Optimal villi density for maximal oxygen uptake in the human placenta

We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a 2D+1D geometry for a wide range of villi densities. For each set of physiological parameters, we observe the existence of an optimal villi density providing a maximal oxygen uptake as a trade-off between the incoming oxygen flow and the absorbing villus surface. The predicted optimal villi density $0.47\pm0.06$ is compatible to previous experimental measurements. Several other ways to experimentally validate the model are also proposed. The proposed stream-tube model can serve as a basis for analyzing the efficiency of human placentas, detecting possible pathologies and diagnosing placental health risks for newborns by using routine histology sections collected after birth

Gamma-ray burst jet propagation, development of angular structure, and the luminosity function

The fate and observable properties of gamma-ray burst jets depend crucially on their interaction with the progenitor material that surrounds the central engine. We present a semi-analytical model of such interaction, which builds upon several previous analytical and numerical works, aimed at predicting the angular distribution of jet and cocoon energy and Lorentz factor after breakout, given the properties of the ambient material and of the jet at launch. Using this model, we construct synthetic populations of structured jets, assuming either a collapsar (for long gamma-ray bursts -- LGRBs) or a binary neutron star merger (for short gamma-ray bursts -- SGRBs) as progenitor. We assume all progenitors to be identical, and we allow little variability in the jet properties at launch: our populations therefore feature a quasi-universal structure. These populations are able to reproduce the main features of the observed LGRB and SGRB luminosity functions, although several uncertainties and caveats remain to be addressed.Comment: 15 pages, 12 figures. Revised version, submitted to A&A (several new figures and expanded discussion. Conclusions unchanged). Comments and suggestions are welcome

Electromagnetic counterparts of black hole-neutron star mergers: dependence on the neutron star properties

Detections of gravitational waves (GWs) may soon uncover the signal from the coalescence of a black hole - neutron star (BHNS) binary, that is expected to be accompanied by an electromagnetic (EM) signal. In this paper, we present a composite semi-analytical model to predict the properties of the expected EM counterpart from BHNS mergers, focusing on the kilonova emission and on the gamma-ray burst afterglow. Four main parameters rule the properties of the EM emission: the NS mass $M_\mathrm{NS}$, its tidal deformability $\Lambda_\mathrm{NS}$, the BH mass and spin. Only for certain combinations of these parameters an EM counterpart is produced. Here we explore the parameter space, and construct light curves, analysing the dependence of the EM emission on the NS mass and tidal deformability. Exploring the NS parameter space limiting to $M_\mathrm{NS}-\Lambda_\mathrm{NS}$ pairs described by a physically motivated equations of state (EoS), we find that the brightest EM counterparts are produced in binaries with low mass NSs (fixing the BH properties and the EoS). Using constraints on the NS EoS from GW170817, our modeling shows that the emission falls in a narrow range of absolute magnitudes. Within the range of explored parameters, light curves and peak times are not dissimilar to those from NSNS mergers, except in the B band. The lack of an hyper/supra-massive NS in BHNS coalescences causes a dimming of the blue kilonova emission in absence of the neutrino interaction with the ejecta.Comment: 22 pages, 20 figures. Accepted for publication on EPJA, in Topical Issue "First joint gravitational wave and electromagnetic observations: Implications for nuclear and particle physics

Spectroscopic identification of r-process nucleosynthesis in a double neutron-star merger.

The merger of two neutron stars is predicted to give rise to three major detectable phenomena: a short burst of γ-rays, a gravitational-wave signal, and a transient optical-near-infrared source powered by the synthesis of large amounts of very heavy elements via rapid neutron capture (the r-process). Such transients, named 'macronovae' or 'kilonovae', are believed to be centres of production of rare elements such as gold and platinum. The most compelling evidence so far for a kilonova was a very faint near-infrared rebrightening in the afterglow of a short γ-ray burst at redshift z = 0.356, although findings indicating bluer events have been reported. Here we report the spectral identification and describe the physical properties of a bright kilonova associated with the gravitational-wave source GW170817 and γ-ray burst GRB 170817A associated with a galaxy at a distance of 40 megaparsecs from Earth. Using a series of spectra from ground-based observatories covering the wavelength range from the ultraviolet to the near-infrared, we find that the kilonova is characterized by rapidly expanding ejecta with spectral features similar to those predicted by current models. The ejecta is optically thick early on, with a velocity of about 0.2 times light speed, and reaches a radius of about 50 astronomical units in only 1.5 days. As the ejecta expands, broad absorption-like lines appear on the spectral continuum, indicating atomic species produced by nucleosynthesis that occurs in the post-merger fast-moving dynamical ejecta and in two slower (0.05 times light speed) wind regions. Comparison with spectral models suggests that the merger ejected 0.03 to 0.05 solar masses of material, including high-opacity lanthanides

Target of Opportunity Observations of Gravitational Wave Events with LSST

The discovery of the electromagnetic counterparts to the binary neutron star merger GW170817 has opened the era of GW+EM multi-messenger astronomy. Exploiting this breakthrough requires increasing samples to explore the diversity of kilonova behaviour and provide more stringent constraints on the Hubble constant, and tests of fundamental physics. LSST can play a key role in this field in the 2020s, when the gravitational wave detector network is expected to detect higher rates of merger events involving neutron stars ($\sim$10s per year) out to distances of several hundred Mpc. Here we propose comprehensive target-of-opportunity (ToOs) strategies for follow-up of gravitational-wave sources that will make LSST the premiere machine for discovery and early characterization for neutron star mergers and other gravitational-wave sources.Comment: White paper for LSST cadence optimization- ToO

