Mechanical Control of Sensory Hair-Bundle Function

Hair bundles detect sound in the auditory system, head position and rotation in the vestibular system, and fluid flow in the lateral-­‐‑line system. To do so, bundles respond to periodic, static, and hydrodynamic forces contingent upon the receptor organs in which they are situated. As the mechanosensory function of a hair bundle varies, so too do the mechanical properties of the bundle and its microenvironment. Hair bundles range in height from 1 μμm to 100 μμm and in stiffness from 100 μμN·∙m-­‐‑1 to 10,000 μμN·∙m-­‐‑1. They are composed of actin-­‐‑filled, hypertrophic microvilli—stereocilia—that number from fewer than 20 through more than 300 per bundle. In addition, bundles may or may not possess one true cilium, the kinocilium. Hair bundles differ in shape across organs and organisms: they may be isodiametric, fan-­‐‑shaped, or V-­‐‑shaped. Depending on the organ in which they occur, bundles may be free-­‐‑standing or they may be coupled to a tectorial membrane, otolithic membrane, cupula, or sallet. Because all hair bundles are comprised of similar molecular components, their distinct mechanosensory functions may instead be regulated by their mechanical loads. Dynamical-­‐‑systems analysis provides mathematical predictions of hair-­‐‑bundle behavior. One such model captures the effects of mechanical loading on bundle function in a state diagram. A mechanical-­‐‑load clamp permits exploration of this state diagram by robustly controlling the loads—constant force, load stiffness, virtual drag, and virtual mass—imposed on a hair bundle. Upon changes in these mechanical parameters, the bundle’s response characteristics alter. Subjected to particular control parameters, a bundle may oscillate spontaneously or remain quiescent. It may respond nonlinearly to periodic stimuli with high sensitivity, sharp frequency tuning, and easy entrainment; or it may respond linearly with low sensitivity, broad tuning, and reluctant entrainment. The bundle’s response to a force pulse may resemble that of an edge-­‐‑detection system or a low-­‐‑pass filter. Finally, a bundle from an amphibian vestibular organ can operate in a manner qualitatively similar to that from a mammalian auditory organ, implying an essential similarity between hair bundles. The bifurcation near which a bundle’s operating point resides controls its function: the state diagram provides a functional map of mechanosensory modalities. Auditory function is best tuned near a supercritical Hopf bifurcation, whereas vestibular function is captured by a subcritical Hopf bifurcation and a cusp bifurcation. Within the proposed region vestibular responsiveness, a hair bundle exhibits mechanical excitability analogous to the electrical excitability of neurons. This behavior implies for the first time a direct relationship between the mechanical behaviors of sensory organelles and the electrical behaviors of afferent neurons. Man-­‐‑made detectors function in limited capacities, each designed for a unique purpose. A single hair bundle, on the other hand, evolved to serve multiple purposes with the requirement of only two functional traits: adaptation and nonlinear channel gating. The remarkable conservation of these capabilities thus provides unique insight into the evolution of sensory systems

Landing of ‘Flying Gurnard’ in Mumbai

A rare fish ‘flying gurnard’ was landed by a trawler operating in 70-100 m depth in the sea off Mumbai. The species was identified as Dactyloptena peterseni (Nystrom, 1887) and it is reported for the first time along the Indian coast

Skeleton and fractal scaling in complex networks

We find that the fractal scaling in a class of scale-free networks originates from the underlying tree structure called skeleton, a special type of spanning tree based on the edge betweenness centrality. The fractal skeleton has the property of the critical branching tree. The original fractal networks are viewed as a fractal skeleton dressed with local shortcuts. An in-silico model with both the fractal scaling and the scale-invariance properties is also constructed. The framework of fractal networks is useful in understanding the utility and the redundancy in networked systems.Comment: 4 pages, 2 figures, final version published in PR

Molecular detection of parasites (Trematoda, Digenea: Bucephalidae and Monorchiidae) in the European flat oyster Ostrea edulis (Mollusca: Bivalvia)

Members of the globally distributed bivalve family Ostreidae (oysters) have a significant role in marine ecosystems and include species of high economic importance. In this work, we report the occurrence of digenean parasites of the families Bucephalidae (Prosorhynchoides sp.) and Monorchiidae (Postmonorchis sp.) in Mediterranean native populations of Ostrea edulis (but not in the introduced Magallana gigas). Molecular detection was based on DNA sequencing of the ribosomal intergenic spacer 2 (ITS2) marker. The importance of detecting the presence of overlooked digenean parasites in Mediterranean oysters is discussed. © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

A characterization of particular symmetric (0,1) matrices

AbstractA characterization of a class of symmetric (0, 1) matrices A such that AP is a symmetric matrix too, where P is a permutation matrix, is given, and an application to double coverings of graphs is considered

A multilocus view on Mediterranean aeolid nudibranchs (Mollusca): Systematics and cryptic diversity of Flabellinidae and Piseinotecidae

