2 expression in stage III colorectal adenocarcinoma. Methods: Expression levels of EMX2 in human colorectal cancer and adjacent mucosa were assessed by qRT-PCR technology, and results were correlated with clinical and survival data. siRNA-mediated knockdown and adenoviral delivery-mediated overexpression of EMX2 were performed in order to investigate its effects on the migration of colorectal cancer cells in vitro. Results: Compared to corresponding healthy mucosa, colorectal tumor samples had decreased EMX2 expression levels. Furthermore, EMX2 down-regulation in colorectal cancer tissue was associated with distant metastasis (M1) and impaired overall patient survival. In vitro knockdown of EMX2 resulted in increased tumor cell migration. Conversely, overexpression of EMX2 led to an inhibition of tumor cell migration. Conclusions: EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. EMX2 might thus represent a promising therapeutic target in colorectal cancer

A membrane-associated movement protein of Pelargonium flower break virus shows RNA-binding activity and contains a biologically relevant leucine zipper-like motif

[EN] Two small viral proteins (DGBp1 and DGBp2) have been proposed to act in a concerted manner to aid intra- and intercellular trafficking of carmoviruses though the distribution of functions and mode of action of each protein partner are not yet clear. Here we have confirmed the requirement of the DGBps of Pelargonium flower break virus (PFBV), p7 and p12, for pathogen movement Studies focused on p12 have shown that it associates to cellular membranes, which is in accordance to its hydrophobic profile and to that reported for several homologs. However, peculiarities that distinguish p12 from other DGBp52 have been found. Firstly, it contains a leucine zipper-like motif which is essential for virus infectivity in plants. Secondly, it has an unusually long and basic N-terminal region that confers RNA binding activity. The results suggest that PFBV p12 may differ mechanistically from related proteins and possible roles of PFBV DGBps are discussed. (C) 2011 Elsevier Inc. All rights reserved.We gratefully thank Dr. Vicente Pallas for critical reading of the manuscript and Dolores Arocas and Isabella Avellaneda for their technical assistance. This research was supported by grant BFU2006-11230 and BFU2009-11699 from the Ministerio Ciencia e Innovacion (MICINN, Spain) and by grants ACOM/2006/210 and ACOMP/2009/040 (Generalitat Valenciana, GV) to C. H. S. M.-T. was the recipient of a predoctoral fellowship from GV and of a predoctoral contract from MICINN.Martínez Turiño, S.; Hernandez Fort, C. (2011). A membrane-associated movement protein of Pelargonium flower break virus shows RNA-binding activity and contains a biologically relevant leucine zipper-like motif. Virology. 413(2):310-319. https://doi.org/10.1016/j.virol.2011.03.001S310319413

Diabetes in pregnancy among indigenous women in Australia, Canada, New Zealand, and the United States: a method for systematic review of studies with different designs

<p>Abstract</p> <p>Background</p> <p>Diabetes in pregnancy, which includes gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM), is associated with poor outcomes for both mother and infant during pregnancy, at birth and in the longer term. Recent international guidelines recommend changes to the current GDM screening criteria. While some controversy remains, there appears to be consensus that women at high risk of T2DM, including indigenous women, should be offered screening for GDM early in pregnancy, rather than waiting until 24-28 weeks as is current practice. A range of criteria should be considered before changing screening practice in a population sub-group, including: prevalence, current practice, acceptability and whether adequate treatment pathways and follow-up systems are available. There are also specific issues related to screening in pregnancy and indigenous populations. The evidence that these criteria are met for indigenous populations is yet to be reported. A range of study designs can be considered to generate relevant evidence for these issues, including epidemiological, observational, qualitative, and intervention studies, which are not usually included within a single systematic review. The aim of this paper is to describe the methods we used to systematically review studies of different designs and present the evidence in a pragmatic format for policy discussion.</p> <p>Methods/Design</p> <p>The inclusion criteria will be broad to ensure inclusion of the critical perspectives of indigenous women. Abstracts of the search results will be reviewed by two persons; the full texts of all potentially eligible papers will be reviewed by one person, and 10% will be checked by a second person for validation. Data extraction will be standardised, using existing tools to identify risks for bias in intervention, measurement, qualitative studies and reviews; and adapting criteria for appraising risk for bias in descriptive studies. External validity (generalisability) will also be appraised. The main findings will be synthesised according to the criteria for population-based screening and summarised in an adapted "GRADE" tool.</p> <p>Discussion</p> <p>This will be the first systematic review of all the published literature on diabetes in pregnancy among indigenous women. The method provides a pragmatic approach for synthesizing relevant evidence from a range of study designs to inform the current policy discussion.</p