The brightest GRB ever detected: GRB 221009A as a highly luminous event at z = 0.151

Context: The extreme luminosity of gamma-ray bursts (GRBs) makes them powerful beacons for studies of the distant Universe. The most luminous bursts are typically detected at moderate/high redshift, where the volume for seeing such rare events is maximized and the star-formation activity is greater than at z = 0. For distant events, not all observations are feasible, such as at TeV energies. Aims: Here we present a spectroscopic redshift measurement for the exceptional GRB 221009A, the brightest GRB observed to date with emission extending well into the TeV regime. Methods: We used the X-shooter spectrograph at the ESO Very Large Telescope (VLT) to obtain simultaneous optical to near-IR spectroscopy of the burst afterglow 0.5 days after the explosion. Results: The spectra exhibit both absorption and emission lines from material in a host galaxy at z = 0.151. Thus GRB 221009A was a relatively nearby burst with a luminosity distance of 745 Mpc. Its host galaxy properties (star-formation rate and metallicity) are consistent with those of LGRB hosts at low redshift. This redshift measurement yields information on the energy of the burst. The inferred isotropic energy release, $E_{\rm iso} > 5 \times 10^{54}$ erg, lies at the high end of the distribution, making GRB 221009A one of the nearest and also most energetic GRBs observed to date. We estimate that such a combination (nearby as well as intrinsically bright) occurs between once every few decades to once per millennium.Comment: 9 pages, 4 figures, submitted to Astronomy & Astrophysic

The Association between Intrauterine Inflammation and Spontaneous Vaginal Delivery at Term: A Cross-Sectional Study

BACKGROUND:Different factors contribute to the onset of labor at term. In animal models onset of labor is characterized by an inflammatory response. The role of intrauterine inflammation, although implicated in preterm birth, is not yet established in human term labor. We hypothesized that intrauterine inflammation at term is associated with spontaneous onset of labor. METHODS/RESULTS:In two large urban hospitals in the Netherlands, a cross-sectional study of spontaneous onset term vaginal deliveries and elective caesarean sections (CS), without signs of labor, was carried out. Placentas and amniotic fluid samples were collected during labor and/or at delivery. Histological signs of placenta inflammation were determined. Amniotic fluid proinflammatory cytokine concentrations were measured using ELISA. A total of 375 women were included. In term vaginal deliveries, more signs of intrauterine inflammation were found than in elective CS: the prevalence of chorioamnionitis was higher (18 vs 4%, p = 0.02) and amniotic fluid concentration of IL-6 was higher (3.1 vs 0.37 ng/mL, p<0.001). Similar results were obtained for IL-8 (10.93 vs 0.96 ng/mL, p<0.001) and percentage of detectable TNF-alpha (50 vs 4%, p<0.001). CONCLUSIONS:This large cross-sectional study shows that spontaneous term delivery is characterized by histopathological signs of placenta inflammation and increased amniotic fluid proinflammatory cytokines

Preterm Birth in Caucasians Is Associated with Coagulation and Inflammation Pathway Gene Variants

Spontaneous preterm birth (<37 weeks gestation—PTB) occurs in ∼12% of pregnancies in the United States, and is the largest contributor to neonatal morbidity and mortality. PTB is a complex disease, potentially induced by several etiologic factors from multiple pathophysiologic pathways. To dissect the genetic risk factors of PTB a large-scale high-throughput candidate gene association study was performed examining 1536 SNP in 130 candidate genes from hypothesized PTB pathways. Maternal and fetal DNA from 370 US Caucasian birth-events (172 cases and 198 controls) was examined. Single locus, haplotype, and multi-locus association analyses were performed separately on maternal and fetal data. For maternal data the strongest associations were found in genes in the complement-coagulation pathway related to decidual hemorrhage in PTB. In this pathway 3 of 6 genes examined had SNPs significantly associated with PTB. These include factor V (FV) that was previously associated with PTB, factor VII (FVII), and tissue plasminogen activator (tPA). The single strongest effect was observed in tPA marker rs879293 with a significant allelic (p = 2.30×10−3) and genotypic association (p = 2.0×10−6) with PTB. The odds ratio (OR) for this SNP was 2.80 [CI 1.77–4.44] for a recessive model. Given that 6 of 8 markers in tPA were statistically significant, sliding window haplotype analyses were performed and revealed an associating 4 marker haplotype in tPA (p = 6.00×10−3). The single strongest effect in fetal DNA was observed in the inflammatory pathway at rs17121510 in the interleukin-10 receptor antagonist (IL-10RA) gene for allele (p = 0.01) and genotype (p = 3.34×10−4). The OR for the IL-10RA genotypic additive model was 1.92 [CI 1.15–3.19] (p = 2.00×10−3). Finally, exploratory multi-locus analyses in the complement and coagulation pathway were performed and revealed a potentially significant interaction between a marker in FV (rs2187952) and FVII (rs3211719) (p<0.001). These results support a role for genes in both the coagulation and inflammation pathways, and potentially different maternal and fetal genetic risks for PTB