Recent molecular studies revealed high level of endemism and numerous cryptic species within opisthobranchs, with Mediterranean taxa clearly understudied. Here we used genetic data from both mitochondrial and nuclear gene fragments as well as morphological data from taxonomically relevant characters to investigate the phylogenetic relationships and systematics of Mediterranean taxa of the Flabellinidae and Piseinotecidae families. Phylogenetic analyses based on Bayesian and Maximum-Likelihood methods indicate that Flabellinidae and Pisenotecidae taxa and species within the genera Flabellina, Calmella and Piseinotecus do not form monophyletic clades. These results are supported by our morphological analyses which allowed the re-evaluation of the triseriate radula condition in Pisenotecidae and Calmella taxa and their inclusion in the genus Flabellina as Flabellina gaditana comb. nov. (synonym of F. confusa), Flabellina gabinierei comb. nov. and Flabellina cavolini comb. nov. Species delimitation and barcoding gap analyses allowed uncovering cryptic species within Flabellina gracilis (Alder and Hancock, 1844), F. trophina (Bergh, 1890), F. verrucosa (M. Sars, 1829) and F. ischitana Hirano and Thompson, 1990, the latter with an Atlantic form which is under description. This study corroborates the relevance of combining molecular and morphological data from multiple populations and species in the assessment of nudibranch diversity and classification

Energy flexible CHP-DHN systems: Unlocking the flexibility in a real plant

The purpose of this paper is to identify and analyze the impact of flexibility enablers in cogeneration and district heating network (CHP-DHN) plants by means of a real case study located in central Italy. A wider definition of energy flexibility applicable to the entire energy supply chain (i.e. production, transport and usage) is used in this analysis. In particular the flexibility is intended as the capability of each part of the system to produce a variation in its load curve, while ensuring the required performance. In this sense energy efficiency technologies, the use of energy storage and advanced control techniques can be seen as flexibility enablers potentially available in each section of the energy system. The innovative contribution of this work is to propose flexibility strategies in compliance with the constraints imposed by both the managers and users. The study aims to show possible ways to activate flexibility services to be used with known instruments and to quantify their impact with a simulation-based approach. In particular, three different flexibility instruments are identified in different sections of the plant: (i) the use of a thermal energy storage (TES) in the generation side, (ii) the optimal management of the DHN supply temperature (energy distribution side) and (iii) the management of the thermostatically controlled loads (TCLs) of the final users (demand side) connected to the network. Through the implementation of simulation models calibrated with available measurements, the influence of these flexibility instruments on the energy/environmental performance is evaluated in comparison to the current configuration of the plant. Results confirm the great impact of the TES to increase the CHP working hours and, as a consequence, a primary energy saving increase is obtained in mid-season and in summer season. Whereas the optimal management of the water supply temperature in the DHN allows to obtain 1% fuel reduction in a typical winter week and 2% in a typical summer week. As far as the activation of the demand side flexibility is concerned, the effect of the management of TCLs on energy conservation is demonstrated: 1 °C reduction of the setpoint of all the residential users during a typical winter day produces a 7.3% reduction of the DHN thermal demand. However, its impact on the generation side (i.e. to reduce the electricity/thermal production of the CHP at specific times) is limited due to the characteristics of the considered CHP plant (the CHP engine is sized to cover only the thermal baseload and it scarcely affected by thermal demand variations). The analysis proposed helps to obtain valuable hints on unlocking the energy flexibility in CHP-DHN plants useful for a better management of such systems

Evolutionary history of the Maltese wall lizard Podarcis filfolensis : insights on the 'expansion-contraction' model of Pleistocene biogeography

The expansion-contraction (EC) model predicts demographic and range contraction of temperate species during Pleistocene glaciations as a consequence of climate-related habitat changes, and provides a paradigm for explaining the high intraspecific diversity found in refugia in terms of long-term demographic stability. However, recent evidence has revealed a weak predictive power of this model for terrestrial species in insular and coastal settings. We investigated the Pleistocene EC dynamics and their evolutionary consequences on temperate species using the Maltese archipelago and its endemic lizard Podarcis filfolensis as a model system. The evolutionary and demographic history of P. filfolensis as inferred from mitochondrial and nuclear sequences data does not conform to the EC model predictions, supporting (i) demographic and spatial stability or expansion, rather than contraction, of the northern and southern lineages during the last glacial period; and (ii) a major role for allopatric differentiation primed by sea-level dynamics, rather than prolonged demographic stability, in the formation of the observed genetic diversity. When combined with evidence from other Mediterranean refugia, this study shows how the incorporation of Pleistocene sea-level variations in the EC model accounts for a reverse demographic and range response of insular and coastal temperate biotas relative to continental ones. Furthermore, this cross-archipelago pattern in which allopatric diversity is formed and shaped by EC cycles resembles that seen between isolated populations within mainland refugia and suggests that the EC model, originally developed to explain population fluctuations into and out-of refugia, may be appropriate for describing the demographic and evolutionary dynamics driving the high genetic diversity observed in these areas.peer-reviewe

Multiple carcasses of Olive Ridleys along Malvan Beach

The Olive Ridley turtle (Lepidochelys olivacea) is protected under the Indian Wildlife (Protection) Act, 1972. Maharashtra government along with NGOs are undertaking several efforts in conservation of sea turtles along the coast. There is a state sponsored incentive program of `500 for locating and sharing information with forest officials. Malvan coast in Sindhudurg district of Maharashtra is known for turtle and fisheries interactions. Occasional turtle nestings can be seen between November to April