Interpreting History Through Fiction

In ‘Interpreting History Through Fiction: Three Writers Discuss their Methods’, creative historical authors Thom Conroy, Joanna Grochowicz and Cristina Sanders engage in a conversation about the intersection of history and fiction. Arising from a session of the 2021 New Zealand Historical Association Conference entitled ‘Learning History Through Fiction’, the three-way dialogue interrogates the role of learning history from creative texts, navigates the fact/fiction balance in creative historical writing, explores concerns about the potential for harm in historical fiction, outlines the authors' own motives for adopting a creative approach to history, and examines what Hilary Mantel calls the ‘readerly contract’ in historical fiction. The conversation does not seek consensus nor finality in the answers offered to the questions the authors have put to one another. Rather, the authors allow contradictions and disagreements to remain intact, thus conveying their collective sense of open-endedness regarding creative approaches to history. This open-endedness is intentional, as the answers that arise from dialogue are intended to be as provisional and contingent as the evolving genre of historical fiction itself

Poster 458 Improvement of Premorbid Developmental Delay Following Treatment of Post Traumatic Hydrocephalus: A Case Report

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146829/1/pmrjs310.pd

Effects Of Land Cover And Riparian Buffers On Cold-Water Fish Assemblages In Upper South Fork New River Headwater Streams

Climate change combined with expanding urbanization and changes to land-use pose a serious threat to many cold-water species as temperature continues to increase. This study focused on the effects of biogeophysical components on cold-water fish assemblages within headwater sub-basins that vary widely in ability to support sensitive and endemic fish species. The relative abundance of cold-water fish were sampled by electrofishing 16 sites during the spring and summer then compared to riparian corridor density and height measurements, the percentage of sub-basin wide impervious surfaces, Bank Erosion Hazard Index (BEHI), Wolman Pebble Count, water temperature, and specific conductivity. The monthly maximum stream temperature did surpass static laboratory determined thermal suitability limits for brook and brown trout; and diurnal fluctuating laboratory determined limits for rainbow trout (20.0-22.5 °C) in 14 sites. However, the regression analyses of riparian heights (R2 = 0.05) and densities (R2 = 0.07) within each sampling reach did not significantly reduce stream temperature between sites. Temperature and conductivity were not found to significantly impact cold-water fish conditions, however; bank erosion, benthic substrate, riparian height, and impervious surfaces did. The relative abundances of cold-water fish were found to increase with the quality of the habitat

Improving Diagnostic Yield of Capsule Endoscopy in Coeliac Disease: Can Flexible Spectral Imaging Colour Enhancement Play a Role?

Introduction: Flexible spectral imaging colour enhancement (FICE) is a form of virtual chromoendoscopy that is incorporated in the capsule reading software and that can be used by reviewers to enhance the delineation of lesions in the small bowel. This has been shown to be useful in the detection of pigmented (ulcers, angioectasias) lesions. However, its application to coeliac disease (CD) images from small bowel capsule endoscopies (SBCEs) has rarely been studied. Methods: This was a European, multicentre study that included 5 expert capsule reviewers who were asked to evaluate a number of normal and abnormal de-identified images from SBCEs of patients with CD to determine whether the use of FICE and blue light can improve the detection of CD-related changes. Results: Sensitivity and specificity of conventional white light in the delineation of CD-related changes were 100%. The next best image modification was FICE 1 with a sensitivity of 80% and a specificity of 100%. There was no difference between conventional white light, FICE and blue light for the identification of CD-related changes. There was a low agreement (Fleiss kappa 0.107; p = 0.147) between expert reviewers in selecting the best image modification that detected CD-related changes. Conclusions: FICE and blue light were not found to be superior to conventional white light in the delineation of macroscopic changes related to CD on SBCEs

Development of a new CEDAR for kaon identification at the NA62 experiment at CERN

The NA62 experiment at CERN utilises a differential Cherenkov counter with achromatic ring focus (CEDAR) for tagging kaons within an unseparated monochromatic beam of charged hadrons. The CEDAR-H detector was developed to minimise the amount of material in the path of the beam by using hydrogen gas as the radiator medium. The detector was shown to satisfy the kaon tagging requirements in a test-beam before installation and commissioning at the experiment. The CEDAR-H performance was measured using NA62 data collected in 2023

A PERCEPÇÃO DE CRIANÇAS E CUIDADORES SOBRE A IMPORTÂNCIA DO BRINCAR ESPONTÂNEO PARA O DESENVOLVIMENTO INFANTIL

Objetivando compreender como crianças e cuidadores percebem o brincar espontâneo como fator importante para o desenvolvimento e quando os adultos acreditam que devem intervir neste processo, realizou-se um estudo qualitativo, de caráter exploratório e analítico com crianças e seus cuidadores, em um parque público e em um condomínio residencial, na cidade de Salvador-BA. Os dados coletados foram analisados qualitativamente, a partir da elaboração de categorias. Crianças e cuidadores compreenderam o brincar espontâneo como imprescindível para o desenvolvimento, e os adultos pontuaram intervir apenas quando as brincadeiras ficam perigosas ou agressivas. Identificou-se que poucos espaços e horários são disponibilizados para que as crianças brinquem espontaneamente, indicando uma necessidade de reflexão acerca da infância na contemporaneidade e suas novas configurações, já que é um conceito construído com bases sociais, históricas e culturais

