Mutated N-ras does not induce p19arf in CO25 cell line

The mouse cell line (CO25) used in this study was transfected with a glucocorticoid inducible mutated human N-ras oncogene under transcriptional control of the steroid-sensitive promoter of the mouse mammary tumors virus long terminal repeat MMTV-LTR. This study was aimed to investigate the expression of p19arf and MDM2 genes under the effect of N-ras oncogene induction and to invent the role of p19arf, MDM2 in N-ras pathway during various periods (12, 24, 48, 72, 96 h) using western blotting method. The levels of â-actin proteins in the same periods were our control group. The observations showed no increase of p19arf protein expression in normal, cancer and differentiated CO25 cells. MDM2 was accumulated until 72 h and after 96 h, it showed a dramatical decrease while β-actin levels were increased correlated to the volume of protein loaded to the gel. Because of the role of p19arf as tumor suppressor and p53-MDM2 linker, it is highly recommended to  investigate the relationship between N-ras and p53 and MDM2 in the same system to recognize the molecule that may play a linker molecule between p53 and MDM2 in p19arf lack system.Key words: Oncogene, N-ras, p19arf, myoblast, CO25 cells, differentiation, MDM2

Characterization of absorption loss for UWB body tissue propagation model

The paper presents the results of absorption loss for body tissue propagation model which is characterized by the specific absorption rate (SAR) investigated on heterogeneous normal and tumour affected tissues of numerical human breast models. The absorption loss is evaluated using UWB signals of 4 to 8 GHz. The analysis of the study shows that the absorption loss in the body tissue models increases with frequency and varies with the change in dielectric properties of body tissue models. Deviation of absorption loss up to 0.9 dB is observed in tumour affected model compared to normal model

A UWB imaging system to detect early breast cancer in heterogeneous breast phantom

This paper presents an experimental early breast cancer detection system in terms of heterogeneous breast phantom. The system consists of commercial Ultrawide-Band (UWB) transceivers and our developed Neural Network (NN) based Pattern Recognition (PR) software for imaging. A simple way to construct cancer- tissue and heterogeneous breast phantom using available low cost materials and their mixtures is also proposed here. The materials are: (i) A mixture of petroleum jelly, soy oil, wheat flour and water as heterogeneous tissue; (ii) A particular glass as skin; and (iii) A specific mixture of water and wheat flour as cancer- tissue. All the materials and their mixtures are considered according to the ratio of the dielectric properties of the breast tissues. To experimentally detect cancer, the UWB signals are transmitted from one side of the breast phantom and received from opposite side diagonally. By using discrete cosine transform (DCT) of the received signals, a Neural Network (NN) is trained, tested and interfaced with the UWB transceiver to form the complete system. The achieved detection rate of cancer cell's existence, size and location are approximately 100%, 93.1% and 93.3% respectively

Why do Saudi Nurses Leave Bedside Nursing: Findings from a Pilot Study

Aim: To explore the salient factors that account for Saudi nurses leaving bedside nursing to work in other fields of nursing.   Method: A non-experimental descriptive quantitative design was used to answer the research question of this pilot study. A valid and reliable questionnaire was used as an instrument for data collection. A snowball / purposive sample was used to collect the data from 46 Saudi nurses who had left bedside nursing in three hospitals in the Aseer region in southwest of Saudi Arabia. Data were analyzed by a professional statistician using descriptive statistics.   Findings: The salient factors for Saudi nurses’ decision to leave bedside nursing that were identified included: income (including allowances and financial incentives), administrative regulations, job satisfaction, and other miscellaneous factors   Conclusion: Although this pilot study has several limitations, the findings indicate that health care planners and policy staff, and nursing leaders in the Kingdom of Saudi Arabia need to develop strategies to address the issues expressed by Saudi nurses in regard to bedside nursing, particularly the need to improve (a) financial allowances and incentive systems, (b) the bedside work environment (e.g., by decreasing weekly working hours), and (c) the image of bedside Saudi nurses in the eyes of Saudi society.   Keywords: Saudi Nurses, Pilot Study, Bedside Nursing &nbsp

Synergistic Effects Of Multidisciplinary Healthcare Approaches On Patient Care Quality In Hospital: A Meta-Analysis

The research conducts a meta-analysis to explore the effects of multidisciplinary healthcare approaches on patient care quality in hospitals. It includes a comprehensive review of literature on public health initiatives, nursing care, medical devices, and more, emphasizing their impact on patient outcomes. The methodology involves analyzing peer-reviewed articles to assess the impact of these approaches. Results show significant improvements in patient care quality, emphasizing the benefits of team-based, coordinated, comprehensive, and patient-centered care. The discussion highlights the synergy between different care components and the need for strategic planning to address resource allocation and information overload. Recommendations are provided for healthcare practitioners, policymakers, and future research, focusing on enhancing collaboration, continuous education, supportive policies, and resource allocation. The conclusion underscores the importance of multidisciplinary strategies in improving patient care quality and outcomes, advocating for a shift towards integrated team-based care

3D experimental detection and discrimination of malignant and benign breast tumor using NN-based UWB imaging system

This paper presents both simulation and experimental study to detect and locate breast tumors along with their classification as malignant and/or benign in three dimensional (3D) breast model. The contrast between the dielectric properties of these two tumor types is the main key. These dielectric properties are mainly controlled by the water and blood content of tumors. For simulation, electromagnetic simulator software is used. The experiment is conducted using commercial Ultrawide-Band (UWB) transceivers, Neural Network (NN) based Pattern Recognition (PR) software for imaging and homogenous breast phantom. The 3D homogeneous breast phantom and tumors are fabricated using pure petroleum jelly and a mixture of wheat flour and water respectively. The simulation and experimental setups are performed by transmitting the UWB signals from one side of the breast model and receiving from opposite side diagonally. Using discrete cosine transform (DCT) of received signals, we have trained and tested the developed experimental Neural Network model. In 3D breast model, the achieved detection accuracy of tumor existence is around 100%, while the locating accuracy in terms of (x, y, z) position of a tumor within the breast reached approximately 89.2% and 86.6% in simulation and experimental works respectively. For classification, the permittivity and conductivity detection accuracy are 98.0% and 99.1% in simulation, and 98.6% and 99.5% in experimental works respectively. Tumor detection and type specification 3D may lead to successful clinical implementation followed by saving of precious human lives in the near future

Prevalence and correlates of diastolic dysfunction in patients with hypertension: a cross-sectional study from in The Kingdom of Saudi Arabia

Introduction: diastolic dysfunction refers to impaired ventricular relaxation or filling regardless of ejection fraction and symptoms. It accounts for 8% and 25% in the hospitalized and general population, respectively. The present study was conducted to determine the prevalence and correlates of diastolic dysfunction in hypertensive patients living in Saudi Arabia. Methods: a multicentric, cross-sectional study was conducted from February 2019 to February 2020 at King Khalid Hospital and Prince Sultan Center for Health Services, Prince Sattam Bin Abdulaziz University hospital in Al Kharj, and Al Kharj Military Industries Corporation hospital, KSA. All patients with hypertension who underwent an echocardiography were included in the study. Logistic regression analysis was performed to determine factors associated with left ventricular diastolic dysfunction (LVDD). Results: the study included a total of 104 participants, where 51.9% were females andthe mean age of the patients was 48.01±12.81 years.Most patients had an abnormal echocardiography finding (64.4%, n = 67). The most common abnormalities were left ventricular (LV) hypertrophy (44.2%, n = 46), and diastolic dysfunction, (35.6%, n = 37). The study revealed that age (aOR: 6.1, 95% CI 1.17-31.3; p = 0.032) and dyslipidemia (aOR: 3.45, 95% CI 1.16-10.24; p = 0.026) have significant association with LVDD in the patients with hypertension. Conclusion: in conclusion, diastolic dysfunction is prevalent among older hypertensive patients and those with dyslipidaemia. Age and dyslipidaemia were non-modifiable and modifiable factors associated with LVDD in hypertensive patients, respectively

