A system to integrate unstructured and semistructured information resources: an application in an innovation design process

A system that integrates different tools, from multicriteria analysis and mathematical programming but also cognitive and social psychology, can be proposed to cope with complexities and uncertainties that generate criticality in the socio technical approach. The purpose of this paper is to examine the potentialities of this system, above all in terms of information fusion and use in various contexts, and to propose an application in relation to an industrial project, in order to support the conceptual phase of the design processre

Column generation for minimizing total completion time in a parallel-batching environment

This paper deals with the 1 | p- batch , sj≤ b| ∑ Cj scheduling problem, where jobs are scheduled in batches on a single machine in order to minimize the total completion time. A size is given for each job, such that the total size of each batch cannot exceed a fixed capacity b. A graph-based model is proposed for computing a very effective lower bound based on linear programming; the model, with an exponential number of variables, is solved by column generation and embedded into both a heuristic price and branch algorithm and an exact branch and price algorithm. The same model is able to handle parallel-machine problems like Pm| p- batch , sj≤ b| ∑ Cj very efficiently. Computational results show that the new lower bound strongly dominates the bounds currently available in the literature, and the proposed heuristic algorithm is able to achieve high-quality solutions on large problems in a reasonable computation time. For the single-machine case, the exact branch and price algorithm is able to solve all the tested instances with 30 jobs and a good amount of 40-job examples

Bioorthogonal catalytic activation of Platinum and Ruthenium anticancer complexes by FAD and flavoproteins

Recent advances in bioorthogonal catalysis promise to deliver new chemical tools for performing chemoselective transformations in complex biological environments. Herein, we report how FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), and four flavoproteins act as unconventional photocatalysts capable of converting PtIV and RuII complexes into potentially toxic PtII or RuII-OH2 species. In the presence of electron donors and low doses of visible light, the flavoproteins mini singlet oxygen generator (miniSOG) and NADH oxidase (NOX) catalytically activate PtIV prodrugs with bioorthogonal selectivity. In the presence of NADH, NOX catalyzes PtIV activation in the dark as well, indicating for the first time that flavoenzymes may contribute to initiating the activity of PtIV chemotherapeutic agents

Dynamic origin of chirality transfer between chiral surface and achiral ligand in Au38 clusters

The transfer of chirality between nanomolecules is at the core of several applications in chiral technology such as sensing and catalysis. However, the origin of this phenomenon and how exactly nanoscale objects transfer chirality to molecules in their vicinity remain largely obscure. Here, we show that the transfer of chirality for the intrinsically chiral gold cluster Au38(SR)24 is site dependent; that is, it differs depending on the ligand-binding sites. This is closely related to the dynamic nature of the ligands on the cluster surface. Using a combination of NMR techniques and molecular dynamics simulations, we could assign the four symmetry- unique ligands on the cluster. The study reveals largely different conformational dynamics of the bound ligands, explaining the diverse diastereotopicities observed for the CH2 protons of the ligands. Although chirality is a structural property, our study reveals the importance of dynamics for the transfer of chirality

A Distributed IoT Infrastructure to Test and Deploy Real-Time Demand Response in Smart Grids

© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. In this paper, we present a novel distributed framework for real-time management and co-simulation of demand response (DR) in smart grids. Our solution provides a (near-) real-time co-simulation platform to validate new DR-policies exploiting Internet-of-Things approach performing software-in-the-loop. Hence, the behavior of real-world power systems can be emulated in a very realistic way and different DR-policies can be easily deployed and/or replaced in a plug-and-play fashion, without affecting the rest of the framework. In addition, our solution integrates real Internet-connected smart devices deployed at customer premises and along the smart grid to retrieve energy information and send actuation commands. Thus, the framework is also ready to manage DR in a real-world smart grid. This is demonstrated on a realistic smart grid with a test case DR-policy

Hemina estimula la maduración eritroide, induciendo la vía autofágica

La autofagia es un mecanismo por el cual macromoléculas citosólicas e incluso organelas, son secuestradas en estructuras membranosas y degradadas en los lisosomas. La autofagia ha sido asociada a procesos tan importantes como la diferenciación de algunos tipos celulares, como los reticulocitos, ya que es necesario el remodelamiento y la eliminación de ciertas estructuras internas

A Case of Corticotroph Carcinoma that Caused Multiple Cranial Nerve Palsies, Destructive Petrosal Bone Invasion, and Liver Metastasis

A 52-year-old woman experienced sudden onset of double vision due to a right abducens nerve palsy and was diagnosed as having a pituitary macroadenoma that invaded into the right cavernous sinus. Otherwise, she was asymptomatic despite marked elevation of ACTH (293 pg/ml) and cortisol (24.6 μg/dl) levels. The patient underwent transsphenoidal surgery followed by γ-knife radiosurgery (GKR), which healed the diplopia and ameliorated the hypercortisolemia. The excised tumor was diffusely stained for ACTH with a high (15%) Ki-67 labeling index. Early tumor recurrence occurred twice thereafter, producing right lower cranial nerve palsies with petrosal bone destruction at 8 months and an ipsilateral oculomotor nerve palsy at 12 months after GKR; all palsies resolved completely with the second and third GKRs. Hypercortisolemia worsened rapidly soon after the third GKR, and the patient developed marked weight gain, hypokalemia, and hypertension. Multiple liver lesions were incidentally detected with computer tomography and identified as metastatic pituitary tumor on immunohistochemistry. An ACTH-producing adenoma should be followed carefully for early recurrence and/or metastatic spread when the tumor is an invasive macroadenoma with a high proliferation marker level. The unique aggressive behavior and high potential for malignant transformation of this case are discussed

Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective.

Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and adverse events