Design of an autonomous software platform for future symbiotic service management

Nowadays, public as well as private communication infrastructures are all contending for the same limited amount of bandwidth. To optimally share network resources, symbiotic networks have been proposed, which cross logical and physical boundaries to improve the reliability, scalability, and energy efficiency of the network as a whole as well as its constituents. This paper focuses on software services in such symbiotic networks. We propose a platform for the intelligent composition of services provided by symbiotically connected parties, resulting in novel cooperation opportunities. The platform harvests Semantic Web technology to describe services in a highly expressive manner, and constructs service compositions using SeCoA, our tunable best-first search algorithm. The resulting compositions are then enacted via CaPI, a reconfigurable middleware infrastructure. By means of an illustrative scenario, we provide further insight into the platform's functioning

Does virulence assessment of Vibrio anguillarum using sea bass (Dicentrarchus labrax) larvae correspond with genotypic and phenotypic characterization?

Background: Vibriosis is one of the most ubiquitous fish diseases caused by bacteria belonging to the genus Vibrio such as Vibrio (Listonella) anguillarum. Despite a lot of research efforts, the virulence factors and mechanism of V. anguillarum are still insufficiently known, in part because of the lack of standardized virulence assays. Methodology/Principal Findings: We investigated and compared the virulence of 15 V. anguillarum strains obtained from different hosts or non-host niches using a standardized gnotobiotic bioassay with European sea bass (Dicentrarchus labrax L.) larvae as model hosts. In addition, to assess potential relationships between virulence and genotypic and phenotypic characteristics, the strains were characterized by random amplified polymorphic DNA (RAPD) and repetitive extragenic palindromic PCR (rep-PCR) analyses, as well as by phenotypic analyses using Biolog's Phenotype MicroArray (TM) technology and some virulence factor assays. Conclusions/Significance: Virulence testing revealed ten virulent and five avirulent strains. While some relation could be established between serotype, genotype and phenotype, no relation was found between virulence and genotypic or phenotypic characteristics, illustrating the complexity of V. anguillarum virulence. Moreover, the standardized gnotobiotic system used in this study has proven its strength as a model to assess and compare the virulence of different V. anguillarum strains in vivo. In this way, the bioassay contributes to the study of mechanisms underlying virulence in V. anguillarum

ConvDTW-ACS: Audio Segmentation for Track Type Detection During Car Manufacturing

This paper proposes a method for Acoustic Constrained Segmentation (ACS) in audio recordings of vehicles driven through a production test track, delimiting the boundaries of surface types in the track. ACS is a variant of classical acoustic segmentation where the sequence of labels is known, contiguous and invariable, which is especially useful in this work as the test track has a standard configuration of surface types. The proposed ConvDTW-ACS method utilizes a Convolutional Neural Network for classifying overlapping image chunks extracted from the full audio spectrogram. Then, our custom Dynamic Time Warping algorithm aligns the sequence of predicted probabilities to the sequence of surface types in the track, from which timestamps of the surface type boundaries can be extracted. The method was evaluated on a real-world dataset collected from the Ford Manufacturing Plant in Valencia (Spain), achieving a mean error of 166 milliseconds when delimiting, within the audio, the boundaries of the surfaces in the track. The results demonstrate the effectiveness of the proposed method in accurately segmenting different surface types, which could enable the development of more specialized AI systems to improve the quality inspection process.Comment: 12 pages, 2 figure

Towards Managing Variability in the Safety Design of an Automotive Hall Effect Sensor

ABSTRACT This paper discusses the merits and challenges of adopting software product line engineering (SPLE) as the main development process for an automotive Hall Effect sensor. This versatile component is integrated into a number of automotive applications with varying safety requirements (e.g., windshield wipers and brake pedals). This paper provides a detailed explanation as to why the process of safety assessment and verification of the Hall Effect sensor is currently cumbersome and repetitive: it must be repeated entirely for every automotive application in which the sensor is to be used. In addition, no support is given to the engineer to select and configure the appropriate safety solutions and to explain the safety implications of his decisions. To address these problems, we present a tailored SPLEbased approach that combines model-driven development with advanced model composition techniques for applying and reasoning about specific safety solutions. In addition, we provide insights about how this approach can reduce the overall complexity, improve reusability, and facilitate safety assessment of the Hall Effect sensor

Effect of a carotenoid-producing Bacillus strain on intestinal barrier integrity and systemic delivery of carotenoids : a randomised trial in animals and humans

The aim of the present study was to investigate effects of the carotenoid-producing Bacillus indicus strain PD01 on intestinal barrier function and its ability to survive passage through the gastrointestinal tract and to assess systemic bioavailability of these carotenoids in vivo. As model for impaired barrier function, 16 early weaned piglets were randomly assigned to a control diet or control diet with PD01 for 23 days. In addition, 67 overweight/obese, otherwise healthy individuals were randomly assigned to groups receiving PD01 or placebo for 6 weeks. PD01 survived passage through the gastrointestinal tract in piglets and human subjects and resulted in significant accumulation of PD01 derived carotenoids (methyl-glycosyl-apo-8'-lycopenoate and glycosyl-apo-8'- lycopene) in human plasma after 3- and 6-weeks supplementation versus baseline (0.044 and 0.076 vs 0 mu M, respectively; p = 0.104). In summary, PD01 survived transit through the gastrointestinal tract, resulted in systemic carotenoid accumulation and improved compromised barrier function outcomes

Towards Managing Variability in the Safety Design of an Automotive Hall Effect Sensor

International audienceThis paper discusses the merits and challenges of adopting software product line engineering (SPLE) as the main development process for an automotive Hall Effect sensor. This versatile component is integrated into a number of automotive applications with varying safety requirements (e.g., windshield wipers and brake pedals). This paper provides a detailed explanation as to why the process of safety assessment and verification of the Hall Effect sensor is currently cumbersome and repetitive:~it must be repeated entirely for every automotive application in which the sensor is to be used. In addition, no support is given to the engineer to select and configure the appropriate safety solutions and to explain the safety implications of his decisions. To address these problems, we present a tailored SPLE-based approach that combines model-driven development with advanced model composition techniques for applying and reasoning about specific safety solutions. In addition, we provide insights about how this approach can reduce the overall complexity, improve reusability, and facilitate safety assessment of the Hall Effect sensor

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Funder: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)Funder: National Center for Research Resources under award number 1 C06 RR12463-01, VA Merit Review Award IBX004121A from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service, the DOD Prostate Cancer Idea Development Award (W81XWH-15-1-0558), the DOD Lung Cancer Investigator-Initiated Translational Research Award (W81XWH-18-1-0440), the DOD Peer Reviewed Cancer Research Program (W81XWH-16-1-0329), the Ohio Third Frontier Technology Validation Fund, the Wallace H. Coulter Foundation Program in the Department of Biomedical Engineering and the Clinical and Translational Science Award Program (CTSA) at Case Western Reserve University.Funder: Susan G Komen Foundation (CCR CCR18547966) and a Young Investigator Grant from the Breast Cancer Alliance.Funder: The Canadian Cancer SocietyFunder: Breast Cancer Research Foundation (BCRF), Grant No. 17-194Abstract: Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Funder: Breast Cancer Research Foundation (BCRF); doi: https://doi.org/10.13039/100001006Abstract: Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting