Innovations for Hydropower and Other Renewables: Potential Benefits to the Energy-Water Nexus

Hydropower is the largest energy user of water in the U.S., although most of that water use is not consumptive. In 1995, USGS estimated that hydropower annual water uses was 3,160,000 million gallons per day, or about 16 times more than what is used for thermoelectric cooling. Water used in hydroelectric turbines is generally not consumed, but the timing of water releases may be shifted in time relative to natural flows through reservoir storage and release. Hydropower’s regulation of river flows may compete with other water uses or complement them. Advanced hydropower technologies, such as more efficient turbines with improved environmental performance and higher hydraulic capacity, plus optimized project operations, offer substantial opportunities to reduce competition over scarce water resources. Other non-hydropower renewable energy sources also can contribute the challenges facing the energy-water nexus, where those renewables have low water-use intensity and can power water treatment and distribution. Case study examples will be used to illustrate these opportunities

DOE Hydropower Program Biennial Report for FY 2005-2006

SUMMARY The U.S. Department of Energy (DOE) Hydropower Program is part of the Office of Wind and Hydropower Technologies, Office of Energy Efficiency and Renewable Energy. The Program's mission is to conduct research and development (R&D) that will increase the technical, societal, and environmental benefits of hydropower. The Department's Hydropower Program activities are conducted by its national laboratories: Idaho National Laboratory (INL) [formerly Idaho National Engineering and Environmental Laboratory], Oak Ridge National Laboratory (ORNL), Pacific Northwest National Laboratory (PNNL), and National Renewable Energy Laboratory (NREL), and by a number of industry, university, and federal research facilities. Programmatically, DOE Hydropower Program R&D activities are conducted in two areas: Technology Viability and Technology Application. The Technology Viability area has two components: (1) Advanced Hydropower Technology (Large Turbine Field Testing, Water Use Optimization, and Improved Mitigation Practices) and (2) Supporting Research and Testing (Environmental Performance Testing Methods, Computational and Physical Modeling, Instrumentation and Controls, and Environmental Analysis). The Technology Application area also has two components: (1) Systems Integration and Technology Acceptance (Hydro/Wind Integration, National Hydropower Collaborative, and Integration and Communications) and (2) Supporting Engineering and Analysis (Valuation Methods and Assessments and Characterization of Innovative Technology). This report describes the progress of the R&D conducted in FY 2005-2006 under all four program areas. Major accomplishments include the following: Conducted field testing of a Retrofit Aeration System to increase the dissolved oxygen content of water discharged from the turbines of the Osage Project in Missouri. Contributed to the installation and field testing of an advanced, minimum gap runner turbine at the Wanapum Dam project in Washington. Completed a state-of-the-science review of hydropower optimization methods and published reports on alternative operating strategies and opportunities for spill reduction. Carried out feasibility studies of new environmental performance measurements of the new MGR turbine at Wanapum Dam, including measurement of behavioral responses, biomarkers, bioindex testing, and the use of dyes to assess external injuries. Evaluated the benefits of mitigation measures for instream flow releases and the value of surface flow outlets for downstream fish passage. Refined turbulence flow measurement techniques, the computational modeling of unsteady flows, and models of blade strike of fish. Published numerous technical reports, proceedings papers, and peer-reviewed literature, most of which are available on the DOE Hydropower website. Further developed and tested the sensor fish measuring device at hydropower plants in the Columbia River. Data from the sensor fish are coupled with a computational model to yield a more detailed assessment of hydraulic environments in and around dams. Published reports related to the Virtual Hydropower Prospector and the assessment of water energy resources in the U.S. for low head/low power hydroelectric plants. Convened a workshop to consider the environmental and technical issues associated with new hydrokinetic and wave energy technologies. Laboratory and DOE staff participated in numerous workshops, conferences, coordination meetings, planning meetings, implementation meetings, and reviews to transfer the results of DOE-sponsored research to end-users

Inspiratory muscle training reduces blood lactate concentration during volitional hyperpnoea

Although reduced blood lactate concentrations ([lac−]B) have been observed during whole-body exercise following inspiratory muscle training (IMT), it remains unknown whether the inspiratory muscles are the source of at least part of this reduction. To investigate this, we tested the hypothesis that IMT would attenuate the increase in [lac−]B caused by mimicking, at rest, the breathing pattern observed during high-intensity exercise. Twenty-two physically active males were matched for 85% maximal exercise minute ventilation (V˙Emax) and divided equally into an IMT or a control group. Prior to and following a 6 week intervention, participants performed 10 min of volitional hyperpnoea at the breathing pattern commensurate with 85% V˙Emax

Changes in body composition and performance with supplemental HMB-FA+ATP (Manuscript Clarification)

Additional co-authors: Matthew D. Vukovich, Colin Wilborn, and Darryn S. Willoughb

Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerism.

