Argentina's labor markets in an era of adjustment

The current economic crisis in Argentina is only partly the result of inappropriate domestic policies to cope with the recent external shocks. Years of inappropriate policies have damaged Argentina's economy. Even if no external shocks had occurred, the country would still have to change the structure of production. Argentina has had trouble sustaining a program of structural adjustment. Its experiences provide policymakers with some lessons in designing a sustainable program to achieve price stability and change the incentive system : a) macroeconomic and trade policies must be consistent; b) labor relations and labor market institutions must be changed including the decentralization of wage bargaining and the elimination of traditional wage policies and general government intervention; c) rigidities and restrictions on labor mobility must be eliminated, leading to less pervasive government intervention in the form of restrictive regulations and spending patterns; and d) public spending must be profoundly changed to reduce social costs during the transition period.Economic Stabilization,Banks&Banking Reform,Municipal Financial Management,Environmental Economics&Policies,Economic Theory&Research

Collective Bargaining under Complete Information

In this paper, we build and structurally estimate a complete information bargaining model of collective negotiation for Spain. For large firms, the assumption of complete information seems a sensible one, and it matches the collective bargaining environment better than the one provided by private information models. The specification of the model with players having different discount factors allows us to measure their relative bargaining power, a recurrent question in the theory of bargaining. We find that both entrepreneurs and workers have high discount factors, and no evidence that entrepreneurs have bigger bargaining power as usually assumed.Delays, sequential bargaining, structural estimation

Fuzzy Control Strategy for an Anaerobic Wastewater Treatment Process

In this paper, a fuzzy control strategy (FCS) for an anaerobic wastewater treatment process is proposed in order to reject large disturbances on input substrate allowing a high methane production. This strategy is composed of: i) a state observer, which is based on a principal components analysis (PCA) and Takagi-Sugeno (TS) algorithm; it is designed to estimate variables hard to measure: biomass and substrate, ii) proportional-integral (PI) controllers based on a combination of the L/A(logarithm/antilogarithm) and fuzzy approaches; these controllers have variable gains and are designed to regulate bicarbonate in the reactor by two control actions: a base supplying (binc) and dilution rate (D) changes, iii) a TS supervisor which detects the process state, selects and applies the most adequate control action, allowing a smooth switching between open loop and closed loop. Applicability of the proposed structure in a completely stirred tank reactor (CSTR) is illustrated via simulations. The obtained results show that the process works in open loop in presence of small disturbances. For large disturbances, the supervisor allows the control actions to be applied avoiding washout; after that, the process returns to open loop operation. In general, the FCS improves the performances of the anaerobic process and is feasible for application in real processes, since the control scheme shows a good compromise between efficiency and complexity

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads

Allosteric compounds that stimulate Hsp90 adenosine triphosphatase (ATPase) activity were rationally designed, showing anticancer potencies in the low micromolar to nanomolar range. In parallel, the mode of action of these compounds was clarified and a quantitative model that links the dynamic ligand-protein cross-talk to observed cellular and in vitro activities was developed. The results support the potential of using dynamics-based approaches to develop original mechanism-based cancer therapeutics

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.

Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine. Increasingly, laboratories are creating their own banks of iPSCs derived from diverse donors. However, there are not yet standardized guidelines for qualifying these cell lines, i.e., distinguishing between bona fide human iPSCs, somatic cells, and imperfectly reprogrammed cells. Here, we report the establishment of a panel of 30 iPSCs from CD34+ peripheral blood mononuclear cells, of which 10 were further differentiated in vitro into all three germ layers. We characterized these different cell types with commonly used pluripotent and lineage specific markers, and showed that NES, TUBB3, and OTX2 cannot be reliably used as ectoderm differentiation markers. Our work highlights the importance of marker selection in iPSC authentication, and the need for the field to establish definitive standard assays

Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry

Biologic DMARD; Inflammatory arthritis; RemissionFARME biológico; Artritis inflamatoria; RemisiónFARME biològic; Artritis inflamatòria; RemissióBackground: The objectives of this study were to assess the discontinuation of biologic therapy in patients who achieve remission and identify predictors of discontinuation of biologics in patients with inflammatory arthritis in remission. Methods: An observational retrospective study from the BIOBADASER registry comprising adult patients diagnosed with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA) and receiving 1 or 2 biological disease-modifying drugs (bDMARDs) between October 1999 and April 2021. Patients were followed yearly after initiation of therapy or until discontinuation of treatment. Reasons for discontinuation were collected. Patients who discontinued bDMARDs because of remission as defined by the attending clinician were studied. Predictors of discontinuation were explored using multivariable regression models. Results: The study population comprised 3,366 patients taking 1 or 2 bDMARDs. Biologics were discontinued owing to remission by 80 patients (2.4%): 30 with RA (1.7%), 18 with AS (2.4%), and 32 with PsA (3.9%). The factors associated with a higher probability of discontinuation on remission were shorter disease duration (OR: 0.95; 95% CI: 0.91-0.99), no concomitant use of classic DMARDs (OR: 0.56; 95% CI: 0.34-0.92), and shorter usage of the previous bDMARD (before the decision to discontinue biological therapy) (OR: 1.01; 95% CI: 1.01-1.02); in contrast, smoking status (OR: 2.48; 95% CI: 1.21-5.08) was associated with a lower probability. In patients with RA, positive ACPA was associated with a lower probability of discontinuation (OR: 0.11; 95% CI: 0.02-0.53). Conclusions: Discontinuation of bDMARDs in patients who achieve remission is uncommon in routine clinical care. Smoking and positive ACPA in RA patients were associated with a lower probability of treatment discontinuation because of clinical remission

INDICADORES AMBIENTALES EN LOS MUNICIPIOS DE MONTELÍBANO, PUERTO LIBERTADOR Y SAN JOSÉ DE URÉ, PARA EL RECURSO FORESTAL.

Environmental indicators are important tools for the periodic monitoring of a system’s components, allowing to execute controls and to apply politics that improve unfavorable situations in the system itself. The present investigation work has as objective designing environmental indicators in the municipalities of Montelíbano, Puerto Libertador and San José de Uré, for forest resource, using the model PSR (Pressure-State-Response). To its development, a bibliographical review was made related to the study area and environmental indicators to achieve the identification and selection of the potential tools to be adjusted to the regional context with the structuring of specific methodological sheets. As a result, three indicators were obtained in the biotic system for the terrestrial vegetation component and the occupied surface factor, under the supervision of professionals with experience in the field. It must be taken into account that the conceptual development and the sources of information are a key input to design an indicator to monitor any environmental component, so its absence limits the structuring of these tools in a specific context

Triazole-Functionalized Mesoporous Materials Based on Poly(styrene- block -lactic acid): A Morphology Study of Thin Films

We report the synthesis of poly(styrene- block -lactic acid) (PS- b -PLA) copolymers with triazole rings as a junction between blocks. These materials were prepared via a ‘click’ strategy which involved the reaction between azide-terminated poly(styrene) (PS-N 3 ) and acetylene-terminated poly(D,L-lactic acid) (PLA-Ac), accomplished by copper-catalyzed azide-alkyne cycloaddition reaction. This synthetic approach has demonstrated to be effective to obtain specific copolymer structures with targeted self-assembly properties. We observed the self-assembly behavior of the PS- b -PLA thin films as induced by solvent vapor annealing (SVA), thermal annealing (TA), and hydrolysis of the as-spun substrates and monitored their morphological changes by means of different microscopic techniques. Self-assembly via SVA and TA proved to be strongly dependent on the pretreatment of the substrates. Microphase segregation of the untreated films yielded a pore size of 125 nm after a 45-min SVA. After selectively removing the PLA microdomains, the as-spun substrates exhibited the formation of pores on the surface, which can be a good alternative to form an ordered pattern of triazole functionalized porous PS at the mesoscale. Finally, as revealed by scanning electron microscopy–energy dispersive X-ray spectroscopy, the obtained triazole-functionalized PS-porous film exhibited some affinity to copper (Cu) in solution. These materials are suitable candidates to further study its metal-caption properties