Efecto de la inoculación Rhizophagus irregularis y de la fertilización fosfatada sobre la comunidad local de hongos formadores de micorrizas arbusculares

Arbuscular Mycorrhizal Fungi (AMF) are important microorganisms in agricultural soils because of their positive effect on plant acquisition of phosphorus (P); of one of the fundamental nutrients for plants. Available P in the soils of the Colombian Orinoquía are low, so phosphate fertilization is necessary in crops such as cassava. The objective of this work was to study the effect of phosphate fertilization and inoculation with Rhizophagus irregularis (the model AMF species), on the resident AMF communities. The AMF diversity was described by morphological and molecular techniques from the spores present in the rhizosphere of cassava plants maintained under traditional agronomic conditions. The richness and diversity of the AMF communities were affected by the experim’ental treatments AMF inoculation and P fertilization. Changes in abundance were detected in the genera Glomus and Acaulospora. This was significantly influenced by inoculation and phosphate fertilization. The findings of this study suggest that the use of phosphate fertilizer and the application of R. irregularis in agricultural processes affect the biodiversity of native AMF communities in soils of the Colombian Orinoquía. Further research is required to understand the relationship between AMF community composition and host plant response.Los Hongos Formadores de Micorrizas Arbusculares (HFMA) son microorganismos cruciales en los suelos agrícolas por el efecto positivo que tienen sobre la movilización de uno de los nutrientes fundamentales para las plantas como es el fósforo (P). Los contenidos disponibles de P en los suelos de la Orinoquía Colombiana son bajos, por lo que la fertilización con fosfato es indispensable en cultivos comerciales como la yuca. El objetivo de este trabajo fue estudiar el efecto de la fertilización fosfatada y de la inoculación con Rhizophagus irregularis (hongo modelo de los HFMA), sobre las comunidades residentes de este grupo de hongos. La diversidad de los HFMA fue descrita a partir de las esporas presentes en la rizósfera de plantas de yuca mantenidas bajo condiciones agronómicas tradicionales. La riqueza y diversidad de las comunidades de HFMA se afectaron por la interacción de los factores analizados. En términos de estructura de la comunidad de HFMA en la rizósfera de las plantas de yuca, se detectaron cambios en la abundancia de los géneros Glomus y Acaulospora; asociados respectivamente a la inoculación y a la fertilización fosfatada. Los hallazgos de este estudio sugieren que prácticas agrícolas como la aplicación de fertilizante fosfatado y la inoculación con R. irregularis, son procesos que pueden afectar el ensamblaje de la comunidad de estos hongos, así también la diversidad de las comunidades de HFMA nativas en suelos de la Orinoquía Colombiana. Se requieren investigaciones adicionales para entender la relación entre la composición de las comunidades de HFMA y la respuesta de la planta hospedera

RTP801 is involved in mutant huntingtin-induced cell death

RTP801 expression is induced by cellular stress and has a pro-apoptotic function in non-proliferating differentiated cells such as neurons. In several neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease, elevated levels of RTP801 have been observed, which suggests a role for RTP801 in neuronal death. Neuronal death is also a pathological hallmark in Huntington's disease (HD), an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. Currently, the exact mechanisms underlying mutant huntingtin (mhtt)-induced toxicity are still unclear. Here, we investigated whether RTP801 is involved in (mhtt)-induced cell death. Ectopic exon-1 mhtt elevated RTP801 mRNA and protein levels in nerve growth factor (NGF)-differentiated PC12 cells and in rat primary cortical neurons. In neuronal PC12 cells, mhtt also contributed to RTP801 protein elevation by reducing its proteasomal degradation rate, in addition to promoting RTP801 gene expression. Interestingly, silencing RTP801 expression with short hairpin RNAs (shRNAs) blocked mhtt-induced cell death in NGF-differentiated PC12 cells. However, RTP801 protein levels were not altered in the striatum of Hdh(Q7/Q111) and R6/1 mice, two HD models that display motor deficits but not neuronal death. Importantly, RTP801 protein levels were elevated in both neural telencephalic progenitors differentiated from HD patient-derived induced pluripotent stem cells and in the putamen and cerebellum of human HD postmortem brains. Taken together, our results suggest that RTP801 is a novel downstream effector of mhtt-induced toxicity and that it may be relevant to the human disease