Dogs given nonmyeloablative conditioning and marrow grafts from 2 dog leukocyte antigen (DLA)-identical littermate donors developed stable trichimerism and stably accepted a subsequent kidney graft from one of the marrow donors without the need for immunosuppression. In this study, we used trichimeras to evaluate strategies for adoptive immunotherapy to solid tumors, using the kidney as a tumor surrogate. Three DLA-identical trichimeric recipients were established by simultaneously infusing marrow from 2 DLA-identical donor dogs into a DLA-identical recipient conditioned with 2 Gy of total body irradiation (TBI) and given a short course of postgraft immunosuppression. After stable hematopoietic engraftment was confirmed, a kidney was transplanted from 1 of the 2 marrow donors into each respective trichimeric recipient. Peripheral blood lymphocytes from each kidney donor were then used to sensitize the alternate marrow donor. The trichimeric recipients were given donor lymphocyte infusions (DLIs) from the sensitized dogs and monitored for chimerism, graft-versus-host disease (GVHD), and kidney rejection. After DLI, we observed both prompt rejection of the transplanted marrow and donor kidney and disappearance of corresponding hematopoietic chimerism. Presumably due to shared minor histocompatibility antigens, host chimerism also disappeared, and GVHD in skin, gut, and liver developed. The native kidneys, although exhibiting lymphocytic infiltration, remained functionally normal. This study demonstrates that under certain experimental conditions, the kidney--an organ ordinarily not involved in graft-versus-host reactions--can be targeted by sensitized donor lymphocytes

Synthesis and Assessment Product

This document, part of the Synthesis and Assessment Products described in the U.S. Climate Change Science Program (CCSP) Strategic Plan. Climate affects the design, construction, safety, operations, and maintenance of transportation infrastructure and systems. The prospect of a changing climate raises critical questions regarding how alterations in temperature, precipitation, storm events, and other aspects of the climate could affect the nation's roads, airports, rail, transit systems, pipelines, ports, and waterways. Phase I of this regional assessment of climate change and its potential impacts on transportation systems addresses these questions for the region of the U.S. central Gulf Coast between Galveston, Texas and Mobile, Alabama. This region contains multimodal transportation infrastructure that is critical to regional and national transportation services. Historical trends and future climate scenarios were used to establish a context for examining the potential effects of climate change on all major transportation modes within the region. Climate changes anticipated during the next 50 to 100 years for the central Gulf Coast include warming temperatures, changes in precipitation patterns, and increased storm intensity. The warming of the oceans and decline of polar ice sheets is expected to accelerate the rate of sea level rise globally. The effects of sea level rise in most central Gulf Coast counties will be exacerbated by the sinking of the land surface, which is accounted for in this assessment. The significance of these climate factors for transportation systems was assessed

Chemical crosslinking and mass spectrometry studies of the structure and dynamics of membrane proteins and receptors.

Membrane proteins make up a diverse and important subset of proteins for which structural information is limited. In this study, chemical cross-linking and mass spectrometry were used to explore the structure of the G-protein-coupled photoreceptor bovine rhodopsin in the dark-state conformation. All experiments were performed in rod outer segment membranes using amino acid 'handles' in the native protein sequence and thus minimizing perturbations to the native protein structure. Cysteine and lysine residues were covalently cross-linked using commercially available reagents with a range of linker arm lengths. Following chemical digestion of cross-linked protein, cross-linked peptides were identified by accurate mass measurement using liquid chromatography-fourier transform mass spectrometry and an automated data analysis pipeline. Assignments were confirmed and, if necessary, resolved, by tandem MS. The relative reactivity of lysine residues participating in cross-links was evaluated by labeling with NHS-esters. A distinct pattern of cross-link formation within the C-terminal domain, and between loop I and the C-terminal domain, emerged. Theoretical distances based on cross-linking were compared to inter-atomic distances determined from the energy-minimized X-ray crystal structure and Monte Carlo conformational search procedures. In general, the observed cross-links can be explained by re-positioning participating side-chains without significantly altering backbone structure. One exception, between C3 16 and K325, requires backbone motion to bring the reactive atoms into sufficient proximity for cross-linking. Evidence from other studies suggests that residues around K325 for a region of high backbone mobility. These findings show that cross-linking studies can provide insight into the structural dynamics of membrane proteins in their native environment