Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells.

Glial cells play a pivotal role in brain fatty acid metabolism and membrane biogenesis. However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in glial cells has been barely investigated. Here, we show that physiologically relevant concentrations of various saturated, monounsaturated, and polyunsaturated fatty acids significantly reduce [1-(14)C]acetate incorporation into fatty acids and cholesterol in C6 cells. Oleic acid was the most effective at depressing lipogenesis and cholesterologenesis; a decreased label incorporation into cellular palmitic, stearic, and oleic acids was detected, suggesting that an enzymatic step(s) of de novo fatty acid biosynthesis was affected. To clarify this issue, the activities of acetyl-coenzyme A carboxylase (ACC) and FAS were determined with an in situ digitonin-permeabilized cell assay after incubation of C6 cells with fatty acids. ACC activity was strongly reduced ( approximately 80%) by oleic acid, whereas no significant change in FAS activity was observed. Oleic acid also reduced the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). The inhibition of ACC and HMGCR activities is corroborated by the decreases in ACC and HMGCR mRNA abundance and protein levels. The downregulation of ACC and HMGCR activities and expression by oleic acid could contribute to the reduced lipogenesis and cholesterologenesis

New forms of land grabbing due to the bioeconomy. The case of Brazil

The present study discusses new forms of land grabbing related to biofuel production in the light of bioeconomic development. With a specific focus on Brazil, this article debates whether biofuel production is associated with (i) an expansion of agricultural land use-regarded as a process of unsustainable crop intensification or (ii) an increase in crop yield, driven by technical innovation with stable land use-intended as a form of sustainable intensification. We conclude that, in the case of Brazil, the current bioeconomy cannot be assumed to be environmentally sustainable. Starting from Brazil's experience, the (apparent and latent) relationship between bioeconomy and land grabbing requires a refined investigation in both wealthier and emerging economies, with the aim of proposing effective strategies to achieve truly sustainable development in the primary sector

The IDIPOS project: is a multidisciplinary data infrastructure for weather and space weather feasible?

The Italian National Antarctic Programme (PNRA) has long supported scientific and technological activities addressed to the implementation, upgrade and maintenance of infrastructure and instruments supporting geosciences and physical sciences in the polar region. This report describes the first results of the Italian Database Infrastructure for Polar Observation Sciences (IDIPOS) project, which was recently approved by the PNRA. The project aims to study the feasibility of the hardware and software infrastructure for the construction of relational databases of acquisitions from past and current experiments in the polar areas. The study is based on the fundamental characteristics of the infrastructure: its implementation in Italy, with locations across the country, and its integration into the existing and future telematics infrastructure that will be available at the Italian bases. The project proposes a modern and hightech infrastructure dedicated to data treatment, accessibility and archiving, in line with international standards. This infrastructure will allow modern, rapid and reliable treatment of the acquired data. The IDIPOS infrastructure is crucial during the planning phase of scientific and monitoring activities of the PNRA, especially of those included in the Scientific Committe for Antarctic Research (SCAR) projects, the International Polar Year, and the framework of international cooperation. In the first phase of the project, the observations are related to research projects in different PNRA sectors. The infrastructure will be potentially extendable to other observational activities. In this report, the infrastructure is introduced, while highlighting its usefulness for weather and space-weather forecasting for the scientific community and in the framework of Global Navigation Satellite System (GNSS) Research and Application for Polar Environment (GRAPE) in particular

XMM-Newton observations of ULIRGs I: A Compton-thick AGN in IRAS19254-7245

We present the XMM-Newton observation of the merging system IRAS 19254-7245, also known as The Superantennae, whose southern nucleus is classified as a Seyfert 2 galaxy. The XMM-Newton data have allowed us to perform a detailed X-ray imaging and spectral analysis of this system. We clearly detect, for the first time in this system, a strong EW ~ 1.4 keV Fe emission line at 6.49+/-0.1 keV (rest-frame). The X-ray spectrum requires a soft thermal component (kT~0.9 keV; L(0.5-2) ~ 4E41 cgs), likely associated with the starburst, and a hard power-law continuum above 2 keV (observed L(2-10) ~ 4E42 cgs). We confirm the flatness of this latter component, already noted in previous ASCA data. This flatness, together with the detection of the strong Fe-Kalpha line and other broad band indicators, suggest the presence of a Compton-thick AGN with intrinsic luminosity > 1E44 cgs. We show that a Compton-thick model can perfectly reproduce the X-ray spectral properties of this object.Comment: 6 pages, 4 figures, Latex manuscript, Accepted for publication in Astronomy and Astrophysic

