TANMANA BHOJANGATAH CHITAH (PSCHYE AND FOOD)

Three million ago of the south Asian region, India had his own traditional system of medicine which known as Ayurveda. It explains the Rasa, Guna, Virya, and Vipaka of the Dravyas (Medicinal as well as food materials). It gives us some unique concepts to take the food (Asta ahar vidhi Visheshayatana) and its effect on body and mind. Ayurveda is science of wellness which primarily deals in food and behavioural aspects. Food and psychology has a good relation in Ayurveda. Emotions and psychological state has a very profound role in the proper digestion and metabolism of food. Ayurveda explains different psychological and emotional state of digestion, and establishment of ground rule that we should have food with psychological relaxation without any mental disturbance. As well as impact of occupational stress and weight conscious diet on digestion according to modern medical science is discussed. Ayurveda already have many references in many places of different Samhitas especially in Charak, Sushrut and Astang. They clearly told that we have to follow the rules of Asht-Aharvidhi Visheshayatana and they coded that, food has his own properties which helps to enhance the physical factors as well as mental factors of the body. Balanced food habits complete the both Prayojana of the Ayurveda which is “Swasthasya Swastha Rakshanam and Aturasya Vikara Prashamanm Cha”. Emotional status of the person at the food taking time also plays an important role of its digestion and metabolism in the body. A big question arise here that whether first psychology effect in digestion of food or food affecting the psychology of the person

UNDERSTANDING LASUNA AS RASAYANA - A CRITICAL REVIEW

The Medicinal use of Garlic is not new to the world today. Garlic plays important role in daily diet and also helps in maintaining good health thats why it is widely suggested by physicians. Lasuna is a most potent herb used in many conditions mainly used as a Rasayana in Vatavyadhi, Amavata etc. The essential chemical components of Garlic are helpful in daily routine for making physic fit and it acts over Hypercholesterolemia. The wide range of Garlic, health benefits come mainly from its main ingredient, Allicine. This widely researched component of garlic is highly therapeutic and is used in various drugs and pharmaceutics. Many Acharyas used this potent herb in many formulations like Lashoonadi vati, Lashoona ksheera paka etc. Rejuvenation therapy enhances the energy and the person's mental and physical capabilities. A number of studies suggest that rejuvenation therapy is effective in improving the skin complexion, texture, in modulating the voice and in increasing the sensing capacity of the sense organs. Rasayana is that which provides optimum quality of the bodily tissues due to which it provides both mental and physical health, prevents ageing and disease, thus enables to live for a longer period of youthfulness. In current article importance of Garlic is shown as Rasyana, as its indication and properties of Garlic as per Ayurveda suggest its work as Rasayana

Development of a Polymerase Chain Reaction Assay for Detection of Burkholderia mallei, a Potent Biological Warfare Agent

Burkholderia mallei is the etiological agent of glanders, primarily a disease of equines. B. mallei is closely related to B. pseudomallei, the causative agent of melioidosis. Therefore, detection of B. mallei and its differentiation from B. pseudomallei, has always been troublesome. In present investigation, a B. mallei specific DNA sequence was identified by performing BLASTn search using ~3000 ORFs of B. mallei NCTC 10229. A polymerase chain reaction (PCR) assay with internal amplification control (IAC) was developed for detection of B. mallei and its differentiation from B. pseudomallei. The PCR assay could amplify a specific 224-bp fragment from all the six B. mallei strains used in the study, whereas other closely related organisms were tested negative. The detection limit of the assay was found to be 10 pg of purified DNA of B. mallei. Incorporation of IAC in the assay makes the results reliable as false negative results which may arise due to presence of PCR inhibitors, can be avoided. For validation, the assay was tested on tap water, Bengal gram and grass artificially spiked with B. mallei. The developed assay can be used as a simple and rapid tool for detection of B. mallei

Histopathological alterations in gills of freshwater prawn, Macrobrachium dayanum (Crustacea - Decapoda) after acute and sub-acute exposure of lead nitrate

Lead is a nonessential “grey listed” heavy metal, used in fuels, ceramics, paints and glass wares in industries and vehicles. After taking entry in aquatic ecosystem it becomes toxic and cause serious problem to plants and animals. Haematological, neurological, nephrological and histopathological effects of lead are well known. Fresh water prawn, Macrobrachium dayanum, a potential animal for freshwater aquaculture, subjected to acute and sub-acute concentration of lead nitrate (116.46 mg/l; 96h LC50 and 29.12 mg/l; 25% of 96h LC50) showed severe histopathological alterations in gills after 24, 48, 72 and 96h and 10, 20 and 30 day exposure. Chief alterations during acute exposure were thickening of gill plates, reduction in inter lameller spaces, cuticular irruption, inflammation and necrosis where as clumping of gill plates, hyperplasia, hypertrophied haemocytes with nuclear pycnosis and leakage of haemocytes in inter-lameller spaces as well as deposition of broken tissue debris near gill base were observed during sub-acute exposure. The severity of histopathological alterations was found duration dependant. Present study reveals that histological bio- markers provides complete information regarding heavy metal toxicity particularly lead to these economically important fresh water prawns, which can themselves serve as bio-indicator of worsening status of surface aquatic bodies.&nbsp

