1,164 research outputs found
Galaxy rotation curves: the effect of j x B force
Using the Galaxy as an example, we study the effect of j x B force on the
rotational curves of gas and plasma in galaxies. Acceptable model for the
galactic magnetic field and plausible physical parameters are used to fit the
flat rotational curve for gas and plasma based on the observed baryonic
(visible) matter distribution and j x B force term in the static MHD equation
of motion. We also study the effects of varied strength of the magnetic field,
its pitch angle and length scale on the rotational curves. We show that j x B
force does not play an important role on the plasma dynamics in the
intermediate range of distances 6-12 kpc from the centre, whilst the effect is
sizable for larger r (r > 15 kpc), where it is the most crucial.Comment: Accepted for publication in Astrophysics & Space Science (final
printed version, typos in proofs corrected
Roadmap to the multidisciplinary design analysis and optimisation of wind energy systems
A research agenda is described to further encourage the application of Multidisciplinary Design Analysis and Optimisation (MDAO) methodologies to wind energy systems. As a group of researchers closely collaborating within the International Energy Agency (IEA) Wind Task 37 for Wind Energy Systems Engineering: Integrated Research, Design and Development, we have identified challenges that will be encountered by users building an MDAO framework. This roadmap comprises 17 research questions and activities recognised to belong to three research directions: model fidelity, system scope and workflow architecture. It is foreseen that sensible answers to all these questions will enable to more easily apply MDAO in the wind energy domain. Beyond the agenda, this work also promotes the use of systems engineering to design, analyse and optimise wind turbines and wind farms, to complement existing compartmentalised research and design paradigms
Searching for a Cosmological Preferred Axis: Union2 Data Analysis and Comparison with Other Probes
We review, compare and extend recent studies searching for evidence for a
preferred cosmological axis. We start from the Union2 SnIa dataset and use the
hemisphere comparison method to search for a preferred axis in the data. We
find that the hemisphere of maximum accelerating expansion rate is in the
direction (\omm=0.19) while the hemisphere of
minimum acceleration is in the opposite direction
(\omm=0.30). The level of anisotropy is described by the normalized
difference of the best fit values of \omm between the two hemispheres in the
context of \lcdm fits. We find a maximum anisotropy level in the Union2 data of
\frac{\Delta \ommax}{\bomm}=0.43\pm 0.06. Such a level does not necessarily
correspond to statistically significant anisotropy because it is reproduced by
about of simulated isotropic data mimicking the best fit Union2 dataset.
However, when combined with the axes directions of other cosmological
observations (bulk velocity flow axis, three axes of CMB low multipole moments
and quasar optical polarization alignment axis), the statistical evidence for a
cosmological anisotropy increases dramatically. We estimate the probability
that the above independent six axes directions would be so close in the sky to
be less than . Thus either the relative coincidence of these six axes is a
very large statistical fluctuation or there is an underlying physical or
systematic reason that leads to their correlation.Comment: 10 pages, 7 figures. Accepted in JCAP (to appear). Extended analysis
with redshift tomography of SnIa, included errorbars and increased number of
axes. The Mathematica 7 files with the data used for the production of the
figures along with a Powerpoint file with additional figures may be
downloaded from http://leandros.physics.uoi.gr/anisotrop
Dressing with Control: using integrability to generate desired solutions to Einstein's equations
21 pages, no figures21 pages, no figures21 pages, no figures21 pages, no figuresMotivated by integrability of the sine-Gordon equation, we investigate a technique for constructing desired solutions to Einstein's equations by combining a dressing technique with a control-theory approach. After reviewing classical integrability, we recall two well-known Killing field reductions of Einstein's equations, unify them using a harmonic map formulation, and state two results on the integrability of the equations and solvability of the dressing system. The resulting algorithm is then combined with an asymptotic analysis to produce constraints on the degrees of freedom arising in the solution-generation mechanism. The approach is carried out explicitly for the Einstein vacuum equations. Applications of the technique to other geometric field theories are also discussed
RAS/MAPK activation is associated with reduced Tumor-infiltrating lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors
PURPOSE:
Tumor-infiltrating lymphocytes (TIL) in the residual disease (RD) of triple-negative breast cancers (TNBC) after neoadjuvant chemotherapy (NAC) are associated with improved survival, but insight into tumor cell-autonomous molecular pathways affecting these features are lacking.
EXPERIMENTAL DESIGN:
We analyzed TILs in the RD of clinically and molecularly characterized TNBCs after NAC and explored therapeutic strategies targeting combinations of MEK inhibitors with PD-1/PD-L1-targeted immunotherapy in mouse models of breast cancer.
