1.5V fully programmable CMOS Membership Function Generator Circuit with proportional DC-voltage control

A Membership Function Generator Circuit (MFGC) with bias supply of 1.5 Volts and independent DC-voltage programmable functionalities is presented. The realization is based on a programmable differential current mirror and three compact voltage-to-current converters, allowing continuous and quasi-linear adjustment of the center position, height, width and slopes of the triangular/trapezoidal output waveforms. HSPICE simulation results of the proposed circuit using the parameters of a double-poly, three metal layers, 0.5 μm CMOS technology validate the functionality of the proposed architecture, which exhibits a maximum deviation of the linearity in the programmability of 7 %

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion. Insulin-like growth factor-1 (IGF-1) and signal transducer and activator of transcription 3 (STAT3) stimulate colorectal cancer development and progression via cell autonomous and microenvironmental effects. Using a unique inhibitor, NT157, which targets both IGF-1 receptor (IGF-1R) and STAT3, we show that these pathways regulate many TME functions associated with sporadic colonic tumorigenesis in CPC-APC mice, in which cancer development is driven by loss of the Apc tumor suppressor gene. NT157 causes a substantial reduction in tumor burden by affecting cancer cells, cancer-associated fibroblasts (CAF) and myeloid cells. Decreased cancer cell proliferation and increased apoptosis were accompanied by inhibition of CAF activation and decreased inflammation. Furthermore, NT157 inhibited expression of pro-tumorigenic cytokines, chemokines and growth factors, including IL-6, IL-11 and IL-23 as well as CCL2, CCL5, CXCL7, CXCL5, ICAM1 and TGFβ; decreased cancer cell migratory activity and reduced their proliferation in the liver. NT157 represents a new class of anti-cancer drugs that affect both the malignant cell and its supportive microenvironment

Ultra Low-Power Analog Median Filters

The design and implementation of three analog median filter topologies, whose transistors operate in the deep weak-inversion region, is described. The first topology is a differential pairs array, in which drain currents are driven into two nodes in a differential fashion, while the second topology is based on a wide range OTA, which is used to maximize the dynamic range. Finally, the third topology uses three range-extended OTAs. The proposed weak-inversion filters were designed and fabricated in ON Semiconductor 0.5 micrometer technology through MOSIS. Experimental results of three-input fabricated prototypes for all three topologies are show, where power consumptions of 90nW in the first case, and 270nW in the other two cases can be noticed. A dual power supply +/-1.5 Volts were used

Sentinel-1 interferometric coherence as a vegetation index for agriculture

In this study, the use of Sentinel-1 interferometric coherence data as a tool for crop monitoring has been explored. For this purpose, time series of images acquired by Sentinel-1 and 2 spanning 2017 have been analysed. The study site is an agricultural area in Sevilla, Spain, where 16 different crop species were cultivated during that year. The time series of 6-day repeat-pass coherence measured at each polarimetric channel (VV and VH), as well as their difference, have been compared to the NDVI and to the backscattering ratio (VH/VV) and other indices based on backscatter. The contribution of different decorrelation sources and the effect of the bias from the space-averaged sample coherence magnitude estimation have been evaluated. Likewise, the usage of 12 days as temporal baseline was tested. The study has been carried for three different orbits, characterised by different incidence angles and acquisition times. All results support using coherence as a measure for monitoring the crop growing season, as it shows good correlations with the NDVI (R2>0.7), and its temporal evolution fits well the main phenological stages of the crops. Although each crop shows its own evolution, the performance of coherence as a vegetation index is high for most of them. VV is generally more correlated with the NDVI than VH. For crop types characterised by low plant density, this difference decreases, with VH even showing higher correlation values in some cases. For a few crop types, such as rice, the backscattering ratio outperforms the coherence in following the growth stages of the plants. Since both coherence and backscattering are directly computed from the radar images, they could be used as complementary sources of information for this purpose. Notably, the measured coherence performs well without the need of compensating the thermal noise decorrelation or the bias due to the finite equivalent number of looks.This work was supported in part by the European Space Agency under Project SEOM-S14SCI-Land (SInCohMap), and in part by the Spanish Ministry of Science and Innovation (State Agency of Research, AEI) and the European Funds for Regional Development under Project PID2020-117303GB-C22