Going Conservative or Conventional? Investigating Farm Management Strategies in between Economic and Environmental Sustainability in Southern Italy

The European “Green Deal” strategy is aimed at making Europe the first climate-neutral continent by 2050 through integrated actions relying on healthier agricultural systems grounded in (environmental and economic) sustainable practices, including soil carbon management and biodiversity enhancement. In this vein, the present study contrasts the economic-environmental performances of conventional (deep tillage) and conservative (no-tillage and soil ripping) practices for two varieties of durum wheat (Triticum turgidum spp. durum), namely a modern (Anco Marzio) and an ancient landrace (Saragolla Lucana) variety in the Basilicata region (Southern Italy). Field and laboratory analysis (granulometry, mineralogy, and geochemistry) as well as satellite data (RapidEye) were used to characterize the soil and vegetation patterns. The empirical results indicate a higher biomass production and vegetative potential together with higher grain yields in soils managed with conventional deep tillage compared with soil managed with conservative practices. Similarly, the modern wheat variety exhibited better performance with respect to the old landrace. The soils managed with conventional practices had a distribution of exchangeable macro-nutrients characterized by a reduction in Ca+ and an increase in Mg2+ and K+ between pre-sowing and post-harvesting. Such a distribution was also genotype-dependent, with a higher variability for Saragolla Lucana than Anco Marzio, showing a diverging adsorption of macro-elements between the modern and ancient landrace varieties

Modeling Spatio-Temporal Divergence in Land Vulnerability to Desertification with Local Regressions

Taken as a classical issue in applied economics, the notion of ‘convergence’ is based on the concept of path dependence, i.e., from the previous trajectory undertaken by the system during its recent history. Going beyond social science, a ‘convergence’ perspective has been more recently adopted in environmental studies. Spatial convergence in non-linear processes, such as desertification risk, is a meaningful notion since desertification represents a (possibly unsustainable) development trajectory of socio-ecological systems towards land degradation on a regional or local scale. In this study, we test—in line with the classical convergence approach—long-term equilibrium conditions in the evolution of desertification processes in Italy, a European country with significant socioeconomic and environmental disparities. Assuming a path-dependent development of desertification risk in Italy, we provided a diachronic analysis of the Environmental Sensitive Area Index (ESAI), estimated at a disaggregated spatial resolution at three times (1960s, 1990s, and 2010s) in the recent history of Italy, using a spatially explicit approach based on geographically weighted regressions (GWRs). The results of local regressions show a significant path dependence in the first time interval (1960–1990). A less significant evidence for path-dependence was observed for the second period (1990–2010); in both cases, the models’ goodness-of-fit (global adjusted R2) was satisfactory. A strong polarization along the latitudinal gradient characterized the first observation period: Southern Italian land experienced worse conditions (e.g., climate aridity, urbanization) and the level of land vulnerability in Northern Italy remained quite stable, alimenting the traditional divergence in desertification risk characteristic of the country. The empirical analysis delineated a more complex picture for the second period. Convergence (leading to stability, or even improvement, of desertification risk) in some areas of Southern Italy, and a more evident divergence (leading to worse environmental conditions because of urban sprawl and crop intensification) in some of the land of Northern Italy, were observed, leading to an undesired spatial homogenization toward higher vulnerability levels. Finally, this work suggests the importance of spatially explicit approaches providing relevant information to design more effective policy strategies. In the case of land vulnerability to degradation in Italy, local regression models oriented toward a ‘convergence’ perspective, may be adopted to uncover the genesis of desertification hotspots at both the regional and local scale