A Molecular Docking and Pharmacokinetic Prediction of Thiazolidine-2, 4-dione Derivatives: Toward Novel Therapeutic Targets for Type-2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is a leading endocrine disorder that affects millions of people worldwide. It is characterized by hyperglycemia and high insulin resistance. The commonly prescribed oral therapeutic for insulin resistance in T2DM is Thiazolidine-2, 4-diones (TZDs). TZDs are a class of oral hypoglycemic agents that act on Peroxisome proliferator activating receptor-γ (PPAR-γ) receptors and are mainly expressed in the adipose tissues. In this work, we derive novel classes of TZDs and predict the nature of structural affinity using docking studies against the PPAR-γ.

24 Hours chronomics of ambulatory blood pressure and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift health care workers

Background: Night shift workers have altered circadian pattern of blood pressure/heart rate and hormones like melatonin and cortisol. Due to this variation, night shift worker suffers from various cardiovascular disorders and hormonal disturbances.Methods: The Present study was aimed to investigate the effects of rotating night shift on 24 hours chronomics of BP/HR and its relation with 6-sulfatoxy melatonin levels. 62 healthy nursing professionals, aged 20-40 year, performing day and night shift duties were recruited. Each month scheduled to continuous 9 days night shift (12 hours in regular 9 nights, from 20:00 to 08:00); after 9 days night shift they perform remaining duties in day shift and 4 days off in each month.Results: Ambulatory BP and HR were recorded at every 30 min intervals in day time and each hour in night time synchronically with circadian pattern of 6 sulfatoxy melatonin during shift duties. Highly Significant difference was found in double amplitude (2DA) of blood pressure between night and day shift (p<0.001). In night shift, hyperbaric index (HBI) of mean systolic blood pressure was found to be increased at 00-03 am (midnight) while during day shift, peak was found at 06-09 am. Peak melatonin was to be found in early morning as compared to mid night in both the shift.Conclusions: The present study concluded that the desynchronization was appeared during night shift and entrainment of circadian rhythm in the day shift.

Daksha: On Alert for High Energy Transients

We present Daksha, a proposed high energy transients mission for the study of electromagnetic counterparts of gravitational wave sources, and gamma ray bursts. Daksha will comprise of two satellites in low earth equatorial orbits, on opposite sides of earth. Each satellite will carry three types of detectors to cover the entire sky in an energy range from 1 keV to >1 MeV. Any transients detected on-board will be announced publicly within minutes of discovery. All photon data will be downloaded in ground station passes to obtain source positions, spectra, and light curves. In addition, Daksha will address a wide range of science cases including monitoring X-ray pulsars, studies of magnetars, solar flares, searches for fast radio burst counterparts, routine monitoring of bright persistent high energy sources, terrestrial gamma-ray flashes, and probing primordial black hole abundances through lensing. In this paper, we discuss the technical capabilities of Daksha, while the detailed science case is discussed in a separate paper.Comment: 9 pages, 3 figures, 1 table. Additional information about the mission is available at https://www.dakshasat.in

Science with the Daksha High Energy Transients Mission

We present the science case for the proposed Daksha high energy transients mission. Daksha will comprise of two satellites covering the entire sky from 1~keV to $>1$~MeV. The primary objectives of the mission are to discover and characterize electromagnetic counterparts to gravitational wave source; and to study Gamma Ray Bursts (GRBs). Daksha is a versatile all-sky monitor that can address a wide variety of science cases. With its broadband spectral response, high sensitivity, and continuous all-sky coverage, it will discover fainter and rarer sources than any other existing or proposed mission. Daksha can make key strides in GRB research with polarization studies, prompt soft spectroscopy, and fine time-resolved spectral studies. Daksha will provide continuous monitoring of X-ray pulsars. It will detect magnetar outbursts and high energy counterparts to Fast Radio Bursts. Using Earth occultation to measure source fluxes, the two satellites together will obtain daily flux measurements of bright hard X-ray sources including active galactic nuclei, X-ray binaries, and slow transients like Novae. Correlation studies between the two satellites can be used to probe primordial black holes through lensing. Daksha will have a set of detectors continuously pointing towards the Sun, providing excellent hard X-ray monitoring data. Closer to home, the high sensitivity and time resolution of Daksha can be leveraged for the characterization of Terrestrial Gamma-ray Flashes.Comment: 19 pages, 7 figures. Submitted to ApJ. More details about the mission at https://www.dakshasat.in

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum