Primary Kidney Lymphoma in a Dog

Background: Lymphoma is a malignant lymphoid tumor originating in the lymph nodes or other solid organs and comprises 90% of all hematopoietic tumors in dogs. However, primary renal lymphoma is rare and is associated with nonspecific clinical signs. Tumor invasion in both kidneys can cause severe clinical signs due to renal failure, complicating the patient's treatment and prognosis. The aim of this case was to report the case of a dog affected by bilateral primary renal lymphoma. In addition, to characterize the clinical and histopathological presentation due to the intense morphological changes. Case:  A 5-year-old male Poodle canine was admitted showing apathy and emesis for 5 days. On physical examination, the dog showed 10% of dehydration, reddish oral mucous membranes, poor body condition (score 1/5), uremic breath, and pain in the kidney area. Complementary tests revealed severe low white blood cells count, high BUN levels, high levels of potassium, calcium, and phosphorus (serum biochemistry). Abdominal ultrasound showed bilateral kidney enlargement. Fine needle aspiration of the mass (guided by ultrasound) revealed round cell tumor. Radiographs showed no alterations. The dog died due to his poor condition and necropsy was performed. On post-mortem examination, the kidneys were both enlarged, pale, and with an irregular subcapsular surface. The histopathological diagnostic was primary renal lymphoma. Immunohistochemical staining revealed that neoplastic cells were strongly positive for anti CD20 and PAX5, while negative for CD3, supporting the diagnosis of B-cell lymphoma. Discussion: The diagnosis was based on clinical, complementary tests, fine needle aspiration, histopathological and immunohistochemical findings. In dogs, primary kidney tumors are uncommon and usually malignant. The presence of vomiting, uremic breath, dehydration, weight loss, and erosive and ulcerative lesions on the tongue (uremic glossitis) are clinical signs of chronic renal failure, and this condition was later confirmed by laboratory tests and histopathological findings. Dogs diagnosed with extra-nodal renal lymphoma, present clinical signs such as polydipsia, polyuria, vomiting, and uremic breath in some cases. These changes are compatible with changes observed in cases of renal failure. In this case, the severe azotemia, hyperphosphatemia, hypocalcemia, and hyperkalemia were due to the neoplastic infiltration in both kidneys. Additionally, the abdominal ultrasound revealed the tumor in both kidneys. Almost 38% of dogs with renal lymphoma presented in urine evaluation normal urine density and a large amount of protein in the urine, similar to those observed in this dog. When the lesions are on both kidneys, kidney failure develops and uremic extra-renal lesions appear, as observed in this case. The prevalence of primary kidney tumors in domestic animals corresponds to less than 1% of the total of the tumors reported, and they are usually in one kidney. In dogs, almost 60 - 70% of lymphomas are B cells, 30 - 40% are T cells, and less than 1% are null cells. B-cell lymphomas usually show less aggressive behavior when compared to T-cell lymphomas. Kidney lymphoma can be included as an important cause of kidney failure, and has slow and progressive development, making early diagnosis and treatment difficult. Keywords: dog disease, lymphoproliferative disorder, renal neoplasm, uremia. Título: Linfoma renal primário em cãoDescritores: doença de cão, distúrbio linfoproliferativo, neoplasma renal, uremia.

IMPACTO DE ANTIMICROBIANOS NOS PARÂMETROS CINÉTICOS DE ESPERMATOZOIDES CRIOPRESERVADOS DE CATETOS

The objective was to verify the impact of the addition of antimicrobials on the kinetic parameters of sperm in the cryopreserved semen of collared peccaries. Ejaculates from 10 adult male, obtained by electroejaculation, were used. The samples had their kinetic parameters evaluated by computer analysis (CASA). Subsequently, they were cryopreserved in Tris plus egg yolk (20%) and glycerol (3%), whether or not(control) added gentamicin (70μg/mL) or the combination penicillin (1000 IU/mL) and streptomycin (1mgE/mL) (P+E). After one week, the samples were thawed and evaluated similarly to fresh semen. In fresh semen, total motility of 95.3±0.8% and 72.1±3.5% progressive motility were observed. After thawing, there were no differences between treatments, except for the cross-beat frequency (BCF) parameter, which was negatively influenced by P+E, in relation to fresh semen (p<0.05). In conclusion, it is suggested the use of gentamicin as an antimicrobial for the cryopreservation of semen from peccaries.The objective was to verify the impact of the addition of antimicrobials on the kinetic parameters of sperm in the cryopreserved semen of collared peccaries. Ejaculates from 10 adult male, obtained by electroejaculation, were used. The samples had their kinetic parameters evaluated by computer analysis (CASA). Subsequently, they were cryopreserved in Tris plus egg yolk (20%) and glycerol (3%), whether or not(control) added gentamicin (70μg/mL) or the combination penicillin (1000 IU/mL) and streptomycin (1mgE/mL) (P+E). After one week, the samples were thawed and evaluated similarly to fresh semen. In fresh semen, total motility of 95.3±0.8% and 72.1±3.5% progressive motility were observed. After thawing, there were no differences between treatments, except for the cross-beat frequency (BCF) parameter, which was negatively influenced by P+E, in relation to fresh semen (p<0.05). In conclusion, it is suggested the use of gentamicin as an antimicrobial for the cryopreservation of semen from peccaries

Contribuição da enfermagem obstétrica para promoção do protagonismo da mulher durante o período gravídico-puerperal

Um profissional qualificado e capacitado, é necessário para garantir um atendimento humanizado no qual forneça as informações pertinentes sobre a gestação, o trabalho de parto e parto para a gestante. o presente trabalho tem o objetivo de avaliar os procedimentos desnecessários realizados pela equipe de enfermagem durante o trabalho de parto e parto que inibem o protagonismo da parturiente. Uma vez que, segundo o documento divulgado pela Defensoria Pública de São Paulo a Violência Obstétrica (VO). Este estudo trata-se de uma revisão integrativa, que por sua vez as etapas operacionais foram divididas em seis fases, sendo: elaboração da pergunta norteadora, busca na literatura, coleta de dados, análise crítica dos estudos incluídos, discussão dos resultados e apresentação da revisão integrativa.Podemos observar que através da utilização do partograma, rebozo, massagem terapêutica, estimulação da deambulação, mudança de posicionamento à escolha da parturiente, etc, fica implícito o desenvolvimento da autonomia da mulher, pois a mesma pode escolher o que fazer, quando fazer e como fazer, o enfermeiro estará presente para auxiliar em casos de distocia e não para intervir nesse processo

Consequências da resistência antimicrobiana no tratamento das infecções hospitalares / Consequences of antimicrobial resistance in the treatment of hospital infections

Introdução: A resistência a antimicrobianos em ambientes hospitalares representa uma enorme preocupação, constituindo-se um importante problema de saúde pública. Os microrganismos multirresistentes têm sido alvo de elevada implicação no tratamento das infecções hospitalares. O objetivo do estudo foi verificar na literatura vigente quais as consequências e desafios que a resistência antimicrobiana vem provocando para o tratamento das infecções hospitalares. Método: Trata-se de uma revisão integrativa da literatura pautada com estudos utilizando as seguintes bases de dados: Scientific Eletronic Library Online (SCIELO); Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Medical Literature Analysis and Retrieval System Online (MEDLINE). Descritores em Ciências da Saúde - DeCS: Antibióticos, Infecções Hospitalares e Terapêutica. A seleção respeitou critérios de inclusão e exclusão dos artigos disponíveis de forma completa e gratuita, entre os anos de 2014 a 2020, nos idiomas português, inglês e espanhol. Foram excluídos estudos que se mostravam incompletos e repetidos, assim como estudos de revisão. Resultados: Foram encontrados 30 estudos dos quais 19 cumpriram os critérios previamente estabelecidos e foram incluídos na revisão. No qual, o ambiente hospitalar, além de permitir a propagação de agentes infecciosos resistentes, pode afetar diretamente na prevenção e o tratamento eficaz de cada paciente. Considerações finais: Embora a resistência antimicrobiana seja um desafio atual é necessário a implementação de políticas nacionais de prevenção e controle de infecção que visam segurança hospitalar e uso racional de antimicrobianos para melhor adesão na farmacoterapia dos pacientes internados