CAUSES AND MANAGEMENT OF VIRAL EYE INFECTION

Introduction: The eye is a fascinating organ for several reasons. It is not only have a composite structure, however it is considered an immune-privileged organ. The anatomy of the eye is composed of the anterior and posterior parts, the line of division is posterior to the lens. The anterior chamber lies within the anterior segment and is an immuneprivileged anatomical location, this is due to the fact that the T-cell response in this area is suppressed This protects the eye from potentially destructive immune attacks however it also makes defence against infectious agents challenging, particularly where T-cell responses are critical for immunological defence. Viruses could get into the eye by direct inoculation, or through haematogenous or neuronal spread. The diagnoses of viral eye infections are usually clinical one, helped by taking a thorough history and performing ophthalmic examination. But in challenging cases the lab tests are essential. In this review, we will discuss the most recent evidence regarding Causes and management of viral eye infection Aim of work: In this review, we will discuss the most recent evidence regarding Causes and management of viral eye infection Methodology: We did a systematic search for Causes and management of viral eye infection using PubMed search engine (http://www.ncbi.nlm.nih.gov/) and Google Scholar search engine (https://scholar.google.com). All relevant studies were retrieved and discussed. We only included full articles. Conclusions: A wide range of of viruses can affect the eye and cause viral eye infections, either as a primary infection or reactivation. Some affect the eye directly while the others indirectly but may still manifest with eye disease. One virus may affect several parts of the eye, while different viruses may cause the same eye disease. This could complicate the clinical diagnosis of viral eye disease, but the lab tests like PCR and antibody tests could assist in challenging cases where there may be diagnostic dilemma. The HIV epidemic has had an huge impact on ophthalmology clinics, this is because the virus can cause different eye diseases, and the associated decrease in cell-mediated immunity makes the person highly susceptible to opportunistic viral eye infections, sometimes with severe morbidity. There could be other viruses that may affect the eye that we did not discuss. Key words: Causes, management, viral eye infection

Structural and electrochemical studies of proton conducting biopolymer blend electrolytes based on MC:Dextran for EDLC device application with high energy density

This study shows preparation and characterization of solid biopolymer electrolyte based on glycerolized methylcellulose (MC): dextran-doped with ammonium thiocyanate (NH4SCN). The nature of electrolyte composition in terms of interaction is characterized using Fourier transform infrared (FTIR) technique. Lowering and shifting in the intensity of the bands are observed with increasing the quantity of glycerol as a plasticizer, confirming complexation between electrolyte components. Ion transport parameters are determined using both of the methods of EIS and FTIR where the parameters are found to be increased with glycerol concentration. The transport number measurement indicates that ions are the primary charge carrier in the conduction mechanism where tion is found to be 0.961. The maximum DC ionic conductivity value is achieved that found to be 1.63 � 10�3 S cm�1. The ESR values are ranged from 300 to 580 O throughout 450 cycles. The technique of linear sweep voltammetry (LSV) shows the electrochemical stability window of 2 V for the conducting samples. The response of cyclic voltammetry (CV) shows an almost rectangular shape without Faradaic peaks. A galvanostatic charge–discharge investigation has shown the initial specific capacitance, energy density, and power density are 133 F g�1, 18.3 Wh Kg�1, and 680 W Kg�1, respectively

Impact Of Bariatric Surgery on Gastroesophageal Reflux Disease: A Cross-Sectional Study

Objective: To assess the occurrence of GERD after bariatric surgery and surgery impact on GERD. Methods: This research employs a cross-sectional study design to investigate the impact of bariatric surgery on Gastroesophageal Reflux Disease (GERD) among individuals who have undergone various types of bariatric surgeries. Results: The study included 302 participants. The most frequent weight among them was more than 96 kg (n= 130, 43%) followed by 76-85 kg (n= 51, 16.9%). The most frequent height among study participants was 1.61-1.70 m (n= 100, 33.1%) followed by 1.51-1.60 m (n= 99, 32.8%). The most frequent body mass index (BMI) value among study participants was more than 35 kg/m2 (n= 126, 41.7%) followed by 25-29.9 kg/m2 (n= 67, 22.2%). The most frequent age among study participants was 26-36 years (n= 104, 34.4%) followed by 15-25 years (n= 83, 27.5%). The most frequent gender among study participants was Female (n= 162, 53.6%) followed by Male (n= 140, 46.4%). Participants were asked about the type of obesity surgery. The most frequent was Gastric sleeve (n=222, 73.5%), followed by Gastric bypass (n=33, 10.9%).   Conclusion: Study results showed that most of the study participants are extremely obese according to their BMI. The most common obesity surgery type was a Gastric sleeve followed by a Gastric bypass. The most of participants were a non-smoker. Most of them had weight loss. In addition, most of the study participants had good social connection