Das Ende des Heidentums in Hispania.

Die Quellen zur spätantiken Religionsgeschichte der Iberischen Halbinsel werden durch eine christliche determinierte Voreingenommenheit dominiert. Die Tendenz der Quellen geht dahin, die Existenz des Heidentum im 5., 6. und 7. Jahrhundert zu bestreiten: Stattdessen wird behauptet, alle Einwohner seien Christen und religiöse Konfl ikte ergäben sich lediglich aufgrund von Aberglauben, magischen Praktiken oder christlichen Häresien. Dieser Aufsatz stellt die Th ese auf, dass das Heidentum sehr viel länger mit dem Christentum koexistiert hat, als allgemein angenommen wird.Sources about the religious history of the Iberian Peninsula in Late Antiquity are dominated by a Christian bias. The general tendency of those sources is to negate the very existence of Paganism in the 5th, 6th and 7th century: Instead, it is claimed that all inhabitants are Christians and religious confl icts are explained as arising from superstition, magical practices or Christian heresies. Th is article argues that Paganism coexisted with Christianity much longer than is commonly assumed

Hygia pecoris, salus populi ¿Atención y compromiso se reflejan en bienestar emocional?

Desde un enfoque “one health”, la salud de los animales se refleja en la salud pública y la salud medioambiental. ¿La buena praxis de los profesionales responsables de la salud animal, se refleja en el bienestar emocional de estos profesionales sanitarios?. La OMS define el bienestar emocional como ese estado de ánimo en el cual la persona se da cuenta de sus propias aptitudes, puede afrontar las presiones normales de la vida, trabajar productivamente y contribuir a la comunidad. El estudio WSAVA 2019, sobre bienestar veterinario, ansiedad y depresión, muestra que la salud mental de los profesionales más jóvenes está seriamente en riesgo. EL estrés laboral ha sido catalogado por la OMS como la epidemia del siglo XXI. El desarrollo del programa atención consciente y gestión emocional, en el marco académico en el que se integra, se alinea con los objetivos de desarrollo sostenible de la ONU (Agenda 2030) ODS3 y transversalmente con ODS5 y ODS16

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Proyecto Comenius

El Proyecto COMENIUS se realiza para que los escolares europeos intercambien experiencias y conozcan a través de diversos medios, entre los que juegan especial importancia las nuevas tecnologías, las constumbres y riqueza cultural de los pueblos que forman Europa. Está integrado dentro del Proyecto Educativo Europeo, instrumento a través del cual se realiza la cooperación entre centros escolares de diversos países. Trabajar en estos proyectos proporciona una experiencia práctica y dinámica sobre la dimensión europea de la educación. Una vez identificados los centros asociados se elige el área temática para el Proyecto Educativo Europeo que se va a desarrollar en común. El proyecto debe desarrollar uno o más temas de interés europeo y debe tener un impacto claro en las experiencias de aprendizaje de los alumnos. En este CD-ROM se presentan dos proyectos realizados por el CEIP Vicente Blasco Ibáñez. 1.Una voz para Europa: retrato de las identidades locales a través de las tradiciones, de las manifestaciones artísticas y de la actividad humana. 2.Los cuentos en Internet: El patrimonio cultural de los pueblos europeos a través de los contenidos populares de los cuentos, desde la tradición hasta la actualidad, conociendo costumbres y carácter propio de cada pueblo para poder comprenderlos.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

Hygia pecoris, salus populi ¿Atención y compromiso se reflejan en bienestar emocional?

Proyecto desarrollado en colaboración con el Instituto Académico Pedagógico de Ciencias Básicas y Aplicadas, de la Universidad Nacional de Villa María. Carrera de Medicina Veterinaria (UNVM-Argentina).Desde un enfoque “one health”, la salud de los animales se refleja en la salud pública y la salud medioambiental. ¿La buena praxis de los profesionales responsables de la salud animal, se refleja en el bienestar emocional de estos profesionales sanitarios?. La OMS define el bienestar emocional como ese estado de ánimo en el cual la persona se da cuenta de sus propias aptitudes, puede afrontar las presiones normales de la vida, trabajar productivamente y contribuir a la comunidad. El estudio WSAVA 2019, sobre bienestar veterinario, ansiedad y depresión, muestra que la salud mental de los profesionales más jóvenes está seriamente en riesgo. EL estrés laboral ha sido catalogado por la OMS como la epidemia del siglo XXI. El desarrollo del programa atención consciente y gestión emocional, en el marco académico en el que se integra, se alinea con los objetivos de desarrollo sostenible de la ONU (Agenda 2030) ODS3 y transversalmente con ODS5 y ODS16.Sección Deptal. de Farmacología y Toxicología (Veterinaria)Fac. de VeterinariaFALSEsubmitte

X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients

Rett syndrome (RTT) is a severe neurological disorder usually caused by mutations in the MECP2 gene. Since the MECP2 gene is located on the X chromosome, X chromosome inactivation (XCI) could play a role in the wide range of phenotypic variation of RTT patients; however, classical methylation-based protocols to evaluate XCI could not determine whether the preferentially inactivated X chromosome carried the mutant or the wild-type allele. Therefore, we developed an allele-specific methylation-based assay to evaluate methylation at the loci of several recurrent MECP2 mutations. We analyzed the XCI patterns in the blood of 174 RTT patients, but we did not find a clear correlation between XCI and the clinical presentation. We also compared XCI in blood and brain cortex samples of two patients and found differences between XCI patterns in these tissues. However, RTT mainly being a neurological disease complicates the establishment of a correlation between the XCI in blood and the clinical presentation of the patients. Furthermore, we analyzed MECP2 transcript levels and found differences from the expected levels according to XCI. Many factors other than XCI could affect the RTT phenotype, which in combination could influence the clinical presentation of RTT patients to a greater extent than slight variations in the XCI pattern

Easy Reading: development of a manual cognitively adapted to young people with intellectual disabilities in the Animal Care Specialty of the Liceo University Diploma

A partir del material elaborado en los Proyectos INNOVA-Docencia 244/2021 y 164/2022, se pretende crear un manual en lectura fácil, dirigido al estudiantado con discapacidad intelectual de la Especialidad de Cuidado de Animales del Diploma Liceo.Depto. de Farmacología y ToxicologíaFac. de VeterinariaFALSEsubmitte