Electron-positron energy deposition rate from neutrino pair annihilation in the equatorial plane of rapidly rotating neutron and quark stars

The neutrino-antineutrino annihilation into electron-positron pairs near the surface of compact general relativistic stars could play an important role in supernova explosions, neutron star collapse, or for close neutron star binaries near their last stable orbit. General relativistic effects increase the energy deposition rates due to the annihilation process. We investigate the deposition of energy and momentum due to the annihilations of neutrinos and antineutrinos in the equatorial plane of the rapidly rotating neutron and quark stars, respectively. We analyze the influence of general relativistic effects, and we obtain the general relativistic corrections to the energy and momentum deposition rates for arbitrary stationary and axisymmetric space-times. We obtain the energy and momentum deposition rates for several classes of rapidly rotating neutron stars, described by different equations of state of the neutron matter, and for quark stars, described by the MIT bag model equation of state and in the CFL (Color-Flavor-Locked) phase, respectively. Compared to the Newtonian calculations, rotation and general relativistic effects increase the total annihilation rate measured by an observer at infinity. The differences in the equations of state for neutron and quark matter also have important effects on the spatial distribution of the energy deposition rate by neutrino-antineutrino annihilation.Comment: 29 pages, 6 figures, accepted for publication in MNRA

The State of the Circumstellar Medium Surrounding Gamma-Ray Burst Sources and its Effect on the Afterglow Appearance

We present a numerical investigation of the contribution of the presupernova ejecta of Wolf-Rayet stars to the environment surrounding gamma-ray bursts (GRBs), and describe how this external matter can affect the observable afterglow characteristics. An implicit hydrodynamic calculation for massive stellar evolution is used here to provide the inner boundary conditions for an explicit hydrodynamical code to model the circumstellar gas dynamics. The resulting properties of the circumstellar medium are then used to calculate the deceleration of a relativistic, gas-dynamic jet and the corresponding afterglow light curve produced as the shock wave propagates through the shocked-wind medium. We find that variations in the stellar wind drive instabilities that may produce radial filaments in the shocked-wind region. These comet-like tails of clumps could give rise to strong temporal variations in the early afterglow lightcurve. Afterglows may be expected to differ widely among themselves, depending on the angular anisotropy of the jet and the properties of the stellar progenitor; a wide diversity of behaviors may be the rule, rather than the exception.Comment: 17 pages, 7 figures, ApJ in pres

Gamma-Ray Bursts via the Neutrino Emission from Heated Neutron Stars

A model is proposed for gamma-ray bursts based upon a neutrino burst of about 10^52 ergs lasting a few seconds above a heated collapsing neutron star. This type of thermal neutrino burst is suggested by relativistic hydrodynamic studies of the compression, heating, and collapse of close binary neutron stars as they approach their last stable orbit, but may arise from other sources as well. We present a hydrodynamic simulation of the formation and evolution of the pair plasma associated with such a neutrino burst. This pair plasma leads to the production of ~10^51 - 10^52 ergs in gamma-rays with spectral and temporal properties consistent with observed gamma-ray bursts.Comment: Final version. 30 pages, 10 figures, 6 tables, accepted for publication in The Astrophysical Journa

Spectral Lags and the Lag-Luminosity Relation: An Investigation with Swift BAT Gamma-ray Bursts

Spectral lag, the time difference between the arrival of high-energy and low-energy photons, is a common feature in Gamma-ray Bursts (GRBs). Norris et al. 2000 reported a correlation between the spectral lag and the isotropic peak luminosity of GRBs based on a limited sample. More recently, a number of authors have provided further support for this correlation using arbitrary energy bands of various instruments. In this paper we report on a systematic extraction of spectral lags based on the largest Swift sample to date of 31 GRBs with measured redshifts. We extracted the spectral lags for all combinations of the standard Swift hard x-ray energy bands: 15-25 keV, 25-50 keV, 50-100 keV and 100-200 keV and plotted the time dilation corrected lag as a function of isotropic peak luminosity. The mean value of the correlation coefficient for various channel combinations is -0.68 with a chance probability of ~ 0.7 x 10^{-3}. In addition, the mean value of the power-law index is 1.4 +/- 0.3. Hence, our study lends support for the existence of a lag-luminosity correlation, albeit with large scatter.Comment: 19 Pages, 11 Figures and 5 Tables; Accepted to The Astrophysical Journa

Lorentz Violation of Quantum Gravity

A quantum gravity theory which becomes renormalizable at short distances due to a spontaneous symmetry breaking of Lorentz invariance and diffeomorphism invariance is studied. A breaking of Lorentz invariance with the breaking patterns $SO(3,1)\to O(3)$ and $SO(3,1)\to O(2)$, describing 3+1 and 2+1 quantum gravity, respectively, is proposed. A complex time dependent Schr\"odinger equation (generalized Wheeler-DeWitt equation) for the wave function of the universe exists in the spontaneously broken symmetry phase at Planck energy and in the early universe, uniting quantum mechanics and general relativity. An explanation of the second law of thermodynamics and the spontaneous creation of matter in the early universe can be obtained in the symmetry broken phase of gravity.Comment: 10 pages, minor change and reference added. Typos corrected. To be published in Class. Quant. Grav

European Medicines Agency review of ixazomib (Ninlaro) for the treatment of adult patients with multiple myeloma who have received at least one prior therapy

