A priori bounds for elliptic operators in weighted Sobolev spaces

This paper is concerning with the study of a class of weight functions and their properties. As an application, we prove some a priori bounds for a class of uniformly elliptic second order linear differential operators in weighted Sobolev spaces

The Dirichlet problem for elliptic equations in weighted Sobolev spaces on unbounded domains of the plane

This paper deals with the Dirichlet problem for second order linear elliptic equations in unbounded domains of the plane in weighted Sobolev spaces. We prove an a priori bound and an existence and uniqueness result

On the solvability of linear PDEs in weighted Sobolev spaces

2010 - 2011In this work we are interested in strong solutions of a Dirichlet problem for an elliptic linear operator... [edited by author]X n.s

The Role of Platelets in Viral Hemorrhagic Fevers

Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae are all RNA viruses that can induce a coagulopathy in infected patients. While there is a paucity of information on the cause of this coagulopathy, these viruses all produce a severe thrombocytopenia. Here, we review the literature on viral hemorrhagic fever and discuss the role played by platelets in the coagulopathy. We also discuss the possibility of using anti-platelet agents to moderate the coagulopathy, a strategy that might have a role to play in treating patients infected by these viruses

Role of the Fas/FasL pathway in HIV or SIV disease

Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Both depletion in immune cell numbers as well as defects in their effector functions are responsible for this immunodeficiency The broad impact of HIV reflects a similarly broad pattern of cell depletion including subsets that do not express viral receptors or support viral replication. Indirect cell killing, the destruction of uninfected cells, is due partly to activation of the Fas/FasL system for cell death. This death-signaling pathway is induced during HIV disease and contributes significantly to viral pathogenesis and disease

Modeling the Effects of Avian Flu (H5N1) Vaccination Strategies on Poultry

The work in this article addresses a problem posed by Dr. Maria Salvato to the CODEE community. The task was to model costs associated with varying vaccination strategies for the Avian Flu virus (H5N1) on chicken populations. The vaccination strategies proposed included vaccination varying proportions of the flock with live virus vaccine, dead virus vaccine, and no vaccination. This article encompasses the construction of a model for the problem using a modification to the SIER model and the subsequent analysis of that model. The analysis of the model revealed the most cost effective vaccination strategy to be vaccination of half the flock with dead virus vaccine

ENEA PAES: A Web Platform for Supporting Italian Municipalities in Sustainable Energy Action Plan

The Covenant of Mayors promotes the Sustainable Energy Action Plan (SEAP), aiming to mitigate greenhouse gas (GHG) emissions in line with the European Union’s 2030 and 2050 targets. The Covenant signatories could take enormous advantage from a digital platform that allows SEAP drafting also to no technically skilled users, like majority of them are. The Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA) has developed the PAES platform in order to provide digital support to public administrations (PA) adhering to the Covenant of Mayors. The platform exploits open data and it is fed by energetic data aggregated on a municipal level. The platform offers appropriate functionalities for baseline CO2 emissions inventory (BEI) filling out and a best practice (BP) simulation tool. The latter allows to contextualize each BP and to estimate its effects in terms of the main GHG emission. The BP showing the best estimation results can then be converted into concrete adaptation actions. So, this digital system facilitates local Italian municipalities in the strategic planning and monitoring of adaptation actions taken over time

Combining Real Time Classifiers for Fast and Reliable Electronic Nose Response Analysis for Aerospace NDTs

AbstractFast response and reliability are a prerogative in non- destructive tests s p e c i f i c a l l y in aerospace industry for safety and efficiency reasons. Currently, composite panels bonding, in green aircraft concept, is lacking a validated NDT technique for the bond quality. E-noses equipped with PARC algorithms appear a promising choice to acquire speedily a complete pattern response maximizing reliability. In this paper, combining real time classifiers, we show how to obtain a rapid first- hand response with the possibility of increasing accuracy awaiting for the end of the e-nose measurement cycle. A reject option is casted on the base of classifier self-perceived reliability to nullify false negatives while keeping the false positive rate at minimum

Lettura e dispersione

Reading and dispersion constitute, in different ways, two crucial points of scholastic reality and of educational research. This book highlights the multiple cognitive and emotional effects of reading and, more generally, the different ways to prevent and combat school dropouts. Therefore the volume has a double interest: on the one hand, to help the understanding of the school dispersion and the perception that it has in the field; on the other hand, identify effective prevention and recovery interventions, with particular attention to reading aloud and narrative orientation

Attenuated Disease in SIV-Infected Macaques Treated with a Monoclonal Antibody against FasL

Acute SIVmac infection in macaques is accompanied by high levels of plasma viremia that decline with the appearance of viral immunity and is a model for acute HIV disease in man. Despite specific immune responses, the virus establishes a chronic, persistent infection. The destruction of CD4+ and CD4- lymphocyte subsets in macaques contributes to viral persistence and suggests the importance of mechanisms for depleting both infected and uninfected (bystander) cells. Bystander cell killing can occur when FasL binds the Fas receptor on activated lymphocytes, which include T and B cell subpopulations that are responding to the infection. Destruction of specific immune cells could be an important mechanism for blunting viral immunity and establishing persistent infection with chronic disease. We inhibited the Fas pathway in vivo with a monoclonal antibody against FasL (RNOK203). Here we show that treatment with anti-FasL reduced cell death in circulating T and B cells, increased CTL and antibody responses to viral proteins, and lowered the setpoint viremia. By blocking FasL during only the first few weeks after infection, we attenuated SIVmac disease and increased the life span for infected and treated macaques