The spherical collapse model with shell crossing

In this work, we study the formation and evolution of dark matter halos by means of the spherical infall model with shell-crossing. We present a framework to tackle this effect properly based on the numerical follow-up, with time, of that individual shell of matter that contains always the same fraction of mass with respect to the total mass. In this first step, we do not include angular momentum, velocity dispersion or triaxiality. Within this framework - named as the Spherical Shell Tracker (SST) - we investigate the dependence of the evolution of the halo with virial mass, with the adopted mass fraction of the shell, and for different cosmologies. We find that our results are very sensitive to a variation of the halo virial mass or the mass fraction of the shell that we consider. However, we obtain a negligible dependence on cosmology. Furthermore, we show that the effect of shell-crossing plays a crucial role in the way that the halo reaches the stabilization in radius and the virial equilibrium. We find that the values currently adopted in the literature for the actual density contrast at the moment of virialization, delta_vir, may not be accurate enough. In this context, we stress the problems related to the definition of a virial mass and a virial radius for the halo. The question of whether the results found here may be obtained by tracking the shells with an analytic approximation remains to be explored.Comment: 15 pages, 4 figures, 9 tables, replaced to match the published MNRAS versio

Impact of internal bremsstrahlung on the detection of gamma-rays from neutralinos

We present a detailed study of the effect of internal bremsstrahlung photons in the context of the minimal supersymmetric standard models and their impact on gamma-ray dark matter annihilation searches. We find that although this effect has to be included for the correct evaluation of fluxes of high energy photons from neutralino annihilation, its contribution is relevant only in models and at energies where the lines contribution is dominant over the secondary photons. Therefore, we find that the most optimistic supersymmetric scenarios for dark matter detection do not change significantly when including the internal bremsstrahlung. As an example, we review the gamma-ray dark matter detection prospects of the Draco dwarf spheroidal galaxy for the MAGIC stereoscopic system and the CTA project. Though the flux of high energy photons is enhanced by an order of magnitude in some regions of the parameter space, the expected fluxes are still much below the sensitivity of the instruments.Comment: 5 pages, twocolumn format, 3 figures:3 references added, accepted as Brief Report in PR

The Origin of the Extragalactic Gamma-Ray Background and Implications for Dark-Matter Annihilation

The origin of the extragalactic $\gamma$-ray background (EGB) has been debated for some time. { The EGB comprises the $\gamma$-ray emission from resolved and unresolved extragalactic sources, such as blazars, star-forming galaxies and radio galaxies, as well as radiation from truly diffuse processes.} This letter focuses on the blazar source class, the most numerous detected population, and presents an updated luminosity function and spectral energy distribution model consistent with the blazar observations performed by the {\it Fermi} Large Area Telescope (LAT). We show that blazars account for 50$^{+12}_{-11}$\,\% of the EGB photons ($>$0.1\,GeV), and that {\it Fermi}-LAT has already resolved $\sim$70\,\% of this contribution. Blazars, and in particular low-luminosity hard-spectrum nearby sources like BL Lacs, are responsible for most of the EGB emission above 100\,GeV. We find that the extragalactic background light, which attenuates blazars' high-energy emission, is responsible for the high-energy cut-off observed in the EGB spectrum. Finally, we show that blazars, star-forming galaxies and radio galaxies can naturally account for the amplitude and spectral shape of the background in the 0.1--820\,GeV range, leaving only modest room for other contributions. This allows us to set competitive constraints on the dark-matter annihilation cross section.Comment: On behalf of the Fermi-LAT collaboration. Contact authors: M. Ajello, D. Gasparrini, M. Sanchez-Conde, G. Zaharijas, M. Gustafsson. Accepted for publication on ApJ

Gut microbiota composition and arterial stiffness measured by pulse wave velocity: Case-control study protocol (MIVAS study)