Exposição ao risco cardíaco por referencia e perimetria em indivíduos da cidade de João Pessoa

Objetivo: Analisar os fatores de exposição ao risco cardíaco (FERC) por referenda e perimetria em areas publicas para a atividade física na cidade de João Pessoa - PB. Metodobgja Estudo descritivo e transversal; amostra de 153 indivíduos, idade media 53,88±13,98anos. Resultados: Encontrou-se: 53,88% faixa etária (FE), 77,5% excesso de peso, 61,9% hereditariedade, 9,9% tabagismo, 19,6% intensidade do exercicio e atividade ocupacional, 52,2% hipercolesterolemia (HIP), 25,5% PA máxima p0,600.Coneliisoes: Os FERC prevalentes são a hereditariedade, HIP, FE, gênero (maior para o fem.), massa corporal, IMC e RCQ elevados e se associam

Primary Kidney Lymphoma in a Dog

Background: Lymphoma is a malignant lymphoid tumor originating in the lymph nodes or other solid organs and comprises 90% of all hematopoietic tumors in dogs. However, primary renal lymphoma is rare and is associated with nonspecific clinical signs. Tumor invasion in both kidneys can cause severe clinical signs due to renal failure, complicating the patient's treatment and prognosis. The aim of this case was to report the case of a dog affected by bilateral primary renal lymphoma. In addition, to characterize the clinical and histopathological presentation due to the intense morphological changes. Case:  A 5-year-old male Poodle canine was admitted showing apathy and emesis for 5 days. On physical examination, the dog showed 10% of dehydration, reddish oral mucous membranes, poor body condition (score 1/5), uremic breath, and pain in the kidney area. Complementary tests revealed severe low white blood cells count, high BUN levels, high levels of potassium, calcium, and phosphorus (serum biochemistry). Abdominal ultrasound showed bilateral kidney enlargement. Fine needle aspiration of the mass (guided by ultrasound) revealed round cell tumor. Radiographs showed no alterations. The dog died due to his poor condition and necropsy was performed. On post-mortem examination, the kidneys were both enlarged, pale, and with an irregular subcapsular surface. The histopathological diagnostic was primary renal lymphoma. Immunohistochemical staining revealed that neoplastic cells were strongly positive for anti CD20 and PAX5, while negative for CD3, supporting the diagnosis of B-cell lymphoma. Discussion: The diagnosis was based on clinical, complementary tests, fine needle aspiration, histopathological and immunohistochemical findings. In dogs, primary kidney tumors are uncommon and usually malignant. The presence of vomiting, uremic breath, dehydration, weight loss, and erosive and ulcerative lesions on the tongue (uremic glossitis) are clinical signs of chronic renal failure, and this condition was later confirmed by laboratory tests and histopathological findings. Dogs diagnosed with extra-nodal renal lymphoma, present clinical signs such as polydipsia, polyuria, vomiting, and uremic breath in some cases. These changes are compatible with changes observed in cases of renal failure. In this case, the severe azotemia, hyperphosphatemia, hypocalcemia, and hyperkalemia were due to the neoplastic infiltration in both kidneys. Additionally, the abdominal ultrasound revealed the tumor in both kidneys. Almost 38% of dogs with renal lymphoma presented in urine evaluation normal urine density and a large amount of protein in the urine, similar to those observed in this dog. When the lesions are on both kidneys, kidney failure develops and uremic extra-renal lesions appear, as observed in this case. The prevalence of primary kidney tumors in domestic animals corresponds to less than 1% of the total of the tumors reported, and they are usually in one kidney. In dogs, almost 60 - 70% of lymphomas are B cells, 30 - 40% are T cells, and less than 1% are null cells. B-cell lymphomas usually show less aggressive behavior when compared to T-cell lymphomas. Kidney lymphoma can be included as an important cause of kidney failure, and has slow and progressive development, making early diagnosis and treatment difficult. Keywords: dog disease, lymphoproliferative disorder, renal neoplasm, uremia. Título: Linfoma renal primário em cãoDescritores: doença de cão, distúrbio linfoproliferativo, neoplasma renal, uremia.