RESULTS:
Presence of TILs in the RD was significantly associated with improved prognosis. Genetic or transcriptomic alterations in Ras-MAPK signaling were significantly correlated with lower TILs. MEK inhibition upregulated cell surface MHC expression and PD-L1 in TNBC cells both in vivo and in vitro. Moreover, combined MEK and PD-L1/PD-1 inhibition enhanced antitumor immune responses in mouse models of breast cancer.
CONCLUSIONS:
These data suggest the possibility that Ras-MAPK pathway activation promotes immune-evasion in TNBC, and support clinical trials combining MEK- and PD-L1-targeted therapies. Furthermore, Ras/MAPK activation and MHC expression may be predictive biomarkers of response to immune checkpoint inhibitors
Acculturation Influences Postpartum Eating, Activity, and Weight Retention in Low-Income Hispanic Women
Background: Low-income Hispanic women experience elevated rates of high postpartum weight retention (PPWR), which is an independent risk factor for lifetime obesity. Sociocultural factors might play an important role among Hispanic women; however, very few studies have examined this association. Objective: The purpose of our study was to examine the associations between acculturation and maternal diet, physical activity, and PPWR. Design: This is a cross-sectional study of baseline data from 282 Hispanic women participating in the FitMoms/Mamás Activas study, a randomized controlled trial examining the impact of primarily an internet-based weight control program, in reducing PPWR among low-income women. We performed multivariable linear regression to examine the association of acculturation with diet quality, physical activity, and PPWR at study entry. Results: A total of 213 (76%) women had acculturation scores reflecting Mexican orientation or bicultural orientation, whereas 69 (24%) had scores that represented assimilation to Anglo culture. Women who were more acculturated had lower intakes of fruits and vegetables, lower HEI scores, and lower physical activity levels than women who were less acculturated (p < 0.05). We found an association between acculturation and PPWR in that for every 1-unit increase in acculturation score, PPWR increased, on average, by 0.80 kg. Conclusion: Higher acculturation was associated with poorer diet and physical activity behaviors and greater PPWR
Demonstration of the temporal matter-wave Talbot effect for trapped matter waves
We demonstrate the temporal Talbot effect for trapped matter waves using
ultracold atoms in an optical lattice. We investigate the phase evolution of an
array of essentially non-interacting matter waves and observe matter-wave
collapse and revival in the form of a Talbot interference pattern. By using
long expansion times, we image momentum space with sub-recoil resolution,
allowing us to observe fractional Talbot fringes up to 10th order.Comment: 17 pages, 7 figure
Longitudinal double-spin asymmetry and cross section for inclusive neutral pion production at midrapidity in polarized proton collisions at sqrt(s) = 200 GeV
We report a measurement of the longitudinal double-spin asymmetry A_LL and
the differential cross section for inclusive Pi0 production at midrapidity in
polarized proton collisions at sqrt(s) = 200 GeV. The cross section was
measured over a transverse momentum range of 1 < p_T < 17 GeV/c and found to be
in good agreement with a next-to-leading order perturbative QCD calculation.
The longitudinal double-spin asymmetry was measured in the range of 3.7 < p_T <
11 GeV/c and excludes a maximal positive gluon polarization in the proton. The
mean transverse momentum fraction of Pi0's in their parent jets was found to be
around 0.7 for electromagnetically triggered events.Comment: 6 pages, 3 figures, submitted to Phys. Rev. D (RC
Azimuthal anisotropy and correlations in p+p, d+Au and Au+Au collisions at 200 GeV
We present the first measurement of directed flow () at RHIC. is
found to be consistent with zero at pseudorapidities from -1.2 to 1.2,
then rises to the level of a couple of percent over the range . The latter observation is similar to data from NA49 if the SPS rapidities
are shifted by the difference in beam rapidity between RHIC and SPS.
Back-to-back jets emitted out-of-plane are found to be suppressed more if
compared to those emitted in-plane, which is consistent with {\it jet
quenching}. Using the scalar product method, we systematically compared
azimuthal correlations from p+p, d+Au and Au+Au collisions. Flow and non-flow
from these three different collision systems are discussed.Comment: Quark Matter 2004 proceeding, 4 pages, 3 figure
Azimuthal anisotropy: the higher harmonics
We report the first observations of the fourth harmonic (v_4) in the
azimuthal distribution of particles at RHIC. The measurement was done taking
advantage of the large elliptic flow generated at RHIC. The integrated v_4 is
about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8)
harmonics upper limits on the magnitudes are reported.Comment: 4 pages, 6 figures, contribution to the Quark Matter 2004 proceeding
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