On 21 November 2016, the European Commission issued a marketing authorisation valid throughout the European Union for ixazomib in combination with lenalidomide and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. Ixazomib was evaluated in one, randomised, double-blind, phase III study comparing ixazomib plus lenalidomide and dexamethasone (n=360; ixazomib arm) versus placebo plus lenalidomide and dexamethasone (n=362; placebo arm) in adult patients with relapsed and/or refractory multiple myeloma who had received at least one prior therapy. The median progression-free survival (PFS) in the intent-to-treat population was 20.6 months in patients treated with ixazomib compared with 14.7 months for patients in the placebo arm (stratified HR=0.742, 95% CI 0.587 to 0.939, stratified p-value=0.012). The most frequently reported adverse reactions (≥20%) within the ixazomib and placebo arms were diarrhoea (42% vs 36%), constipation (34% vs 25%), thrombocytopaenia (28% vs 14%), peripheral neuropathy (28% vs 21%), nausea (26% vs 21%), peripheral oedema (25% vs 18%), vomiting (22% vs 11%) and back pain (21% vs 16%). The scientific review concluded that the gain in PFS of 5.9 months observed with ixazomib was considered clinically meaningful. Concerning the possible uncertainty about the magnitude of the effect, this uncertainty was acceptable given the favourable toxicity profile, and considering that ixazomib is the first agent to allow oral triple combination therapy in this patient population which represents a therapeutic innovation in terms of convenience for patients. Therefore, the benefit-risk for ixazomib in combination with lenalidomide and dexamethasone was considered positive, although the efficacy evidence was not as comprehensive as normally required

Correlations Between Lag, Luminosity, and Duration in Gamma-ray Burst Pulses

We derive a new peak lag vs. peak luminosity relation in gamma-ray burst (GRB) pulses. We demonstrate conclusively that GRB spectral lags are pulse rather than burst properties and show how the lag vs. luminosity relation determined from CCF measurements of burst properties is essentially just a rough measure of this newly derived relation for individual pulses. We further show that most GRB pulses have correlated properties: short-lag pulses have shorter durations, are more luminous, and are harder within a burst than long-lag pulses. We also uncover a new pulse duration vs. pulse peak luminosity relation, and indicate that long-lag pulses often precede short-lag pulses. Although most pulse behaviors are supportive of internal shocks (including long-lag pulses), we identify some pulse shapes that could result from external shocks.Comment: 14 pages, 4 figures, 1 table; accepted for publication in Astrophysical Journal Letter

A Detailed Study on the Equal Arrival Time Surface Effect in Gamma-Ray Burst Afterglows

Due to the relativistic motion of gamma-ray burst remnant and its deceleration in the circumburst medium, the equal arrival time surfaces at any moment are not spherical, but should be distorted ellipsoids. This will leave some imprints in the afterglows. In this article, we study the effect of equal arrival time surfaces numerically under various conditions, i.e., for isotropic fireballs, collimated jets, density jump conditions, and energy injection events. For each condition, direct comparison between the two instances when the effect is and is not included, is presented. For isotropic fireballs and jets viewed on axis, the effect slightly hardens the spectra and postpones the peak time of afterglows, but does not change the shapes of the spectra and light curves significantly. In the cases when a density jump or an energy injection is involved, the effect smears the variability of the afterglows markedly.Comment: Accepted for publication in: Chin. J. Astron. Astrophys., 15 pages, 8 embedded eps figure

Jet Precession Driven by Neutrino-Cooled Disc for Gamma-Ray Bursts

A model of jet precession driven by a neutrino-cooled disc around a spinning black hole is present in order to explain the temporal structure and spectral evolution of gamma-ray bursts (GRBs). The differential rotation of the outer part of a neutrino dominated accretion disc may result in precession of the inner part of the disc and the central black hole, hence drives a precessed jet via neutrino annihilation around the inner part of the disc. Both analytic and numeric results for our model are present. Our calculations show that a black hole-accretion disk system with black hole mass $M \simeq 3.66 M_\odot$, accretion rate $\dot{M} \simeq 0.54 M_\odot \rm s^{-1}$, spin parameter $a=0.9$ and viscosity parameter $\alpha=0.01$ may drive a precessed jet with period P=1 s and luminosity $L=10^{51}$ erg s$^{-1}$, corresponding to the scenario for long GRBs. A precessed jet with $P=0.1$s and $L=10^{50}$ erg s$^{-1}$ may be powered by a system with $M \simeq 5.59 M_\odot$, $\dot{M} \simeq 0.74 M_\odot \rm s^{-1}$, $a=0.1$, and $\alpha=0.01$, possibly being responsible for the short GRBs. Both the temporal and spectral evolution in GRB pulse may explained with our model. GRB central engines likely power a precessed jet driven by a neutrino-cooled disc. The global GRB lightcurves thus could be modulated by the jet precession during the accretion timescale of the GRB central engine. Both the temporal and spectral evolution in GRB pulse may be due to an viewing effect due to the jet precession.Comment: 5 pages, 4 figures, accepted for publication in Astronomy and Astrophysic

Structured frameworks to increase the transparency of the assessment of benefits and risks of medicines: current status and possible future directions

Structured frameworks for benefit-risk analysis in drug licensing decisions are being implemented across a number of regulatory agencies worldwide. The aim of these frameworks is to aid the analysis and communication of the benefit-risk assessment throughout the development, evaluation, and supervision of medicines. In this review, authors from regulatory agencies, pharmaceutical companies, and academia share their views on the different frameworks and discuss future directions