A strong excess in the 20-100 keV emission of NGC 1365

We present a new Suzaku observation of the obscured AGN in NGC 1365, revealing an unexpected excess of X-rays above 20 keV of at least a factor ~2 with respect to the extrapolation of the best-fitting 3-10 keV model. Additional Swift-BAT and Integral-IBIS observations show that the 20-100 keV is concentrated within ~1.5 arcmin from the center of the galaxy, and is not significantly variable on time scales from days to years. A comparison of this component with the 3-10 keV emission, which is characterized by a rapidly variable absorption, suggests a complex structure of the circumnuclear medium, consisting of at least two distinct components with rather different physical properties, one of which covering >80% of the source with a column density NH~3-4x10^24 cm^(-2). An alternative explanation is the presence of a double active nucleus in the center of NGC 1365.Comment: 13 pages, 3 figures. Accepted for publication in ApJ Letter

Therapeutic approach in glioblastoma multiforme with primitive neuroectodermal tumor components: case report and review of the literature

Glioblastoma multiforme (GBM) is the most common and aggressive malignant glioma that is treated with first-line therapy, using surgical resection followed by local radiotherapy and concomitant/adjuvant temozolomide (TMZ) treatment. GBM is characterised by a high local recurrence rate and a low response to therapy. Primitive neuroectodermal tumour (PNET) of the brain revealed a low local recurrence rate; however, it also exhibited a high risk of cerebrospinal fluid (CSF) dissemination. PNET is treated with surgery followed by craniospinal irradiation (CSI) and platinum-based chemotherapy in order to prevent CSF dissemination. GBM with PNET-like components (GBM/PNET) is an emerging variant of GBM, characterised by a PNET-like clinical behaviour with an increased risk of CSF dissemination; it also may benefit from platinum-based chemotherapy upfront or following failure of GBM therapy. The results presented regarding the management of GBM/PNET are based on case reports or case series, so a standard therapeutic approach for GBM/PNET is not defined, constituing a challenging diagnostic and therapeutic dilemma. In this report, a case of a recurrent GBM/PNET treated with surgical resection and radiochemotherapy as Stupp protocol, and successive platinum-based chemotherapy due to the development of leptomeningeal dissemintation and an extracranial metastasis, is discussed. A review of the main papers regarding this rare GBM variant and its therapeutic approach are also reported. In conclusion, GBM/PNET should be treated with a multimodal approach including surgery, chemoradiotherapy, and/or the early introduction of CSI and platinum-based chemotherapy upfront or at recurrence

Delineating the Intrinsic, Long-Term Path of Land Degradation: A Spatially Explicit Transition Matrix for Italy, 1960–2010

Vulnerability to land degradation in southern Europe has increased substantially in the last decades because of climate and land-use change, soil deterioration, and rising human pressure. The present work focuses on a quantitative evaluation of changes over time in the level of vulnerability to land degradation of a Mediterranean country (Italy) using a composite indicator, the environmentally sensitive area index (ESAI), which is the final outcome of a complex model conceived to assess land vulnerability on the basis of climate, soil, vegetation, and human pressure. Considering four different levels of vulnerability to land degradation (not affected, potentially affected, fragile, and critical), the main trajectories of this index were highlighted in a long-time perspective (1960–2010), discriminating dynamics over two sub-periods (1960–1990 and 1990–2010). The empirical results at a very detailed spatial scale (1 km2 grid) reflect spatial consolidation of degradation hot-spots over time. However, aggregated trajectories of change indicate an overall improvement in the environmental conditions between 1990 and 2010 compared with what is observed during the first period (1960–1990). Worse environmental conditions concerned southern Italian regions with a dry climate and poor soil conditions in the first time interval, large parts of northern Italy, traditionally recognized as a wet and affluent agricultural region, experienced increasing levels of land vulnerability in the second time interval. Being classified as an unaffected region according with the Italian national action plan (NAP), the expansion of (originally sparse) degradation hot-spots in northern Italy, reflective of an overall increase in critical areas, suggests a substantial re-thinking of the Italian NAP. This may lead to a redesign of individual regional action plans (RAPs) implementing place-specific approaches and comprehensive measures to be adopted to mitigate land degradation