[Introduction]: Intestinal microbiota is arising as a new element in the physiopathology of cardiovascular diseases. A healthy microbiota includes a balanced representation of bacteria with health promotion functions (symbiotes). The aim of this study is to analyse the relationship between intestinal microbiota composition and arterial stiffness. [Methods and analysis]: An observational case—control study will be developed. Cases will be defined by the presence of at least one of the following: carotid-femoral pulse wave velocity (cf-PWV), Cardio-Ankle Vascular Index (CAVI), brachial ankle pulse wave velocity (ba or ba-PWV) above the 90th percentile, for age and sex, of the reference population. Controls will be selected from the same population as cases. The study will be developed in Primary Healthcare Centres. We will select 500 subjects (250 cases and 250 controls), between 45 and 74 years of age. Cases will be selected from a database that combines data from EVA study (Spain) and Guimarães/Vizela study (Portugal). Measurements: cf-PWV will be measured using the SphygmoCor system, CAVI, ba-PWV and Ankle-Brachial Index will be determined using VaSera device. Gut microbiome composition in faecal samples will be determined by 16S ribosomal RNA sequencing. Lifestyle will be assessed by food frequency questionnaire, adherence to the Mediterranean diet and IPAQ (International Physical Activity Questionnaire). Body composition will be evaluated by bioimpedance. [Ethics and dissemination]: The study has been approved by ‘Committee of ethics of research with medicines of the health area of Salamanca’ on 14 December 2018 (cod. 2018-11-136) and the ’Ethics committee for health of Guimaraes’ (Portugal) on 15 October 2019 (ref: 67/2019).All study participants will sign an informed consent form agreeing to participate in the study, in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow a better description of gut microbiota in patients with arterial stiffness.The project has been funded by the Carlos III Health Institute (Spain) through the Network of preventive activities and health promotion (redIAPP, RD16/0007), co-financed with European funds for regional development (FEDER) and the Autonomous Government of Castilla y León (GRS 1820/B/18; GRS 1944/B/19 and intensification programme)

Observation of Pulsed Gamma-rays Above 25 GeV from the Crab Pulsar with MAGIC

One fundamental question about pulsars concerns the mechanism of their pulsed electromagnetic emission. Measuring the high-end region of a pulsar's spectrum would shed light on this question. By developing a new electronic trigger, we lowered the threshold of the Major Atmospheric gamma-ray Imaging Cherenkov (MAGIC) telescope to 25 GeV. In this configuration, we detected pulsed gamma-rays from the Crab pulsar that were greater than 25 GeV, revealing a relatively high cutoff energy in the phase-averaged spectrum. This indicates that the emission occurs far out in the magnetosphere, hence excluding the polar-cap scenario as a possible explanation of our measurement. The high cutoff energy also challenges the slot-gap scenario.Comment: Slight modification of the analysis: Fitting a more general function to the combined data set of COMPTEL, EGRET and MAGIC. Final result and conclusion is unchange

First bounds on the high-energy emission from isolated Wolf-Rayet binary systems

High-energy gamma-ray emission is theoretically expected to arise in tight binary star systems (with high mass loss and high velocity winds), although the evidence of this relationship has proven to be elusive so far. Here we present the first bounds on this putative emission from isolated Wolf-Rayet (WR) star binaries, WR 147 and WR 146, obtained from observations with the MAGIC telescope.Comment: (Authors are the MAGIC Collaboration.) Manuscript in press at The Astrophysical Journal Letter

Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells

In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically distinct classes of parvalbumin neurons that target the perisomatic region of pyramidal neurons, chandelier cells (ChCs) and basket cells (BCs), are generally thought to have the same "fast-spiking" phenotype, which is characterized by a short action potential and high frequency firing without adaptation. However, findings from studies in different species suggest that certain electrophysiological membrane properties might differ between these two cell classes. In this study, we assessed the physiological heterogeneity of fast-spiking interneurons as a function of two factors: species (macaque monkey vs. rat) and morphology (chandelier vs. basket). We showed previously that electrophysiological membrane properties of BCs differ between these two species. Here, for the first time, we report differences in ChCs membrane properties between monkey and rat. We also found that a number of membrane properties differentiate ChCs from BCs. Some of these differences were species-independent (e.g., fast and medium afterhyperpolarization, firing frequency, and depolarizing sag), whereas the differences in the first spike latency between ChCs and BCs were species-specific. Our findings indicate that different combinations of electrophysiological membrane properties distinguish ChCs from BCs in rodents and primates. Such electrophysiological differences between ChCs and BCs likely contribute to their distinctive roles in cortical circuitry in each species. © 2013 Povysheva et al