An X-ray study of the SNR G344.7-0.1 and the central object CXOU J170357.8-414302

Aims. We report results of an X-ray study of the supernova remnant (SNR) G344.7-0.1 and the point-like X-ray source located at the geometrical center of the SNR radio structure. Methods. The morphology and spectral properties of the remnant and the central X-ray point-like source were studied using data from the XMM-Newton and Chandra satellites. Archival radio data and infrared Spitzer observations at 8 and 24 $\mu$m were used to compare and study its multi-band properties at different wavelengths. Results. The XMM-Newton and Chandra observations reveal that the overall X-ray emission of G344.7-0.1 is extended and correlates very well with regions of bright radio and infrared emission. The X-ray spectrum is dominated by prominent atomic emission lines. These characteristics suggest that the X-ray emission originated in a thin thermal plasma, whose radiation is represented well by a plane-parallel shock plasma model (PSHOCK). Our study favors the scenario in which G344.7-0.1 is a 6 x 10^3 year old SNR expanding in a medium with a high density gradient and is most likely encountering a molecular cloud on the western side. In addition, we report the discovery of a soft point-like X-ray source located at the geometrical center of the radio SNR structure. The object presents some characteristics of the so-called compact central objects (CCO). However, its neutral hydrogen absorption column (N_{H}) is inconsistent with that of the SNR. Coincident with the position of the source, we found infrared and optical objects with typical early-K star characteristics. The X-ray source may be a foreground star or the CCO associated with the SNR. If this latter possibility were confirmed, the point-like source would be the farthest CCO detected so far and the eighth member of the new population of isolated and weakly magnetized neutron stars.Comment: 9 pages, 8 figures, accepted for publication in Astronomy and Astrophysics. Higher resolution figures can be seen on A&

Is emamectin benzoate effective against the different stages of Spodoptera exigua (Hübner) (Lepidoptera, Noctuidae)?

peer-reviewedThis work was partially supported by the Spanish Ministry of Science and Innovation (project AGL 2007-66130-C03-02 to P. Medina). F. Amor and P. Bengochea acknowledge the ministry of Education and Culture and the Technical University of Madrid (UPM) for the doctoral fellowships. Special thanks to Syngenta Agro S.A. for their support.The beet armyworm, Spodoptera exigua (Hübner) (Lepidoptera, Noctuidae), is a major polyphagous pest in greenhouses and open fields worldwide and also a main problem in sweet pepper greenhouses. The effectiveness of the pesticide emamectin benzoate was tested in the laboratory on different stages of S. exigua using different concentrations and uptake routes. After dipping young (48-h-old) S. exigua eggs in emamectin benzoate at 0.5, 1 and 1.5 mg/L a.i. the chemical did not exhibit any ovicidal activity. There was, however, progressive neonate mortality at all concentrations, culminating at 72 hours after hatching, when 100% of the larvae from the treated young eggs died. Second and fourth instar S. exigua larvae did not exhibit significant mortality when exposed to the inert surfaces which were treated. In contrast, ingesting a diet contaminated with 0.5 mg/L a.i. of emamectin benzoate caused 100% mortality in L2 and L4 larvae 24 and 72 hours after ingestion, respectively. The LC50 value of the compound against L4 larvae that fed on sprayed sweet pepper leaves for 24 hours was 0.81 mg/L a.i.. When adults were fed on a solution of 0.5 mg/L a.i., there was a reduction in the female and male lifespan of 29.3% and 55.3%, respectively. Fecundity was reduced by more than 99%. These data suggest that emamectin benzoate is not only a useful insecticide when ingested by beet armyworm larvae but it also has ovolarvicidal and adult activity.Spanish Ministry of Science and Innovatio